Stem cell mammary adult mammalian cells. Medical search. Frequent questions

Mammalian adult stem cells resemble the blastomeres of planktonic and benthic organisms with small eggs and may have evolved in mature organisms as an adaptation to the growth and maintenance of tissues via proliferation and the regulation of organ size via cell loss (e.g., terminal differentiation). (iospress.com)
The Hedgehog signaling pathway is a signaling pathway that transmits information to embryonic cells required for proper cell differentiation. (wikipedia.org)
2017). MMP-2 and MMP-14 Silencing Inhibits VEGFR2 Cleavage and Induces the Differentiation of Porcine Adipose-Derived Mesenchymal Stem Cells to Endothelial Cells. (sciendo.com)
Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)
2012 Nevertheless the in vivo systems that restrict epithelial lineage plasticity to guard differentiation and exactly how such systems control stem cell function during MG morphogenesis and regeneration stay poorly understood. (buyresearchchemicalss.net)
We used primary acute myeloid leukemia (AML) samples and human AML cell lines to investigate the regulatory mechanisms of autophagy and its role in AML differentiation. (hindawi.com)
In this review we summarized the recent progress in study of basic stem cell biology, on the prospective identification of NSCs, the elucidation of the mechanisms of ontogenic changes, potential differentiation, and their therapeutic applications. (kiev.ua)
Zozulya Yu.A., Lisyaniy NI, Tsymbalyuk VI, Semenova VM Neurogenic differentiation of stem cells. (kiev.ua)
Our research focuses on characterising the stem and progenitor cells that build the hypothalamus and characterising the molecular networks that direct hypothalamic morphogenesis, growth and differentiation. (sheffield.ac.uk)
Cellular differentiation and lineage programming The generation of therapeutically important cells like cardiomyocytes using readily available cell types remains a considerable challenge for biologists. (cancerrealitycheck.com)
Initial hypotheses in the late 1800s advocated that cellular differentiation happens through permanent deficits of hereditary info.10 However German embryologists Hans Dreisch and Hans Spemann found that separation of the early blastomeres of recently fertilized animal eggs generates two fully-formed animals.11 These "twinning" experiments challenged the hypothesis that cells permanently shed developmental potential as they become more differentiated. (cancerrealitycheck.com)
Homeostatic epidermal stem cell self-renewal is driven by local differentiation. (ucsf.edu)
Cell fate decisions within these hierarchical brain cell lineages are tightly controlled and irreversible: e.g. cells in the state of differentiation will not turn into progenitor cells or stem cells. (stanford.edu)
This is especially true for malignant glioma cells, which simultaneously express markers of different lineages and states exhibiting incomplete differentiation. (stanford.edu)

Mammalian embryonic stem cells would seem adapted to rapid proliferation, functioning in part to enclose yolk or to acquire access to maternal resources. (iospress.com)
The cellular products of embryonic stem cells routinely come under global influences and give rise to the cells of germ layers and organ rudiments. (iospress.com)
Strategies for regenerative therapies in adult mammals, therefore, might be based on stimulating growth of adult stem cells or their surrogates in specific tissues rather than on introducing embryonic stem cells into adults. (iospress.com)
Pluripotent embryonic stem cells (ESC) can either self-renew or differentiate in what was long thought to be a unidirectional manner towards increasingly specialized cell types of the three embryonic germ layers. (cancerrealitycheck.com)

The conversion of an epithelial cell to a mesenchymal cell is critical to metazoan embryogenesis and a defining structural feature of organ development. (rupress.org)
Expression of AND-34 regulates epithelial cell growth pattern, motility, and growth factor dependence. (molvis.org)
Hepatocyte growth factor (HGF) is produced by stromal and mesenchymal cells, and it stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its cognate receptor, Met. (spandidos-publications.com)

The mammary gland is an ideal tissue in which to study a range of developmental processes, as discussed below. (biologists.com)
Current interest in this process, which is described as an epithelial-mesenchymal transition (EMT), stems from its developmental importance and its involvement in several adult pathologies. (rupress.org)
Developmental Cell 47, 697-710.e3. (ucsf.edu)
The meeting will also showcase novel approaches for investigating Developmental Genetics from stem cell-mediated Embryoid Models to Mathematical and Computational Modelling. (bsdb.org)
In addition to leading research initiatives, Marysia is a passionate Developmental Biology teacher: running modules in Developmental Biology, Developmental Neurobiology, and Stem & Regenerative Biology. (bsdb.org)

