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Bone Marrow TransplantationTransplantation, AutologousBone MarrowTransplantation, HomologousBone Marrow CellsCombined Modality TherapyHematopoietic Stem Cell TransplantationGraft vs Host DiseaseWhole-Body IrradiationBone Marrow PurgingAntineoplastic Combined Chemotherapy ProtocolsBone and BonesTransplantation ConditioningHematopoietic Stem CellsStem Cell TransplantationLeukemiaStem CellsCyclophosphamideTissue DonorsAnemia, AplasticGraft SurvivalBusulfanLymphoma, Non-HodgkinTreatment OutcomeHistocompatibility TestingHematologic NeoplasmsRecurrenceTransplantation ChimeraLeukemia, Myeloid, AcuteHistocompatibilityImmunosuppressive AgentsCytomegalovirus InfectionsTime FactorsBone Marrow DiseasesRemission InductionHematopoiesisCarmustineKidney TransplantationPrecursor Cell Lymphoblastic Leukemia-LymphomaMelphalanLeukemia, Myelogenous, Chronic, BCR-ABL PositiveRetrospective StudiesColony-Forming Units AssayHodgkin DiseaseTransplantation, IsogeneicSurvival AnalysisGraft RejectionImmunosuppressionLeukemia, MyeloidImmunocompromised HostHematologic DiseasesHepatic Veno-Occlusive DiseaseAcute DiseaseMice, Inbred C57BLOpportunistic InfectionsTransplantationBone Marrow ExaminationCyclosporineBone RemodelingEtoposideCell DifferentiationRadiation ChimeraSurvival RateFollow-Up StudiesBone Marrow NeoplasmsMultiple MyelomaPeripheral Blood Stem Cell TransplantationMyelodysplastic SyndromesLiver TransplantationT-LymphocytesLymphocyte DepletionActuarial AnalysisCytarabineDisease-Free SurvivalHLA AntigensAntigens, CD34Granulocyte Colony-Stimulating FactorSalvage TherapyMycosesFatal OutcomeLymphomaHematopoietic Stem Cell MobilizationCells, CulturedLeukocyte TransfusionFlow CytometryCytomegalovirusHeart TransplantationGraft vs Host ReactionLeukocyte CountMesenchymal Stem Cell TransplantationBone DensityAspergillosisTransplantation ImmunologyPrognosisProspective StudiesCell SeparationNeutropeniaThiotepaChimeraPolymerase Chain Reaction
Multiple myelomaMesenchymal stemHematopoietic stemASCTHSCTHigh-dose chemotherapyOncologyAcute leukemiaPeripheral blood stem cell transRecipientsProgenitorPatient's own cellsHematologySurvivalPerson'sUmbilicalDonors2000AbnormalHealthy blood cells and plateletsBloodIndication for transplantationMyelomaLymphomaBiopsyAllogeneic transplantsClinicalImmuneTherapiesSpongy tissueDonorTumorsCancerImmunologyTherapyUndergone2018AdultNewly diagnosedProcedure is calledOrgan transplantationPediatricEmbryonic StemLymphomas2016CancersChemotherapy or radiationMorbidity and mortaHaploidenticalTissueOrgansOutcomesAmyloidOutcomeSystemicKidneyTherapeutic
Multiple myeloma23
Mesenchymal stem3
  • While the origin of these tumors is still not definitively known, the two theories with the most support suggest that these tumors arise from a primitive cell derived either from an embryologic tissue called the neural crest, or from resident cells in the body (called mesenchymal stem cells) that have a capability to become one of a variety of tissue types. (sarcomahelp.org)
  • The transplantation of bone marrow-derived mesenchymal stem cells (BMMSCs) alleviates neuropathology and improves cognitive deficits in animal models with Alzheimer's disease. (biomedcentral.com)
  • Ma DD , 2007 , 'Expression of Neurofilament Proteins in Adult Bone Marrow Mesenchymal Stem Cells and Embryonic Stem Cells and Their Clinical Potential' , in Davenport LP (ed. (edu.au)
Hematopoietic stem4
  • The transplant procedure requires the harvesting of hematopoietic stem cells from a donor. (medscape.com)
  • Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
  • To describe the psychological suffering developed by patients transplanted with hematopoietic stem cells from a referral service in the state of Rio Grande do Norte. (bvsalud.org)
  • HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
ASCT7
  • OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
  • METHODS: Patient charts and our prospective ASCT database were assessed for the impact of documented variables on event free survival (EFS) and overall survival (OS), including salvage and conditioning regimens used, and PET/CT results before and after ASCT. (smw.ch)
  • But there is a current lack of data regarding the clinical benefit of autologous stem cell transplantation (ASCT) for patients with myeloma achieving early MRD-negative status after induction treatment, in addition to the interaction of longitudinal MRD status with ASCT. (bvsalud.org)
  • Our study revealed the enhanced clinical significance of ASCT in patients with transplant-eligible myeloma, regardless of early MRD status, particularly for high-risk patients. (bvsalud.org)
  • Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
  • PI) and immunomodulatory (IMiD) [eg, bortezomib thalidomide and dexamethasone (VTd), lenalidomide, bortezomib and dexamethasone (RVd)] with or without a CD38 monoclonal antibody, or Velcade® (bortezomib), cyclophosphamide, dexamethasone (VCd), and followed by a single or tandem autologous stem cell transplantation (ASCT). (who.int)
  • Participants within 12 months from initiation of induction therapy who achieved at least a partial response (PR) after autologous stem cell transplantation (ASCT) with or without consolidation, according to International Myeloma Working Group (IMWG 2016) criteria. (who.int)
HSCT19
  • Hematopoietic stem cell transplantation (HSCT) results in the alteration of several components of the immune system. (medscape.com)
  • Patients who undergo HSCT experience a sequential suppression of host defenses, resulting in varying infectious risk at different phases of the transplantation process. (medscape.com)
  • Although outcomes after HSCT have improved markedly since transplants were first utilized, infection remains an important source of morbidity. (medscape.com)
  • This article focuses on the common infections in patients who have undergone HSCT, the risk factors for these infections, and the approaches to their prevention and treatment. (medscape.com)
  • 30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
  • this is used in both autologous and allogenic HSCT. (bdbiosciences.com)
  • Body iron disorders have been reported after myeloablative conditioning in patients undergoing hematopoietic stem cell transplantation (HSCT). (karger.com)
  • In order to better understand the LPI kinetics and its determinants and implications, we undertook sequential LPI determinations before and after conditioning until engraftment in 25 auto-HSCT patients. (karger.com)
  • His research focus is on haematopoietic stem cell transplantation (HSCT) and translational research of normal and malignant stem cells. (edu.au)
