Stem cell imaging molecular imaging. Medical search. Frequent questions

Its ever-expanding functionality has made it a versatile data analysis and visualization solution, applicable to and being used in many fields, such as microscopy in biology and materials science, molecular biology, quantum physics, astrophysics, computational fluid dynamics (CFD), finite element modeling (FEM), non-destructive testing (NDT), and many more. (wikipedia.org)
An insight into the biology of ischemic stroke indicates that a stream of molecular events initiates instantly after the onset of ischemic stroke, such as oxidative stress, increased level of intracellular calcium, excitotoxicity, and inflammation which results in apoptotic or necrotic neuronal cell death [ 12 - 14 ]. (hindawi.com)
I returned full time to Imperial College in 1999 to take up a lectureship in cell biology and tissue engineering and was also actively involved in establishing the Tissue Engineering Centre. (nottingham.ac.uk)
I cover mainly cell biology and physiology. (nottingham.ac.uk)
The graduate program in Bioscience of Health and Disease offers study in fundamental cell and molecular biological areas including cancer biology and genomics, cellular growth and differentiation mechanisms, developmental biology, skeletal biology, stem cell biology, visual science, and biomedical imaging and spectroscopy. (mun.ca)
We've entered what can be considered the third phase of the human genome project," said Job Dekker, PhD, Howard Hughes Medical Institute Investigator , professor of biochemistry & molecular pharmacology and co-director of the Program in Systems Biology. (umassmed.edu)
Understanding mitosis is a major aim of fundamental molecular cell biology but is also vitally important for understanding cancer and stem cells. (gla.ac.uk)
Your work in the lab will be directly advised and taught by me, the PI of the lab, and even if you don't have much lab experience, you will learn a range of vital molecular and cell-biology techniques with my direct guidance. (gla.ac.uk)
Research includes translational heart research and efforts into atherosclerosis, cardiovascular genomics and stem cell research, lung biology and pulmonary disease, nanotechnology related to air pollution injury and drug delivery and clinical outcomes in lung cancer and critical care medicine. (usc.edu)
Training in developmental and stem cell biology is not a requirement. (mskcc.org)
ACTR covers - Neuroregeneration, Soft Tissue Repair, Cartilage/Tendon and Bone/Ligament Regeneration as well as competence centers for molecular biology, miRNA analysis, polymer synthesis, bioprinting, preclinical in vivo facilities incl. (icgeb.org)
Developmental and Stem Cell Biology seminar by Dr. Ollie Rando, UMass Medical School, Biochemistry and Molecular Pharmacology laboratory, Worcester, MA, USA: " Daddy issues: effects of the paternal environment on the next generation in mammals. (pasteur.fr)
The Contag laboratory develops macroscopic and microscopic optical imaging tools and uses imaging to assess tissue responses to stress, reveal immune cell migration patterns, understand stem cell biology and advance biological therapies. (msu.edu)
Uncovering the molecular mechanisms of premalignancy and the signals that convert these cells to cancer lies at the foundation of cancer biology and will impact the diagnosis, treatment and management of all cancers. (msu.edu)
In addition, since the imaging tools we develop are sensitive and image over a range of scales from micro- to macroscopic, and are well-suited for the in vivo study of cellular and molecular biology, we are developing, and using, advanced microscopic tools with the aims of detecting and studying cancer at high resolution in vivo. (msu.edu)
My prior and current works take advantage of both traditional techniques (gene targeting, lineage tracing) and state-of-the-art technologies (Single cell RNA sequencing, Chromatin Immunoprecipitation (ChIP-seq), Imaging Mass Cytometry) to elucidate fundamental molecular mechanisms underlying signaling in tissue biology. (stanford.edu)
Welcome to the website of StemJournal , a vehicle for communicating outstanding stem cell research, including basic biology, clinical applications, disease modeling, computational and systems biology, and data science. (stemjnl.org)
Development: For advances in developmental biology and stem cells. (lu.se)

https://learn.genetics.utah.edu/content/cells/videos. (utah.edu)
He is also a professor in the Department of Microbiology and Molecular Genetics. (msu.edu)
The study, led by Dr. Owen Witte, founding director of the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and professor of microbiology, immunology and molecular genetics, was published in the journal Science . (medicalxpress.com)