Acceleration of mouse mammary tumor virus-induced murine mammary tumorigenesis by a p53 172H transgene: influence of FVB background on tumor latency and identification of novel sites of proviral insertion. (rochester.edu)

A surprising recent discovery has been that mammary epithelial cells commit to differentiated lineages using the same signalling pathways that regulate lineage determination in T helper cells. (biologists.com)
2013 high light the exceptional lineage plasticity of somatic cells. (buyresearchchemicalss.net)
MG goes through dramatic tissue development and redecorating during puberty and being pregnant generating not merely luminal epithelial cells but also a distinctive mesenchymal-like epithelial inhabitants specifically basal/myoepithelial cells (Watson and Khaled 2008 Hence MG acts as a perfect system to review the hereditary circuits that control epithelial lineage plasticity. (buyresearchchemicalss.net)
2006 Adult stem cells with bipotential or unipotential are also within the mammary basal area via lineage tracing under physiological circumstances (Rios et al. (buyresearchchemicalss.net)
2006 WYE-354 Using conditional lineage-tracing and knockout techniques we demonstrate that loss-induced mammary flaws. (buyresearchchemicalss.net)
Three-dimensional imaging and lineage-specific RiboTag induction within the stem cell compartment indicated that ISCs expressed IL-33 in response to radiation injury. (bvsalud.org)
the discipline of cell lineage reprogramming is in its infancy and further research will become needed to improve the efficiency of the reprogramming course of action and the fidelity of the reprogrammed cells to their in vivo counterpart. (cancerrealitycheck.com)
As a result researchers became more interested in the mechanisms that result in changes that distinguish cells of one lineage from another even as they share the same genome. (cancerrealitycheck.com)
The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice. (progen.com)
Lineage-Specific Induced Pluripotent Stem Cell-Derived Smooth Muscle Cell Modeling Predicts Integrin Alpha-V Antagonism Reduces Aortic Root Aneurysm Formation in Marfan Syndrome Mice. (stanford.edu)

Following PhD research on proviral integration sites in mouse mammary carcinomas with Gordon Peters at the ICRF (1987-1992), Marysia moved to New York as a post-doc with Jane Dodd at Columbia University. (bsdb.org)

What was special about Dolly is that her "parents" were actually a single cell originating from mammary tissue of an adult ewe. (wptv.com)
Hh proteins are secreted morphogens that play essential roles in regulation of embryogenesis, development, tissue homeostasis, regeneration and stem cell maintenance in a concentration-dependent manner [ 6 ]. (biomedcentral.com)
Equine mesenchymal stem cells from bonemarrow, adipose tissue and umbilical cord:immunophenotypic characterization anddifferentiation potential. (sciendo.com)
Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells from Sheep: Culture Characteristics. (sciendo.com)
Takahashi and Yamanaka 2006 as well as the lifetime of pluripotent cells in physiological adult tissue (Roy et al. (buyresearchchemicalss.net)
However, the growing interest in the development of innovative treatments that are aimed at the regeneration damaged tissue CNS is based on the latest research in the field of stem cells and neurology. (kiev.ua)
Tissue bioengineering and stem/progenitor cell treatments have both been individually pursued for stroke neural repair therapies, with some benefit in tissue recovery. (researchgate.net)
Emerging directions in stroke neural repair approaches combine these two therapies to use biopolymers with stem/progenitor transplants to promote greater cell survival in the transplant and directed delivery of bioactive molecules to the transplanted cells and the adjacent injured tissue. (researchgate.net)
Conditional Met KO mice were generated using Cre‑loxP methodology and characterization of these mice indicated that the HGF‑Met signaling pathway is essential in regeneration, protection, and homeostasis in various tissue types and cells. (spandidos-publications.com)
We believe these cells, called neural progenitor cells, are present in the optic nerve tissue at birth and remain for decades, helping to nourish the nerve fibers that form the optic nerve," said study leader Steven Bernstein, MD, Ph.D., Professor and Vice Chair of the Department of Ophthalmology and Visual Sciences at the University of Maryland School of Medicine. (debuglies.com)
Marysia uncovered how tissue interactions and combinations of signals regulate the organisation of cell fate and assembly of neural circuits in the spinal cord and hypothalamus. (bsdb.org)

