Stem cell research using fetal tissue fetal cells fetal tissue research. Medical search. Frequent questions

Embryonic stem cell research "uses special cells found in three-to-five day old human embryos to seek cures for a host of chronic disease" (PRC). (ipl.org)
Pro-cloning forces have been working hard to convince state governments to pass constitutional amendments enshrining a "right" to clone and to destroy embryos for research. (flfamily.org)
Then they were told these cells could be grown from 1) excess human embryos or 2) fetal tissue donated to research. (lifeissues.org)
This poll asked whether people opposed or supported research in which live human embryos would be destroyed or discarded. (lifeissues.org)
Also in May, a presidential advisory commission judged that it was ethical for the government to pay for such controversial research, as long as the embryos are not created solely for research purposes. (lifeissues.org)
The Alternative Pluripotent Stem Cell Therapies Enhancement Act (S.2754) would fund efforts to derive and study cells which have the capabilities of embryonic stem cells but which are not obtained by destroying living human embryos. (christiannewswire.com)
It would prevent the use of human fetal tissue (such as fetal stem cells) obtained by growing human embryos in a human or animal uterus in order to provide such tissue. (christiannewswire.com)
Let's face it," said Casey, "this bill would nullify the Bush Administration's wise policy of permitting federal funding only on pre-existing embryonic stem cell lines, and promote research using 'new' embryonic stem cell lines that can only be obtained by destroying countless living human embryos that are now 'frozen and unchosen' in IVF fertility clinics or creating such human embryos for research destruction. (christiannewswire.com)
Depending on the source, stem cells can be classified into two broad categories i.e. embryonic stem cells that are derived from embryos and non-embryonic stem cells that are derived from adult and fetal tissues. (benthamscience.com)
Stem cells originating in human embryos can be categorized as either embryonic stem cells or embryonic germ cells . (orthodoxwiki.org)
In Vitro Fertilization - some of the embryos used in human stem cells research were initially created for infertility purposes through in vitro fertilization procedures. (orthodoxwiki.org)
President Bush, saying he wanted to "proceed with great care," announced in a national address on August 9 that he would allow federal funding of an existing 60 stem-cell lines but would not permit tax dollars to pay for the destruction of any additional human embryos. (christianitytoday.com)
The rule circumvented a 1995 congressional ban on using federal money for biomedical research on embryos outside the womb by allowing researchers to use stem cells extracted by a third party. (christianitytoday.com)
The groups argue that rather than waste embryos that will be destroyed along with their stem cells, researchers should use them to help save those whose lives are being cut short by disease. (christianitytoday.com)
Indeed, some observers believe the demand for stem cells is dangerously close to spawning a huge commercial industry around the sale of and experimentation on human embryos. (christianitytoday.com)
Already, news that Advanced Cell Technology-a Massachusetts-based, privately held biotech company-and Virginia Medical School's Jones Institute had created or planned to create human embryos for the sole purpose of extracting their stem cells has troubled those on both sides of the debate. (christianitytoday.com)
The laboratory, which is supported by the National Institutes of Health, can supply tissue from normal or abnormal embryos and fetuses of desired gestational ages between 40 days and term. (blessedquietness.com)

Dr. Tara Sander Lee of the Charlotte Lozier Institute testified that human fetal tissue was never needed for research because of viable alternatives such as adult stem cells. (breitbart.com)
As Vice President and Research Director for the Charlotte Lozier Institute, an organization promoting deeper public understanding of the value of human life, Prentice confirms what many Californians are unaware of. (californiafamily.org)

Beta-galactosidase of ROSA26 mice is a useful marker for detecting the definitive erythropoiesis after stem cell transplantation" (PDF). (wikipedia.org)
However, tissue rejection following ESCs derivatives transplantation greatly hinders its application. (benthamscience.com)
after transplantation to the recipient region, single cells are vulnerable to the interference of various factors, such as ischemia and inflammation, leading to cell loss or death [ 16 ]. (biomedcentral.com)
We monitor our cells after transplantation using standard in vivo assessments as listed above. (lu.se)
The specific medications administered depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation. (medscape.com)
My major research achievements have been in the field of cell transplantation and brain repair. (lu.se)
The studies are performed in 6-hydroxydopamine lesioned immunosuppressed (or immunodeficient) rats, following transplantation of cells into either the striatum, or into the substantia nigra where these cells normally reside. (lu.se)
Трансплантація гемопоетичних стовбурових клітин Hematopoietic stem cell (HSC) transplantation is a rapidly evolving technique that offers a potential cure for hematologic cancers ( leukemias, lymphomas, myeloma) and other hematologic disorders. (msdmanuals.com)
Трансплантати шкіри Many different types of tissues can be transplanted, including skin, bone, cartilage, adrenal tissue, fetal thymus, corneas, and composite transplantation of tissues to restore the face or extremities. (msdmanuals.com)

