Loading...
  • immunity
  • The low number of T cells (T cell lymphopenia) and other lymphocytes appears to be responsible for the susceptibility to infections, and the poor humoral immunity is responsible for low response to vaccines. (wikipedia.org)
  • cardiac surgery
  • Supported by the Bavarian Research Foundation (Bayerische Forschungsstiftung, grant 219/96) together with his research team as a consultant of cardiac surgery he investigated the xenogeneic transplantation of multi-transgenic pig hearts as a possible future organ replacement therapy in man since 1997. (wikipedia.org)
  • infection
  • The major drawback of this technique is that it takes three weeks for the new skin to be ready for transplantation, leaving the patient vulnerable to dehydration and infection in the interim. (bionews.org.uk)
  • Skin grafting is often used to treat: Extensive wounding or trauma Burns Areas of extensive skin loss due to infection such as necrotizing fasciitis or purpura fulminans Specific surgeries that may require skin grafts for healing to occur - most commonly removal of skin cancers Skin grafts are often employed after serious injuries when some of the body's skin is damaged. (wikipedia.org)
  • renal
  • Involvement of the CB2 cannabinoid receptor in cell growth inhibition and G0/G1 cell cycle arrest via the cannabinoid agonist WIN 55,212-2 in renal cell carcinoma. (springer.com)
  • Grafts
  • Transplantation of allogeneic bone marrow helps establish chimerism that may induce tolerance to tissue grafts. (nature.com)
  • Skin grafts can be: Split-thickness A split-thickness skin graft (STSG) is a skin graft including the epidermis and part of the dermis. (wikipedia.org)
  • Hair transplantation differs from skin grafting in that grafts contain almost all of the epidermis and dermis surrounding the hair follicle, and many tiny grafts are transplanted rather than a single strip of skin. (wikipedia.org)
  • The grafts are obtained in one or both of the two primary methods of surgical extraction, follicular unit transplantation, colloquially referred to as "strip harvesting", or Follicular Unit Extraction (FUE), in which follicles are transplanted individually. (wikipedia.org)
  • It was through Burnet and Fenner's work that Peter Medawar learned of Owen's findings and used it to help explain his findings that dizygotic twin calves accept each other's skin grafts after birth. (wikipedia.org)
  • cancers
  • Type VII collagen defects cause recessive dystrophic epidermolysis bullosa (RDEB), a blistering skin disorder often accompanied by epidermal cancers. (clinicaltrials.gov)
  • immune system
  • There are substitutes available to cover wounds during this period - including specially treated skin from human corpses (although donations of this are in short supply) - but all of these currently carry high risk of rejection by the patient's immune system or transmission of disease. (bionews.org.uk)
  • because the cells are taken from the person, that person's immune system will not reject them. (wikipedia.org)
  • This observation demonstrated that self was "learned" by the immune system during development and paved the way for research involving induction of immune tolerance and early tissue grafting. (wikipedia.org)
  • He co-authored papers that described "the use of radiation as a means of blocking or resetting the immune system before transplantation of bone marrow or other tissues. (wikipedia.org)
  • neural
  • The study is the first successful attempt to employ human induced pluripotent stem cells (hiPSC) to produce a population of cells that are critical to neural signaling in the brain. (healthcanal.com)
  • Pharmacological activation of endogenous neural stem cells has been reported to induce neuroprotection and behavioral recovery in adult rat models of neurological disorder. (wikipedia.org)
  • functional
  • By using the method of induced pluripotent stem cells we have been able to generate cells which express those markers which are typical for nerve cells in the cerebral cortex and we have also shown that the new nerve cells are functional," says Zaal Kokaia, professor of experimental medical research. (mdtmag.com)
  • Our functional, genetic and pharmacologic studies uncovered a novel linkage between Notch1, IKKα and NF-κB pathway activation in maintaining the CD133+ stem SCC phenotypes. (aacrjournals.org)
  • Recent data have shown that the endocannabinoid system is fully functional in the skin and is responsible for maintaining many aspects of skin homeostasis, such as proliferation, differentiation, and release of inflammatory mediators. (springer.com)
  • Twelve weeks later the mice had areas of completely normal and functional human skin. (bionews.org.uk)
  • a donor's healthy bone marrow reintroduces functional stem cells to replace the cells lost in the host's body during treatment. (wikipedia.org)
  • Stem cells can also be identified by functional assays. (wikipedia.org)
  • Below is a list of genes/protein products that can be used to identify various types of stem cells, or functional assays that do the same. (wikipedia.org)
  • When it is mutated, an incorrect protein is produced, so there is, at most, a trace level of functional DOCK8 protein in the cell. (wikipedia.org)
  • rejection
