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Stem CellsHematopoietic Stem CellsStem Cell TransplantationLeukemia, B-CellEmbryonic Stem CellsAdult Stem CellsLymphoma, B-CellPluripotent Stem CellsMultiple MyelomaHematopoietic Stem Cell TransplantationNeoplasms, Plasma CellStem Cell NicheCell DifferentiationLymphomaNeural Stem CellsInduced Pluripotent Stem CellsMultipotent Stem CellsMesenchymal Stem Cell TransplantationB-LymphocytesNeoplasms, Germ Cell and EmbryonalLeukemia, Plasma CellLeukemiaMesenchymal Stromal CellsStem Cell FactorLymphoma, T-CellLeukemia, LymphoidLeukemia, T-CellFlow CytometryCell LineageLeukemia, Lymphocytic, Chronic, B-CellMice, SCIDPlasmacytomaCell Line, TumorAntigens, CD20Stem Cell ResearchAntigens, CD19Testicular NeoplasmsLymphoproliferative DisordersHematologic NeoplasmsChromosomes, Human, Pair 14Plant StemsAntineoplastic AgentsFetal Stem CellsCell ProliferationT-LymphocytesAntibodies, MonoclonalBurkitt LymphomaSignal TransductionPhenotypeBone MarrowLymphoma, Non-HodgkinCells, CulturedTranslocation, GeneticNeoplastic Stem CellsCell Transformation, NeoplasticHematopoietic Stem Cell MobilizationApoptosisImmunoglobulin Heavy ChainsAntigens, NeoplasmGenes, ImmunoglobulinTumor Cells, CulturedBone Marrow CellsMice, TransgenicAntigens, SurfaceRegenerationOctamer Transcription Factor-3NeoplasmsTransplantation, AutologousGene Expression Regulation, NeoplasticTransplantation, HomologousCell Culture TechniquesHematopoiesisCell SeparationPeripheral Blood Stem Cell TransplantationRegenerative MedicineAntigens, CD34Mice, Inbred C57BLTotipotent Stem CellsMolecular Sequence DataEmbryo, MammalianSOXB1 Transcription FactorsColony-Forming Units AssayReverse Transcriptase Polymerase Chain ReactionSpermatogoniaImmunohistochemistryCord Blood Stem Cell TransplantationCell LineGene Expression ProfilingProto-Oncogene Proteins c-kitCell- and Tissue-Based TherapyGene Expression Regulation, DevelopmentalTissue EngineeringTime FactorsBone Marrow TransplantationCell SurvivalCell DivisionNestinTransplantation ConditioningHomeodomain ProteinsModels, Biological
Hematological malignanciesMyeloid malignanciesHematologic MalignancyTransplantHSCTHaematological malignancyAntigen receptorUmbilical cordPatients with haematologicalMalignantHaematopoietic stem cell transplantSecondary malignanciesSolid malignanciesTherapiesLymphomaCancerAssociated with hematopoietic stemProgressionReceptorTumorsAllogeneic hematopoietic stem cChimericHematopoietic Cell TransplantationImmune deficienciesDonorRequiring stem cell transplantPathwaysGlioma cellsOutcomesChronicMyelodysplasticDiseaseProliferationLeukemiaPotentially curativeChemotherapyBone marrow mesenchymalKeratinocyteMesenchymalRenalExtracellularBenzeneNeural Stem
Hematological malignancies13
  • Therefore, the current descriptive and cross-sectional study sought to determine the cytogenetic analysis of frequent hematological malignancies in Pakistan. (scielo.br)
  • T cell immune protection plays a pivotal role in the treatment of patients with hematological malignancies. (hindawi.com)
  • However, T cell exhaustion might lead to the possibility of immune escape of hematological malignancies. (hindawi.com)
  • Adoptive cell therapy (ACT) with chimeric antigen receptor T (CAR-T) cells can restore the activity of exhausted T cell through reprogramming and is widely used in the treatment of relapsed/refractory (r/r) hematological malignancies. (hindawi.com)
  • However, CAR-T cells can also produce some adverse events after treatment of hematological malignancies, such as cytokine release syndrome (CRS), neurotoxicity, and on-target/off-tumor toxicity, which may cause systemic immune stress inflammation, destruction of the blood-brain barrier, and even normal tissue damage. (hindawi.com)
  • Over the last few decades, the treatment of hematological malignancies has gained tremendous headway, but these diseases still have high morbidity and mortality [ 1 - 3 ]. (hindawi.com)
  • Traditionally, the treatment of hematological malignancies is administrated by chemotherapy, radiotherapy, and stem cell transplantation. (hindawi.com)
  • In recent years, with the increased understanding of the molecular genetic basis of these malignancies, immune-targeted therapy has become a new possibility for the treatment of hematological malignancies. (hindawi.com)
  • It is noted that T cell has great potential for immunotherapy of hematological malignancies. (hindawi.com)
  • In addition, the isolation and storage of umbilical cord blood hematopoietic stem cells have been used to rebuild the immune system for the treatment of hematological malignancies and might be promising for the dynamic equilibrium expansion of functional T cells [ 12 ]. (hindawi.com)