Early work on multi-modal 3D optical imaging is based on confocal laser scanning microscopy (LSM), where a confocal pinhole is applied for the depth sectioning and a stack of transverse images are taken for 3D reconstruction 1 . (nature.com)

Here, the use of an obliquely scanning laser eliminates the z-stacking process, then allows highly efficient 3D OCT and fluorescence imaging by using only one raster scan. (nature.com)
The current setup provides ~3.6 × 4.2 × 6.5 μm resolution in fluorescence imaging, ~7 × 7 × 3.5 μm in OCT in three dimensions, and the current speed of imaging is up to 100 frames per second (fps) over a volume about 0.8 × 1 × 0.5 mm 3 . (nature.com)
We demonstrate several mechanisms for molecular imaging, including intrinsically expressed GFP fluorescence, autofluorescence from Flavin proteins, and exogenous antibody-conjugated dyes. (nature.com)
In addition to the fluorescence mode for molecular specificity, LSM can simultaneously detect the backscattered light in the reflectance mode which is sensitive to structural heterogeneity 2 , 3 . (nature.com)
In situ multiphoton microscopy (MPM) imaging method combining two-photon fluorescence (TPF) and second harmonic generation (SHG) optical signals helped to discover localized disaggregation and restructuring of collagen fibers within 3D hydrogels as a result of stem cell culture. (rsc.org)
Fluorescence Digital Image Gallery showing fluorescence-stained images of cells in culture. (utah.edu)
Kleinmanns K, Fosse V, Davidson B, de Jalón EG, Tenstad O, Bjørge L, McCormack E. CD24-targeted intraoperative fluorescence image-guided surgery leads to improved cytoreduction of ovarian cancer in a preclinical orthotopic surgical model. (uib.no)
You are also likely to use many standard, molecular techniques such PCR, Golden-gate cloning, Western blotting, fluorescence in-situ hybridisation, immunofluorescence and Q-PCR. (gla.ac.uk)
Dr. Contag was a founder of Xenogen Corp., now part of PerkinElmer, a company with the mission of commercializing in vivo bioluminescence and fluorescence imaging, and is a founder of BioEclipse Inc., a company aimed at improving cancer immunotherapy, and a founder of PixelGear , a point-of-care pathology company. (msu.edu)

We evaluated nine possible scenarios of how embryonic stem cells could be set up to interact with collagen scaffolds when used in tissue engineering or regenerative medicine applications. (rsc.org)
Targeted faculty recruitment in these areas is ongoing - in some cases in partnership with Eli & Edythe Broad Center for Regenerative Medicine & Stem Cell Research at USC - with the goal to sustain excellence on the cutting edge of translational science and to create critical mass for new center initiatives. (usc.edu)

We use CRISPR/Cas9 to introduce patient mutation in the frog genome to characterize the disease phenotype and identify underlying cell biological function using advanced microscopy and biochemistry techniques. (virginia.edu)

Recently, a growing number of studies are focusing on mesenchymal stem cell-based therapies for neurodegenerative disorders. (hindawi.com)
The objective of this study was to provide a generalized critique for the role of mesenchymal stem cell therapy in ischemic stroke injury, its underlying mechanisms, and constraints on its preclinical and clinical applications. (hindawi.com)
The recent decade has seen encouraging outcomes of mesenchymal stem cell therapy that holds promise to alleviate the burden of neurological disorders Moreover, initial study data of preclinical trials have also indicated the effectiveness, tolerance, and safety of MSC-based therapy [ 10 ]. (hindawi.com)

