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  • spinal cord i
  • NIH researchers are hard at work using stem cells as a powerful tool to study neurological disorders like Parkinson's, Huntington's disease, amyotrophic lateral sclerosis (ALS), and spinal cord injury, to name a few. (nih.gov)
  • Stem cells restore motor function in spinal cord injury. (nih.gov)
  • Scientists
  • Just a few years ago, scientists discovered how to make a third type, by reprogramming ordinary skin cells that have already "grown up" into those that look and act like cells from an embryo. (nih.gov)
  • Scientists at the National Eye Institute (NEI), part of the National Institutes of Health, report that tiny tube-like protrusions called primary cilia on cells of the retinal pigment epithelium (RPE)-a layer of cells in the back of the eye-are. (nih.gov)
  • The teams - selected to receive grants for scientific excellence and practical feasibility through a peer review process involving Canadian scientists outside Ontario - are working to restore vision in macular degeneration cases, use heart muscle derived from stem cells to fix damaged hearts, and develop novel stem cell strategies for immunotherapy. (theglobeandmail.com)
  • Scientists from the Department of Clinical Pharmacology, University Hospital of Tübingen , Tübingen, Germany have reported today a new way of delivering stem cells: via the nose. (cellmedicine.com)
  • laboratory
  • The ability to create iPS cells is a significant breakthrough, since the reprogramming technique is relatively simple to perform with standard laboratory methods, and because skin cells are easy to gather and grow. (nih.gov)
  • Dr Schmitz is Head of the Computational BioMedicine Laboratory within Centenary's Gene and Stem Cell Program. (centenary.org.au)
  • Retina
  • A proposal to create a living model of the human retina, the light-sensitive tissue at the back of the eye, won $90,000 in the National Eye Institute (NEI) 3-D Retina Organoid Challenge (3-D ROC). (nih.gov)
  • A new study in rats shows that stem cell secretions, called exosomes, appear to protect cells in the retina, the light-sensitive tissue in the back of the eye. (nih.gov)
  • An experimental 'rescue' of retinas by treating eyes with certain stem cells has been shown to preserve visual function in mice that were genetically predisposed to degenerative diseases of the retina. (nih.gov)
  • human
  • Thus the question, 'Should the stem cells of an unborn human be harvested to save the life of an ill human? (icr.org)
  • The body's immune system is unable to recognize human umbilical cord tissue (HUCT)-derived mesenchmyal stem cells as foreign and therefore they are not rejected. (cellmedicine.com)
  • This breakthrough, published in the journals Nature and Cell Stem Cell and developed independently by two teams in China, may possibly depreciate the usage of stem cells obtained from human embryos. (wikipedia.org)
  • tumors
  • Only a small percentage of cells in tumors, the cancer stem or initiating cells, drive the growth and metastatic capability of tumors. (stanford.edu)
  • Other thyroid malignancies include thyroid lymphoma, various types of thyroid sarcoma, smooth muscle tumors, teratoma, squamous cell thyroid carcinoma and other rare types of tumors. (wikipedia.org)
  • cancer
  • The Program postulates that self-renewal is a critical function of both cancer stem cells and their normal counterparts and that self-renewal pathways may be co-opted in the process of oncogenesis to support tumor growth. (stanford.edu)
  • He subsequently did an internal medicine residency at New England Deaconess Hospital and a fellowship in medical oncology at Dana-Farber Cancer Institute. (wikipedia.org)
  • and Alfred G. Knudson Award, National Cancer Institute, 2016. (wikipedia.org)
  • The Institute was incorporated with an initial donation of $500 million in 1994 by James E. Stowers and his wife Virginia Stowers, cancer survivors and founders of American Century Investments. (wikipedia.org)
  • Initiative
  • We are a part of the Starr Foundation-funded Tri-Institutional Stem Cell Initiative that provides shared stem cell expertise and resources among Memorial Sloan Kettering, Weill-Cornell, and Rockefeller University. (mskcc.org)
  • Faculty
  • The institute, located within the Shanghai Jiao Tong University under the School of Medicine faculty, is entirely funded by the government of the People's Republic of China. (wikipedia.org)
  • He has been on the Harvard Medical School faculty since the late 1970s and has been a Howard Hughes Medical Institute investigator since 1986. (wikipedia.org)
  • She also is a faculty member for Albany Medical College, Rensselaer Polytechnic Institute, and SUNY Albany. (wikipedia.org)
  • rats
  • In rats that received the stem cells intranasally it was possible to find stem cells in the olfactory bulb, cortex, hippocampus, striatum, cerebellum, brainstem, and spinal cord. (cellmedicine.com)
  • Out of 1 × 10(6) MSCs applied intranasally, 24% of the stem cells could be detected for least 4.5 months in the brains of 6-OHDA rats. (cellmedicine.com)