  • In this report, we summarize the case of a patient with MM status post autologous HSCT and chronic kidney disease who experienced worsening hypertension along with a substantial increase in proteinuria shortly after the initiation of carfilzomib for the treatment of refractory disease. (biomedcentral.com)
  • For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
  • HSCT patients are presumed immunocompetent if they are at least 24 months post-HSCT, are not receiving immunosuppressive therapy, and do not have graft- versus-host disease (GVHD). (cdc.gov)
  • There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
  • are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
  • and phase mended strategies for preventing OIs in HSCT patients. (cdc.gov)
  • Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
  • Data were collected between March and September of 2016, through the evaluation of the medical records of 43 patients who underwent HSCT and developed some type of psychological distress. (bvsalud.org)
  • HSCT) has significantly modified the prognosis of when the pathological process involves BM or when patients with hereditary or acquired hematological, hematopoietic toxicity is the limiting factor in the oncological and immunological diseases and it is the aggressive treatment of the disease. (bvsalud.org)
  • Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
High-dose chemotherapy7
  • We extract blood cells, treat the cancer with high-dose chemotherapy , then place the cells back into the patient. (mdanderson.org)
  • Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
  • High-dose chemotherapy with autologous bone marrow transplantation: 11 years' experience in Zurich. (smw.ch)
  • however, Lalla et al, while reviewing published trials for the 2014 Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) guidelines, found that mucositis occurs in approximately 20-40% of patients receiving conventional chemotherapy and in 80% of patients receiving high-dose chemotherapy. (medscape.com)
  • Doctors extract stem cells from your blood or bone marrow, place them in frozen storage, and re-infuse them back into your body following high-dose chemotherapy to eliminate blood cancers. (bidmc.org)
  • The administration of bone marrow usually occurs after a patient has received high-dose chemotherapy or radiation. (ucsfhealth.org)
  • For autologous transplantation, the patient receives his or her own bone marrow or stem cells that were collected and frozen before admission for high-dose chemotherapy or radiation. (ucsfhealth.org)
Oncology1
  • The Division of Oncology cares for patients with various malignancies. (nymc.edu)
Acute leukemia1
Peripheral blood stem cell trans2
  • Now, stem cells are more often collected from blood (a peripheral blood stem cell transplant). (gomedii.com)
  • When the stem cells are collected from the blood, after stimulating the stem cells with a hormone called G-CSF, the transplant is called a peripheral blood stem cell transplant. (ucsfhealth.org)
Recipients8
  • In preparation for receipt of the stem cells, recipients undergo myeloablation to eliminate their own myeloid cells. (medscape.com)
  • Gassas A , Grant R , Richardson S , Dupuis LL , Doyle J , Allen U , Predictors of viridans streptococcal shock syndrome in bacteremic children with cancer and stem-cell transplant recipients. (cdc.gov)
  • It reportedly occurs primarily in autologous recipients. (nih.gov)
  • Strikingly, 12 cases occurred in 1997 with the majority in recipients of allogeneic matched sibling donor stem cells. (nih.gov)
  • Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
  • Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • In May 2010, the Sixty-third World Health Assembly adopted resolution WHA63.22,1 in which it endorsed the updated WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation and provided strategic directions to support progress in human organ, tissue and cell donation with the aim of maximizing the benefits of transplantation, meeting the needs of recipients, protecting donors and ensuring the dignity of all involved. (who.int)
  • Corneal disease (scarring or perforation) can be successfully addressed through transplantation in 80% of affected individuals.3 Tissue transplantation allows many recipients to return to economically productive lives and promotes their independence. (who.int)
Progenitor9
  • 2 Evaluation of harvest adequacy requires the use of reliable progenitor cell assays and this is usually achieved by CD34 cell counting using flow cytometry. (bdbiosciences.com)
  • CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
  • For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
  • Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
  • Flow cytometric applications for CD34+ cell identification and enumeration provide a rapid, quantitative and reproducible method to evaluate the progenitor cell population. (bdbiosciences.com)
  • The bone morrow contains several stem cell types including hematopoetic stem cells, endothelial progenitor cells, mesenchymal (stromal) stem cells and multipotent adult progenitor cells. (escardio.org)
  • Although there is no definitive evidence, combinations of progenitor cells seem to be more benefical than specific stem cell type for cardiac repair (3). (escardio.org)
  • Interestingly, contradictory data exist for transformation of bone marrow derived progenitor cells (BMPC) into new cardiomyocytes and alternative mechanisms as enhanced neovascularization, enhanced scar tissue formation due to augmented inflammatory response and decreased apoptosis have been suggested for the benefical effects of these cells on myocardial function after myocardial infarction (4). (escardio.org)
  • This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
Patient's own cells2
Hematology1
  • 8 The BD ® Stem Cell Enumeration Kit incorporates BD Trucountâ„¢ tubes to determine the absolute cell count, thereby eliminating variability associated with hematology-derived absolute counts. (bdbiosciences.com)
Survival12
  • 7 6 The 5-year survival rate from 2006 to 2012 was 62% for patients with DLBCL, 56% for those with MCL, and 88% for those with FL. (haematologica.org)
  • Cell therapy is a potential new treatment for post MI patients, but the main challenges are : the necessity to preserve immune competency and to gain adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
  • Repair of scar tissue constitutes a challenge for cardiac stem cell therapy due to lack of adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