Cancer stem cells (CSCs) play an important role during metastasis, but the dynamic behavior and induction mechanisms of CSCs are not well understood. (nature.com)
Herein, we presented an overview of a previously published work regarding the role of stem cell therapy in ischemic stroke and its underlying molecular mechanisms. (hindawi.com)
Research in Dr. Guo-li Ming's laboratory centers on understanding molecular mechanisms underlying neurodevelopment and how its dysregulation may contribute to developmental neurological disorders. (upenn.edu)
Individuals in the final stages of their graduate studies who are interested in working on mechanisms driving pluripotency transitions, lineage differentiation and the morphogenesis of nascent organs in mammalian models, and/or the construction of stem cell-derived mammalian embryo-like structures, are always encouraged to apply for Postdoctoral Fellow positions in the lab. (mskcc.org)
Bio My research interests are focused on understanding the molecular basis of early development and stem cells, as it is often aberrations in stem cells or signaling mechanisms between tissues that lead to diseased states, including tumor development and cancer progression. (stanford.edu)
These shared molecular mechanisms could lead to the development of drugs to treat not just prostate and lung cancers, but small cell cancers of almost any organ. (medicalxpress.com)
Previous research hinted that small cell cancers from different organs may be driven by common mechanisms, but the UCLA study is the first to so clearly describe the steps in their evolution. (medicalxpress.com)

In this paper, we present a method termed oblique scanning laser microscopy (OSLM) to combine optical coherence tomography (OCT), for simultaneously volumetric structural and molecular imaging with cellular resolution in all three dimensions. (nature.com)
A combination of coherence gating and structured illumination allows a 3D multimodal imaging under a wide field microscopy with only incoherent sources 7 . (nature.com)
To perform these studies, the Chaichana lab uses the most advanced tools and techniques in genetic and molecular analyses, microscopy, biomedical engineering and surgical therapy. (mayo.edu)
However, these fluorophores have several limitations, such as photobleaching, that restrict their utility in applications such as cell proliferation, stem-cell differentiation, and realtime microscopy experiments lasting several hours. (nanowerk.com)
Chao Zhou, associate professor of biomedical engineering in the McKelvey School of Engineering, plans to develop expansion optical coherence microscopy (ExOCM), a super-resolution imaging method that will provide multi-color imaging of organoids, which are 3D organ-like tissue cultures derived from stem cells. (wustl.edu)
Compared with standard expansion microscopy, ExOCM can image extra-thick samples at high speed," Zhou said. (wustl.edu)
Now, he and his team will combine OCT with expansion microscopy to obtain up to a 300-nanometer resolution in images. (wustl.edu)

Exp Cell res 2020 May 15, 390(2):111961. (uib.no)
Front Cell Dev Biol 2020 Feb 25, 8:109. (uib.no)
Cell Stem Cell 27: 937-950, Dec 2020. (upenn.edu)
Cell Stem Cell 26: 766-781, May 2020. (upenn.edu)
Cell 180: 188-204, Jan 2020. (upenn.edu)

At this time I also began working with mouse and human embryonic stem cells resulting in the publication of some of the first papers describing the osteogenic differentiation of mouse ES and human cells in vitro and in vivo . (nottingham.ac.uk)
Ghila L, Bjørlykke Y, Legøy TA, Vethe H, Furuyama K, Chera S, Ræder H. Bioinformatics analyses of miRNA-mRNA signature during hiPSC differentiation towards insulin-producing cells upon HNF4a mutation. (uib.no)
MDS affects hematopoiesis at the stem cell level, as indicated by cytogenetic abnormalities, molecular mutations, and morphologic and physiologic abnormalities in maturation and differentiation of one or more of the hematopoietic cell lines. (medscape.com)