2001 These results imply both epithelial plasticity-promoting and -restricting systems might be very important to the morphogenic potential of TEB WYE-354 stem/progenitor cells (Godde et al. (buyresearchchemicalss.net)
We think that defective cell fate decisions fuel the intra-humoral heterogeneity and plasticity that makes treatment of human brain tumors so challenging. (stanford.edu)

2009 whereas incomplete and reversible EMT takes place during morphogenesis of specific epithelial tissues such as for example mammary gland WYE-354 (MG) (Nakaya and Sheng 2013 Although very much has been learned all about the molecular systems that promote EMT during early advancement and in tumor cells hereditary pathways that regulate incomplete EMT during tissues morphogenesis to keep epithelial lineages are badly characterized. (buyresearchchemicalss.net)
This promotes the death of tumor cells. (scitcentral.com)
Taken together, the work presented here provides a platform to identify novel therapeutics to target pancreatic tumor cells using PDOs. (bvsalud.org)
We therefore work to gain an understanding of how brain cells control the fate of their progeny, whereby we unravel novel points of vulnerabilities in brain tumor cells, that could be exploited therapeutically. (stanford.edu)
It is known that brain tumor cells, on the other hand, defy many general principles of neurobiology. (stanford.edu)
Tumor cell hierarchies are poorly understood, providing no explanation for why tumor cells with stem-like, progenitor-like, and differentiated features co-exist and interact with normal brain cells and immune-infiltrating cells within a single tumor entity, and how this heterogeneity relates to the lack of active immune infiltration. (stanford.edu)

Bovine fetal mesenchymal stem cells exert antiproliferative efect against mastitis causing pathogen Staphylococcus aureus. (sciendo.com)
Cryopreserved allogeneic mesenchymal stem cells enhance wound repair in full thickness skin wound model and cattle clinical teat injuries. (sciendo.com)

Recent studies point to the role of Hedgehog signaling in regulating adult stem cells involved in maintenance and regeneration of adult tissues. (wikipedia.org)
Comparison of human mesenchymal stromal cells from four neonatal tissues: Amniotic membrane, chorionic membrane, placental decidua and umbilical cord. (sciendo.com)
Right here we offer in vivo proof to get a previously unrecognized system that defends epithelial identification during mammary tissues morphogenesis and regeneration that involves Ovo-like 2 (Ovol2) an associate from the Ovo category of zinc finger TFs that are recognized to regulate epithelial advancement in epidermis aswell as mammalian epidermis and testis (Dai et al. (buyresearchchemicalss.net)
HGF is produced and secreted by adjacent stromal and mesenchymal cells, it contributes to the development of epithelial organs in a paracrine fashion, exerts regenerative effects on epithelia in the liver, kidney, lung, and other tissues, and promotes the regression of fibrosis in numerous organs ( 7 , 8 ). (spandidos-publications.com)

Thus, the introduction or mobilization of NSCs could be expected to lead to CNS regeneration by recapitulating normal CNS development, in terms of the activation of the endogenous regenerative capacity and cell transplantation therapy. (kiev.ua)
Neighboring Paneth cells responded to IL-33 by augmenting production of EGF, which promoted ISC recovery and epithelial regeneration. (bvsalud.org)
These findings reveal an unknown pathway of niche regulation and crypt regeneration whereby the niche responds dynamically upon injury and the stem cells orchestrate regeneration by regulating their niche. (bvsalud.org)

After birth, mammary development is arrested until puberty, when extensive elongation of the ducts, accompanied by secondary branching, takes place, thus providing a readily accessible system in which to study branching morphogenesis. (biologists.com)
At puberty mammary epithelial stem/progenitor cells that have a home in the terminal end buds (TEBs) go through collective migration to operate a vehicle ductal morphogenesis (Ewald et al. (buyresearchchemicalss.net)