The Obama-appointed director of the National Institutes of Health (NIH) says that human fetal tissue from elective abortions "will continue to be the mainstay" for federal research. (breitbart.com)
Prior to Collins' comments, some pro-life members of Congress were encouraged last week when NIH announced it would spend up to $20 million on alternatives to the use of fetal tissue from elective abortions for research. (breitbart.com)
In its announcement, NIH said in the near future it would be seeking grant applications for the development of "models that closely mimic and can be used to faithfully model human embryonic development or other aspects of human biology, for example, the human immune system, that do not rely on the use of human fetal tissue obtained from elective abortions. (breitbart.com)
The NIH is funding a $20 million program to "develop, demonstrate, and validate experimental models that do not rely on human fetal tissue from elective abortions. (chicagotribune.com)
NIH "has directed funding toward the development of alternative research methods that do not rely on human fetal tissue from elective abortions and I remain supportive of that effort. (chicagotribune.com)
The new policy bans testing HIV therapies on fetal tissue taken from elective abortions. (queerty.com)

Kuldip S. Sidhu , " Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials Bench-to-Bedside ", Bentham Science Publishers (2012). (benthamscience.com)
Induced pluripotent stem cells, another types of pluripotent stem cells derived from any tissue by reprogramming and are the homologous source of stem cells. (benthamscience.com)
The cells that form the inner cell mass of the blastocyst are called pluripotent stem cells . (orthodoxwiki.org)
1. Development of a ML/AI pipeline for the prediction of subtypes and differentiation stage of developing mouse cardiac cells from mesoderm to birth and from in vitro differentiation of human induced pluripotent stem cells (hiPSCs). (stanford.edu)
Here are their technical properties: AECs have multipotent differentiation potential and expression of pluripotent stem cell specific transcription factors including Oct4 and Nanog. (parentsguidecordblood.org)
The cells are called induced neurons (iNs) and offer a shortcut over induced pluripotent stem cells (iPSc) for generating patient and disease-specific neurons. (lu.se)
Similarly, destruction of neonatally abundant pluripotent stem cells would likely have a more pervasive outcome than destruction of The value of incorporating immunologic appeared more severe and/or persistent when single lineages or differentiated cells that pre- data for the toxicologic assessment of drugs, the exposure occurred perinatally when com- dominate in adults. (cdc.gov)

Noninvasive detection and imaging of molecular markers in live cardiomyocytes derived from human embryonic stem cells Biophysical Journal. (nottingham.ac.uk)
In collaboration with Malin Parmar´s group at the Wallenberg Neurosciece Center we are studying the in vivo efficacy and performance of dopamine neuron precursors derived from human embryonic stem cells. (lu.se)

They argue that the research supports abortions but have taken part in receiving vaccines and therapy that comes from the research. (ipl.org)

The rapidly emerging "regenerative" field of medicine is relying heavily on the use of ethically obtained stem cells. (flfamily.org)
Prohibiting valuable research that uses fetal tissue that is otherwise going to be discarded doesn't make any sense," said Dr. Lawrence Goldstein, a regenerative medicine specialist at the University of California, San Diego. (chicagotribune.com)
Stem cells are emerging as an important source of material for diseases in regenerative medicine. (benthamscience.com)
The study of biology of stem cells is the hallmark of the recent emerging field of regenerative medicine and medical biotechnology. (benthamscience.com)
Atta-ur-Rahman, Shazia Anjum , " Frontiers in Stem Cell and Regenerative Medicine Research ", Bentham Science Publishers (2017). (eurekaselect.com)
Earlier this month, Orange County State Senator John Moorlach unsuccessfully tried to persuade his fellow senators to defund the California Institute for Regenerative Medicine (CIRM) , the state's stem cell research agency, created by voters in 2004 by Proposition 71 . (californiafamily.org)
Conclusion: The information provided in this study makes a significant contribution to the investigation into the differences between adult reparative and fetal regenerative cells and supports the concept of using ESC-derived tenocytes as a cellular therapy. (cam.ac.uk)
Many studies have demonstrated tissue bioengineering's potential and its applications for dentistry and regenerative medicine 3-5 . (bvsalud.org)

This week, the Archdiocese of Cincinnati specifically asked Catholic school leaders at 113 schools to "immediately cease" any fundraising plans connected to the challenge, because the ALS Association funds at least one study using embryonic stem cells -- "in direct conflict with Catholic teaching. (salon.com)