  • Anti-CD45 radioimmunotherapy using (211)At with bone marrow transplantation prolongs survival in a disseminated murine leukemia model. (fredhutch.org)
  • Single-agent chemotherapy improved the average survival to four months and the development of combination chemotherapy regimens has further increased the average survival to approximately nine months with some patients surviving two years or longer. (yourcancercare.com)
  • Targeted therapies are anticancer drugs that interfere with specific pathways involved in cancer cell growth or survival. (yourcancercare.com)
  • Studies examining the survival and toxicity of therapies administered to treatment-refractory pediatric MB patients will be included. (biomedcentral.com)
  • Although applying multi-modal therapies (radiation, chemotherapy, and surgery) has increased 5-year survival amongst standard-risk MB patients, overall survival (OS) rates seem to have plateaued. (biomedcentral.com)
  • The benefits of human tissue transplantation can be seen in both children and adults, including in survival rates following severe burn trauma, recovery of movement, closure of chronic wounds, rehabilitation of heart function and restoration of sight. (who.int)
  • Kidney transplantation is a far more favourable treatment modality versus dialysis in terms of survival, quality of life and cost-effectiveness. (who.int)
  • Measuring the effect of newborn screening on survival after haematopoietic cell transplantation for severe combined immunodeficiency: a 36-year longitudinal study from the Primary Immune Deficiency Treatment Consortium. (cdc.gov)
  • The area of research for our group is malignant lymphomas - all possible aspects, aiming for the improvement of the quality of life and survival of these patients. (lu.se)
Person's5
Umbilical5
Donors4
20001
Abnormal3
  • Through this process, the cells that produced the abnormal cells are replaced with healthy cells that produce normal blood cells. (bidmc.org)
  • Myeloma cells produce excess abnormal proteins, called paraproteins, in the bone marrow that can cause your blood to become so thick that it flows sluggishly in your body, a condition called hyperviscosity. (webmd.com)
  • Abnormal proteins from myeloma cells can also damage the kidneys. (webmd.com)
Healthy blood cells and platelets2
Blood49
  • He also conducted research on the peritumoral vasculature in head and neck cancer, revealing that patients with metastatic disease were more likely to have high peritumoral blood microvessel density (MVD). (wikipedia.org)
  • Wisplinghoff H , Reinert RR , Cornely O , Seifert H . Molecular relationships and antimicrobial susceptibilities of viridans group streptococci isolated from blood of neutropenic cancer patients. (cdc.gov)
  • Leukemia can refer to all cancers affecting the white blood cells. (healthline.com)
  • Leukemia is a cancer of the blood cells. (healthline.com)
  • There are several broad categories of blood cells, including red blood cells (RBCs), white blood cells (WBCs), and platelets. (healthline.com)
  • Myeloid cells are immature blood cells that would normally become granulocytes or monocytes. (healthline.com)
  • An experienced medical team that is specially trained in blood and bone marrow transplantation. (templehealth.org)
  • In order to assess the incidence and analyze reasons which cause prolongation of hospital stay in patients engrafted after peripheral blood stem cell transplantation (PBSCT), we performed this retrospective analysis. (nature.com)
  • Peripheral blood stem cell and bone marrow transplantation for solid tumors and lymphomas: hematologic recovery and costs. (nature.com)
  • Bone marrow, the spongy tissue inside our bones, is the factory for blood cells. (mdanderson.org)
  • Blood cancers multiply uncontrollably, hindering the growth of these cells. (mdanderson.org)
  • The patient has low blood counts until the replaced cells replenish the patient's body with healthy cells. (mdanderson.org)
  • With a peripheral blood cell transplant, the donor receives growth factor shots to stimulate the bone marrow to push the stem cells into the blood. (mdanderson.org)
  • For many patients who don't have a well-matched, healthy donor, a cord blood transplant is a viable option. (mdanderson.org)
  • 2 HSCs are primarily found in bone marrow niches, but a small fraction of HSCs can also be found in the peripheral blood. (bdbiosciences.com)
  • 3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
  • This pharmacologically induced egress of HSCs into peripheral blood, called mobilization, is utilized as the preferred strategy for generating HSCs for transplantation. (bdbiosciences.com)
  • 3 Autologous stem cell transplantation almost exclusively uses peripheral blood, while for allogeneic SCT, T-lymphocytes in the peripheral blood could pose some danger. (bdbiosciences.com)
  • These include bone marrow-derived cells, peripheral blood derived stem cells and skeletal myoblasts (3). (escardio.org)
  • They then injected the patients with their own immune stem cells, obtained from the patients' blood before the chemotherapy, to create a new immune system. (scienceblog.com)
  • The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
  • Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
  • Bone marrow transplantation, begun in 1983, and stem cell transplantation have grown to encompass allogeneic, unrelated, cord blood, autologous transplants and mini-allogeneic (reduced intensity conditioning) transplantation strategies. (nymc.edu)
  • In patients with diabetes the increased levels of glucose in the blood, the increased level of inflammation, and the problems at the level of beta cells all facilitate the emergence of symptoms that are more severe. (diabetesresearch.org)
  • Acute lymphoblastic leukemia (ALL), also called acute lymphocytic leukemia, is a cancer of the white blood cells. (bidmc.org)
  • In ALL, the bone marrow (the soft, spongy center of bones) produces too many lymphocytes, a type of white blood cells that do not mature as they should. (bidmc.org)
  • Acute lymphoblastic leukemia is similar to acute myeloid leukemia (AML) , except that AML affects the myeloid white blood cells instead of lymphocytes. (bidmc.org)
  • biopsy - either a bone marrow biopsy to examine blood cells, or a surgical or CT-guided biopsy to obtain lymph node tissue samples. (bidmc.org)
  • Stem cell transplant - also called bone marrow transplant, in this procedure a donor's stem cells are transfused into your blood. (bidmc.org)
  • The transplanted stem cells go from your blood to your bone marrow. (bidmc.org)