Also covered in detail was the basic cell biology of EMT and its role in cancer and fibrosis, as well as the identification of new markers to facilitate the observation of EMT in vivo. (rupress.org)
Chalmers SB, van der Wal T , Fre S, Jonkers J (2023), 'Fourteenth Annual ENBDC Workshop: Methods in Mammary Gland Biology and Breast Cancer' , J Mammary Gland Biol Neoplasia. (vanamerongenlab.nl)
first available as pre-print ) van de Grift YBC , Heijmans N , van Amerongen R (2021), 'How to use online tools to generate new hypotheses for mammary gland biology research: a case study for Wnt7b' , J Mammary Gland Biol Neoplasia (2021). (vanamerongenlab.nl)
4 ] in 1951 cell culturing has become one of the most widely used methods with exceptional contribution to the advances in almost all fields of contemporary biology - cell biology, genetics, cell biochemistry, physiology etc. (intechopen.com)
Nature Cell Biology 20, 979-989. (ucsf.edu)
It is well established in cell biology that gap junctions facilitate intercellular communication and increase electric conductivity.Acupuncture and meridian points have also been found to have higher temperature 13 , higher metabolic rate and carbon dioxide release. (med-vetacupuncture.org)
Cold Spring Harbor, NY -- Cold Spring Harbor Laboratory Press (CSHLP) announced the release of The Digital Cell: Cell Biology as a Data Science, available on its website in hardcover format. (cshlpress.com)
N. den Elzen, C. V. Buttery, M. P. Maddugoda, G. Ren and A. S. Yap, "Cadherin Adhesion Receptors Orient the Mitotic Spindle during Symmetric Cell Division in Mammalian Epithelia," Molecular Biology of the Cell, Vol. 20, No. 16, 2009, pp. 3740-3750. (scirp.org)

Our work represents the most in-depth characterization of a mammalian ribosomal protein paralog to date and highlights the importance of considering both protein function and expression when investigating paralogs. (stanford.edu)

Mammary glands are epidermal appendages that possibly evolved from ancient apocrine glands that were associated with the skin( Oftedal, 2002 ). (biologists.com)

The basal/myoepithelial inhabitants of adult MG provides the so-called multipotent mammary stem cells (MaSCs) that upon transplantation can handle regenerating a whole epithelial network made up of both luminal and basal/myoepithelial lineages (Shackleton et al. (buyresearchchemicalss.net)

Mammary gland development occurs through distinctive stages throughout embryonic and pubertal development and reproductive life. (biologists.com)
There are three main stages of mammary gland development both in rodents and humans: embryonic, pubertal and adult. (biologists.com)
In this review, we provide a comprehensive overview of the canonical Hh signalling pathway in mammals, highlight its roles in mammary gland development and breast carcinogenesis and discuss its potential therapeutic value in BLBC. (biomedcentral.com)

Likewise, strategies for the containment of cancer might be based on promoting normal pathways of cell loss, the basal mode for handling excess cells. (iospress.com)
There are two main types of epithelium in the mammary gland: luminal and basal. (biologists.com)
The luminal epithelium forms the ducts and the secretory alveoli, whereas the basal epithelium consists essentially of myoepithelial cells. (biologists.com)
Animal cells are generally cultured in basal media supplemented with fetal bovine serum (FBS) which provides the various factors essential for cell growth. (nature.com)
Basal macroautophagy (thereafter referred to as autophagy), a catabolic recycling system in cells, is key to maintaining cellular homeostasis and survival. (hindawi.com)

2011 Latest generally in vitro research have implicated many EMT-inducing transcription elements (EMT-TFs) such as for example Snail Slug and Zeb1 as critical indicators that promote stemness in regular and malignant mammary epithelial cells (MECs) (Chaffer et al. (buyresearchchemicalss.net)

Somatic cell cloning (cloning or nuclear transfer) is a technique in which the nucleus (DNA) of a somatic cell is transferred into an enucleated metaphase-II oocyte for the generation of a new individual, genetically identical to the somatic cell donor (Figure 1 ). (biomedcentral.com)
A matured oocyte (c) is then enucleated (d) and a donor cell is transferred into the enucleated oocyte (e). (biomedcentral.com)
The somatic cell and the oocyte is then fused (f) and the embryos is allowed to develop to a blastocyst in vitro (g). (biomedcentral.com)
A role of Pumilio 1 in mammalian oocyte maturation and maternal phase of embryogenesis. (ucsf.edu)

While Akt Ser 473 phosphorylation was readily detectable in AND-34 +/+ lens epithelial cells, it was markedly reduced in the AND-34 −/− lens epithelium. (molvis.org)