Science reports that NIH director Francis S. Collins, M.D., Ph.D . noted Thursday that while research on alternatives to the use of aborted fetal tissue is "scientifically, highly justified," fetal tissue will nevertheless "continue to be the mainstay. (breitbart.com)
The government's own top medical scientist, NIH Director Francis Collins, said as recently as last December that he believes "there's strong evidence that scientific benefits come from fetal tissue research ," and that fetal tissue, rather than any alternatives, would "continue to be the mainstay" for certain types of research for the foreseeable future. (chicagotribune.com)

Tissue engineering is a multidisciplinary field that applies the principles of engineering and life-sciences for regeneration of damaged tissues. (wjgnet.com)
Epimorphic regeneration is a process by which damaged tissues or severed body parts are restored to the original. (eurekaselect.com)
This type of sophisticated regeneration is observed in urodeles and fetal mammals. (eurekaselect.com)
During limb epimorphic regeneration: committed mesenchymal cells at the stump site dedifferentiate, forming a cluster of heterogeneous population of stem cells, known as the blastema. (eurekaselect.com)
Epimorphic regeneration and retrodifferentiation both have the capacity to recreate and reconstruct tissue with precise positional integration of cells in such a way that will enable us to heal without scars and to understand how to maintain tissue integrity and architecture in the face of a hostile environment. (eurekaselect.com)
The present study results indicated that compared with the same number of 2D-cultured cells, microtissue could secrete more nerve regeneration related cytokines to promote SCs proliferation and axons growth. (biomedcentral.com)
Tissue bioengineering has the capacity to accelerate regeneration and repair of damaged tissues using patients' natural curative potential and it is facilitated by several types of biomaterials 2 . (bvsalud.org)

This policy is similar to that of other countries, including Israel, where scientists are funded by Government to study embryonic stem cells despite the aforementioned bioethical issue. (jcpa.org)

After over 100 years of research, no therapies have been discovered or developed that require aborted fetal tissue," she continued. (breitbart.com)
It blocks important future research vital to the development of new therapies. (chicagotribune.com)
Biotechnology companies specializing in stem-cell research stand to reap huge financial windfalls from successful therapies developed via this science," said the CPI report. (christianitytoday.com)

The heated debate in our society over reproductive cloning, as well as therapeutic cloning to obtain embryonic stem cells, has been fueled by misconceptions and hyperbole on both sides. (flfamily.org)
Most researchers obtain embryonic stem cells from the inner mass of a blastocyst, an embryonic stage when a fertilized egg has divided into 128 cells. (jcpa.org)

We now know that some of the stem cells and stem-like cells of the placenta and fetal membranes have a vital role to play in this immunological switch. (parentsguidecordblood.org)
The MSCs represent less than 1% of the cells present in the placenta, while the average yield of MSCs from chorions and amnions is between 1 to 10 million per gram of tissue. (parentsguidecordblood.org)
In summary, the placenta and other perinatal tissues are a rich source of stem cells and stem-like cells, which can potentially be banked in a similar manner to cord blood. (parentsguidecordblood.org)

Dr. Svendsen received his most recent grant of $6.2 million last Fall to fund a clinical trial where "they will implant middle-man "progenitor" cells made by maturing stem cells from fetal tissue," into the spinal cords of patients with hope the damaged neural cells will be repaired. (californiafamily.org)
Recent Accomplishments - Starting in 2013, we incorporated Fluidigm-based multiplex single cell PCR equipment HD Biomark to analyze the differentiation of single cardiac progenitor cells in vitro and found that Nkx2.5 expression marks a subpopulation of committed endocardial precursor cells in the mouse heart (Li et al, Development 2015). (stanford.edu)

At this time I also began working with mouse and human embryonic stem cells resulting in the publication of some of the first papers describing the osteogenic differentiation of mouse ES and human cells in vitro and in vivo . (nottingham.ac.uk)
Pulp stem cells (PSCs) are able to form ectopic dentin in vitro and in vivo and also to generate a dentine-pulp complex composed of a mineralized matrix, with dentinal tubules that are aligned and filled with odontoblastic prolongations, containing vascularized pulp tissue, in a similar arrangement to that observed in natural dental structures 3,6 . (bvsalud.org)
This also allows us the unique opportunity to directly compare our hESC-derived dopamine neurons with those sourced from human fetal tissue both in vitro and in vivo. (lu.se)