  • Allogeneic hemopoietic stem cell transplantation (HSCT) is the only curative option for many patients with hematological malignancies. (nih.gov)
  • Hence the outcome of reduced intensity HSCT with lymphodepleting antibodies in older patients with intermediate/high-risk hematological malignancies appears comparable to that obtained with fully ablative transplantation in younger patients, even when these older recipients lack HLA-identical sibling donors. (nih.gov)
  • The myeloproliferative neoplasms (MPNs) are a heterogeneous group of chronic hematological malignancies that are generally divided into the Philadelphia chromosome-positive (Ph-positive) MPNs, which refers to chronic myelogenous leukemia (CML) and the Philadelphia chromosome-negative (Ph-negative) MPNs. (cancernetwork.com)
Myeloid malignancies4
  • recipient mice exhibited a higher incident of myeloid malignancies and a significantly reduced survival rate compare with WT recipient mice. (ox.ac.uk)
  • driven myeloid malignancies. (ox.ac.uk)
  • Conclusion: These results highlight the critical role of TET2 in the maintenance of BMSC functions and osteoblast differentiation, and provide evidence that dysregulation of epigenetic modifier in BMSCs contributes to the progression of myeloid malignancies. (ox.ac.uk)
  • MSCs have a lower ability to differentiate into osteoblasts but a higher ability to differentiate into adipocytes, which could be linked to myeloid malignancies ( Woods and Guezguez, 2021 ). (techscience.com)
Hematologic Malignancy1
  • Pulmonary mucormycosis generally occurs in patients with hematologic malignancy or profound neutropenia. (cdc.gov)
Transplant20
  • high-risk patients included male subjects, recipients of stem cells from female donors, patients younger than 10 years, those with nonidentical donors, and those who received radiation therapy in the transplant preparative regimen. (medscape.com)
  • 4 It also occurs in neutropenic cancer patients and hematopoietic stem cell transplant or solid organ transplant recipients. (cdc.gov)
  • Recently published data suggest that enteral nutrition (EN), given as systematic artificial nutrition support, could decrease grade III-IV graft-versus-host disease (GVHD) and infectious events, which are associated with early toxicity after allo-HSCT and then have an impact on early transplant-related mortality (D100 mortality). (biomedcentral.com)
  • The impacts of nutritional support should exceed the limits of nutritional status improvement: EN may directly reduce immunological and infectious events, as well as decrease early transplant-related morbidity and mortality. (biomedcentral.com)
  • This pilot clinical trial studies the side effects of irradiated donor cells following stem cell transplant in controlling cancer in patients with hematologic malignancies. (bioseek.eu)
  • Transfusion of irradiated donor cells (immune cells) from relatives may cause the patient's cancer to decrease in size and may help control cancer in patients receiving a stem cell transplant. (bioseek.eu)
  • New stem cell transplantation research conducted by physicians at selected stem cell transplant centers and at Miami Cancer Institute , part of Baptist Health, is showing promise in the fight against relapse, a leading cause of death in patients with hematologic cancers. (broadcastmed.net)
  • By eliminating the protein on the stem cells with this technology, there is a chance to specifically target residual leukemia, expressing CD33, with the donor's immune system following a stem cell transplant. (broadcastmed.net)
  • While many of the Cancer Institute's patients are able to receive the most advanced therapies for their diagnosis close to home, people who needed hematopoietic cell transplant or cellular immunotherapy have always needed to travel outside of the Lehigh Valley for these treatments. (lvhn.org)
  • That changes this year with the development of Lehigh Valley Topper Cancer Institute's Stem Cell Transplant and Cellular Therapy Program. (lvhn.org)
  • The Cancer Institute's membership in the Memorial Sloan Kettering Cancer Alliance will also connect the new program to additional stem cell transplant and cellular therapy education and resources. (lvhn.org)
  • Dr. Toor and Dr. Nair hope to launch the Stem Cell Transplant and Cellular Therapy Program in fall 2023. (lvhn.org)
  • Initially, the program will offer consultative services (regarding donor selection, transplant eligibility and post-transplant follow-up) for people with a variety of hematologic malignancies as well as transplant procedures in select individuals. (lvhn.org)
  • Abbey Jenkins, president and CEO of Gamida, called the approval "a major advancement in the treatment of patients with hematologic malignancies that we believe may increase access to stem cell transplant and help improve patient outcomes. (medscape.com)