While the importance of autophagy for cell homeostasis and survival has long been appreciated, its role in tumorigenesis and cancer progression is still developing [ 10 , 11 ]. (hindawi.com)
Loss‑of‑function NOTCH1 mutations are early events during esophageal tumorigenesis, whereas gain‑of‑function NOTCH1 mutations are late events during T‑cell leukemogenesis and B‑cell lymphomagenesis. (spandidos-publications.com)

Cancer stem cells, instrumental in metastasis, would seem to ignore mechanisms normally functioning in the removal of excess cells. (iospress.com)
This simplified approach towards understanding the essence of the mechanisms, underlying the processes determining life and death of a cell has undoubtedly provided scientists with enormous amount of knowledge. (intechopen.com)
Intestinal stem cells (ISCs) maintain the epithelial lining of the intestines, but mechanisms regulating ISCs and their niche after damage remain poorly understood. (bvsalud.org)
Her research identified conserved mechanisms of cell fate determination in mammalian brain progenitors and led to a paradigm shift in understanding how brain progenitor cells self-renew and differentiate. (stanford.edu)
The mechanisms for cell fate decisions in the human brain are largely unknown. (stanford.edu)
By using patient-derived cells from brain surgeries, we investigate cell fate decision mechanisms in the normal brain and in brain malignancies. (stanford.edu)

In contrast, Dolly was produced by what's called somatic cell nuclear transfer. (wptv.com)
Dolly demonstrated that adult somatic cells also could be used as parents. (wptv.com)
By my calculations, Dolly was the single success from 277 tries at somatic cell nuclear transfer. (wptv.com)
Sometimes the process of cloning by somatic cell nuclear transfer still produces abnormal embryos, most of which die. (wptv.com)
Cloning by nuclear transfer using mammalian somatic cells has enormous potential application. (biomedcentral.com)
Because cattle are a species widely used for nuclear transfer studies, and more laboratories have succeeded in cloning cattle than any other specie, this review will be focused on somatic cell cloning of cattle. (biomedcentral.com)
By contrast, somatic alterations in the genes encoding Notch signaling components drive various types of human cancer, such as breast cancer, small-cell lung cancer (SCLC) and T-cell acute lymphoblastic leukemia (T-ALL) ( 6 - 9 ). (spandidos-publications.com)

Recent studies have provided new insights into the origin, specification and fate of mammary stem and progenitor cells and into how the differentiated lineages that comprise the functional mammary gland are determined. (biologists.com)
The Hh pathway is an evolutionarily conserved system for regulating patterning and cell fate from Drosophila to humans. (biomedcentral.com)
Normally, Hh ligand secreted by the notochord induces the ventral cell fate specification in the entire neural tube. (biomedcentral.com)
With this model more potent cells sit in the peaks of a landscape before rolling irreversibly downward towards deeper valleys representing more differentiated claims as the genome activates and silences fate-specific epigenetic markers. (cancerrealitycheck.com)
Her postdoctoral studies on neural stem cells and asymmetric cell division in the Lab of Dr. Yuh Nung Jan at the Howard Hughes Medical Institute and University of San Francisco, California implied for the first time a minus-end directed myosin in the process of cell fate determination. (stanford.edu)
During two years as an instructor and head of a research group in Munich, Germany, Dr. Petritsch and her team showed that cell fate determinants use a bimodal mechanism (diffusion and active capturing) for proper intracellular location. (stanford.edu)
Proper cell fate decisions by neuroglia stem cells are critical for growing the cell lineages that form the brain during development and to maintain adult brain homeostasis. (stanford.edu)
Defects in cell fate control could explain many key defects present in brain tumors Of special emphasis, we study the establishment of cell fates within normal hierarchical brain lineages for comparison to the dysregulated cell-fate hierarchies seen in brain tumors. (stanford.edu)

Their larval and adult cells have narrow potencies, sometimes coupled to virtually unlimited … proliferation, and function in the growth, maintenance and regulation of body size. (iospress.com)
The embryos of larger arthropods and deuterostomes with well-provisioned eggs or viviparity, on the other hand, exhibit regulative development, while their larval "set-aside" or adult stem cells function in the growth, maintenance, and regulation of organ size coupled to constrained proliferation and cell turnover. (iospress.com)
This serum-free and grain-derived-nutrient-free medium promoted the proliferation of bovine myoblasts, the main cell source for cultured beef. (nature.com)
Cellular senescence is a multifaceted process that arrests the proliferation of cells that are at risk of neoplastic transformation. (nature.com)

