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  • EBMT
  • Origin electricity faults 1, 2, 3, 4 The annual activity survey of the European Society of Blood and Marrow Transplantation (EBMT), describing the status of HSCT in Europe and affiliated countries, has become an instrument used to observe trends and to monitor changes in technology use. (gaselectricity.in)
  • Provides both EBMT members and other physicians involved in bone marrow transplant with information on related meetings, registries and data management, transplant guidelines, accreditation and corporate sponsorship. (dmoztools.net)
  • acute
  • Another stem-cell therapy called Prochymal, was conditionally approved in Canada in 2012 for the management of acute graft-vs-host disease in children who are unresponsive to steroids. (wikipedia.org)
  • PLX-R18 were initially developed with Prof Raphael Gorodetsky at Hadassah Hospital for the treatment of acute radiation syndrome and enhancement of bone marrow regeneration. (wikipedia.org)
  • The U.S. National Institutes of Health is currently evaluating Pluristem's PLX-R18 cells as a treatment for acute radiation syndrome. (wikipedia.org)
  • 2001
  • Pluristem was founded in 2001 by Shai Meretzki of the Technion, who made use of a stem cell patent which was developed during his Ph.D studies at The Rappaport Faculty Of Medicine, Technion, under the supervision of Dr. Shosh Merchav, together with Professors Dov Zipori and Avinoam Kadouri from the Weizmann Institute of Science. (wikipedia.org)
  • Cancer
  • Gale has published over 1000 scientific articles and more than 20 books, mostly on leukemia (biology and treatment), transplantation (biology, immunology and treatment), cancer immunology and radiation (biological effects and accident response). (wikipedia.org)
  • For example, T cells capable of fighting cancer cells via cell-mediated immunity may be injected in the course of immunotherapy. (wikipedia.org)
  • myocardial infarction
  • Among several clinical trials that have reported that adult stem-cell therapy is safe and effective, powerful effects have been reported from only a few laboratories, infarcts as well as heart failure not arising from myocardial infarction. (wikipedia.org)
  • An example of this is the use of cells to replace cardiomyocytes after myocardial infarction. (wikipedia.org)
  • Organization
  • Electricity notes pdf This coincides with the recent interest of the World Health Organization (WHO) ( www.who.org) in cell and tissue transplants, and further stresses the need for adequate and timely information. (gaselectricity.in)
  • therapy
  • Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition. (wikipedia.org)
  • this is the only form of stem-cell therapy that is widely practiced. (wikipedia.org)
  • Adult stem cell therapy for treating heart disease was commercially available in at least five continents as of 2007. (wikipedia.org)
  • Cell therapy originated in the nineteenth century when scientists experimented by injecting animal material in an attempt to prevent and treat illness. (wikipedia.org)
  • Today two distinct categories of cell therapy are recognized. (wikipedia.org)
  • The first category is cell therapy in mainstream medicine. (wikipedia.org)
  • Cell therapy can be defined as therapy in which cellular material is injected into a patient. (wikipedia.org)
  • The origins of cell therapy can perhaps be traced to the nineteenth century, when Charles-Édouard Brown-Séquard (1817-1894) injected animal testicle extracts in an attempt to stop the effects of aging. (wikipedia.org)
  • In 1931 Paul Niehans (1882-1971) - who has been called the inventor of cell therapy - attempted to cure a patient by injecting material from calf embryos. (wikipedia.org)
  • Bone marrow transplants have been found to be effective, along with some other kinds of human cell therapy - for example in treating damaged knee cartilage. (wikipedia.org)
  • In recent times, cell therapy using human material has been recognized as an important field in the treatment of human disease. (wikipedia.org)
  • The experimental field of Stem cell therapy has shown promise for new types of treatment. (wikipedia.org)
  • In mainstream medicine, cell therapy is supported by a distinct healthcare industry which sees strong prospects for future growth. (wikipedia.org)
  • Cell therapy is targeted at many clinical indications in multiple organs and by several modes of cell delivery. (wikipedia.org)