Contrary to popular belief, stem cells are present in the human body throughout life and are found in many adult organs. (jcpa.org)
My PhD focussed on investigating the distributions and possible functions of nitric oxide/nitric oxide synthases in the physiology and pathology of a variety of tissues and organs and I was fortunate enough to publish some of the first papers on the involvement of these molecules in human diseases, notably in the cardiovascular system. (nottingham.ac.uk)
Cells of the same type make tissues, and tissues make organs. (orthodoxwiki.org)
Adult stem cells give the body its ability to repair and replace the cells and tissues of some organs. (orthodoxwiki.org)
Following the release, last May, of a powerful LifeTalk video featuring "Kelly," a fetal tissue procurer for the Maryland-based Anatomic Gifts Foundation, Life Dynamics has released documentation obtained from fetal tissue wholesalers, that is, companies which place their employees in abortion facilities to harvest tissue, limbs, organs, etc. (blessedquietness.com)
Yet, Planned Parenthood's interest might have something to do with the millions CIRM spends on research using aborted baby organs as a source of stem cells. (californiafamily.org)
It is unclear exactly how much money CIRM has spent over the years funding research using pre-born baby organs, but according to CIRM's 2016 annual report , it spent seven percent of its $262 million 2016 grant budget on stem cell research on projects designated as "Other. (californiafamily.org)
Dr. Svendsen, a native of England, started using pre-born baby organs as part of his research during his studies at University of Cambridge in the 1990s. (californiafamily.org)
We also use human stem cells as a test-tube model to study the process of heart formation and to create new human heart tissues and organs from these stem cells. (stanford.edu)

Mouse nuclear transfer embryonic stem cells (NT-ESCs) were first established in 2000, and then proved to be able to differentiate either in vivo or in vitro, and give rise to individual tissues through germ line transmission or tetraploid complementation. (benthamscience.com)
Germ cells and stem cells also differ with respect to their growth characteristics in vitro and their behavior in vivo. (orthodoxwiki.org)
The robustness and efficacy of the retrodifferentiation process in generating unprecedented quantities of stem cells belonging to the three germ layers will enable organ and tissue reconstruction ex vivo, using bio-printing and various scaffold materials. (eurekaselect.com)
This includes long-term survival of transplanted cells in vivo to assess cell fate, maturation and integration, as well as functional behavioural assessment for graft function in vivo. (lu.se)
Relating in vitro to in vivo exposures with physiologically-based tissue dosimetry and tissue response models. (cdc.gov)

Through its Law of Life Project, CLS supports ethical stem cell research and opposes the destructive human embryonic stem cell research. (christiannewswire.com)
The prolife lobby also received help from Do No Harm, a coalition of researchers, bioethicists, and doctors who spearheaded a nationwide petition urging Bush to oppose destructive human embryonic stem-cell research. (christianitytoday.com)

The medical community has widely characterized the practice as vital to disease research since the fetal tissue can be used to mimic a variety of cells found in the human body. (queerty.com)
Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)
however, whether they can mimic the properties of fetal tenocytes is unknown. (cam.ac.uk)
Through the use of human embryonic stem cells (hESCs), we can mimic brain development towards different regions of the human brain, and thereby investigate the effect of novel genes on neural differentiation. (lu.se)
In this project, involving engineers from LTH, we apply advanced microfluidic techniques to culture hESCs under the influence of chemical gradients to mimic the environment around the developing brain in the fetus, thereby generating neural tissue with anatomical characteristics resembling the developing human brain. (lu.se)

Embryonic stem cells (ESCs) can grow infinitely and give rise to all types of cells in human body, thus of tremendous therapeutic potentials for a variety of diseases, such as Parkinson's disease, spinal cord injury, and diabetes. (benthamscience.com)
What is more, by deriving NT-ESCs from patient cells, the problem of immune rejection may be avoided. (benthamscience.com)
Results: No qualitative differences in three-dimensional tendon constructs generated from adult, fetal and ESCs were found using histological and morphological analysis. (cam.ac.uk)

Casey said that CLS, "as a founding member of DO NO HARM, The Coalition of Americans for Research Ethics ( www.stemcellresearch.org ), supports the ethical research permitted by this bill using stem cells from adult tissues and umbilical cord blood that have been shown to have the versatility or to be convertible to the versatility once thought to only exist in embryonic stem cells. (christiannewswire.com)
In some adult tissues, such as bone marrow, muscle, and brain, discrete populations of adult stem cells generate replacement cells. (orthodoxwiki.org)

