Loading...
  • biopsy
  • A diagnosis of Waldenström's macroglobulinemia depends on a significant monoclonal IgM spike evident in blood tests and malignant cells consistent with the disease in bone marrow biopsy samples. (wikipedia.org)
  • multiple myeloma
  • G-CSF stem cell transplants are used in treatment of leukemia, lymphoma and multiple myeloma resulting in prolonged remission and, in some cases, cure. (wikipedia.org)
  • Similar to other plasma cell dyscrasias that, for example, lead to multiple myeloma, WM is commonly preceded by two clinically asymptomatic but progressively more pre-malignant phases, IgM monoclonal gammopathy of undetermined significance (i.e. (wikipedia.org)
  • 2001
  • Pluristem was founded in 2001 by Shai Meretzki of the Technion, who made use of a stem cell patent which was developed during his Ph.D studies at The Rappaport Faculty Of Medicine, Technion, under the supervision of Dr. Shosh Merchav, together with Professors Dov Zipori and Avinoam Kadouri from the Weizmann Institute of Science. (wikipedia.org)
  • 10,000
  • Megakaryocytes usually account for 1 out of 10,000 bone marrow cells in normal people, but can increase in number nearly 10-fold during the course of certain diseases. (wikipedia.org)
  • regeneration
  • PLX-R18 were initially developed with Prof Raphael Gorodetsky at Hadassah Hospital for the treatment of acute radiation syndrome and enhancement of bone marrow regeneration. (wikipedia.org)
  • cancer
  • born January 18, 1944) is the Enid A. Haupt Chair of Cell Biology at the Memorial Sloan-Kettering Cancer Center. (wikipedia.org)
  • He was the first (1970) to prove the existence of cancer stem cells in a study of leukemia. (wikipedia.org)
  • Waldenström's macroglobulinemia (WM), also known as lymphoplasmacytic lymphoma, is a type of cancer affecting two types of B cells, lymphoplasmacytoid cells and plasma cells. (wikipedia.org)
  • treatment
  • The primary treatment for CAMT is bone marrow transplantation. (wikipedia.org)
  • Information provided about the pediatric program includes the stem cell collection, conditions treated, and treatment areas. (dmoztools.net)
  • a donor's healthy bone marrow reintroduces functional stem cells to replace the cells lost in the host's body during treatment. (wikipedia.org)
  • A Phase III trial of PLX-(PAD)-peripheral arterial disease cells in the treatment of critical limb ischemia has been cleared to start enrolling patients by the U.S. Food and Drug Administration. (wikipedia.org)
  • The U.S. National Institutes of Health is currently evaluating Pluristem's PLX-R18 cells as a treatment for acute radiation syndrome. (wikipedia.org)
  • The USFDA has conferred orphan drug status on Pluristem's PLX cells for the treatment of Buerger's disease (2011) and aplastic anemia (2013). (wikipedia.org)
  • In May 2012, Pluristem reported that its experimental PLacental eXpanded cells were injected into the muscles of a 7-year-old Romanian girl undergoing treatment for bone marrow aplasia disease at the Hadassah Medical Center in Jerusalem. (wikipedia.org)
  • In September 2012 Pluristem reported saving the life of a third bone marrow disease patient using its PLacental eXpanded cell treatment, again at Jerusalem's Hadassah Medical Center and again under the terms of compassionate use. (wikipedia.org)
  • vitro
  • MicroRNA-155 regulates the proliferation and growth of WM cells in vitro and in vivo, by inhibiting MAPK/ERK, PI3/AKT, and NF-κB pathways. (wikipedia.org)
  • functional
  • Many of these genes share substantial structural and functional similarity, but they are specialized to cell type and/or conditions under which they are normally produced. (wikipedia.org)
  • differentiation
  • Many of the morphological features of megakaryocyte differentiation can be recapitulated in non-hematopoietic cells by the expression of Class VI β-tubulin (β6) and they provide a mechanistic basis for understanding these changes. (wikipedia.org)
  • Stochastic differentiation: when one stem cell develops into two differentiated daughter cells, another stem cell undergoes mitosis and produces two stem cells identical to the original. (wikipedia.org)
  • tissues
  • Combining two-photon microscopy with fluorescent tracers, we successfully visualized the engrafted tissues at the single cell level in live mice over several months. (jove.com)