Dr. Contag served as the Associate Chief of the Division of Neonatal and Developmental Medicine, the director of Stanford's Center for Innovation in In Vivo Imaging (SCI 3 ) and co-director of both the Molecular Imaging Program at Stanford (MIPS) and Child Health Research Institute (CHRI) at Stanford University. (msu.edu)
Here we introduce adeno-associated virus (AAV)-mediated direct in vivo single-cell CRISPR screening, termed AAV-Perturb-seq, a tuneable and broadly applicable method for transcriptional linkage analysis as well as high-throughput and high-resolution phenotyping of genetic perturbations in vivo. (bvsalud.org)
To complement the in vivo system of chick embryos, we employ patient omics data, single cell RNA sequencing, human and mouse embryos, human cancer cell cultures, human pluripotent stem cells, chick embryo neural crest-derived in vitro crestosphere cultures, and zebrafish and mouse in vivo models. (lu.se)

Noninvasive detection and imaging of molecular markers in live cardiomyocytes derived from human embryonic stem cells Biophysical Journal. (nottingham.ac.uk)
Dr. Contag has developed and used noninvasive imaging approaches to reveal molecular processes in living subjects, to understand host pathogen interactions, to advance diagnostic and therapeutic strategies for cancer, and to reveal the nuances of stem cell engraftment and expansion. (msu.edu)
The research mission of the Contag laboratory is to develop and use noninvasive imaging tools that can simultaneously reveal the nuances of biological processes and provide an overall picture of disease states for the purpose of developing and refining novel interventions. (msu.edu)
Zhou's lab developed optical coherence tomography (OCT), a fast, safe and noninvasive imaging method that detects differences in how tissue refracts light and can acquire high-resolution 3D images with a depth of up to 1 to 2 millimeters in less than a minute. (wustl.edu)

The function of limbal stem/progenitor cells (LSCs) is critical to maintain corneal epithelial homeostasis. (ca.gov)

I was also affiliated with the Wolfson Centre for Stem Cells, Tissue Engineering and Modelling (STEM), part of the Centre for Biomolecular Sciences, which is now the Biodiscovery Institute. (nottingham.ac.uk)
COVID-19-associated pulmonary aspergillosis in ICU patients in a German reference centre: Phenotypic and molecular characterisation of Aspergillus fumigatus isolates. (cdc.gov)

The morphology of the cells was viewed under an inverted microscope and the analysis of cell proliferation was performed using a Cell Counting kit‑8 (CCK‑8) assay on days 1, 3, 5 and 7. (spandidos-publications.com)
As the disease progresses and converts into leukemia, further gene mutation occurs, and a proliferation of leukemic cells overwhelms the healthy marrow. (medscape.com)
boi controls follicle stem cell proliferation. (cellimagelibrary.org)
Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate. (medscape.com)

Ngen EJ and Artemov D.Advances in monitoring cell-based therapies with magnetic resonance imaging: Future perspectives. (hopkinsmedicine.org)
Ngen EJ , Wang L, Gandhi N, Kata Y, Armour M, Wong J, Gabrielson K, Artemov D. A preclinical murine model for the early detection of radiation-induced brain injury using magnetic resonance imaging and behavioral tests for learning and memory with applications for the evaluation of possible stem cell imaging agents and therapies. (hopkinsmedicine.org)
In the bone field we study cell based therapies using hypertrophic bone marrow or adipose derived MSC and iPS derived MSC. (icgeb.org)
Knowledge of stem cells and development is also critical to develop appropriate cell-based therapies for various diseases or injuries. (stanford.edu)
The future of medical research relies on the ability of scientists to bridge biomedical and computational expertise to deconvolute such complex layers of molecular data and pave the way for delineating novel therapies for infectious and immune-related diseases. (lu.se)

Using chromosome conformation capture technologies in conjunction with advanced computational modeling and a range of imaging methods, the center will generate three-dimensional models of the human genome inside fibroblast cells during metaphase and interphase, as well as in embryonic stem cells in undifferentiated and differentiated states. (umassmed.edu)

