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  • engraftment
  • Once these MSCs are ready for re-implanation, they are usually transferred with growth factors to allow for continued cell growth and engraftment to the damaged tissue. (wikipedia.org)
  • transplants
  • Other conditions treated with stem cell transplants include sickle-cell disease , myelodysplastic syndrome , neuroblastoma , lymphoma , Ewing's sarcoma , desmoplastic small round cell tumor , chronic granulomatous disease , Hodgkin's disease and Wiskott-Aldrich syndrome . (wikipedia.org)
  • Allogeneic stem cell transplants for patients who are older or have overall poor health are relatively uncommon. (lls.org)
  • However, reduced intensity allogeneic stem cell transplants may be an appropriate treatment for some older or sicker patients. (lls.org)
  • HSCTs
  • Candidates for HSCTs include pediatric cases where the patient has an inborn defect such as severe combined immunodeficiency or congenital neutropenia with defective stem cells, and also children or adults with aplastic anemia who have lost their stem cells after birth. (wikipedia.org)
  • More than 25,000 hematopoietic stem cell transplantations (HSCTs) are performed each year for the treatment of lymphoma, leukemia, immune-deficiency illnesses, congenital metabolic defects, hemoglobinopathies, and myelodysplastic and myeloproliferative syndromes. (dovepress.com)
  • progenitor
  • A recent study conducted in mice, baboons, and human volunteers has shown that a non-steroidal anti-inflammatory drug approved by the U.S. Food and Drug Administration (FDA), called meloxicam, significantly increased the number of blood (hematopoietic) stem cells (HSCs) and their descendent hematopoietic progenitor cells (HPCs) entering the circulation from the bone marrow, where they typically reside until needed. (nih.gov)
  • The levels of HSCs and HPCs normally found in blood are very low, and strategies have been devised to mobilize HSCs and progenitor cells out of the bone marrow and into the circulation. (nih.gov)
  • Differential stem‑ and progenitor‑cell trafficking by prostaglandin E2. (nih.gov)
  • Dr. Khay-Yong Saw and his team evaluated the quality of the repair knee cartilage after arthroscopic microdrilling (also microfracture) surgery followed by post-operative injections of autologous peripheral blood progenitor cells (PBPC) in combination with hyaluronic acid(HA). (wikipedia.org)
  • infantile osteopetrosis
  • Neuropathic infantile osteopetrosis Infantile osteopetrosis with renal tubular acidosis Infantile osteopetrosis with immunodeficiency IO with leukocyte adhesion deficiency syndrome (LAD-III) Intermediate osteopetrosis Autosomal dominant osteopetrosis (Albers-Schonberg) Pyknodysostosis (osteopetrosis acro-osteolytica) Osteopoikilosis (Buschke-Ollendorff syndrome) Osteopathia striata with cranial sclerosis Mixed sclerosing bone dysplasia Progressive diaphyseal dysplasia (Camurati-Engelmann disease) SOST-related sclerosing bone dysplasias The only effective line of treatment for malignant infantile osteopetrosis is hematopoietic stem cell transplantation. (wikipedia.org)
  • citation needed] Radiographs of at least one case with malignant infantile osteopetrosis have demonstrated bone remodeling and recanalization of medullar canals following hematopoietic stem cell transplantation. (wikipedia.org)
  • antigens
  • A lab technician examines the surface of the sample tissue cells to identify the proteins that give everyone his or her own unique tissue type, called human leukocyte antigens (HLAs). (lls.org)
  • proliferation
  • The researchers performed in-depth analysis of the effects of labeling on the stem cells, including its effects on cell proliferation, differentiation, survival and electrophysiology. (photonics.com)
  • Granulocyte colony stimulating factor (GCSF) are naturally occurring glycoproteins that stimulate white blood cell proliferation. (wikipedia.org)
  • PBSC donors are given a course of GCSF prior to PBSC collection, this ensures a better outcome, as stem cell proliferation increases, thus increasing the number of peripheral stem cells in circulation. (wikipedia.org)
  • Differentiation and proliferation of hematopoietic stem cells require a lot of energy and this energy is supplied by the mitochondria. (wikipedia.org)
  • antibodies
  • B cell immune responses are measured by analyzing antibodies produced through the humoral immune response. (wikipedia.org)
  • It is similar to the ELISA assay in that antibodies bound to plastic wells are used to bind the cytokines secreted by T cells. (wikipedia.org)
  • Tests for T cell function: skin tests for delayed-type hypersensitivity, cell responses to mitogens and allogeneic cells, cytokine production by cells Tests for B cell function: antibodies to routine immunisations and commonly acquired infections, quantification of IgG subclasses Tests for phagocyte function: reduction of nitro blue tetrazolium chloride, assays of chemotaxis, bactericidal activity. (wikipedia.org)
  • MSCs
  • This study used MSCs, cells which are believed to be "immune-privileged," with no rejection issues. (medindia.net)
  • cyclophosphamide
  • Cyclophosphamide is designed to interfere with the multiplication of cancer cells, which may slow or stop their growth and spread throughout the body. (knowcancer.com)
  • tumor
  • In addition to producing the new bone marrow, the donated cells also fight any residual tumor cells that might have remained in the body. (bioportfolio.com)
  • Duplicated segments of the LMO1 gene within neuroblastoma tumor cells have been shown to increase the risk of developing an aggressive form of the cancer. (wikipedia.org)
  • survival
  • The hematopoietic niche of the bone marrow supports the survival and self-renewal of HSCs and HPCs, yet prevents the ill-timed release of these cells into the circulation. (nih.gov)
  • This suggested that the transplanted cells could have a beneficial impact when they released trophic factors, agents that stimulate differentiation and survival of cells and then engrafted into the smooth muscle of the urethra and vagina, as demonstrated previously in prior studies. (medindia.net)
  • Abnormal
  • to treat the cancer Abnormal cell growth that cannot be controlled by the body's natural defenses. (lymphoma.org)
  • In practice, this is inferred by the detection of only one of the mutually exclusive antibody light chains, kappa or lambda, on the entire population of the abnormal B cells. (wikipedia.org)