While at the hospital she was unaware that the doctors there were experimenting on her taking cell samples from her body, to help find a resolution to multiple diseases. (ipl.org)
All of this debate raises an important question, Should embryonic stem cell research be conducted for treatment of present and future diseases? (ipl.org)
On the other hand, people who believe that embryonic stem cell research creates means of curing diseases reply that the research should be conducted. (ipl.org)
NIH continued that while human fetal tissue and embryonic stem cell-derived systems have been used for researching human development and diseases, "new technologies raise the potential of reconstituting these model systems without fetal tissue yielding more replicable and reproducible system for broader uses. (breitbart.com)
The regional research centres concentrate on research pertaining to the diseases of their particular region, where there is often a lack of proper government infrastructure for health care delivery. (who.int)
While there is a great deal published on the potential medical applications of stem cell research to treat or cure diseases such as diabetes, Alzheimer's disease, Parkinson's disease, cancer, and heart disease, much less has been published on the future impact of stem cell research in reproductive medicine. (jcpa.org)
Casey noted from DO NO HARM's research of the medical literature from around the world that it "remains absolutely true that adult stem cells have benefited patients suffering from at least 72 diseases and conditions, where patient improvement is documented by peer-reviewed scientific publications. (christiannewswire.com)
Advancements in science have been able to alter adult tissue to study systemic immune diseases. (queerty.com)
Most of the diseases known to medical science are due to the malfunction of cells, to premature cell death, or to cells' wrong multiplication rates. (orthodoxwiki.org)
The cells carry the potential to cure neurological diseases, diabetes, and many other illnesses. (christianitytoday.com)
Since then, according to his resume , Dr. Svendsen has been involved in study after study, writing article after article regarding the use of pre-born baby brains and other fetal tissue to treat neurological diseases like Parkinson's and Lou Gehrig's disease. (californiafamily.org)
We believe that by understanding the mechanisms regulating the formation of the heart during fetal development we can then apply these principles to understand the causes of adult heart diseases such as heart attack and heart failure. (stanford.edu)
I started this line of research in the mid 1970ies, based on the idea that immature neurons can be used to replace lost neurons, restore brain circuitry, and promote functional recovery in animal models of neurodegenerative diseases. (lu.se)

Development: For advances in developmental biology and stem cells. (lu.se)
In contrast, when adult and fetal tenocytes were cultured in 3D, large distinctions in gene expression between these two developmental stages were found, with 542 genes being differentially expressed. (cam.ac.uk)
Comparing two- and three-dimensional culture also indicates three-dimensional culture as being a more physiologically relevant culture system for determining transcriptomic difference between the same cell types from different developmental stages. (cam.ac.uk)
We were interested in the developmental potential of single cardiac progenitor cell into cardiomyocytes, smooth muscle cells, and endothelial cells. (stanford.edu)
We subsequently became interested in developing a developing heart expression atlas in order to identify the cell type, developmental stage, and anatomical location of each single cardiac cells during mouse heart development using a random forest-based computational algorithm that we termed ATLAS-seq. (stanford.edu)

Researchers investigating many other conditions, including Parkinson's , also have been known to use embryonic stem cells. (salon.com)
Today, fetal tissue is still making an impact, with clinical trials underway using cells from fetal tissue to treat conditions including Parkinson's disease, ALS, and spinal cord injury," said Doug Melton, co-director of Harvard's Stem Cell Institute and president of the International Society for Stem Cell Research. (chicagotribune.com)
During the past 12 years, CIRM has spent several billion dollars to fund stem cell research in hopes of finding cures for a variety of ailments including Parkinson's disease, cerebral palsy, and spinal cord injuries, but with little success . (californiafamily.org)
As we have a strong focus on developing cells for cell replacement therapy in Parkinson's disease, we are currently adapting our protocols for GMP compliance through the EU-funded network NeuroStemcellRepair. (lu.se)

After they located this special locus, they began developing experiments and attempting to strengthen, fix, and even recreate this heart valve in amniotic fluid with different forms of genetic engineering and with a new form of stem-cell research. (majortests.com)
Chorionic and amniotic MSCs suppress T cell proliferation to the same extent as bone marrow derived MSCs. (parentsguidecordblood.org)

Dr. Steenblock has repaired spinal cord damage and other critical nerve elements using adult stem cells. (commutefaster.com)
So far CIRM has given Dr. Svendsen $26 million , most of which has funded research to find treatments for Lou Gehrig's disease, also known as Amyotrophic Lateral Sclerosis (ALS) , a fatal condition that damages motor neurons in the brain and spinal cord. (californiafamily.org)
the other half was held fresh at 4°C. Upon receipt, we collected small pieces of fresh and formalin-fi xed tissue from several locations in the cerebrum and cerebellum and along the brain stem and cervical spinal cord. (cdc.gov)

Bush promised in January to review a Clinton administration rule that allowed federal funding for researchers experimenting on embryo cells from fertility clinics. (christianitytoday.com)
Researchers value the cells for their ability to replicate quickly and turn into any kind of human tissue. (christianitytoday.com)
Researchers later determined that the genetic mismatch was due to chimerism, a condition in which two genetically distinct cell lines are present in one body. (asu.edu)
To better understand how these repetitive genetic sequences influence brain development, researchers analyzed both fetal and adult brain tissue samples. (lu.se)