Bone marrow cells display aberrant morphology and maturation (dysmyelopoiesis), resulting in ineffective blood cell production. (medscape.com)
MDS develops when a clonal mutation predominates in the bone marrow, suppressing healthy stem cells. (medscape.com)
Hematopoietic stem cell transplantation (bone marrow, cord blood, or peripheral blood stem cells) may cure aplastic anemia and prevent myelodysplastic syndrome or leukemia. (medscape.com)

Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
Molecular Profiling Reveals Characteristic and Decisive Signatures in Patients after Allogeneic Stem Cell Transplantation Suffering from Invasive Pulmonary Aspergillosis. (cdc.gov)

Mr Hunt observed ongoing research designed to better understand the causes of dementia and changes to the brain and met scientists working on understanding the molecular basis of Alzheimer's disease and other forms of dementia using stem cells as a model. (ucl.ac.uk)

2. Molecular epidemiology of HCV among injection drug users in Iran by phylogenetic analysis. (who.int)

In breast cancers from patients, the density of TMEM doorways correlates with the proportion of cancer cells expressing stem cell markers, indicating that in human breast cancer TMEM doorways are not only cancer cell intravasation portals but also CSC programming sites. (nature.com)
Fluorescent markers highlight a variety of cell structures. (utah.edu)
A variety of cells labeled with fluorescent markers. (utah.edu)
New ocular imaging modalities and molecular markers are now available to standardize the diagnosis criteria and stage the severity of the disease. (ca.gov)

Multi-modal three dimensional (3D) optical imaging combining both structural sensitivity and molecular specificity is highly desirable in biomedical research. (nature.com)

Tepe B, Hill MC, Pekarek BT, Hunt PJ, Martin TJ, Martin JF, Arenkiel BR " Single-Cell RNA-Seq of Mouse Olfactory Bulb Reveals Cellular Heterogeneity and Activity-Dependent Molecular Census of Adult-Born Neurons . (bcm.edu)
Zika virus directly infects peripheral neurons and induces cell death. (upenn.edu)
of the Rambam Health Care Campus and the Technion Israel Institute of Technology (TIIT) in Haifa and team reprogrammed human hair follicle cells to produce what are called induced pluripotent stem cells (iPSC) ―cells in a primitive developmental state that can be coaxed to mature into any one of a number of different cell types, including brain cell types and functional neurons. (bbrfoundation.org)
Hair follicle cells originate from the same embryonic germ layer that gives rise to neurons, and thus represent an attractive source of iPSC that can be reprogrammed into neurons. (bbrfoundation.org)
In 2011, Dr. Ben-Shachar's previous Brain & Behavior Research Foundation -funded study, showed that it was possible to take hair follicle cells from healthy human donors and reprogram them into iPSC that were then grown into neurons of various lineages. (bbrfoundation.org)
In the current study, her team reprogrammed hair follicle cells from three schizophrenia patients and two healthy subjects into iPSC that later developed into neurons to study neurodevelopmental-related changes in the brains of people with schizophrenia. (bbrfoundation.org)
She and her team found that neurons derived from the reprogrammed hair follicle cells of schizophrenia patients showed various abnormalities, including the inability to differentiate and mature. (bbrfoundation.org)

Volumetric optical imaging with cellular and sub-cellular resolution is essential for our fundamental understanding of biological systems. (nature.com)
For his fundamental contributions in the field of molecular imaging, he was awarded the Achievement Award from the Society for the Molecular Imaging. (msu.edu)

The developments in high-resolution multimodal retinal imaging have also transformed our ability to make accurate and more timely diagnoses and more sensitive quantitative assessment of disease progression, and allowed the design of optimised clinical trial endpoints for novel therapeutic interventions. (bmj.com)
Thus, we attempted to present an overview of previously published reports to evaluate the progress and provide molecular basis of mesenchymal stem cells (MSCs) therapy and its application in preclinical and clinical settings, which could aid in designing an effective regenerative therapeutic strategy in the future. (hindawi.com)
Identifying the molecular mediators of the changes that precede progression to cancer in otherwise histologically normal cells and tissues would lead to new therapeutic targets that would enable disease prevention in high-risk populations including relapse from treated cancers. (msu.edu)