  • therapy
  • Dr Gerard Chu from Centenary's Gene and Stem Cell Therapy Program , has been awarded a three-year Postgraduate Scholarship grant. (centenary.org.au)
  • Head of Centenary's Gene and Stem Cell Therapy Program and 2018 ABC Boyer Lecturer, Professor John Rasko, spoke to ABC RN Breakfast host Fran Kelly about the serious ethical concerns surrounding the claim. (centenary.org.au)
  • Want to learn more about how stem cell therapy is disrupting medicine and transforming lives? (cellmedicine.com)
  • Purchase a copy of Dr. Riordan's new book about stem cell therapy today! (cellmedicine.com)
  • In September 2015, Orkin published a study in the journal Nature showing a small section of DNA which could be responsive to gene therapy for sickle-cell disease. (wikipedia.org)
  • Patients with medullary, anaplastic, and most Hurthle cell cancers do not benefit from this therapy. (wikipedia.org)
  • intravenous
  • Additionally some groups have used intravenous administration but the washout and number of cells being stuck in the lung and liver was reported as a potential problem. (cellmedicine.com)
  • mice
  • A total of 27 mice were successfully born from the first generation of mice created from the IPS cells which were able to reproduce without any issues. (wikipedia.org)
  • cultures
  • describe this product as a growth factor supplement that is able to grow FGF2 dependent stem cell cultures in a more efficient way. (wikipedia.org)
  • Sciences
  • He is a member of the National Academy of Sciences and the Institute of Medicine. (wikipedia.org)
  • In 2003 he was appointed a Personal Chair as Professor of Stem Cell Sciences at Monash University, was awarded a Doctor Honoris Causa by the Faculties of Medical Sciences and Physical Education and Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium, and was named Australian Humanist of the Year. (wikipedia.org)
  • embryo
  • In an early embryo, the cells have not yet differentiated into their specific forms, and can be "harvested" for other uses. (icr.org)
  • Immune
  • We go through a very high throughput screening process to find cells that we know have the best anti-inflammatory activity, the best immune modulating capacity, and the best ability to stimulate regeneration. (cellmedicine.com)
  • The stem cells with the best anti-inflammatory activity, immune modulating capacity, and ability to stimulate regeneration can be screened and selected. (cellmedicine.com)
  • Tyrosine kinase receptors are typically expressed on vascular endothelial cells and specific macrophages for immune responses. (wikipedia.org)
  • University
  • In collaboration with Dr. Molly Shoichet, also of University of Toronto, and the CCRM, the team has already developed biomaterials that help anchor these cells within the eye following the transplant. (theglobeandmail.com)
  • Born on May 24, 1964 in the south Indian state of Tamil Nadu, Sowdhamini earned a post graduate degree from the Indian Institute of Technology, Madras in basic chemistry and enrolled at the Indian Institute of Science for her doctoral studies from where she secured a PhD. Subsequently, she did her post-doctoral work in the UK, first at Birkbeck, University of London and later, at the University of Cambridge. (wikipedia.org)
  • primarily
  • Previous experiments administering stem cells for the treatment of Parkinson's were primarily aimed at injection directly into the brain using sterotactic methods. (cellmedicine.com)
  • interactions
  • Cell biologists have long focused on the tiniest of interactions: those between molecules. (icr.org)
  • Tie-2/Ang-1 signaling activates β1-integrin and N-cadherin in LSK-Tie2+ cells and promotes hematopoietic stem cell (HSC) interactions with extracellular matrix and its cellular components. (wikipedia.org)
  • patients
  • Early attempts to utilize stem cells in needy patients have yielded questionable results. (icr.org)
  • By harvesting the original stem cells before their specialization and by controlling their environment and later growth, medical science hopes to be able to regenerate damaged tissue in patients. (icr.org)
  • This gives us hope for future therapeutic intervention using patients' own re-programmed cells in our far future," according to Professor Fanyi Zeng. (wikipedia.org)
  • Professor
  • Broad worked as an accountant for two years and taught night classes at the Detroit Institute of Technology as an assistant professor of accounting in 1956. (wikipedia.org)
  • divisions
  • This led to the discovery that the number of cell divisions the cell underwent was determined by internal counting mechanisms. (wikipedia.org)
  • cellular
  • This quiescence or slow cell cycling of HSCs induced by Tie-2/Ang-1 signaling contributes to the maintenance of long-term repopulating ability of HSC and the protection of the HSC compartment from various cellular stresses. (wikipedia.org)
  • tumor cell
  • Additionally, our outcomes also claim that TRPC3 shows up as a fresh mediator of breasts cancer tumor cell migration/invasion and represents a potential focus on for a fresh course of anticancer agent. (cancercurehere.com)