Policymakers have the opportunity to hear expert witnesses attest to amazing scientific advancements and discoveries using ethical alternatives to fetal tissue. (flfamily.org)
However, in his comments Thursday, Collins said that even if alternatives are found, "you're going to have to compare it to the current standard, which is using fetal tissue. (breitbart.com)
Collins provided his comments just as a House Oversight subcommittee was holding what turned out to be a highly combative hearing to explore alternatives to the use of fetal tissue for research. (breitbart.com)
The Susan B. Anthony List, a group that works to elect lawmakers opposed to abortion, said in a statement that taxpayer funding ought to go to promoting alternatives to using fetal tissue in medical research. (chicagotribune.com)

Embryonic germ cells share many of the characteristics of the embryonic stem cells but differ in significant ways. (orthodoxwiki.org)
They are derived from the primordial germ cells, which occur in a specific part of the embryo/fetus called the gonadal ridge. (orthodoxwiki.org)
Germ cells do not proliferate as long as stem sells. (orthodoxwiki.org)
Under certain conditions, germ cells do differentiate into specialized cells. (orthodoxwiki.org)

We do not need fetal body parts from aborted babies to achieve future scientific and medical advancements," Lee said in her prepared testimony. (breitbart.com)

Although the anemia is often normocytic, mild macrocytosis can also be observed in association with stress erythropoiesis and elevated fetal hemoglobin levels. (medscape.com)

Embryonic stem cell transplants have been an ethical, social, and legal controversy since the first successful transplant of human stem cells in 1998. (ipl.org)

In addition, specific proteins or biological substances can be added to these stem cell cultures to transform them in the laboratory into a large variety of specialized cell types, such as nerve, liver, muscle, bone, and blood cells. (jcpa.org)
From 1999 onwards my research has been focused primarily on osteoblast biology and approaches to tissue engineer and model bone biology, pathology and repair. (nottingham.ac.uk)
My research interests focus mainly on stem cells (embryonic, 'adult' and fetal origins) and their applications in tissue engineering, particularly the osteoblast and bone tissue. (nottingham.ac.uk)
Despite improved surgical techniques, the tendon-to-bone healing rate is unsatisfactory due to difficulties in restoring the delicate transitional tissue between bone and tendon. (wjgnet.com)
Low-power view of hematoxylin-eosin-stained bone marrow showing hypocellularity, with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)
The clinical presentation of patients with aplastic anemia includes signs and symptoms related to the decrease in bone marrow production of hematopoietic cells. (medscape.com)

Scientists around the country denounced the decision, saying that fetal tissue was critically needed for research on HIV vaccines, treatments that harness the body's immune system to battle cancer, and other health threats, including some to fetuses themselves. (chicagotribune.com)
On December 14, the United States Conference of Catholic Bishops issued a response [2] to a question that many Catholics had recently been asking: Is it permissible to get vaccinated for COVID-19 if the development of the vaccine involved cell lines derived from aborted fetuses? (commonwealmagazine.org)
In 1986 our team in Lund obtained permission to use tissue from aborted human fetuses in a series of open-label clinical trials in patients with Parkinson´s disease (PD). (lu.se)
An important aspect of the work is the direct comparison of stem cell-derived cells with authentic midbrain dopamine neurons obtained from 6-9 week old aborted human fetuses. (lu.se)

Paul Wagle, M.A., discusses his experience with a life-saving adult stem cell treatment, and the importance of promoting ethical approaches to medical research. (flfamily.org)
For decades, proponents of destructive embryo research have given at least lip service recognition to the serious ethical concerns inherent to such research. (flfamily.org)
There is strong evidence that scientific benefits can come from fetal tissue research, which can be done with an ethical framework," Collins, a physician-geneticist, said. (breitbart.com)

Israeli policy is based on the belief that such a pre-embyro does not confer personhood and that many therapeutic applications can be derived from such research. (jcpa.org)
In recent years, the rapid development of tissue engineering technology provides a new therapeutic method for repairing PNI. (biomedcentral.com)
To this end, understanding the unique expression profile of normal adult and fetal tenocytes is crucial to allow validation of ESC-derived tenocytes as a cellular therapeutic. (cam.ac.uk)

The NIH director's statements drew strong reactions from pro-life leaders, including Family Research Council president Tony Perkins, who said Collins' views are more reflective of the Obama administration. (breitbart.com)
The Family Research Council, Focus on the Family, Concerned Women for America, the National Right to Life Committee and the Catholic Alliance had all stepped up pressure on Bush, arguing that federal funding would condone the destruction of human lives in the name of medical research. (christianitytoday.com)