  • Because these cells - created by using the recipient's own skin - would be a genetic match, the likelihood of rejection upon transplantation is significantly diminished. (healthcanal.com)
  • This makes the possibility of rejection of the cells by the recipient tissue less likely. (wikipedia.org)
  • Using a patented combination (EP 1181034 B1, EP 1980263A1, US 8,435,520 B2) consisting of transgenic organs/cells and immunoadsorption (elimination of antibodies from the recipient) and a special combination of immunosuppressive drugs hyperacute and delayed xenograft rejection should be prevented and long-term survival of a xenograft should be enabled and realized. (wikipedia.org)
  • malignant
  • Also, amniotic epithelial cells are known to promote natural wound healing as well as the inhibition of angiogenesis, which is the basic conversion of a tumor into malignant cancer. (wikipedia.org)
  • Treatments
  • This project will explore the role of novel agents for stem cell treatments in cancer. (cancervic.org.au)
  • Edmonton) James Shapiro, one of the world's leading experts in emerging treatments of diabetes, can't help but be excited about his latest research. (eurekalert.org)
  • Other treatments used in DOCK8 deficiency include sodium cromoglycate, which improves white blood cell function, and isotretinoin, which improves skin condition. (wikipedia.org)
  • follicular units
  • Since hair naturally grows in follicles in groups of 1 to 4 hairs, transplantation takes advantage of these naturally occurring follicular units. (wikipedia.org)
  • In FUT, a strip of skin containing many follicular units is extracted from the patient and dissected under a stereoscopic microscope. (wikipedia.org)
  • lesions
  • Immunosuppressive drugs can also potentiate the effects of other carcinogens, such as ultraviolet radiation, that cause premalignant lesions and skin carcinoma. (clinmedjournals.org)
  • Frederic E. Mohs, developed the Mohs Micrographic Surgery technique (MMS) aka Mohs surgery in 1938 to remove skin cancer lesions. (wikipedia.org)
  • citation needed] Symptoms of hair loss include hair loss in patches usually in circular patterns, dandruff, skin lesions, and scarring. (wikipedia.org)
  • laboratory
  • Costimulation is the name of the body s natural process for providing an extra stimulus, and can be performed on cells in the laboratory. (clinicaltrials.gov)
  • In the new study, the research team took ES cells derived from early human embryos and grew them in the laboratory for 40 days using several techniques to coax the ES cells into forming keratinocytes. (bionews.org.uk)
  • Between 1996 and 1999, he was an assistant professor at Osaka City University Medical School, but found himself mostly looking after mice in the laboratory, not doing actual research. (wikipedia.org)
  • As a postdoctoral fellow in the Immunogenetics Laboratory at the University of Wisconsin, Owen's research interests moved from fowl to cattle. (wikipedia.org)
  • acute
  • Another stem-cell therapy called Prochymal, was conditionally approved in Canada in 2012 for the management of acute graft-vs-host disease in children who are unresponsive to steroids. (wikipedia.org)
  • experimental
  • As he considered the future possibility of transplanting human stem cells in place of islets, he realized a better, safer site to implant experimental cells was needed. (eurekalert.org)
  • In this study, we developed an experimental pipeline to isolate a highly enriched CD133+CD31-CD45-CD61-CD24- (CD133+) cell population from primary cSCC specimens by flow cytometry. (aacrjournals.org)
  • Experimental procedures are being tested for burn victims using stem cells in solution which are applied to the burned area using a skin cell gun. (wikipedia.org)
  • tumor
  • The T cells may be especially effective at controlling tumor if they are given an additional stimulus to become active. (clinicaltrials.gov)
  • Tumor size is monitored every month with CT scans, and possibly also with a PET or bone marrow aspiration and biopsy, for the first 3 months after the cells are infused. (clinicaltrials.gov)
  • The CD133+ cells show enhanced stem-like phenotypes, which were verified by spheroid and colony formation in vitro and tumor generation in vivo. (aacrjournals.org)
  • It is hypothesized that antigens associated with the tumor trigger an immune response resulting in blistering of the skin and mucous membranes. (wikipedia.org)
  • Recent research developments aim to treat the underlying tumor in order to alleviate the symptoms of PNP. (wikipedia.org)
  • clinical
  • More research will be needed before the technique can be tried in humans, but Dr Marc Peschanski, a member of the team, commented: 'we have a timeframe [for clinical trials] by 2011, although. (bionews.org.uk)
  • Clinical and animal studies have been conducted into the use of stem cells in cases of spinal cord injury. (wikipedia.org)
  • NIH is the primary federal agency that conducts and supports basic, clinical and translational medical research. (wikipedia.org)
  • NIAMS supports and conducts basic, clinical, translational and epidemiologic research and research training at universities and medical centers. (wikipedia.org)
  • researcher
  • Play media Shinya Yamanaka (山中 伸弥, Yamanaka Shin'ya, born September 4, 1962) is a Japanese Nobel Prize-winning stem cell researcher. (wikipedia.org)