  • In all, 16 patients had high-risk disease, including 12 with active malignancy at the time of transplant. (nih.gov)
  • Detection of galactomannan (a component of the Aspergillus cell wall) in serum or bronchoalveolar lavage fluid is recommended as an accurate marker for the diagnosis of invasive aspergillosis in adults and children, when used in certain patient subpopulations, such as hematopoietic stem cell transplant recipients or patients with hematologic malignancies. (medscape.com)
  • Aerosolized formulations of amphotericin B may be considered as prophylaxis in patients with prolonged neutropenia (patients receiving induction/reinduction therapy for acute leukemia and allogeneic hematopoietic stem cell transplant recipients following conditioning or during treatment of graft versus host disease) and in lung transplant recipients. (medscape.com)
  • This type of transplantation, also known as a bone marrow transplant, is one of the common treatments used to treat several blood malignancies. (lu.se)
  • If it weren't for the hematopoietic stem cells, this transplant would only be a transient therapy meaning its effects would only last a short time. (lu.se)
  • 202. Autologous stem cell transplant within 6 weeks of planned KTE-X19 or axicabtagene ciloleucel infusion. (who.int)
HSCT14
  • Likewise, many children are now surviving hematopoietic stem-cell transplantation (HSCT) (see related histology slide below) and require structured long-term follow-up care. (medscape.com)
  • Myeloablative allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a major procedure usually accompanied by multifactorial malnutrition, prompting the recommendation of systematic artificial nutritional support. (biomedcentral.com)
  • We report on the NEPHA trial: an open-label, prospective, randomised, multi-centre study on two parallel groups, which has been designed to evaluate the effect of EN compared to PN on early toxicity after an allo-HSCT procedure. (biomedcentral.com)
  • Two hundred forty patients treated with allo-HSCT for a haematological malignancy will be randomly assigned to two groups to receive either EN or PN. (biomedcentral.com)
  • Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a major procedure, and is usually conducted to consolidate remission of haematological malignancies. (biomedcentral.com)
  • Allo-HSCT includes administration of a chemotherapy-based conditioning regimen (myelo-ablative or non-myelo-ablative), followed by infusion of alloreactive haematopoietic stem cells, with the aim of inducing an active immunological anti-tumoral effect. (biomedcentral.com)
  • COHORT I: Within 42 days after hematopoietic engraftment (both neutrophils and platelets) after autologous hematopoietic stem cell transplantation (HSCT), patients receive initial treatment with IHC. (bioseek.eu)
  • Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood in order to replicate inside of a patient and to produce additional normal blood cells. (wikipedia.org)
  • Autologous HSCT requires the extraction (apheresis) of hematopoietic stem cells (HSCs) from the patient and storage of the harvested cells in a freezer. (wikipedia.org)
  • BK polyomavirus (BKPyV) is recognized as a pathogen that causes diseases such as hemorrhagic cystitis and nephritis after allogeneic hematopoietic stem cell transplantation (HSCT) or renal transplantation. (elsevierpure.com)
  • The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
  • Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
  • The growing need for haematopoietic stem cell transplantation (HSCT) is reflected in the increasing number of transplants performed globally each year. (bvsalud.org)
Haematological malignancy1
  • AML (Acute Myeloid Leukemia) is a blood cancer (haematological malignancy), and the standard way of treating older AML patients is chemotherapy. (lu.se)
Antigen receptor4
  • He also has expertise with cellular therapies for hematologic malignancies, specifically chimeric antigen receptor (CAR) T-cell therapy. (lvhn.org)
  • The first area of research, representing a long-term project in the lab, involves characterization of the role of T cell antigen receptor (TCR) signals, and in particular, individual TCR signal transducing subunits and signal transducing motifs in T cell development. (nih.gov)
  • Chimeric antigen receptor (CAR)-T cell therapies are on the verge of becoming powerful immunotherapeutic tools for combating hematological diseases confronted with pressing medical needs. (nature.com)
  • 205. Prior chimeric antigen receptor therapy or other genetically modified T cell therapy 206. (who.int)
Umbilical cord1
  • The US Food and Drug Administration (FDA) approved omidubicel-onlv (Omisirge) for reducing infections and hastening neutrophil recovery for blood cancer patients aged 12 years and older who are undergoing allogeneic umbilical cord blood stem cell transplants. (medscape.com)
