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  • Therapy
  • To study the effect of combined therapy including fetal stem cells (FSCs) on different components of erections. (omicsonline.org)
  • During a period of 2014-2015 years 19 patients with mixed type erectile dysfunction and mandatory vascular factor documented by pharmacodopplerography were under study in Cell Therapy Center EmCell. (omicsonline.org)
  • biological
  • To deeply decode the biological processes is necessary to study the activity and functions of the small components (genes, mRNAs and proteins) within the cells. (europa.eu)
  • The microscopy field aims to gain the highest possible resolution "to see" these smallest components that drive the biological processes inside a cell. (europa.eu)
  • NSCs
  • This approach is useful for the sorting and expansion of NSCs and facilitates the discovery of genes involved in cell proliferation, communication, fate control, and differentiation. (pnas.org)
  • regenerative medicine
  • Having the ability to visualize a stem cell's future will take some of the questions out of using stem cells to help regenerate tissue and treat diseases," says Rosemarie Hunziker , program director for Tissue Engineering and Regenerative Medicine at the National Institute of Biomedical Imaging and Bioengineering . (rutgers.edu)
  • therapy
  • Understanding a stem cell's fate - the type of cell it will eventually become - and how far along it is in the process of development can help scientists better manipulate cells for stem cell therapy . (rutgers.edu)
  • Targeting programmed cell death using small-molecule compounds to improve potential cancer therapy. (springer.com)
  • Stem cells are being investigated as an alternative therapy for treatment of various diseases including diabetes. (springer.com)
  • Hsiao LC, Carr C, Chang KC, Lin SZ, Clarke K. Stem cell-based therapy for ischemic heart disease. (springer.com)
  • Cell therapy for acute myocardial infarction: curb your enthusiasm? (springer.com)
  • Isolation of amniotic stem cell lines with potential for therapy. (springer.com)
  • While replacement therapy remained unrealistic, the clinical efficacy of this therapeutic option could be potentially enhanced if we could better decipher the mechanisms underlying some of the beneficial effects of transplanted cells, and work toward augmenting or combining these in a strategic manner. (degruyter.com)
  • phenotype
  • BM-ECM produced by BM cells from young donors), the number of cells increased ≈ 17,000-fold to 3 × 10 9 cells and retained their "youthful" phenotype. (nih.gov)
  • tissue
  • Our data provide experimental evidence that Exo1 deficiency has a differential impact on the homeostasis and proliferative capacity of tissue stem cells in the brain and bone marrow, suggesting that different tissue stem cells utilize distinct mechanisms for maintaining their genomic stability. (nih.gov)
  • Our current study provides important insight into the role of Exo1-mediated DNA maintenance pathways in the maintenance of genomic stability and the proliferative capacity of tissue stem cells. (nih.gov)
  • Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling. (springer.com)
  • vivo
  • Taking these new approaches together, the direct and indirect labeling methods may provide new insights on the roles of in vivo stem cell monitoring, from bench to bedside. (springer.com)
  • Our study demonstrated that administration of bone mesenchymal stem cell-derived extracellular vesicles (BMSC-EV) reduced brain cell death, enhanced neuronal survival and regeneration, and improved motor function compared with the administration of BMSC-EV free culture media (EV-free CM). Besides, the BSCB was attenuated and pericyte coverage was significantly decreased in vivo . (frontiersin.org)
  • neurons
  • In this study, we asked the question whether a subset of parental cells that are clonogenic in our in vitro system and give rise to neurons and glia could be retrospectively subdivided into distinct subsets of cells with different developmental commitment based on distinct molecular phenotypes of their clonal progeny. (pnas.org)
  • Molecular
  • The molecular imaging techniques allow monitoring of the transplanted cells in the same individuals over time, from early localization to the survival, migration, and differentiation. (springer.com)
  • cardiac
  • 2 Because the c-kit-positive rat cardiac stem cells used by Hosoda et al do express these miRNAs, 1 there is reason to assume that these cells are already more dedicated toward the myogenic lineage than the hCMPC cell population. (ahajournals.org)
  • Recapitulating, both the study by Hosoda et al and our study demonstrate independently the powerful role of miR-499 in directing the myogenic differentiation of cardiac-derived progenitor cells. (ahajournals.org)
  • regenerate
  • We are here to demonstrate in our own resurrecting capacity our individual ability, with you, to regenerate and proliferate our own adult stem cells within my body, and the capacity to demonstrate it within our ideas about our self. (acimi.com)
  • visualize
  • In this ambitious and multi-disciplinary proposal, we aim to develop new technologies that will allow us to visualize in single cells, in parallel and at the systems level, DNA, mRNAs and proteins with nanoscale resolution. (europa.eu)
  • endothelial
  • The homing process is initiated by tethering and rolling of HSPCs to endothelium mediated by the binding of selectins expressed on endothelial cells (E- and P-selectin) ( 9 , 10 ) to selectin ligands expressed on HSPCs (fig. S1), which occurs against the shear stress exerted by blood flow ( 7 , 11 - 13 ). (sciencemag.org)
  • cellular
  • Often, the spatial distribution of ligands and receptors on a cell membrane governs cellular interactions and intracellular signaling ( 3 , 4 ). (sciencemag.org)
  • populations
  • Long-term culture systems allow the continuous propagation of potentially heterogeneous populations of neural stem and progenitor cells in monolayers on substrate-coated plates ( 1 , 2 ) or as suspended, clonal aggregates of cells known as neurospheres ( 3 , 4 ). (pnas.org)
  • survival
  • Pliant culture substrates enabled propagation of additional Pax7 (green) expressing MuSCs and improved survival (middle), while culture on softer (left) or stiffer (right) matrices decreased cell survival (gray) and promoted differentiation. (pubmedcentralcanada.ca)
  • In this review, various imaging strategies to monitor the survival and behavior change of transplanted stem cells are covered. (springer.com)