  • Autologous stem cell transplants , which are stem cells that come from your own bone marrow or blood. (bidmc.org)
  • Microangiopathic hemolytic anemia (MAHA) - MAHA is a descriptive term for non-immune hemolysis (ie, Coombs-negative hemolysis) resulting from intravascular red blood cell fragmentation that produces schistocytes on the peripheral blood smear ( picture 1 ) [ 1 ]. (medilib.ir)
  • The bone marrow makes blood cells. (medlineplus.gov)
  • An autologous stem cell transplant is the process where healthy blood stem cells from your own body are used to replace your damaged bone marrow. (gomedii.com)
  • Allogeneic stem cell transplant uses healthy blood stem cells from a donor to replace bone marrow that's not producing enough healthy blood cells. (gomedii.com)
  • Thomas has been diagnosed with sickle cell disease which affects the red blood cells and needs an urgent Stem cell transplant but it was not available in his country. (gomedii.com)
  • Thomas decided to travel to India where he will go through pre-treatment procedures of Blood tests and stem cell biopsy. (gomedii.com)
  • Peripheral blood has largely replaced bone marrow as a source of stem cells, especially in autologous hematopoietic stem cell transplantation, because stem cell harvest is easier and neutrophil and platelet counts recover faster. (msdmanuals.com)
  • Because cord blood contains immature stem cells, HLA matching appears less crucial than for the other types of hematopoietic stem cell transplantation. (msdmanuals.com)
  • One concern about the procedure is that immune cells in cord blood do not have experience with the viruses responsible for latent infections, leading to a higher percentage of naive T cells and thus increased vulnerability to reactivation of cytomegalovirus or Epstein-Barr virus infection. (msdmanuals.com)
  • A study to determine immune response to the SARS-CoV-2 vaccine in patients who have blood cancers who will be or have been treated with bone marrow transplant. (slu.edu)
  • Professor Ma heads the Blood, Stem Cell and Cancer Research Programme at St Vincent's Centre for Applied Medical Research, Sydney. (edu.au)
  • Professor Ma holds leadership or scientific membership positions in a number of national and international scientific communities including the World Network for Blood & Marrow Transplantation (a WHO affiliated NGO), the AsiaPacific BM Transplant and the Royal College of Pathology of Australasian Quality Assurance Programme. (edu.au)
  • Stem cells are "non-specialized" cells that have the potential to form into other types of specific cells, such as blood, muscles or nerves. (jonathanturley.org)
  • The cells in the bone marrow that develop into all of the different types of blood cells listed above are called stem cells. (ucsfhealth.org)
  • Stem cells are found predominantly in the bone marrow but occasionally can be stimulated to travel out into the blood. (ucsfhealth.org)
  • Currently, most transplant procedures involve collecting stem cells from the peripheral blood. (ucsfhealth.org)
  • When bone marrow or blood stem cells are infused into the recipient, they are administered through an intravenous catheter or central venous catheter, just like a blood transfusion. (ucsfhealth.org)
  • The stem cells are not administered directly back into the bone, but travel to the bones from the blood stream. (ucsfhealth.org)
Indication for transplantation1
Myeloma4
  • Dr. Coombs discussed the results from a survey of patients with myeloma and APPs who treat myeloma. (bloodcancerstoday.com)
  • Before the transplant, drug treatment is used to reduce the number of myeloma cells in the patient's body. (gomedii.com)
  • A study that looked at well-being issues in people with myeloma pointed out that many patients don't feel properly cared for. (webmd.com)
  • Myeloma cells destroy bone , which releases calcium, a condition called hypercalcemia. (webmd.com)
Lymphoma20
  • This multicenter, open-label phase 2 study evaluated buparlisib (BKM120), a pan-class I phosphatidylinositol 3-kinase inhibitor, in patients with relapsed or refractory non-Hodgkin lymphoma. (haematologica.org)
  • Three separate cohorts of patients (with diffuse large B-cell lymphoma, mantle cell lymphoma, or follicular lymphoma) received buparlisib 100 mg once daily until progression, intolerance, or withdrawal of consent. (haematologica.org)
  • Overall, 72 patients (26 with diffuse large B-cell lymphoma, 22 with mantle cell lymphoma, and 24 with follicular lymphoma) were treated. (haematologica.org)
  • two patients (one each with diffuse large B-cell lymphoma and mantle cell lymphoma) achieved a complete response. (haematologica.org)
  • Buparlisib showed activity in relapsed or refractory non-Hodgkin lymphoma, with disease stabilization and sustained tumor burden reduction in some patients, and acceptable toxicity. (haematologica.org)
  • 211At conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model. (fredhutch.org)
  • The most common non-Hodgkin lymphoma diagnoses in children are Burkitt lymphoma, diffuse large B-cell lymphoma, lymphoblastic lymphoma, and anaplastic large cell lymphoma. (dana-farber.org)
  • These diseases include mycosis fungoides and subcutaneous panniculitis-like T-cell lymphoma. (dana-farber.org)
  • Primary central nervous system lymphoma in children is usually of the diffuse large B-cell lymphoma type. (dana-farber.org)
  • Of the NHL patients, 59 (44%) had diffuse large B-cell lymphoma (DLBCL). (smw.ch)
  • Initial lymphoma stage and number of previous treatment lines were identified as independent risk factors for EFS in DLBCL and HL patients. (smw.ch)
  • Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. (smw.ch)
  • High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. (smw.ch)
  • High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
  • High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
  • The program, which is accredited by the Foundation for the Accreditation of Cellular Therapy , has pioneered a tandem stem cell transplant for Hodgkin lymphoma, reduced intensity conditioning treatments utilizing the drug mitoxantrone, ara-C and pentostatin and refrigerated marrow storage techniques that have led to wide acclaim. (nymc.edu)
  • A randomized phase III trial of consolidation with autologous hematopoietic cell transplantation followed by maintenance rituximab vs. maintenance rituximab alone for patients with mantle cell lymphoma in minimal residual disease-negative first complete remission. (slu.edu)
  • Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