Mariano García Arranz has the following conflict of interest: MGA is inventor on 2 patents entitled "Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue" (10157355957US) and "Use of adipose tissue-derived stromal stem cells in treating fistula" (US11/167061). (wjgnet.com)
Rapid onset of systemic insulin resistance and adipose tissue remodeling but initially increased insulin-stimulated glucose transport despite deteriorating insulin signaling with high fat feeding in mice. (lu.se)

The mesenchymal tissue separating the 2 systems is known as the tracheoesophageal septum. (medscape.com)

Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells. (wikipedia.org)
Below is a list of genes/protein products that can be used to identify various types of stem cells, or functional assays that do the same. (wikipedia.org)
Furthermore, this study adds to the growing evidence that monolayer cultured cells' gene expression profiles converge, with adult and fetal tenocytes having only 10 significantly different genes when cultured in this manner. (cam.ac.uk)
This work involves analysis of fetal brain anatomy, and identification of key genes and noncoding RNAs controlling the compartmentalisation of the brain. (lu.se)
We have the same genes everywhere in the cells of the body, yet certain types of protein are expressed in the brain, while others are expressed in the liver. (lu.se)

The report notes that the AAR, which bills itself as the leading citizen advocacy organization for improving the health of older Americans, "also happens to receive funding from private-sector biotechnology companies that have a financial stake in the outcome of the stem-cell debate, including Geron," the for-profit corporation that isolated embryonic stem cells in 1998. (christianitytoday.com)
1998. Armed Forces Radiobiology Research Institute. (cdc.gov)

Living donors are often used for kidney and hematopoietic stem cell transplants, less frequently for segmental liver transplants, and rarely for pancreas and lung transplants. (msdmanuals.com)

It is clear that California taxpayers, through CIRM, are funding projects that rely on aborted fetal tissue for experiments, including experiments injecting human fetal cells into patients," Dr. Prentice said. (californiafamily.org)

and concentrates on methods of applying the research for the benefit of the community. (who.int)
Methods: Equine adult, fetal and ESC-derived tenocytes were cultured in a three-dimensional environment, with histological, morphological and transcriptomic differences compared. (cam.ac.uk)
Methods: Pulp tissue was collected from permanent third molars and digested and then the cells were seeded onto plates containing HDMEM medium. (bvsalud.org)

In this article R. Alta Charo states that we have a right to use fetal tissue for research and therapy (Fetal Tissue, 1) The article goes into how a lot of people find this to be a moral issue and a matter of the conscience and explains how the antiabortion activist that don't agree with the research are actually benefitting from the fetal tissue. (ipl.org)
Tissue-engineered microtissue is an effective strategy for stem cell culture and therapy in nerve tissue engineering. (biomedcentral.com)
Mora MV, Ibán MAR, Heredia JD, Laakso RB, Cuéllar R, Arranz MG. Stem cell therapy in the management of shoulder rotator cuff disorders. (wjgnet.com)
Recently, we have begun to address the pathogenic immune response in patients with myocarditis from treatment with immune checkpoint inhibitors (ICIs) for cancer therapy using single cell immunology tools from 10x Genomics. (stanford.edu)
Conclusions: The cells isolated from dental pulp exhibited characteristics compatible with those expected for mesenchymal stem cells (MSCs) and are good candidates for cell therapy applications and tissue bioengineering. (bvsalud.org)

No matter how simple or complex an organism is, the cell remains the structurally and functionally basic unit of life (there are even unicellular organisms, like bacteria. (orthodoxwiki.org)
Treatment options are limited, and the prognosis is often poor with functionally deficient scar tissue resulting. (cam.ac.uk)

As a member of the European clinical trial TRANSEURO we also perform preclinical validation of human fetal dopamine neurons for clinical use. (lu.se)
Our current efforts are focused on the development of stem cell-derived dopamine neurons, aimed at the development of transplantable neurons derived from human ES cells for clinical application. (lu.se)
Development of stem cell-derived dopamine neurons for neuronal replacement in Parkinson´s disease. (lu.se)

the EST, which assesses the effects of compounds on the differentiation of mouse embryonic stem cells into contracting cardiomyocytes, can be used to rank the potency of chemicals within a series of alkoxyacetic acid metabolites formed from The implementation of the European REACH (Registration, glycol ethers. (cdc.gov)

Asked by reporters what would happen if HHS determines contracts with fetal procurement companies did not meet those regulations, Collins said: "I guess we'll have to cross that bridge when we get to it. (breitbart.com)
As a result, NIH froze procurement of new tissue. (chicagotribune.com)

Advocates of stem cell research believe that the cells are not equivalent to human life because it is inside the womb even facing the fact that the start of a human life is in the moment of conception. (ipl.org)