Patients with haematological1
Malignant9
  • Today cancer can be defined as any malignant growth or tumour caused by abnormal and uncontrolled cell division, able to invade tissues locally and have the ability to spread to other parts of the body through the lymphatic system or the blood stream. (vin.com)
  • A total of 202 peripheral bone marrow or blood samples from patients with benign and malignant hematological malignancy were taken using a conventional G-banding technique. (scielo.br)
  • unexpectedly, single- cell profiling of human NF and MPNST and their animal models reveal a broad range of nestin -expressing SC lineage cells and dynamic acquisition of discrete cancer states during malignant transformation. (bvsalud.org)
  • We uncover a nestin -negative mesenchymal neural crest -like subpopulation as a previously unknown malignant stem -like state common to murine and human MPNSTs, which correlates with clinical severity. (bvsalud.org)
  • The patient is then treated with high-dose chemotherapy with or without radiotherapy with the intention of eradicating the patient's malignant cell population at the cost of partial or complete bone marrow ablation (destruction of patient's bone marrow's ability to grow new blood cells). (wikipedia.org)
  • Allogeneic haemopoietic stem cell transplantation offers a potentially curative treatment option for a wide range of life-threatening malignant and non-malignant disorders of the bone marrow and immune system in patients of all ages. (nih.gov)
  • Minimal residual disease (MRD) refers to the small number of malignant cells that remain after therapy when the patient is in remission and shows no symptoms or overt signs of disease. (smw.ch)
  • Normally, potentially malignant cells are continuously eliminated by the immune system, but cancer cells can accumulate certain mutations, which allow them to escape these mechanisms [ 2 ]. (nature.com)
  • CAR-modified immune cells are expanded until sufficient cell numbers are attained and are adoptively transferred into the patient to fight malignant cells. (nature.com)
Haematopoietic stem cell transplant1
  • HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation. (cdc.gov)
Secondary malignancies1
Solid malignancies1
  • According to the cancer stem cell (CSC) concept, the cellular hierarchy in normal tissues is preserved in a number of hematological and solid malignancies. (medscape.com)
Therapies8
  • Among the most revolutionary therapies for hematologic malignancies is stem cell transplantation, which had its beginnings in the 1950s. (broadcastmed.net)
  • By studying these immature blood cells, he aims to better understand what causes these diseases, as well as the mechanisms by which they sometimes become resistant to standard therapies. (missionbio.com)
  • It is an honor to bring stem cell transplantation and cellular therapies to adults in the Lehigh Valley and its surrounding communities," Dr. Toor says. (lvhn.org)
  • Cellular therapies being offered as standard of care or being evaluated in clinical trials include CAR T-cell therapy, engineered T cell receptors (TCRs), natural killer (NK) cells, cytotoxic lymphocytes, and tumor infiltrating lymphocytes. (dana-farber.org)
  • They devised methods to mark and track the behavior of these tumor-initiating stem cells and discovered that not only are these cells at invasive fronts of the cancers, but they are also responsible for tumor relapse following chemo- and immune-therapies administered to mice with tumors. (rockefeller.edu)
  • Lately, CAR-NK cell therapies have also come into focus as novel therapeutic options to address hurdles related to CAR-T cell therapies, such as therapy-induced side effects. (nature.com)
  • In this review, we are going to take a closer look at the commercial CAR-T cell therapies, as well as on CAR-T and CAR-NK cell products, which are currently under evaluation in clinical trials, that are being conducted in Germany. (nature.com)
  • Gene and cell therapies present novel alternatives to disease management, offering the promise of a single treatment and a lifelong cure. (bvsalud.org)
Lymphoma6
  • We examined the effects of cigarette smoke condensate (CSC) on the formation of cancer stem-like cells, which are rich in octamer-binding transcription factor (OCT)-4, inhibitor of differentiation 1 (ID1), nuclear factor (NF)-κB, and B lymphoma Mo-MLV insertion region 1 homolog (BMI-1). (umn.edu)
  • Other conditions treated with stem cell transplants include sickle cell disease, myelodysplastic syndrome, neuroblastoma, lymphoma, Ewing's sarcoma, desmoplastic small round cell tumor, chronic granulomatous disease, Hodgkin's disease and Wiskott-Aldrich syndrome. (wikipedia.org)