After an incubation period of about 3-7 days, they cause the symptoms of a mild common cold/bronchitis (nasal obstruction, sneezing, runny nose, cough, headache, fever, pneumonia, asthenia, and inflammation in the airway) in avian and mammalian species. (scitcentral.com)
Differential feed intake in mammalian and avian species: Immunization against ghrelin. (aamu.edu)

However, Notch signaling is inactivated in small‑cell lung cancer and squamous cell carcinomas. (spandidos-publications.com)

PR-domain-containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function. (rochester.edu)

Formation of Neu/ErbB2-induced mammary tumors is unaffected by loss of ErbB4. (rochester.edu)
Phase III clinical trials of Rova‑T for patients with small‑cell lung cancer and a phase III clinical trial of nirogacestat for patients with desmoid tumors are ongoing. (spandidos-publications.com)

These germ cells are the only ones in the body that have their genetic material all jumbled up and in half the quantity of every other kind of cell. (wptv.com)

Cultured meat is produced by culturing/proliferating animal muscle cells in vitro. (nature.com)
Hayflick, L. The limited in vitro lifetime of human diploid cell strains. (nature.com)
2018). Development of bovine embryos in vitro in coculture with murine mesenchymal stem clls and embryonic fibroblasts. (sciendo.com)
Cells are collected from donor (a) and cultured in vitro (b). (biomedcentral.com)
A defined synthetic mixture of amino acids, salts, carbohydrates, vitamins and serum was shown to support cells in vitro[ 3 ], thus unifying a major variable in cell culturing experiments and providing a possibility for rapid development of this novel method. (intechopen.com)
Although other irritants in the smoke may have contributed to the incident, there is supporting evidence that stable strontium can stimulate the release of histamine from mast cells in vitro (ATSDR 2001e). (cdc.gov)
Dr. Petritsch is an expert in oligodendrocyte progenitor cells, and cancer stem cells, and her team's emphasis is on intra-tumoral heterogeneity, in vitro and in vivo cancer model development, and tumor-immune interactions. (stanford.edu)

The function of the hedgehog segment polarity gene has been studied for influence on the normally polarized distribution of larval cuticular denticles as well as features on adult appendages such as legs and antennae. (wikipedia.org)
CiR builds up in the cell and diffuses into the nucleus, where it acts as a co-repressor for Hedgehog (Hh) target genes. (wikipedia.org)
Three mammalian Hh ligands have been identified, namely Sonic Hedgehog (SHH), Indian Hedgehog (IHH) and Desert Hedgehog (DHH) [ 3 ]. (biomedcentral.com)

Autophagy is an intracellular degradation system that ensures a dynamic recycling of a variety of building blocks required for self-renewal, homeostasis, and cell survival under stress. (hindawi.com)

Leukemic presentation of diffuse large B-cell lymphoma: an unusual pattern associated with splenic involvement. (rochester.edu)
Notch signaling is aberrantly activated in breast cancer, non‑small‑cell lung cancer and hematological malignancies, such as T‑cell acute lymphoblastic leukemia and diffuse large B‑cell lymphoma. (spandidos-publications.com)

I've been working with mammalian embryos for over 40 years, with some work in my lab specifically focusing on various methods of cloning cattle and other livestock species. (wptv.com)
it's highly variable, though, depending on the cell type used and the species. (wptv.com)

Trends Cell Biol. (nature.com)
J Cell Biol (2006) 172 (7): 973-981. (rupress.org)
first available as pre-print ) van Boxtel AL (2023), 'Whole-Mount In Situ Hybridization for Detection of Migrating Zebrafish Endodermal Cells' , Methods Mol Biol. (vanamerongenlab.nl)
van der Wal T, van Amerongen R (2023), 'Visualizing WNT signaling in mammalian systems' , Curr Top Dev Biol. (vanamerongenlab.nl)
Aarts MT, Wagner M , van der Wal T, van Boxtel AL*, van Amerongen R* (2023), 'A molecular toolbox to study progesterone receptor signaling ' , J Mammary Gland Biol Neoplasia 28, 24 (2023). (vanamerongenlab.nl)

In the healthy brain, neuroglia stem cells generate progenitors, which in turn give rise to differentiating cells that will eventually acquire their final functional state. (stanford.edu)