  • Mantle cell lymphoma (MCL) is recognized in the Revised European-American Lymphoma and World Health Organization classifications as a distinct clinicopathologic entity. (medscape.com)
  • it was frequently categorized as diffuse small-cleaved cell lymphoma (by the International Working Formulation) or centrocytic lymphoma (by the Kiel classification). (medscape.com)
Biopsy3
  • If the biopsy shows that there is cancer, it is important that certain tests (called estrogen and progesterone receptor tests) be done on the cancer cells. (stopgettingsick.com)
  • Tissue from the tumor needs to be taken to the laboratory for estrogen and progesterone tests at the time of biopsy because it may be hard to get enough cancer cells later, although newer techniques can be used on tissue that is not fresh. (stopgettingsick.com)
  • If your provider suspects this type of cancer, a bone marrow biopsy will be performed. (medlineplus.gov)
Allogeneic transplants3
Clinical23
  • Bochud PY , Eggiman P , Calandra T , Van Melle G , Saghafi L , Francioli P . Bacteremia due to viridans streptococcus in neutropenic patients with cancer: clinical spectrum and risk factors. (cdc.gov)
  • Kitten T , Munro CL , Zollar NQ , Lee SP , Patel RD . Oral streptococcal bacteremia in hospitalized patients: taxonomic identification and clinical characterization. (cdc.gov)
  • The patient's clinical condition deteriorated over the next 36 hours despite steroid and antibiotic therapy, and the patient had to undergo a total colectomy and ileostomy. (medscape.com)
  • Preclinical and some small-scaled clinical trials have suggested feasibility and safety of cardiac stem cell therapy. (escardio.org)
  • However, there are still questions waiting for answers and results of large-scale randomized trials are needed for the appearance of myocardial cellular therapy as a clinical therapeutic option for patients with ischemic heart disease. (escardio.org)
  • Cell therapy is currently emerging as a potential new treatment for post MI patients with the assumption that recolonization of the areas of scarred myocardium with exogenously supplied surrogates or precursors of cardiomyocytes can restore function and ultimately affect clinical outcomes. (escardio.org)
  • Various cell types have been tested experimentally for cardiac repair so far, but only those of autologous origin have yet undergone clinical testing due to immune competency. (escardio.org)
  • In experimental and clinical studies unselected mononuclear bone marrow cells as well as specific subpopulations have been used for transplantation. (escardio.org)
  • These data suggest that with appropriate pre-transplant clinical evaluation, high-dose cyclophosphamide and irradiation in the BMT preparative phase does not result in frequent, clinically relevant short-term cardiac toxicity [31]. (slideshare.net)
  • Patients who are interested in participating in a clinical trial should discuss the risks and benefits of clinical trials with their physician. (yourcancercare.com)
  • The progress that has been made in the treatment of small cell lung cancer has resulted from the development of multi-modality treatments, new anti-cancer agents and participation in clinical trials. (yourcancercare.com)
  • Future progress in the treatment of small cell lung cancer will result from continued participation in appropriate clinical trials. (yourcancercare.com)
  • This goal is achieved reliability, reproducibility, clinical applicability, clinical flex- for many patients receiving chemotherapy or radiation ibility, clarity, multidisciplinary process, review of evidence, therapy, and is based on clinical and basic research that has and documentation.4 steadily improved the control of emesis over the last 20 In formulating recommendations for antiemetic usage, years. (marysfamilymedicine.org)
  • not intended to supplant physician judgment with respect to As antiemetic usage has grown, the classes of agents available particular patients or special clinical situations. (marysfamilymedicine.org)
  • appreciates these issues and their applicability to the manage- to interventions performed in the context of clinical ment of patients with cancer. (marysfamilymedicine.org)
  • Unfortunately, the term is often used to describe any patient with a TMA who does not have severe ADAMTS13 deficiency or a documented Shiga toxin, therefore it has little clinical usefulness. (medilib.ir)
  • TARGET-HCC is a longitudinal, observational study of patients being managed for HCC in usual clinical practice. (slu.edu)
  • This is a Phase III, randomized, placebo-controlled, double-blind, multi-center study assessing the efficacy and safety of durvalumab with SoC SBRT versus placebo with SoC SBRT in patients with unresected clinical Stage I/II lymph node-negative (T1 to T3N0M0) NSCLC. (slu.edu)
  • Despite best current therapies, patients with recurrent MB experience have an alarmingly high mortality rate and often have limited therapeutic options beyond inadequate chemotherapy or experimental clinical trials. (biomedcentral.com)
  • By reviewing the efficacy and toxicity of MB salvage therapies, this study will identify effective therapeutic strategies administered to recurrent MB patients and can inform future clinical trials aimed to improve patient survivorship and quality of life. (biomedcentral.com)
  • These clinical benefits were more pronounced in patients with aggressive features (high-risk cytogenetic abnormalities or high tumor burden) compared with standard-risk patients. (bvsalud.org)
  • In view of the previously reported association of bortezomib with thrombotic microangiopathy, the temporal association of the clinical picture with the initiation of carfilzomib, and the partial resolution of symptoms after discontinuation of the drug, we conclude that carfilzomib may have precipitated a case of clinically evident renal thrombotic microangiopathy in our patient. (biomedcentral.com)
  • 14: Laurell H, Hansson LE, Gunnarsson U. Impact of clinical experience and diagnostic performance in patients with acute abdominal pain. (cancercentrum.se)
Immune10
  • Transplants from HLA-matched siblings are associated with a lower risk of GVHD and faster recovery of the recipient's immune system following transplantation. (medscape.com)
  • The transplanted cells kill any remaining cancer cells and restore the patient's immune system. (mdanderson.org)
  • Researchers from Northwestern University's Feinberg School of Medicine appear to have reversed the neurological dysfunction of early-stage multiple sclerosis patients by transplanting their own immune stem cells into their bodies and thereby "resetting" their immune systems. (scienceblog.com)