  • In this review, we aim to summarize the composition of CAR-T cell and its application in the treatment of acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL), Hodgkin's lymphoma (HL), multiple myeloma (MM), and acute myeloid leukemia (AML). (hindawi.com)
  • Methods: A PubMed, EMBASE, and Cochrane search yielded 4 comparative studies reporting allogeneic versus HDT with autologous SCT outcomes in adults (age ≥18) with transformed low-grade lymphoid malignancies, including follicular, chronic/small lymphocytic, and marginal zone lymphoma. (arizona.edu)
  • n = 73), grade 3 FL (n = 23), small lymphocytic lymphoma (n = 20), marginal zone lymphoma (n = 15), mantle cell lymphoma (n = 9), transformed lymphomas (n = 5), lymphoplasmacytic lymphoma (n = 2) and not reported (n = 2). (ox.ac.uk)
  • Pre-emptive treatment with rituximab of molecular relapse after autologous stem cell transplantation in mantle cell lymphoma. (smw.ch)
Cancer39
  • This review attempts to condense our understanding of cancer and offer insights into an alternative theory regarding the existence of true cancer stem cells and how this will inform the development of new therapeutics. (vin.com)
  • In simple terms, cancer can be considered as a breakdown in cellular homeostasis leading to uncontrolled cell division and proliferation, which ultimately leads to a disease state. (vin.com)
  • However, despite the fact that cancer is a common disease and considering the number of cells making up an organism, the change from normal cell to cancer cell is actually a very rare event. (vin.com)
  • Further, we will consider the role of Stem Cells in cancer and how they are challenging conventional wisdom. (vin.com)
  • O-GlcNAcylation of STAT5 could be required for nutrient sensing and metabolism of cancer cells. (nature.com)
  • 16 Cancer cells exhibit elevated levels of O-GlcNAc, possibly to adjust to stringent metabolic demands and O-GlcNAcylation is a key metabolic regulator of glucose metabolism. (nature.com)
  • However, the underlying molecular mechanisms of cigarette smoking-induced HNSCC carcinogenesis are unclear and may involve cancer stem-like cell generation. (umn.edu)
  • Materials and Methods: We used in vitro, in vivo, and archival human HNSCC tissue analysis to evaluate the effects of CSC on cancer stem-like cell formation. (umn.edu)
  • Conclusion: Our data suggest that smoking cigarettes promoted cancer stem-like cell generation in the head and neck area via the OCT-4/ID1/NF-κB/BMI-1 signaling pathway. (umn.edu)
  • 4:00 PM March 8, 2022 - 'Why Don't We Get More Cancer: The critical role of extracellular matrix and microenvironment in malignancy and dormancy? (stanford.edu)
  • Cancer stem cells in haematological malignancies. (scielo.br)
  • Join the experts at the Miami Cancer Institute Global Summit on Immunotherapies for Hematologic Malignancies, March 8-9, 2024, at the JW Marriott Brickell, 1109 Brickell Ave., in Miami, to learn more. (broadcastmed.net)
  • Cancer Stem Cells Market: Global Size, Trends, Competitive, Historical & Forecast Analysis, 2019-2025- Increasing cases of cancer-related morbidity across the world will fuel the demand for cancer stem cells and drive the growth of the global cancer stem cells market. (medgadget.com)
  • Global Cancer Stem Cells Market is valued at USD 827.2 Million in 2018 and expected to reach USD 1717.4 Million by 2025 with the CAGR of 11.0% over the forecast period. (medgadget.com)
  • The cancer stem cells (CSC) are the cells of cancer (which are found inside hematological growths of tumors) which have qualities associated with ordinary stem cells, particularly the capability to offer ascent to all types of cell found in a specific sample of cancer. (medgadget.com)
  • Cancer stem cells are a minor subpopulation of cells inside tumors with capabilities of self-renewal, differentiation, and tumorigenicity when transplanted into an animal host. (medgadget.com)
  • The CSCs are subsequently tumorigenic, may be rather than other non-tumorigenic cells of cancer. (medgadget.com)
  • Cancer stem cells are planned to breed in tumors as a separate population and thereby cause weakening and metastasis of existing tumor through generation of new tumor. (medgadget.com)
  • Global cancer stem cells market report is segmented on the basis of treatment type, disease type, application, end-user and regional & country level. (medgadget.com)
  • Based on treatment type global cancer stem cells market is classified as autologous stem cell transplants, allogeneic stem cell transplants, syngeneic stem cell transplants and bone marrow stem cell transplants. (medgadget.com)