CSCs display the slow-migratory, invadopod-rich phenotype that is the hallmark of disseminating tumor cells. (nature.com)
60% of circulating tumor cells. (nature.com)
Macrophages are emerging as major cellular factors in the tumor ecosystem that can influence the stem phenotype and cancer progression. (nature.com)
Furthermore, macrophages were shown to contribute to a niche that can support and maintain a breast CSC (BCSC) phenotype through heterotypic CD90/EphA4 signaling between macrophage and tumor cell 14 . (nature.com)
Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake. (uni-muenster.de)
The team also identified that for small cell neuroendocrine carcinomas to develop in the prostate, two tumor suppressor genes, TP53 and RB1, which are known for protecting normal cells from transforming into cancer cells, had to be simultaneously inactivated when PARCB was introduced. (medicalxpress.com)

Augmenting this tradition is recently added expertise in the basic sciences of molecular immunology and virology. (usc.edu)

In tests on cell cultures Meyer showed that the mutated Glut1 protein was no longer present on the cell surface, where it takes up glucose. (eurekalert.org)
The Cell Culture Facility (CCF) located in the Life Science Laboratories supports research by providing space, equipment, cell cultures (plant and mammalian), media, supplies and training on a recharge basis for both academic labs and corporate partners. (umass.edu)
The Plant Cell Culture Library (PCCL) at UMass Amherst is a globally unique collection of callus cell cultures representing more than 1,000 diverse plant species. (umass.edu)

These cancers originate from cells of the sympathetic nervous system (SNS), in turn derived from the transient embryonic neural crest stem cell population. (lu.se)
Research indicates that the snail 2 protein is required during embryonic growth for the development of cells called neural crest cells. (medlineplus.gov)
Neural crest cells migrate from the developing spinal cord to specific regions in the embryo and give rise to many tissues and cell types, including melanocytes. (medlineplus.gov)

Clinical Physiology and Functional Imaging. (lu.se)

One critical aspect of optical imaging is the 3D localization of molecular composites in tissues or cells, typically by using specific antibodies with fluorescent reporters. (nature.com)
Within the limits of this study, Cimicifugae Rhizoma influenced the viability of stem cells derived from the gingiva, and its direct application onto oral tissues may have adverse effects at high concentrations. (spandidos-publications.com)
We are examining the role of extracellular vesicles from activated immune cells, and cancer cells, in creating premalignant fields, and characterizing the molecular signals that precondition normal tissues and drive malignant transformation. (msu.edu)
Small cell cancers of the lung, prostate , bladder, and other tissues were long thought to be similar in name alone-and they were treated by oncologists as different entities," Witte said. (medicalxpress.com)

We also demonstrate potential applications in imaging human intestinal organoids (HIOs), colon mucosa, and retina. (nature.com)
We integrate multiple approaches, from machine learning and high-resolution live imaging to skin organoids and mechanobiology. (virginia.edu)
Using OCT, the team will acquire images of living organoids over a three-week period. (wustl.edu)
These 3D time-lapse images will provide a look into the development process of the organoids. (wustl.edu)

With our probe' says Baik, 'the target gene within the chromosome can be localized with the ssDNA-SWNT conjugates, and this method can be used for the in situ detection of the specific genome in cells, tissue sections or infectious agents with the possibility of long term storage and re-evaluation of the results in the future. (nanowerk.com)
Candidates should have experience in quantitative imaging, bioengineering, genome editing, single-cell 'omics and/or related molecular techniques. (mskcc.org)

Therefore, there is an increasing need for multimodal imaging techniques that can provide both molecular specificity and the structural context. (nature.com)
Despite a large body of literatures and long standing efforts on this subject, it is still challenging to provide a multimodal system that can achieve volumetric structural and molecular imaging simultaneously with equivalent high resolutions for both modalities. (nature.com)
Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke. (uni-muenster.de)