  • Within this research, we discovered the functional appearance of TRPC3 in individual MCF-7 breasts cancer tumor cell-mediated Ca2+ entrance. (cancercurehere.com)
  • She discovered that overexpression of ODC and c-Raf activation is sufficient to convert a normal primary keratinocyte into a malignant, invasive tumor cell. (wikipedia.org)
  • peripheral
  • As she explains, one family member, TMEM16A, is typically expressed in peripheral cells and is involved in the rhythmical contraction of smooth muscles in the gastrointestinal tract. (ibiology.org)
  • Internal to this peripheral region is the grey matter, which contains the nerve cell bodies arranged in the three grey columns that give the region its butterfly-shape. (wikipedia.org)
  • National Cancer In
  • According to the "Annual Report to the Nation on the Status of Cancer (1973-1998)," published in the Journal of the National Cancer Institute in 2001, only the youngest of three generations - the Roe v. Wade generation - suffered a more than 40% increase in breast cancer cases since the mid-1980s. (pfli.org)
  • The U.S. National Cancer Institute, the American Cancer Society, and the U.S. Centers for Disease Control and Prevention collaborated on the report. (pfli.org)
  • Her postdoctoral work continued until 1974, when she left to work for Robert Gallo at the National Cancer Institute (NCI). (wikipedia.org)
  • clinical
  • Based out of St. Joseph's Healthcare in Hamilton, Ontario, Canada, the institute is a clinical facility with strong research directions. (wikipedia.org)
  • From 2004-2005, the institute was relocated to four floors of the brand new Juravinski Innovation Tower, where more modern research laboratories and expanded clinical facilities were available. (wikipedia.org)
  • citation needed] New global health clinical and research initiatives include the Global Institute for Community Health and Development and the International Medicine Institute. (wikipedia.org)
  • While at UCSF, he was Director of the Male Reproductive Clinical Laboratory, Program Leader of PROGENI (The Program in the Genetics of Infertility), Director of the UCSF Men's Reproductive Health Clinic and Research Program, and the director of a National Institutes of Health grant to train new faculty in men's reproductive health. (wikipedia.org)
  • grown
  • Components and strategies Cell lifestyle MCF-7 cells had been grown up in DMEM moderate filled with 10% fetal leg serum and 1% penicillin/streptomycin serum as defined (9). (cancercurehere.com)
  • reporter
  • One way to do that is to engineer what is called a reporter cell line. (wisc.edu)
  • Meng Li, a postdoctoral fellow supervised by Zhao and Bhattacharyya, used a technique called CRISPR-Cas9 to precisely position a reporter in the genomes of stem cells derived from individuals with fragile X. The reporter is a highly sensitive luciferase enzyme engineered from the DNA of a deep-sea shrimp Oplophorus gracilirostris . (wisc.edu)
  • You can put a drug on these reporter cells and if the gene is turned on by that drug then you will get a bright luminescence signal," says Bhattacharyya. (wisc.edu)
  • However, the biggest advantage of reporter cell lines is they can be used in high-throughput, automated systems to efficiently test whether any of hundreds of thousands of drugs can turn on the gene of interest without harming the cell. (wisc.edu)
  • anterior
  • Since early 2000 he has used Growth Factors in his treatments and since 2013 stem cells in the repair of anterior cruciate ligament injuries and cartilage. (wikipedia.org)
  • Ventral roots consist of efferent fibers that arise from motor neurons whose cell bodies are found in the ventral (or anterior) gray horns of the spinal cord. (wikipedia.org)
  • immune
  • It also stops the patient's immune system from rejecting the donor's stem cells. (clinicaltrials.gov)
  • Sometimes the transplanted cells from a donor can also make an immune response against the body's normal cells. (clinicaltrials.gov)
  • Although senescent cells can no longer replicate, they remain metabolically active and commonly adopt an immunogenic phenotype consisting of a pro-inflammatory secretome, the up-regulation of immune ligands, a pro-survival response, promiscuous gene expression (pGE) and stain positive for senescence-associated β-galactosidase activity. (wikipedia.org)
  • Council
  • In 1991, a US corporate coalition including the National Coal Association, the Western Fuels Association and Edison Electrical Institute created a public relations organization called the "Information Council on the Environment" (ICE). (wikipedia.org)
  • Founded in 1978 as the Firestone Regional Chest and Allergy Unit (FRCAU), the institute was designated as the Regional Referral Center by the District Health Council. (wikipedia.org)
  • notable
  • The "selective use of data", cherry picking, is identified as a notable form of scientific abuse by the Pacific Institute, an organization created to provide independent research and policy analysis on issues at the intersection of development, environment, and security. (wikipedia.org)