  • Based upon end-user, global cancer stem cells market is classified as hospitals and surgical centers, pharmaceutical and biotech companies, cell banks and tissue banks, academic institutes, research laboratories, and CROs and others. (medgadget.com)
  • The regions covered in this Global Cancer Stem Cells Market report are North America, Europe, Asia-Pacific and Rest of the World. (medgadget.com)
  • Cancer stem cells are under research for various types of cancers such as lung cancer, breast cancer, colorectal cancer, skin cancer, brain cancer and bone cancer. (medgadget.com)
  • Novel understanding in the interaction between immune system and cancer cells of the patient holds great promise for immunotherapy development [ 4 - 6 ]. (hindawi.com)
  • Distinct hallmarks of cancer were examined using in silico analysis, various in vitro cell culture assays, and ex vivo organotypic rat brain slice culture model. (hindawi.com)
  • For this purpose, we designed an MCT4 overexpression and knockdown/inhibition model to explore the functional consequences of MCT4 expression on cancer cell metabolism, survival, proliferation, migration, invasion potential, and angiogenesis as well as on cell cycle profiles and cell death mechanisms. (hindawi.com)
  • How to stop the cancer and let the good stem cells control the pathways? (huffpost.com)
  • Dr. Toor is a renowned transplanter, and he is dedicated to determining the best treatment option for each individual based on their comorbidities and the genomics of their malignancy," says hematologist oncologist Suresh Nair, MD , Physician in Chief, Lehigh Valley Topper Cancer Institute. (lvhn.org)
  • Cite this: FDA OKs Stem Cell Therapy to Reduce Infection Risk in Blood Cancer Patients - Medscape - Apr 18, 2023. (medscape.com)
  • Studies the mechanisms underlying how stem cells make and repair tissues and deviate in stress, aging, and cancer. (rockefeller.edu)
  • Fuchs's group also learned that cancer cells hijack the basic mechanisms that enable stem cells to replenish dying cells and to repair wounds. (rockefeller.edu)
  • While the foundations of normal tissue homeostasis and injury repair are still unfolding, the fundamental discoveries that Fuchs's lab has made already provide insights into how skin and its stem cells cope with different environmental stresses, including aging, inflammation, and cancer, offering new avenues for treating human skin disorders. (rockefeller.edu)
  • The current gold standard of care for first-line therapy in patients with nonsmall cell lung cancer (NSCLC) is a platinum-based doublet chemotherapy, which is recommended for a maximum of six cycles. (deepdyve.com)
  • Cancer immunotherapies aim to support or boost the patient's immune system to enable the effective clearance of cancer cells. (nature.com)
  • CAR-expression on T or NK cells allows them to specifically target cancer cells via recognition of tumor associated antigens. (nature.com)
  • 201. History of malignancy other than non-melanomatous skin cancer or carcinoma in situ (e.g. cervix, bladder, breast) unless disease free for at least 3 years. (who.int)
  • The cancer stem cell theory holds that tumors also contain stem-like cells that drive tumor growth and metastasis formation. (medscape.com)
  • The CSC is defined as a cancer cell with self-renewing capacity that can regenerate the original tumor in all its differentiated heterogeneity. (medscape.com)
  • Cancer stem cell-associated proteins revealed by proteomics. (medscape.com)
Associated with hematopoietic stem1
  • Hematological disorders are typically associated with hematopoietic stem cells mutations and chromosomal aberrations such as aneuploidy or euploidy ( Zagozdzon and Golab, 2015 ZAGOZDZON, R. and GOLAB, J., 2015. (scielo.br)
Progression2
  • Together, our studies reveal the underlying principles of tumor cell - state evolution and their regulatory circuitries during NF-to- MPNST transformation, highlighting a hitherto unrecognized mesenchymal stem -like subpopulation in MPNST disease progression . (bvsalud.org)
  • Clonal hematopoiesis is frequently present, and there is a risk of progression to a myeloid malignancy. (msdmanuals.com)
Receptor4
  • Cytokine binding to the cell surface leads to phosphorylation of the receptor complex by receptor associated Janus kinases (JAKs) at tyrosine residues. (nature.com)
  • The most active T cell endogenous inhibitory pathway is the immunoglobulin superfamily such as CD28/cytotoxic T lymphocyte antigen-4 (CTLA-4): B7-1/B7-2 receptor/ligand grouping, which plays a central role in coordinating immune responses [ 7 , 8 ]. (hindawi.com)
  • Classical " CARs consist of an extracellular binding domain mostly derived from a monoclonal antibody fragment (single-chain variable fragment-scFv), which is linked to intracellular binding domains of the T-cell receptor complex. (nature.com)