Normal CNS development is initiated by the induction of stem cells in the CNS, i.e., neural stem cells (NSCs). (kiev.ua)
The presence of neural stem/progenitor cells opens the door to new treatments to repair damage to the optic nerve, which is very exciting news. (debuglies.com)

Mystification may have been introduced historically with the concepts of determinate and regulative development, but, hopefully, the muddle can be resolved by tracing the evolution of stem cells in Metazoa. (iospress.com)
Hormones and growth factors play a role in these different stages of mammary development and are also implicated in breast cancer. (biologists.com)
This review will provide an update on the Hh signalling pathway and its role in the regulation of normal mammary development and the aetiology of breast cancer. (biomedcentral.com)
Understanding the causes and consequences of cellular senescence has provided novel insights into how cells react to stress, especially genotoxic stress, and how this cellular response can affect complex organismal processes such as the development of cancer and ageing. (nature.com)
References 2 and 3 describe the characteristics of cancer cells and the importance of mutations in cancer development. (nature.com)
Cells of epithelial lineages can go through phenotypic changes to get mesenchymal features via an epithelial-to-mesenchymal changeover (EMT) plan (Kalluri and Weinberg 2009 Full EMT takes place during mesoderm or neural crest development to generate completely dedicated mesenchymal cell types (Thiery et al. (buyresearchchemicalss.net)
Once we currently understand it you will find exceptions to this central dogma that may be exploited for the development of cell-based medical treatments. (cancerrealitycheck.com)

The pathway also has roles in the adult. (wikipedia.org)
Previous studies in other labs had uncovered certain sex differences in the response to stress, but those findings were obtained using research methods that could mask significant differences in the responses of specific cells or even entirely erase the roles played by relatively rare cells. (rna-seqblog.com)

In mammalian organisms, cells that express markers of senescence have been shown to accumulate with age and at sites of certain age-related pathologies. (nature.com)

Geometrical confinement controls the asymmetric patterning of brachyury in cultures of pluripotent cells. (ucsf.edu)

Regarding the central nervous system (CNS), it has been shown that the C/EBPβ gene is expressed in different areas of adult rodents [ 9 ] and different studies, including those from our group, have indicated that C/EBPβ can have important functions in the brain. (biomedcentral.com)

Dolly was the culmination of hundreds of cloning experiments that, for example, showed diploid embryonic and fetal cells could be parents of offspring. (wptv.com)

Adipose stem cells in reparative goat mastitis mammary gland. (sciendo.com)
Cells were blocked by normal goat serum for 30 min, added with primary antibody solutions at 37°C for 1 h, then cultured at room temperature overnight. (pdesignal.com)

Cell Res Ther. (kiev.ua)

Among these is the isolation of the first line of murine stem cells [ 5 , 6 ] in 1981, followed by establishment of the first human embryonic stem cell lines by Thompson [ 7 ]. (intechopen.com)

It increases natural killer cell activity and decreases markers of inflammation. (scitcentral.com)
The researchers were able to confirm the presence of these stem cells by using antibodies and genetically modified animals that identified the specific protein markers on neuronal stem cells. (debuglies.com)

Use of a chronic model of articular cartilage and meniscal injury for the assessment of long-term effects after autologous mesenchymal stromal cell treatment in Steep. (sciendo.com)

Anatomy71

Organisms19

Diseases5

Chemicals and Drugs53

Analytical, Diagnostic and Therapeutic Techniques and Equipment47

Phenomena and Processes58

Disciplines and Occupations4

Technology, Industry, Agriculture1

Information Science3

Differentiation14

Embryonic stem4

Epithelial cell3

Developmental5

Murine mammary1

Lineage10

Mouse mammary1

Tissue11

Plasticity2

Tumor cells6

Mesenchymal stem2

Tissues4

REGENERATION3

Morphogenesis2

Biology8

Characterization1

Epidermal1

Multipotent1

Gland development3

Basal5

Malignant1

Oocyte4

Epithelium1

Tumorigenesis2

Mechanisms6

Somatic7

Fate8

Proliferation4

Avian2

Carcinomas1

Hematopoietic1

Tumors2

Germ1

Vitro7

Hedgehog3

Homeostasis1

Diffuse large B-2

Species2

Biol5

Functional1

Neural stem2

Development7

Roles2

Organisms1

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Rodents1

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Goat2

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Stromal1