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  • centers
  • The study, presented in the plenary session of the 53rd annual American Society of Hematology conference in San Diego, was conducted by the Blood and Marrow Transplant Clinical Trials Network (BMT CTN), a collaborative effort of the Center for International Blood and Marrow Transplant Research (CIBMTR) at the Medical College of Wisconsin, the National Marrow Donor Program (NMDP), and the EMMES Corporation, together with 20 core transplant centers/consortia. (healthcanal.com)
  • The randomized study included 50 transplant centers in the United States and Canada and compared two-year survival rates for 273 patients receiving PBSC with 278 patients receiving bone marrow. (healthcanal.com)
  • Since 2001, the BMT CTN has opened more than 27 multi-institutional phase II and III trials, involved more than 100 transplant centers, and enrolled thousands of patients. (healthcanal.com)
  • BMT CTN is funded through the National Institutes of Health (NIH) and is a collaborative effort of the CIBMTR at the Medical College of Wisconsin, the National Marrow Donor Program (NMDP), and the EMMES Corporation, together with 20 Core Transplant Centers/Consortia. (healthcanal.com)
  • Many stem cell transplant centers will look at more than the crucial six HLA types of antigens in order to a select a donor and insure an ideal match. (wdxcyber.com)
  • The first three phases of this study will have been conducted over a six-year period at approximately 23 collaborating transplant centers and completed enrollment of multi-center cases of March 31, 2006. (knowcancer.com)
  • Aplastic Anemia
  • An incident case will be defined as any transplant recipient, or an immunocompromised patient (i.e., having inherited immunodeficiencies, aplastic anemia or general oncology) with proven or probable invasive fungal infection meeting the criteria for IFI as described by the MSG/EORTC guidelines. (knowcancer.com)
  • proliferation
  • Their work revealed that Del-1 was expressed by at least three cell types in the bone marrow and promoted proliferation and differentiation of hematopoietic stem cells, sending more of these progenitor cells down a path toward becoming myeloid cells, such as macrophages and neutrophils. (medindia.net)
  • Using mice deficient in Del-1, they found that the protein promotes proliferation and differentiation of hematopoetic stem cells, sending more of these progenitor cells down a path toward becoming myeloid cells, such as macrophages and neutrophils, rather than lymphocytes, such as T cells and B cells. (technologynetworks.com)
  • clinical
  • Follow this true story of a former NCI employee, Serena Marshall, as she takes you through her blood stem cell donation experience at the National Institutes of Health Clinical Center in Bethesda, MD. (cinj.org)
  • These claims did not have clinical evidence supporting that an inpatient level of care was required before, during, or after the transplant procedures were performed. (hhs.gov)
  • Additional rounds of bone marrow harvest and clinical applications to mobilize blood stem cells are often required. (redorbit.com)
  • tumors of germ cells
  • The main focuses of research, diagnosis and treatment are on leukemia and lymphomas, malignancies of the gastrointestinal tract, tumors of germ cells (e.g. testicles) and malignancies of bone and connective tissues. (bookinghealth.com)
  • protein
  • Because the hematopoietic stem cell niche is so important for the creation of bone marrow and blood cells and because Del-1 is a soluble protein and easily manipulated, one can see that it could be a target in many potential applications," said senior author George Hajishengallis , Thomas W. Evans Centennial Professor of Microbiology at Penn Dental Medicine. (medindia.net)
  • Human Leukocyte Antigens (HLA) is a type of protein that is found on the outer surfaces of cells. (wdxcyber.com)
  • HLA protein is made up of six antigens, molecules that stimulate an immune response and help your body identify which cells belong to your body and which do not. (wdxcyber.com)
  • Hajishengallis, Chavakis and their colleagues identified the protein on hematopoetic stem cells with which Del-1 interacts, the ß3 integrin, perhaps pointing to a target for therapeutic interventions down the line. (technologynetworks.com)
  • The more HOXB4 protein there is in stem cells, the more they will self-renew and expand their population," Dr. Zhou says. (redorbit.com)
  • Also, other investigators have shown that it is possible to directly insert HOXB4 protein into extracted bone marrow stem cells. (redorbit.com)
  • All you do is add a little tag to the protein, which acts like a vehicle, driving the proteins through the cell membrane, directly into the nucleus," Dr. Zhou says. (redorbit.com)