  • These toxins bind to globotriaosylceramide (Gb3), a glycolipid receptor molecule on the surface of endothelial cells in the gut, kidney, and, occasionally, other organs. (medscape.com)
Tumors2
  • The companies will collaborate to develop and test small molecule agonists that target RIG-I, an innate immunostimulatory pathway that can elicit immunogenic cell death (ICD) in tumors, providing both direct tumor cell killing and enhanced anti-tumor immune responses. (medgadget.com)
  • The epithelial neuroendocrine tumors are further divided into two high-grade carcinomas, large and small cell neuroendocrine carcinomas, and into low-grade typical and intermediate grade atypical carcinoid. (deepdyve.com)
Allogeneic hematopoietic stem c1
Chimeric1
  • One way to achieve this is to genetically modify immune cells, mainly T cells and recently also natural killer (NK) cells, to express chimeric antigen receptors (CARs). (nature.com)
Hematopoietic Cell Transplantation4
  • To stimulate and facilitate further research, the NCI and NHLBI held the First International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation on April 28 and 29, 2011. (medscape.com)
  • Hematopoietic cell transplantation (HCT) provides a life-prolonging or potentially curative treatment option for patients with hematologic malignancies. (nccn.org)
  • He has published extensively on the immunobiology and application of hematopoietic cell transplantation, with nearly 200 scientific abstracts and peer-reviewed publications over the span of his career. (lvhn.org)
  • Genetic Variants Associated with Cytomegalovirus Infection after Allogeneic Hematopoietic Cell Transplantation. (cdc.gov)
Immune deficiencies1
Donor6
  • It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come from a donor) or syngeneic (from an identical twin). (wikipedia.org)
  • In 2014, according to the World Marrow Donor Association, stem-cell products provided for unrelated transplantation worldwide had increased to 20,604 (4,149 bone-marrow donations, 12,506 peripheral blood stem-cell donations, and 3,949 cord-blood units). (wikipedia.org)
  • Omidubicel is made from umbilical cord donor stem cells that are processed with nicotinamide, a form of vitamin B3, to enhance and expand the number of progenitor cells, the product's maker, Israel-based Gamida Cell, explained in a press announcement . (medscape.com)
  • There is also a small risk of infections and malignancies from donor blood. (medscape.com)
  • Here, we report transmission of dengue virus to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (cdc.gov)
  • STUDY DESIGN AND METHODS: We cryopreserved patient or donor HPC(A) products using 10% DMSO or 16% PIM and quantified the recovery of CD34+ cells and CD34+ subpopulations by multicolor flow cytometry. (lu.se)
Requiring stem cell transplant1
Pathways3
  • Her research employs high throughput genomics, single cell sequencing, live imaging, cell biology, and functional approaches to unravel the pathways that balance stem cell self-renewal with tissue regeneration. (rockefeller.edu)
  • They also study the signaling pathways that must be turned on and off at the right time and place for adult skin stem cells to become activated to regenerate tissue. (rockefeller.edu)
  • The aim of these studies is to understand how these molecules participate in TCR mediated signaling and to determine what roles they and the signaling pathways they regulate play in T cell maturation, thymocyte selection and T cell activation. (nih.gov)
Glioma cells2
  • In summary, our data highlight MCT4 /SLC16A3 as a key gene for distinct hallmarks of tumor malignancy in glioma cells. (hindawi.com)
  • We investigated the impact on tumor malignancy in F98 glioma cells using in silico analysis, in vitro cell culture assays, and ex vivo vascular organotypic glioma impact model (VOGIM) [ 35 ] by implanting F98 cells into rat brain slices. (hindawi.com)
Outcomes4
  • Secondary endpoints will compare EN and PN with regards to the main haematological, infectious and nutritional outcomes. (biomedcentral.com)
  • SCT outcomes in transformed low-grade lymphoid malignancies may differ from those of nontransformed disease or other aggressive non-Hodgkin lymphomas. (arizona.edu)
  • We conducted a pooled analysis of the clinical outcomes of allogeneic versus high-dose therapy (HDT) with autologous SCT in adult patients with transformed low-grade lymphoid malignancies. (arizona.edu)
  • High-dose therapy (HDT) combined with autologous stem-cell transplantation (ASCT) provides superior response and survival outcomes versus standard chemotherapy in patients with newly diagnosed (ND) multiple myeloma (MM). 1 , 2 Standard induction chemotherapy regimens, however, are often associated with hematologic stem-cell toxicity, which may compromise the collection of stem cells for ASCT. (haematologica.org)