  • Division
  • Following his training at Hopkins, he served as an associate professor in the university's Department of Cell Biology and Anatomy, Department of Pathology, and Division of Cardiology in the Department of Medicine until 1997. (wikipedia.org)
  • Science
  • This material is based upon work supported by the National Science Foundation and the National Institute of General Medical Sciences under Grant No. MCB-1052331. (ibiology.org)
  • Any opinion, finding, conclusion, or recommendation expressed in these videos are solely those of the speaker and do not necessarily represent the views of iBiology, the National Science Foundation, the National Institutes of Health, or other iBiology funders. (ibiology.org)
  • He has performed and published research in men's reproductive health issues including genetic infertility, ejaculatory duct obstruction, immunologic infertility, quality of life issues with infertility, testis cancer and stem cell science, and has developed several techniques for evaluating and treating male infertility. (wikipedia.org)
  • Establishing the Heart Science Centre, Magdi Yacoub Institute for research into the causes and treatment of cardiac disease. (wikipedia.org)
  • However
  • However, all cicatricial alopecias involve inflammation directed at the upper part of the hair follicle where the stem cells and sebaceous gland (oil gland) are located. (wikipedia.org)
  • blood
  • Photoelectric cells in a spectrophotometer device worn on the forehead measure the amount of each wavelength of light reflected by cerebral blood flow in the activated cortical tissue and send the data to a computer, which then calculates the ratio of red to infrared light and translates it into a visual signal of corresponding to oxygenation level on a graphical interface the patient can see. (wikipedia.org)
  • Development
  • It was through the Global Institute for Community Health and Development that Goldschmidt was able to launch and oversee the medical relief effort in Haiti after the January 2010 earthquake. (wikipedia.org)
  • He was appointed professor at the National Heart and Lung Institute in 1986, and was involved in the development of the techniques of heart and heart-lung transplantation. (wikipedia.org)
  • remain
  • This finding is significant with regard to the stem cell origin of skin cancer, since carcinogen-targeted stem cells can remain dormant for many years until recruited to develop into a tumor. (wikipedia.org)
  • affect
  • Gilmour provided the first evidence that elevated epidermal levels of polyamines alone can positively affect the recruitment of bulge stem cells in the skin. (wikipedia.org)
  • response
  • Cells can also be induced to senesce via DNA damage in response to elevated reactive oxygen species (ROS), activation of oncogenes and cell-cell fusion, independent of telomere length. (wikipedia.org)
  • Treatment
  • The Firestone Institute for Respiratory Health (FIRH) is a center for the investigation and treatment of respiratory diseases. (wikipedia.org)
  • Goldschmidt's research applies genomics and cell therapy to the prevention, diagnosis and treatment of coronary artery disease. (wikipedia.org)
  • specific
  • It would take far too long to apply individual drugs, collect the cells being tested and use traditional methods to check whether a specific gene is on or off in those cells. (wisc.edu)
  • Medical
  • Eight medical organizations and a bioethics journal recognize the independent link - that abortion leaves a woman with more cancer-vulnerable cells than she had before she became pregnant. (pfli.org)
  • RRI is currently a leading institute in the medical robotics field, especially in the area of biomedical micro/nano robotics. (wikipedia.org)
  • Susan K. Gilmour (born 1953) is an American cancer biologist and professor at Lankenau Institute for Medical Research (LIMR), a biomedical research facility in Wynnewood, Pennsylvania, and part of Main Line Health. (wikipedia.org)
  • normal
  • Gilmour continued her research at The Wistar Institute in Philadelphia, Pennsylvania, first as postdoctoral fellow (1984 to 1987) and then as research associate (1988 to 1990 While at Wistar, she began her work in characterizing the regulation and expression of ornithine decarboxylase (ODC) in both normal and tumor tissue. (wikipedia.org)
  • Polyamine levels are dramatically elevated in tumor cells compared to normal cells. (wikipedia.org)
  • Health
  • The institute has maintained this designation, and as of 2006, it services the Hamilton Niagara Haldimand Brant Local Health Integration Network, a community of 1.4 million people. (wikipedia.org)
  • professor
  • Dr' O'Sullivan's co-investigators were PhD student Dharani Sontam, Professor Mark Vickers, and Professor Elwyn Firth, all from the Liggins Institute. (membs.org)
  • long
  • The spinal cord is a long, thin, tubular bundle of nervous tissue and support cells that extends from the medulla oblongata in the brainstem to the lumbar region of the vertebral column. (wikipedia.org)