  • In the procedure, Burt and colleagues treated patients with chemotherapy to destroy their immune system. (scienceblog.com)
  • We focus on destroying only the immune component of the bone marrow and then regenerate the immune component, which makes the procedure much safer and less toxic than traditional chemotherapy for cancer," Burt said. (scienceblog.com)
  • After the transplantation, the patient's new lymphocytes or immune cells are self-tolerant and do not attack the immune system. (scienceblog.com)
  • In previous studies, Burt had transplanted immune stem cells into late-stage MS patients. (scienceblog.com)
  • In adults, PCNSL often occurs in patients with a weakened immune system. (dana-farber.org)
  • and still others stimulate the immune system to recognize and attack the cancer cell. (yourcancercare.com)
  • and since they are the patient's own, autologous cells are better than both cord and embryonic sources as they perfectly match the patient's own DNA, meaning that they will never be rejected by the patient's immune system. (jonathanturley.org)
Therapies6
  • The present invention provides stem cells enriched with healthy functional mitochondria, and therapeutic methods utilizing such cells for the alleviation of debilitating conditions, including aging, and age-related diseases as well as the debilitating effects of anti-cancer therapies in subjects in need thereof. (justia.com)
  • The development of more effective cancer treatments requires that new and innovative therapies be evaluated with cancer patients. (yourcancercare.com)
  • CRS generally occurs with therapies that lead to highly activated T cells, like chimeric antigen receptor T cells or in the case of bispecific T-cell engaging antibodies. (bmj.com)
  • This systematic review will provide an overview of the current literature regarding salvage therapies for relapsed MB patients. (biomedcentral.com)
  • Various stem cell therapies are already practiced, a popular one being bone marrow transplants that are used to treat leukemia. (jonathanturley.org)
  • The present report aims to provide a comprehensive analysis of the current situation and facilitate a forward-looking discussion on actions for improving access to transplantation therapies. (who.int)
Spongy tissue1
  • Bone marrow is the soft, spongy tissue found inside most bones in children and in the front chest bone (sternum) and the pelvis bones in adults. (medlineplus.gov)
Donor17
  • In autologous transplantation, the donor and recipient is the same individual. (medscape.com)
  • When the donor is someone other than the recipient, the procedure is described as allogeneic transplantation. (medscape.com)
  • In syngeneic transplants, the donor is the identical twin of the recipient. (medscape.com)
  • Physicians who specialize in managing all transplant types, including allogeneic (bone marrow from a donor), autologous (bone marrow from the patient) and haploidentical transplants (bone marrow from a half-matched donor). (templehealth.org)
  • Where do allogeneic stem cell transplant donor cells come from? (mdanderson.org)
  • With a bone marrow transplant, the donor receives general anesthesia , and the bone marrow is extracted in a 1-2-hour procedure. (mdanderson.org)
  • This allows us to collect more cells in a short period, decrease patient/donor downtime and freeze the cells for future use. (mdanderson.org)
  • If the donor cells aren't a close enough match, the patient's body may recognize the donor cells as foreign and reject them. (mdanderson.org)
  • Or, the cells from the donor may recognize the new body as foreign and attack. (mdanderson.org)
  • Nuclear transfer efficiency is enhanced by introduction of compatible cytoplasm or mitochondrial DNA (same species or similar to donor cell or nucleus). (justia.com)
  • In such cases, there are cells from your own body and hence have certain advantages over stem cells from a donor. (gomedii.com)
  • Based on the report Thomas will either go through Allogenic (related Donor) or Autologous (healthy cells from their own body) donor selection. (gomedii.com)
  • The transplants include autologous (from the same person, matched sibling (from brother or sister), matched unrelated donor, or haploidentical (from father or mother). (cancerinstitutewia.in)
  • eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)
  • A bone marrow transplant is the replacement of diseased or damaged bone marrow cells with new bone marrow cells that have been stored, frozen or obtained from a bone marrow donor. (ucsfhealth.org)
  • For allogeneic transplantation, the patient receives bone marrow or stem cells from a donor who may or may not be a relative. (ucsfhealth.org)
  • the donor.4,11 In the case of nerve cells obtained from either delivery of dopamine released from cells the developing central nervous system (CNS), the opti- implanted into the ventricle, adjacent to the stria- mal age was shown to be at, or close to, the cell-cycle tum,6,7 or restoration of synaptic dopamine release exit. (lu.se)
Tumors3
  • Tumors in the Ewing's family of sarcomas are made of primitive cells, which are cells that haven't yet decided what type of cell they are. (sarcomahelp.org)
  • The growth of these bone tumors weakens the bones. (medlineplus.gov)
  • Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)
Cancer33
  • Saba is an elected member of the American Head and Neck Society (AHNS) and also specializes in immunotherapy for head and neck cancer, and T cell and B cell activation related to HPV-positive disease. (wikipedia.org)
  • Leukemia can also cause symptoms in organs that have been infiltrated or affected by the cancer cells. (healthline.com)
  • 9 Due to its effects on B-cell signaling, dysregulation of PI3K signaling is associated with cancer development and may play a key role in the pathogenesis of NHL. (haematologica.org)
  • Your gift will help support our mission to end cancer and make a difference in the lives of our patients. (mdanderson.org)
  • Once the cancer is less active and the patient has been pre-treated with chemotherapy (known as conditioning), he or she receives the donor's healthy stem cells. (mdanderson.org)
  • Dana-Farber/Boston Children's also offers a wide array of support services and programs for pediatric patients and their families during and after cancer treatment. (dana-farber.org)
  • Patients should also be educated about the importance of maintaining good oral hygiene throughout the course of their cancer therapy. (medscape.com)
  • Breast cancer, a common cancer in women, is a disease in which cancer (malignant) cells are found in the tissues of the breast. (stopgettingsick.com)