  • Imaging using confocal/two-photon hybrid microscopy enables simultaneous high resolution assessment of uniquely marked cells and their progeny in conjunction with structural components of the tissues. (jove.com)
  • Volumetric analyses over large areas reveal that spectrally coded HSPC-derived cells can be detected non-invasively in various intact tissues, including the bone marrow (BM), for extensive periods of time following transplantation. (jove.com)
  • Another kind of cell-the pluripotent stem cell of mouse teratocarcinomas-was found to give rise to normal tissues in adult chimeras after injection into the mouse blastocyst. (thefreedictionary.com)
  • All the differentiated tissues in the tumor arise from pluripotent stem cells known as embryonal carcinoma (EC) cells. (thefreedictionary.com)
  • When embryonal carcinoma cells are injected into a genetically marked host blastocyst, they continue to divide and participate in normal development, and give rise to fully differentiated cells in all tissues of the adult, including skin, muscle, nerve, kidney, and blood. (thefreedictionary.com)
  • For years, the concept of harvesting stem cells and re-implanting them into one's own body to regenerate organs and tissues has been embraced and researched in animal models. (wikipedia.org)
  • The diagnosis of CLL is based on the demonstration of an abnormal population of B lymphocytes in the blood, bone marrow, or tissues that display an unusual but characteristic pattern of molecules on the cell surface. (wikipedia.org)
  • Ionizing radiation kills lymphoid cells while leaving other tissues of the body intact, and this eliminates immune function. (wikipedia.org)
  • adult
  • However, embryonal carcinoma cells from some other sources fail to integrate, but produce teratocarcinomas in the newborn animal or adult. (thefreedictionary.com)
  • Human T-cell lymphotropic virus type 1 or human T-lymphotropic virus type 1 (HTLV-I), also called the adult T-cell lymphoma virus type 1, is a retrovirus of the human T-lymphotropic virus (HTLV) family that has been implicated in several kinds of diseases including very aggressive adult T-cell lymphoma (ATL), HTLV-I-associated myelopathy, uveitis, Strongyloides stercoralis hyper-infection and some other diseases. (wikipedia.org)
  • Adult T-cell lymphoma (ATL) was discovered in 1977 in Japan. (wikipedia.org)
  • The hospital is also the regional referral center for trauma, perinatal and neonatal intensive care, burns, bone marrow and stem cell transplantation, cystic fibrosis, pediatric and adult AIDS, and is the regional resource center for emergency management. (wikipedia.org)
  • cartilage
  • While cartilage, ligaments, and fat present low antigenicity, bone, muscles, nerves, and vessels present moderate antigenicity, and skin is the component that develops the most severe rejection because of the abundance of dendritic cells within the epidermis and dermis. (springer.com)
  • Osteoarthritis is a common condition of cartilage failure that can lead to limited range of motion, bone damage and invariably, pain. (wikipedia.org)
  • This drives efforts to develop ways of using a person's own cells to grow, or re-grow cartilage tissue to replace missing or damaged cartilage. (wikipedia.org)
  • MSCs have been used to treat a variety of disorders including cardiovascular diseases, spinal cord injury, bone and cartilage repair, and autoimmune diseases. (wikipedia.org)
  • Malignancy
  • Experimental chimeras have been used to study a number of biological questions, including the origin and fate of cell lineages during embryonic development, immunological self-tolerance, tumor susceptibility, and the nature of malignancy. (thefreedictionary.com)
  • The lack of the normal distribution of these B cells is one basis for demonstrating clonality, the key element for establishing a diagnosis of any B cell malignancy (B cell non-Hodgkin lymphoma). (wikipedia.org)
  • rejection
  • The abovementioned methods have been researched extensively, but there remain many areas in immunology that have yet to be covered, ranging from autoimmune diseases to transplant rejection. (wikipedia.org)
  • Rubinstein specializes in immunogenetics, which encompasses the structure and function of genes that regulate immune responses, control the acceptance or rejection of tissue and organ transplants, and affect susceptibility to certain diseases. (wikipedia.org)
  • CD34
  • Conversely, under other circumstances CD34 has been shown to act as molecular "Teflon" and block mast cell, eosinophil and dendritic cell precursor adhesion, and to facilitate opening of vascular lumina. (wikipedia.org)