  • tissue
  • Active enhancement of tissue allografts with antilymphocyte serum and bone marrow. (ac.ir)
  • Adipose tissue (lipid cells), which requires extraction by liposuction. (wikipedia.org)
  • In practice, stem cells are identified by whether they can regenerate tissue. (wikipedia.org)
  • These cells then integrate into the site of injury, replacing damaged tissue, and thus facilitate improved function of the organ or tissue. (wikipedia.org)
  • Program
  • In August 2016, Europe's Horizon 2020 Program awarded Pluristem an $8 million grant to cover a portion of its expenses in Europe for Pluristem's Phase III study of PLX-PAD cells in the treatment of critical limb ischemia. (wikipedia.org)
  • SBUH also encompasses Suffolk County's only Level 4 Regional Perinatal Center, state-designated AIDS Center, state-designated Comprehensive Psychiatric Emergency Program, state-designated Burn Center, the Christopher Pendergast ALS Center of Excellence, and Kidney Transplant Center. (wikipedia.org)
  • He also developed the bone marrow transplant program supported by the NIH. (wikipedia.org)
  • soluble factors
  • Cells that have the capacity to release soluble factors such as cytokines, chemokines, and growth factors which act in a paracrine or endocrine manner. (wikipedia.org)
  • Research
  • Research into stem cells grew out of findings by Ernest A. McCulloch and James E. Till at the University of Toronto in the 1960s. (wikipedia.org)
  • Research is underway to develop various sources for stem cells, and to apply stem-cell treatments for neurodegenerative diseases and conditions such as diabetes, heart disease, and other conditions. (wikipedia.org)
  • Research has been conducted on the effects of stem cells on animal models of brain degeneration, such as in Parkinson's, Amyotrophic lateral sclerosis, and Alzheimer's disease. (wikipedia.org)
  • As of 2008 clinical research at the University of Minnesota has included a bone marrow transplant to a 2-year-old child who is one of 2 brothers with EB. (wikipedia.org)
  • Describes services and research for fighting against malignancies by expanding the effectiveness and applicability of bone marrow transplantation. (dmoztools.net)
  • Although such attempts produced no positive benefit, further research found in the mid twentieth century that human cells could be used to help prevent the human body rejecting transplanted organs, leading in time to successful bone marrow transplantation. (wikipedia.org)
  • patients
  • Wherever appropriate, patient numbers corresponding to the number of patients receiving a first transplant and transplant numbers reflecting the total number of transplants performed are listed. (gaselectricity.in)
  • Transplant rates, defined as the total number of HSCT per 10 million inhabitants, were computed for each country without adjustments for patients who crossed borders and received their HSCT in a foreign country. (gaselectricity.in)
  • The present study investigated the effect of donor stem cells on improving transplant survival and reducing the need to use repressive drugs in patients with kidney transplant. (ac.ir)
  • Five out of eight patients in the control group acutely rejected the transplant in comparison with two out of five patients in the intervention group. (ac.ir)
  • The evaluation of peripheral active chimerism in two patients with stable transplant and normal function showed that peripheral chimerism was detectable up to 3 months after transplantation. (ac.ir)
  • Indeed, at least four patients have died in the course of either preparation for or institution of bone marrow transplantation for epidermolysis bullosa, out of only a small group of patients treated so far. (wikipedia.org)
  • Provides information about bone marrow transplantation procedures offered and clinical trials involving Mayo Clinic patients. (dmoztools.net)
  • For the last two years prior to the merger, the three organisations had been working closely together and the merger was a natural move to work towards high-quality stem cell products worldwide for patients in need of a transplant. (wikipedia.org)
  • A Phase III trial of PLX-(PAD)-peripheral arterial disease cells in the treatment of critical limb ischemia has been cleared to start enrolling patients by the U.S. Food and Drug Administration. (wikipedia.org)
  • types