  • Several genes have been found to be defective in some breast cancer patients. (stopgettingsick.com)
  • Relatives of breast cancer patients who carry these defective genes may be more likely to develop breast or ovarian cancer. (stopgettingsick.com)
  • If a lump in the breast is found, the doctor may need to cut out a small piece of the lump and look at it under the microscope to see if there are any cancer cells. (stopgettingsick.com)
  • The chance of recovery (prognosis) and choice of treatment depend on the stage of the cancer (whether it is just in the breast or has spread to other places in the body), the type of breast cancer, certain characteristics of the cancer cells, and whether the cancer is found in the other breast. (stopgettingsick.com)
  • He observed that this highly aggressive bone cancer was remarkably sensitive to radiation therapy. (sarcomahelp.org)
  • They look blue to a pathologist because of the staining that is used when identifying the cancer, so the cells are referred to as 'small round blue cells. (sarcomahelp.org)
  • The present invention relates to stem cells enriched with functional mitochondria, and therapeutic methods utilizing such cells to diminish the debilitating effects of various conditions, including aging and age-related diseases as well as the debilitating effects of anti-cancer therapy treatments. (justia.com)
  • When small cell lung cancer has spread to both lungs or is detectable beyond the lungs, it is referred to as extensive . (yourcancercare.com)
  • The following is a general overview of the treatment of extensive small cell lung cancer. (yourcancercare.com)
  • Patients with extensive disease small cell lung cancer are rarely curable with currently available standard treatment strategies although many patients experience a response to treatment. (yourcancercare.com)
  • Currently the standard treatment for extensive small cell lung cancer is chemotherapy using a combination of chemotherapy drugs, typically cisplatin or carboplatin combined with etoposide or irinotecan. (yourcancercare.com)
  • Some patients with extensive small cell lung cancer also receive radiation therapy. (yourcancercare.com)
  • While some progress has been made in the treatment of small cell lung cancer, better treatment strategies are clearly needed, as the majority of patients still experience disease recurrence. (yourcancercare.com)
  • There are several areas of active exploration aimed at improving the treatment of small cell lung cancer. (yourcancercare.com)
  • Chemotherapy interferes with cancer cells' ability to grow. (bidmc.org)
  • As the cancer cells grow in the bone marrow, you may have bone pain, most often in the ribs or back. (medlineplus.gov)
  • The cancer cells can weaken bones. (medlineplus.gov)
  • About 20% of cancer patients get hypercalcemia during their illness. (webmd.com)
  • Biomed companies predict that with all of the research activity in stem cell therapy currently being directed toward the technology, a wider range of disease types including cancer, diabetes, spinal cord injury, and even multiple sclerosis will be effectively treated in the future. (jonathanturley.org)
  • I have had patients at nationally ranked, research-based cancer centers and friends and family treated at MSTI. (stlukesonline.org)
  • In essence, a bone marrow transplant uses very high doses of therapy in attempt to cure the cancer. (ucsfhealth.org)
  • When these higher doses are used to kill the cancer cells, the normal bone marrow cells will also be destroyed. (ucsfhealth.org)
  • Advances in the treatment of cancer and improvements in supportive care over the past 10 years have improved the results and tolerability of bone marrow transplantation. (ucsfhealth.org)
  • A male 13-year-old patient with chondroblastic osteosarcoma in the left distal thigh and acute lymphoblastic leukemia undergoing cancer treatment with methotrexate presented with severe oral mucositis. (bvsalud.org)
  • According to the medical record, the patient had been undergoing cancer treatment for one year and eight months. (bvsalud.org)
Immunology1
Therapy10
  • As such, stem cell therapy cannot be regarded as a valid therapeutic option for patients with cardiovascular disease in the present era of evidenced-based medicine, yet it holds great hope for the future. (escardio.org)
  • The place of high-dose BEAM therapy and autologous bone marrow transplantation in poor-risk Hodgkin's disease. (smw.ch)
  • Oral mucositis leads to pain and restriction of oral intake, and, in severe cases (eg, patients undergoing myeloablative therapy prior to HCT), necessitates total parenteral nutrition and increased use of narcotic analgesics. (medscape.com)
  • Patients were excluded if they had disease progression during induction therapy were excluded or if they underwent cytoxan pulsing, as that would artificially extend TTT. (bloodcancerstoday.com)
  • Radiation therapy may be used to relieve bone pain or to shrink a tumor that is pushing on the spinal cord. (medlineplus.gov)
  • Medical researchers and scientists believe that stem cell therapy will, in the near future, advance medicine dramatically and change the course of disease treatment. (jonathanturley.org)
  • It has also been used as a therapy for disorders like aplastic anemia, which are associated with bone marrow failure. (ucsfhealth.org)
  • [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
  • The transplantation of human tissues, organs or cells is an established form of treatment that has been acknowledged as the best and very often only life-saving therapy for several serious and life-threatening congenital, inherited and acquired diseases and injuries. (who.int)
  • Cell Therapy for Parkinsons Disease: What Next? (lu.se)
Undergone1
  • On the 26th, the reporter learned from the Reproductive Medicine Center of the Sixth Affiliated Hospital of Sun Yat-sen University that there have been many cases of uterine endometrial patients who have undergone intrauterine transplantation of autologous stem cells for successful pregnancy and delivery. (zenzen-biotech.com)
20182
  • Researchers identified 1,055 patients diagnosed with MM from 2004 to 2018 who underwent AHSCT within a year of diagnosis. (bloodcancerstoday.com)
  • In June 2018, the Secretariat established the WHO Task Force on Donation and Transplantation of Human Organs and Tissues as an advisory group composed of experts from all WHO regions. (who.int)
Adult4
  • A track record of success, with more than 2,000 adult bone marrow and stem cell transplants performed since the program began. (templehealth.org)