Chronic3
  • However, from the beginning of puberty after thymus degeneration, human cytomegalovirus (HCMV) persists due to the chronic activation of cytomegalovirus in humans causing repeated activation of T cells, which is considered the driving factor of human immune aging [ 9 ]. (hindawi.com)
  • The condition may be indistinguishable from other causes of chronic oral ulcers (eg, tuberculosis, malignancy). (medscape.com)
  • Chronic lymphoid leukaemia and hairy cell leukaemia due to chronic exposure to benzene: Report of three cases. (cdc.gov)
Myelodysplastic1
  • The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
Disease5
  • Dr. Chung will present some of his team's prior work describing cell surface markers aberrantly expressed on disease stem cells in MDS and AML, as well as some preliminary data utilizing the Mission Bio Tapestri single-cell multi-omics platform to identify novel disease stem cell associated markers. (missionbio.com)
  • As a postdoctoral fellow in the Human Oncology and Pathogenesis Program at MSKCC, Dr. Chung's work led to the identification of the hematopoietic stem cell as the cell of origin for hairy cell leukemia, as well as the identification of CD99 as a disease stem cell marker and therapeutic target in MDS and AML. (missionbio.com)
  • Minimal residual disease monitoring: the new standard for treatment evaluation of haematological malignancies? (smw.ch)
  • Besides modification based on a second-generation CAR, more advanced CAR-immune cell therapeutics are being tested, which utilize precise insertion of genes to circumvent graft-versus-host disease (GvHD) or employ a dual targeting approach and adapter CARs in order to avoid therapy resistance caused by antigen loss. (nature.com)
  • Pemphigus vulgaris (PV) is a life-threate- disorders and to shed a light on the role of ning blistering skin disease in which pa- mast cells in autoimmune diseases [ 7 ]. (who.int)
Proliferation6
  • In terms of homeostasis, cell division, proliferation and differentiation are strictly controlled and a balance exists between normal cell birth and the natural cell death. (vin.com)
  • The signal transducer and activator of transcription 5 (STAT5) regulates differentiation, survival, proliferation and transformation of hematopoietic cells. (nature.com)
  • The latter findings point to the participation of Nogo-A/NgR1 signaling in the regulation of other aspects of growth, such as tissue expansion or turnover by cell proliferation. (jneurosci.org)
  • Our results further indicate that MCT4 promotes proliferation and survival by altered cell cycle regulation and cell death mechanisms. (hindawi.com)
  • The Fuchs lab has found that communication between stem cells and their neighbors, particularly immune cells, can become altered, and this can cause the stem cells' proliferation to either accelerate (in the case of inflammation) or slow (as occurs during aging). (rockefeller.edu)
  • It maintains normal hematopoietic function by interacting with hematopoietic stem cells (HSCs) to control their proliferation and differentiation ( Morrison and Scadden, 2014 ). (techscience.com)
Leukemia1
  • The VBP101 (NCT04849910) trial, still open for enrollment, involves CRISPR gene-editing technology, deleting CD33 protein that is also found on the surface of leukemia cells, but also on the normal blood-producing stem cells. (broadcastmed.net)
Potentially curative1
Chemotherapy1
  • Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)
Bone marrow mesenchymal1
Keratinocyte1
  • Little is known about molecular mecha- desmosomal glycoproteins, resulting in the nisms affecting mast cell and T lympho- loss of keratinocyte cell-cell adhesion [ 1 ]. (who.int)
Mesenchymal2
  • Single-cell multiomics identifies clinically relevant mesenchymal stem-like cells and key regulators for MPNST malignancy. (bvsalud.org)
  • The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
Renal1
  • Differential expression of Gb3 on glomerular capillaries compared with other endothelial cells may explain the predominance of renal injury. (medscape.com)
Extracellular1
  • 3 STAT5 regulated signaling controls important functions of innate and acquired immunity, hematopoiesis, and also growth and survival of many cell types in different organs responding to extracellular cytokines. (nature.com)
Benzene2
  • Stem cell and benzene -induced malignancy and hematotoxicity. (cdc.gov)
  • Different types of malignancies due to occupational exposure to benzene: A review of recent observations in Turkey. (cdc.gov)
Neural Stem1
  • In the adult mammalian subventricular zone (SVZ), GFAP-positive neural stem cells (NSCs) generate neuroblasts that migrate tangentially along the rostral migratory stream (RMS) toward the olfactory bulb (OB). (jneurosci.org)