  • Stem cells can now be artificially grown and transformed (differentiated) into specialized cell types with characteristics consistent with cells of various tissues such as muscles or nerves. (wikipedia.org)
  • experimental
  • In May 2012, Pluristem reported that its experimental PLacental eXpanded cells were injected into the muscles of a 7-year-old Romanian girl undergoing treatment for bone marrow aplasia disease at the Hadassah Medical Center in Jerusalem. (wikipedia.org)
  • treatment
  • In addition to its use in bone marrow transplantation, total body irradiation has been explored as a treatment modality for high-risk Ewing sarcoma. (wikipedia.org)
  • Pluristem Therapeutics is an Israeli company engaged in the development of human placental adherent stromal cells for commercial use in disease treatment. (wikipedia.org)
  • Pluristem announced that the treatment led to a significant increase in the girl's red cells, white cells and platelets, effecting a reverse in her condition. (wikipedia.org)
  • In September 2012 Pluristem reported saving the life of a third bone marrow disease patient using its PLacental eXpanded cell treatment, again at Jerusalem's Hadassah Medical Center and again under the terms of compassionate use. (wikipedia.org)
  • treatments
  • Nevertheless, these cells are being investigated as the basis for a number of therapeutic applications, including possible treatments for diabetes and Parkinson's disease. (wikipedia.org)
  • tissues
  • Combining two-photon microscopy with fluorescent tracers, we successfully visualized the engrafted tissues at the single cell level in live mice over several months. (jove.com)
  • Imaging using confocal/two-photon hybrid microscopy enables simultaneous high resolution assessment of uniquely marked cells and their progeny in conjunction with structural components of the tissues. (jove.com)
  • Volumetric analyses over large areas reveal that spectrally coded HSPC-derived cells can be detected non-invasively in various intact tissues, including the bone marrow (BM), for extensive periods of time following transplantation. (jove.com)
  • Another kind of cell-the pluripotent stem cell of mouse teratocarcinomas-was found to give rise to normal tissues in adult chimeras after injection into the mouse blastocyst. (thefreedictionary.com)
  • All the differentiated tissues in the tumor arise from pluripotent stem cells known as embryonal carcinoma (EC) cells. (thefreedictionary.com)
  • When embryonal carcinoma cells are injected into a genetically marked host blastocyst, they continue to divide and participate in normal development, and give rise to fully differentiated cells in all tissues of the adult, including skin, muscle, nerve, kidney, and blood. (thefreedictionary.com)
  • The diagnosis of CLL is based on the demonstration of an abnormal population of B lymphocytes in the blood, bone marrow, or tissues that display an unusual but characteristic pattern of molecules on the cell surface. (wikipedia.org)
  • Genetic
  • Genetic combinatorial marking using lentiviral vectors encoding fluorescent proteins (FPs) enabled cell fate mapping through advanced microscopy imaging. (jove.com)
  • The underlying mechanism involves multiple genetic mutations that results in rapid cell division. (wikipedia.org)
  • undergo
  • In addition, post-meiotic germ cells undergo a dramatic morphological reshaping process as well as a global epigenetic reconfiguration of the germ line chromatin-the histone-to-protamine switch. (jove.com)
  • cartilage
  • While cartilage, ligaments, and fat present low antigenicity, bone, muscles, nerves, and vessels present moderate antigenicity, and skin is the component that develops the most severe rejection because of the abundance of dendritic cells within the epidermis and dermis. (springer.com)
  • susceptibility
  • Experimental chimeras have been used to study a number of biological questions, including the origin and fate of cell lineages during embryonic development, immunological self-tolerance, tumor susceptibility, and the nature of malignancy. (thefreedictionary.com)
  • kidney
  • SBUH also encompasses Suffolk County's only Level 4 Regional Perinatal Center, state-designated AIDS Center, state-designated Comprehensive Psychiatric Emergency Program, state-designated Burn Center, the Christopher Pendergast ALS Center of Excellence, and Kidney Transplant Center. (wikipedia.org)
  • Stony Brook is home to Long Island's first kidney transplantation program which has performed over 1,000 transplants, and initiated the nation's first Pediatric Multiple Sclerosis Center. (wikipedia.org)