  • There are a number of sources of stem cells, namely, adult cells generally extracted from bone marrow, cord cells, extracted during pregnancy and cryogenically stored, and embryonic cells, extracted from an embryo before the cells start to differentiate. (jonathanturley.org)
  • As to source and method of acquiring stem cells, harvesting autologous adult cells entails the least risk and controversy. (jonathanturley.org)
  • Between 1991 and 1997, 23 cases of DAH occurred in 922 adult patients (2.5%) receiving BMT for hematological malignancy. (nih.gov)
Newly diagnosed2
  • Based on a retrospective analysis of patients with newly diagnosed MM, Dr. Charalampous and colleagues concluded that a prolonged time to transplant (TTT) was associated with worse outcomes compared with a more rapid schedule. (bloodcancerstoday.com)
  • METHODS: This study evaluated these ER definitions and further investigated the underlying relationship with static risk distribution in 629 newly diagnosed MM (NDMM) patients from the National Longitudinal Cohort of Hematological Diseases in China (NCT04645199). (bvsalud.org)
Procedure is called2
  • The procedure is called autologous non-myeloablative haematopoietic stem-cell transplantion. (scienceblog.com)
  • When the stem cells are collected from the hip bone by performing many bone marrow aspirations (usually performed in the operating room), the transplant procedure is called a bone marrow transplant. (ucsfhealth.org)
Organ transplantation2
  • Other systemic disorders that can present with MAHA and thrombocytopenia include pregnancy-associated syndromes (eg, preeclampsia with severe features and HELLP syndrome), severe hypertension, systemic infections and malignancies, autoimmune disorders such as systemic lupus erythematosus, and complications of hematopoietic stem cell or solid organ transplantation. (medilib.ir)
  • Organ transplantation is often the best, if not the only, treatment for acute and chronic organ failure. (who.int)
Pediatric1
  • Moreover, oral mucositis induces pediatric patients to reduce food intake, which affects their nutritional status and makes them less responsive to treatment 4-5 . (bvsalud.org)
Embryonic Stem1
Lymphomas4
  • Pretargeted Radioimmunotherapy for B-cell Lymphomas. (fredhutch.org)
  • However, there are several slow growing B-cell lymphomas that occur in this young age group. (dana-farber.org)
  • There are also rare T-cell lymphomas that are more frequently seen in adults but occasionally occur in children. (dana-farber.org)
  • Two courses of four weekly infusions of rituximab with or without interferon-2a: final results from a randomized phase III study in symptomatic indolent B-cell lymphomas. (cancercentrum.se)
20162
Cancers3
  • 6] Among Saba's research is the examination of the role of targeting H-Ras in combination with EGFR inhibition in non-HRas mutated head and neck squamous cell cancers. (wikipedia.org)
  • Comparative analysis of bispecific antibody and streptavidin-targeted radioimmunotherapy for B cell cancers. (fredhutch.org)
  • Haematopoietic stem cell transplants have been performed in more than 1 500 000 patients (both autologous and allogeneic) to date.1 Although haematological cancers remain the main indication, haematopoietic stem cell transplants are increasingly considered in the treatment of non-malignant disorders and genetic diseases such as haemoglobinopathies (sickle cell anaemia, thalassaemia) that can benefit greatly from this type of transplant. (who.int)
Chemotherapy or radiation1
Morbidity and morta1
Haploidentical1
Tissue1
  • This is because stem cells have the ability to grow into any kind of cell and, if transplanted into the body, will relocate to the damaged tissue, replacing it. (jonathanturley.org)
Organs4
  • A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
  • This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)
  • Cells Tissues Organs. (cancercentrum.se)
Outcomes3
  • AI-driven software significantly speeds up the detection of large vessel occlusion in stroke patients, reducing treatment time and potentially improving outcomes. (news-medical.net)
  • 5 Combining rituximab, a monoclonal antibody targeting the CD20 antigen on B cells, with standard chemotherapy has improved NHL treatment outcomes. (haematologica.org)
  • Outcomes of corneal transplantation in Europe: report by the European Cornea and Cell Transplantation Registry. (who.int)
Amyloid2
Outcome4
  • Outcome data are in line with previously reported studies, especially the data for salvage treatment and BEAM conditioning in DLBCL patients confirmed the outcome reported recently in a phase III study. (smw.ch)
  • The prognostic scoring system developed by Morel et al (2009)[1] can help to predict outcome, particularly in patients considered to have high-risk disease. (medscape.com)
  • [ 1 ] can help to predict outcome, particularly in patients considered to have high-risk disease. (medscape.com)
  • Impact of Genetic Diagnosis on the Outcome of Hematopoietic Stem Cell Transplant in Primary Immunodeficiency Disorders. (cdc.gov)
Systemic3
  • [ 1 ] Patients with these conditions do not develop signs of systemic toxicity and, therefore, do not fall into the category of having toxic megacolon (see the image below). (medscape.com)
  • INTRODUCTION - The initial evaluation of a patient with suspected thrombotic thrombocytopenic purpura (TTP) or another primary thrombotic microangiopathy (TMA) syndrome must focus on distinguishing these primary syndromes from other systemic disorders that can present with microangiopathic hemolytic anemia (MAHA) and thrombocytopenia. (medilib.ir)
  • Ulcers caused by oral mucositis can be an important source of systemic infection, especially in immunosuppressed patients 2-3 . (bvsalud.org)
Kidney3
  • They are most often given to prevent complications such as bone fractures and kidney damage. (medlineplus.gov)
  • Hypercalcemia can cause bone pain and bone loss, nausea and vomiting , kidney stones , constipation , and fatigue . (webmd.com)
  • After the second hematopoietic stem cell transplant, he developed acute kidney injury secondary to septic shock and required dialysis for 4 weeks. (biomedcentral.com)
Therapeutic2
  • Transplanting their own (autologous) bone marrow-derived stem cells into 48 patients with end-stage liver disease resulted in therapeutic benefit to a high number of the patients, report researchers publishing in the current issue of Cell Transplantation (19:11). (medicaldaily.com)
  • Forasmuch, the therapeutic effect of transplanted BMMSCs can be enhanced by autophagy and/or apoptosis modulators. (biomedcentral.com)