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  • involves
  • One treatment that was considered promising at the start of the 1990's was use of autograft, which involves transplantation of a woman's own bone marrow or peripheral stem cells to regenerate her bone marrow. (cochrane.org)
  • This usually involves inserting a needle into the back of the patients hip bone and removing the sample from there. (wikipedia.org)
  • Bone marrow suppression due to anti-cancer chemotherapy is much harder to treat and often involves hospital admission, strict infection control, and aggressive use of intravenous antibiotics at the first sign of infection. (wikipedia.org)
  • The WM spectrum of dysplasias differs from other spectrums of plasma cell dyscrasias in that it involves not only aberrant plasma cells but also aberrant lymphoplasmacytoid cells and that it involves IgM while other plasma dyscrasias involve other antibody isoforms. (wikipedia.org)
  • cyclophosphamide
  • Patients receive cyclophosphamide IV over 1 hour on day 1 and paclitaxel IV over 4 or 24 hours on day 2, followed by daily filgrastim (G-CSF) subcutaneously beginning on day 3 and continuing through day 7 or until WBCs are greater than 100,000 cells/mm3. (clinicaltrials.gov)
  • precursors
  • Parvovirus B19 inhibits erythropoiesis by lytically infecting RBC precursors in the bone marrow and is associated with a number of different diseases ranging from benign to severe. (wikipedia.org)
  • blood
  • For some types of blood diseases, transplantation is the standard of care. (uchospitals.edu)
  • The donated tissue repopulated the marrow and restored production of the blood cells. (uchospitals.edu)
  • HLA typing uses a blood test to analyze human lymphocyte antigens (HLA) found on the surface of white blood cells. (mountsinai.org)
  • However, when using this AM, the BMCs are contaminated with peripheral blood with the result that there are more than 20% of T cells in the BMCs, which in turn leads to the induction of GvHD. (omicsonline.org)
  • Approximately 20 ml bone marrow was harvested from iliac crests and 400 - 600 ml peripheral blood was collected to prepare serum for culture. (ahajournals.org)
  • It has been reported that intramyocardial stem cell transplantation can notably increase the perfusion of blood in ischemic myocardium and improve heart functions [ 1 , 2 ]. (omicsonline.org)
  • Stem cells can mature into blood cells (white blood cells, red blood cells, and platelets), which are often damaged by cancer. (doctors-hospital.net)
  • they enter your blood stream and travel to your bone marrow where they replace damaged stem cells and begin to make healthy blood cells. (doctors-hospital.net)
  • Blood samples will also be collected to see if infection fighting cells are working. (knowcancer.com)
  • This allows the bone marrow to recover, proliferate and continue producing healthy blood cells. (wikipedia.org)
  • The transplantation may be autologous (an individual's own blood cells saved earlier), allogeneic (blood cells donated by someone else with matching HLA), or syngeneic (blood cells donated by an identical twin). (wikipedia.org)
  • Bone marrow suppression also known as myelotoxicity or myelosuppression, is the decrease in production of cells responsible for providing immunity (leukocytes), carrying oxygen (erythrocytes), and/or those responsible for normal blood clotting (thrombocytes). (wikipedia.org)
  • The decrease in blood cell counts does not occur right at the start of chemotherapy because the drugs do not destroy the cells already in the bloodstream (these are not dividing rapidly). (wikipedia.org)
  • Instead, the drugs affect new blood cells that are being made by the bone marrow. (wikipedia.org)
  • Because the bone marrow is the manufacturing center of blood cells, the suppression of bone marrow activity causes a deficiency of blood cells. (wikipedia.org)
  • This condition can rapidly lead to life-threatening infection, as the body cannot produce leukocytes in response to invading bacteria and viruses, as well as leading to anaemia due to a lack of red blood cells and spontaneous severe bleeding due to deficiency of platelets. (wikipedia.org)
  • Bernard Babior made key contributions in linking the defect of superoxide production of white blood cells, to the cause of the disease. (wikipedia.org)
  • Evans syndrome is an autoimmune disease in which an individual's antibodies attack their own red blood cells and platelets. (wikipedia.org)
  • Autoimmune hemolytic anemia is a condition in which the red blood cells that normally carry oxygen and carbon dioxide are destroyed by an autoimmune process. (wikipedia.org)
  • Serious side effects may include serotonin syndrome, bone marrow suppression, and high blood lactate levels, particularly when used for more than two weeks. (wikipedia.org)
  • Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). (wikipedia.org)
  • CLL results in the build up of B cell lymphocytes in the bone marrow, lymph nodes, and blood. (wikipedia.org)
  • These cells do not function well and crowd out healthy blood cells. (wikipedia.org)
  • Diagnosis is typically based on blood tests finding high numbers of mature lymphocytes and smudge cells. (wikipedia.org)
  • Most people are diagnosed without symptoms as the result of a routine blood test that shows a high white blood cell count. (wikipedia.org)
  • Less commonly, CLL may present with enlarged lymph nodes without a high white blood cell count or no evidence of the disease in the blood. (wikipedia.org)
  • CLL is usually first suspected by a diagnosis of lymphocytosis, an increase in a type of white blood cell, on a complete blood count test. (wikipedia.org)
  • Most often the lymphocyte count is greater than 5000 cells per microliter (µl) of blood, but can be much higher. (wikipedia.org)
  • The diagnosis of CLL is based on the demonstration of an abnormal population of B lymphocytes in the blood, bone marrow, or tissues that display an unusual but characteristic pattern of molecules on the cell surface. (wikipedia.org)
  • Both cell types are white blood cells. (wikipedia.org)
  • This is attributed to the IgM monoclonal protein increasing the viscosity of the blood by forming aggregates to each other, binding water through their carbohydrate component and by their interaction with blood cells. (wikipedia.org)
  • A diagnosis of Waldenström's macroglobulinemia depends on a significant monoclonal IgM spike evident in blood tests and malignant cells consistent with the disease in bone marrow biopsy samples. (wikipedia.org)
  • antigen
  • MSCs can also produce an immunomodulating effect by stimulating the maturation of antigen presenting cells. (wikipedia.org)
  • proliferation
  • By suppressing the unregulated proliferation of T and B cells, MSCs can potentially minimize and control on-going damage to the CNS. (wikipedia.org)
  • MicroRNA-155 regulates the proliferation and growth of WM cells in vitro and in vivo, by inhibiting MAPK/ERK, PI3/AKT, and NF-κB pathways. (wikipedia.org)
  • anemia
  • Infiltration of the bone marrow may cause pallor from anemia. (wikipedia.org)
  • Autoantibodies targeted at different antigenic determinants on red cells and platelets are assumed to cause isolated episodes of hemolytic anemia and thrombocytopenia, respectively. (wikipedia.org)
  • In some individuals, the disease comes to light only after the cancerous cells overwhelm the bone marrow resulting in anemia producing tiredness or weakness. (wikipedia.org)
  • migrate
  • When the thus-collected cells are intravenously injected (IV-BMT), most become trapped in the lung and only a few are able to migrate to the BM [ 14 ]. (omicsonline.org)
  • endothelial
  • Prussian blue-positive cells were differentiated into new vascular endothelial cells in two cases, among which the gaps were widened in the microbubble destruction group. (omicsonline.org)
  • chronic
  • Chronic granulomatous disease (CGD) (also known as Bridges-Good syndrome, chronic granulomatous disorder, and Quie syndrome) is a diverse group of hereditary diseases in which certain cells of the immune system have difficulty forming the reactive oxygen compounds (most importantly the superoxide radical due to defective phagocyte NADPH oxidase) used to kill certain ingested pathogens. (wikipedia.org)