  • Finally, recent data suggest CD34 may also play a more selective role in chemokine-dependent migration of eosinophils and dendritic cell precursors. (wikipedia.org)
  • Regardless of its mode of action, under all circumstances CD34, and its relatives podocalyxin and endoglycan, facilitates cell migration. (wikipedia.org)
  • transfusion
  • hosting the UK NEQAS external quality assessment scheme for Histocompatibility and Immunogenetics and the Welsh Assessment of Serological Proficiency scheme (WASPS), contribution to the maintenance of quality standards in the transfusion and transplantation community. (wikipedia.org)
  • tissue
  • CBR partners with Quick International, a private medical courier service with 30 years of experience in the transportation of blood and tissue for transplant and research. (stemcellcordblood.net)
  • Although some chimeras do arise naturally, most are produced experimentally, either by mixing cells of very early embryos or by tissue grafting in late embryos or adults. (thefreedictionary.com)
  • Thus, composite tissue structure is considered to be more immunogenic than solid organ transplants. (springer.com)
  • These cells are held in place by a small piece of soft tissue from the tibia, called a periosteal flap, which is sutured over the area to serve as a watertight lid. (wikipedia.org)
  • The cells grow in self-organized spheroid matrices which are implanted via injected fluid or inserted tissue matrix. (wikipedia.org)
  • HSCs constitute 1:10.000 of cells in myeloid tissue. (wikipedia.org)
  • clinical
  • VetStem Technology: Summary VetStem Regenerative Cell Therapy is based on a clinical technology licensed from Artecel Inc. Original patents are from the University of Pittsburgh and Duke University. (stemcelltherapy.me)
  • The non-dilutive funding will support Gamida Cell's ongoing research and development efforts including its Phase III registration study of NiCord ® for hematological malignancies (blood cancers like leukemia and lymphoma), and its clinical trials of CordIn ® for sickle cell disease and thalassemia and NK cells as a potential immune therapy for cancer. (hematopoiesisnews.com)
  • The scope of the journal includes stem cell biology, transplantation immunology, translational research, and clinical results of specific transplant protocols. (wikipedia.org)
  • Bone Marrow Transplantation is abstracted and indexed in BIOBASE/Current Awareness in Biological Sciences, BIOSIS, Current Contents/Clinical Medicine, Current Contents/Life Sciences, EMBASE/Excerpta Medica, MEDLINE/Index Medicus, and Science Citation Index. (wikipedia.org)
  • Rubinstein is also an adjunct clinical professor at Columbia University and is the author of more than 200 research papers on immunogenetics, cord blood banking and transplantation. (wikipedia.org)
  • endothelial cells
  • In vivo, AM administration not only enhanced the differentiation of MNC into endothelial cells but also produced mature vessels that included smooth muscle cells. (ahajournals.org)
  • The initial work, published in the JCI in 2000, described the method enabling successful attainment of blood outgrowth endothelial cells (BOEC). (jci.org)
  • articular
  • Due to a combination of acute stress and chronic fatigue, osteoarthritis directly manifests itself in a wearing away of the articular surface and, in extreme cases, bone can be exposed in the joint. (wikipedia.org)
  • induces
  • Background- Previous studies have shown that adrenomedullin (AM) inhibits vascular endothelial cell apoptosis and induces angiogenesis. (ahajournals.org)
  • cancers
  • The fact that certain embryonal carcinoma cells give rise to tumors when injected under the skin or into the body cavity, but behave normally in the blastocyst, has been used to support the idea that cancers can develop not only as a result of gene mutations but also as a result of disturbances in environmental factors controlling normal cell differentiation (epigenetic theory of cancer). (thefreedictionary.com)
  • Stem cell transplants are procedures that restore blood-forming stem cells in people who have had theirs destroyed by the very high doses of chemotherapy or radiation therapy that are used to treat certain cancers. (stemcelltherapy.me)
  • More recent advances have resulted in the use of HSC transplants in the treatment of cancers and other immune system disorders. (wikipedia.org)