Our mandate is to undertake and support research, not only basic, applied or epidemiological research but also operational research in the area of public health using a variety of tools, including those of modern biology. (who.int)
I returned full time to Imperial College in 1999 to take up a lectureship in cell biology and tissue engineering and was also actively involved in establishing the Tissue Engineering Centre. (nottingham.ac.uk)
I cover mainly cell biology and physiology. (nottingham.ac.uk)
Project Description - The Wu Laboratory was among the earliest labs in the country to engage single cell biology using novel single cell tools as they become available. (stanford.edu)
In the Caraka samhita , the research in the area of public health using ancient text of ayurveda, the physician was a variety of tools, including those of mod- cautioned to avoid institutional entangle- ern biology. (who.int)

Current efforts focus on identifying the optimal starting cell population for neural conversion, identification of gene combinations that yield subtype specificity and analysis of function and integration of the reprogrammed neurons. (lu.se)

under certain conditions, they can be induced to become cells with special functions (like muscle cells, liver cells, neurons, etc. (orthodoxwiki.org)
However, with a growing number of novel cell sources (stem cells and reprogrammed cells) it becomes important to develop new methodologies for a more thorough assessment of human neurons generated using these approaches. (lu.se)
We utilise monosynaptic tracing technology, using pseudotyped rabies vectors, in order to visualise the synaptic contacts formed between host neurons and graft human cells. (lu.se)

Fetal tendon injuries in contrast are capable of healing without forming scar tissue. (cam.ac.uk)

SUMMARY The Indian Council of Medical Research formulates, coordinates and promotes biomedical research in India. (who.int)
Its main function is to formulate, coordinate and promote biomedical research in India through intramural as well as extramural research programmes. (who.int)
While both types of stem cells are very important for biomedical research, the use of embryonic stem cells raises most of the bioethical issues. (orthodoxwiki.org)
There was also belief in spirits, so it was main function is to formulate, coordinate a spirito-religious concept which guided and promote biomedical research in India everyone. (who.int)

While many people say the use of the cell research is a way to advance medical knowledge and expand treatments, there is no guarantee that the treatments will work. (ipl.org)
That life may not even be worth it because it takes multiple tries before the stem cells are even suitable for use in medical treatments. (ipl.org)
The Health and Human Services Department said in a statement that government-funded research by universities that involves fetal tissue can continue for now, subject to additional scrutiny - although it also ended one major university project that used the tissue to test HIV treatments. (chicagotribune.com)
In essence, doctors harvested the leftover tissue to test experimental treatments. (queerty.com)

But the story has taken a new twist as religious groups are now beginning to discourage followers from participating -- because ALS research at times relies on embryonic stem cells. (salon.com)
Very little research is actually being done that currently relies on abortion-derived fetal tissues. (breitbart.com)

physiologically based animals because a mouse embryonic stem cell line is used. (cdc.gov)

Johan Jakobsson, a professor at Lund University and research group leader at MultiPark and Lund Stem Cell Center, explains, "LINE-1 retrotransposons are a rich source of genetic sequences that we suspect have shaped the evolution of the human brain, and we now have the tools to explore their role in brain development. (lu.se)

Anatomy37

Organisms4

Diseases9

Chemicals and Drugs8

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Psychiatry and Psychology4

Phenomena and Processes28

Disciplines and Occupations21

Anthropology, Education, Sociology and Social Phenomena11

Technology, Industry, Agriculture3

Humanities23

Information Science3

Named Groups2

Health Care19

Geographicals2

Embryos17

Charlotte Lozier Institute2

Transplantation9

Elective abortions6

Pluripotent7

Derived from human embryonic stem2

Abortions1

Regenerative8

Study using embryonic1

Continue to be the mainstay2

Regeneration7

Embryonic stem cells de1

Therapies3

Obtain embryonic stem2

Placenta3

Progenitor cells2

Vitro and in vivo3

Organs9

Vivo5

Destructive human embryonic ste2

Mimic5

ESCs3

Adult tissues2

Diseases13

Developmental5

Parkinson's4

Amniotic2

Spinal3

Researchers4

Alternatives4

Germ4

Advancements1

Erythropoiesis1

Human stem cells1

Bone6

Fetuses4

Ethical3

Therapeutic3

Family Researc2

Adipose tissue2

Mesenchymal tissue1

Genes5

19982

Transplants1

Rely1

Methods3

Therapy5

Functionally2

Dopamine neurons3

Cardiomyocytes1

Procurement2

Womb1

Biology5

Neural1

Neurons3

Tendon1

Biomedical research4

Treatments4

Relies2

Physiologically-based1

Lund University1