  • differentiation
  • This includes differentiation from a stem cell population, mitotic amplification, and meiosis. (jove.com)
  • Differentiation and proliferation of hematopoietic stem cells require a lot of energy and this energy is supplied by the mitochondria. (wikipedia.org)
  • This atypical molecular pattern includes the coexpression of cell surface markers clusters of differentiation 5 (CD5) and 23. (wikipedia.org)
  • In CLL, the lymphocytes are genetically clonal, of the B cell lineage (expressing marker molecules clusters of differentiation 19 and 20), and characteristically express the marker molecules CD5 and CD23. (wikipedia.org)
  • adult
  • However, embryonal carcinoma cells from some other sources fail to integrate, but produce teratocarcinomas in the newborn animal or adult. (thefreedictionary.com)
  • The hospital is also the regional referral center for trauma, perinatal and neonatal intensive care, burns, bone marrow and stem cell transplantation, cystic fibrosis, pediatric and adult AIDS, and is the regional resource center for emergency management. (wikipedia.org)
  • involves
  • Aggregation chimeras are produced by a technique that involves removing the zonae pellucidae from around 8-16 cell embryos of different strains of mice and pushing the morulae together so that the cells can aggregate. (thefreedictionary.com)
  • germ cells
  • During spermatogenesis in mammals and in Drosophila melanogaster, male germ cells develop in a series of essential developmental processes. (jove.com)
  • lymphocytes
  • Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). (wikipedia.org)
  • Diagnosis is typically based on blood tests finding high numbers of mature lymphocytes and smudge cells. (wikipedia.org)
  • Normal B lymphocytes consist of a stew of different antibody-producing cells, resulting in a mixture of both kappa- and lambda-expressing cells. (wikipedia.org)
  • These B cells resemble normal lymphocytes under the microscope, although slightly smaller, and are fragile when smeared onto a glass slide, giving rise to many broken cells, which are called "smudge" or "smear" cells. (wikipedia.org)
  • Normal lymphoblasts develop into mature, infection-fighting B-cells or T-cells, also called lymphocytes. (wikipedia.org)
  • proliferation
  • ALL emerges when a single lymphoblast gains many mutations to genes that affect blood cell development and proliferation. (wikipedia.org)
  • Vectors
  • Vectors encoding five different FPs: Cerulean, EGFP, Venus, tdTomato, and mCherry were used to concurrently transduce HSPCs, creating a diverse palette of color marked cells. (jove.com)
  • evaluate
  • The two cell types were transfected with green fluorescent protein to evaluate their fate after implantation in an intraarticular environment of the knee joint. (celltherapynews.com)
  • mice
  • cells in diabetic mice, and that the anti-hyperglycemic efficacy of this combination was better than that of 1-deoxynojirimycin (DNJ) or polysachharide alone. (jove.com)
  • markers
  • Investigators induced dopaminergic (DA) neurons using scalable culture conditions on human laminin fragment, and the sorted CORIN + cells expressed the midbrain DA progenitor markers, FOXA2 and LMX1A. (celltherapynews.com)
  • epigenetic changes
  • Gene expression can be stably altered through epigenetic changes which not only allow cells and organisms to quickly respond to changing environmental stimuli but also confer the ability of the cell to "memorize" these encounters once the stimulus is removed. (jove.com)
  • These rearrangements result in increased expression of blood cell development genes by promoting gene transcription and through epigenetic changes. (wikipedia.org)
  • behavior
  • Two-photon microscopy has enabled the study of individual cell behavior in live animals. (jove.com)
  • different
  • This view was first challenged by the 2002 discovery by the Muller-Sieburg group in San Diego, who illustrated that different stem cells can show distinct repopulation patterns that are epigenetically predetermined intrinsic properties of clonal Thy-1lo Sca-1+ lin− c-kit+ HSC. (wikipedia.org)
  • time
  • Four dimensional (three-dimensional (3D) plus time) information of individual cells was obtained from this imaging. (jove.com)
  • On average, the transport time for stem cells from the hospital to CBR's lab is 19 hours. (stemcellcordblood.net)