  • Genetic
  • Genetic combinatorial marking using lentiviral vectors encoding fluorescent proteins (FPs) enabled cell fate mapping through advanced microscopy imaging. (jove.com)
  • The underlying mechanism involves multiple genetic mutations that results in rapid cell division. (wikipedia.org)
  • lymphocytes
  • These cells include T lymphocytes (T cells), that primarily mediate the immune system, B lymphocytes (B cells) and Natural Killer cells. (wikipedia.org)
  • Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). (wikipedia.org)
  • Diagnosis is typically based on blood tests finding high numbers of mature lymphocytes and smudge cells. (wikipedia.org)
  • Normal B lymphocytes consist of a stew of different antibody-producing cells, resulting in a mixture of both kappa- and lambda-expressing cells. (wikipedia.org)
  • In CLL, the lymphocytes are genetically clonal, of the B cell lineage (expressing marker molecules clusters of differentiation 19 and 20), and characteristically express the marker molecules CD5 and CD23. (wikipedia.org)
  • These B cells resemble normal lymphocytes under the microscope, although slightly smaller, and are fragile when smeared onto a glass slide, giving rise to many broken cells, which are called "smudge" or "smear" cells. (wikipedia.org)
  • This often involves the analysis of antiserum samples that contain specific antibodies against the immunizing antigen, and blood lymphocytes from lymphoid organs for examination of T cell-mediated responses. (wikipedia.org)
  • Fluorescence-activated cell sorter (FACS) analysis, which detects and counts lymphocytes passing through a laser beam. (wikipedia.org)
  • Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes. (wikipedia.org)
  • The excessive immature lymphocytes in the bone marrow interfere with the production of new red blood cells, white blood cells, and platelets. (wikipedia.org)
  • Normal lymphoblasts develop into mature, infection-fighting B-cells or T-cells, also called lymphocytes. (wikipedia.org)
  • Procedure
  • In addition, a safety study showed safety better than surgical alternatives for this cultured cell injection procedure at a 3-year follow-up. (wikipedia.org)
  • undergo
  • In addition, post-meiotic germ cells undergo a dramatic morphological reshaping process as well as a global epigenetic reconfiguration of the germ line chromatin-the histone-to-protamine switch. (jove.com)
  • The medulla is specialized to allow thymocytes to undergo additional rounds of negative selection to remove auto-reactive T cells from the mature repertoire. (wikipedia.org)
  • fetal liver
  • In mammalian embryology, the first definitive HSCs are detected in the AGM (aorta-gonad-mesonephros), and then massively expanded in the fetal liver prior to colonising the bone marrow before birth. (wikipedia.org)
  • immune
  • Together, the results of this study lay the groundwork for future studies to explore the role of DNA replication in immune cell generation and function. (jci.org)
  • The immune system consists of specialized cells that work together to fight off bacteria, fungi and viruses. (wikipedia.org)
  • Since more than one type of immune cell is affected, this disease is classified as a severe combined immunodeficiency disease (SCID). (wikipedia.org)
  • Hematopoietic Stem Cell Transplantation (HSCT) involves intravenous infusion of stem cells to those who have either a damaged bone marrow or defective immune system. (wikipedia.org)
  • B cell immune responses are measured by analyzing antibodies produced through the humoral immune response. (wikipedia.org)
  • T cells are critical to the adaptive immune system, where the body adapts specifically to foreign invaders. (wikipedia.org)
  • Disorders
  • They can differentiate into many cell types including bone, fat, and muscle which allow them to treat a large range of disorders. (wikipedia.org)
  • lineages
  • ESCs possess many of the same therapeutic properties as MSCs, including the ability to self-regenerate and differentiate into a number of cell lineages. (wikipedia.org)
  • phenotype
  • The kind of mature, fully differentiated cell phenotype and the number of those cells created though this can be influenced in three ways. (wikipedia.org)
  • deficiency
  • T-/B+ SCID (T cells predominantly absent): γc deficiency, JAK3 deficiency, interleukin 7 receptor chain α deficiency, CD45 deficiency, CD3δ/CD3ε deficiency. (wikipedia.org)