It highlights the range of innovations in retinal imaging, genotype-phenotype and structure-function associations, animal models of disease and the multiple treatment strategies that are currently in clinical trial or planned in the near future, which are anticipated to lead to significant changes in the management of patients with MDs. (bmj.com)
However, despite having the promising outcome of preclinical studies, the clinical application of stem cell therapy remained elusive due to little or no progress in clinical trials. (hindawi.com)
However, effective dose and appropriate time of MSCs delivery are the main challenges in the clinical translation of stem cell therapy. (hindawi.com)
We aim to provide the basis for establishing a future study to promote the clinical translation of stem cell therapy in ischemic brain diseases. (hindawi.com)

Cell Rep. 2018 Dec 4;25(10):2689-2703.e3. (bcm.edu)
To be published on line in early May 2018 in Cell. (lu.se)
Journal of Molecular Endocrinology (2018) Jan 16. (lu.se)

Our laboratory is equipped with state-of-the art facilities for microscopic imaging, GEM models and stem cellresearch. (mskcc.org)

The shape it takes has a profound influence on which genes in a cell are turned on or turned off. (umassmed.edu)
Dr. Jung Wook Park, the study's first author, and UCLA collaborators explored the potential parallels between the cancer types by transplanting human prostate cells with five genes, known collectively as PARCB, into mice. (medicalxpress.com)
Next, they tested whether PARCB genes could alter healthy cells from human lungs into small cell lung cancers, and the scientists found that they could. (medicalxpress.com)
The team now is working on mapping which genes control the entire cascade of events that underlies the transition to small cell cancer. (medicalxpress.com)
Our study revealed shared 'master gene regulators'-the key proteins that control expression of multiple genes in small cell cancer cells," Witte said. (medicalxpress.com)

Other key Amira features are multi-planar and volume visualization, image registration, filament tracing, cell separation and analysis, tetrahedral mesh generation, fiber-tracking from diffusion tensor imaging (DTI) data, skeletonization, spatial graph analysis, and stereoscopic rendering of 3D data over multiple displays and immersive virtual reality environments, including CAVEs. (wikipedia.org)
Elevate your single-cell research with our spatial molecular imager. (nanostring.com)

Using the mouse, we apply multifaceted experimental approaches that combine genetic engineering, optical imaging and electrophysiological recording techniques to better understand synapse and circuit function. (bcm.edu)
I work on various biochemical and biophysical approaches to investigate and control cell-cell, cell-scaffold interactions. (nottingham.ac.uk)

My research interests focus mainly on stem cells (embryonic, 'adult' and fetal origins) and their applications in tissue engineering, particularly the osteoblast and bone tissue. (nottingham.ac.uk)
The cluster offers state-of-the-art facilities for tissue engineering including (stem/endothelial) cell research. (icgeb.org)

Cimicifugae Rhizoma extract induced G 0 /G 1 cell cycle arrest of hepatocellular carcinoma at a low concentration (25 µg/ml), triggered G 2 /M arrest and apoptosis of the hepatocellular carcinoma at higher concentrations (50 and 100 µg/ml) and inhibited the growth of implanted mouse tumors in a dose-dependent manner, with a growth inhibitory rate of 63.3% at 200 mg/kg ( 10 ). (spandidos-publications.com)
Furthermore, in cultured Fanconi anemia cells, cell cycle arrest in gap 2/mitosis (G2/M) occurs at lower concentrations of clastogens than in normal cells. (medscape.com)

She completed her post-doctoral fellowship in cellular and molecular imaging at the Johns Hopkins University School of Medicine, Department of Radiology and Radiological Science. (hopkinsmedicine.org)

We will obtain 3D structural and molecular profiles of the samples using ExOCM, then correlate those profiles with growth dynamics measured from live samples using OCT, which shows the unique advantages of the combined OCT and ExOCM imaging technique," Zhou said. (wustl.edu)

UCLA researchers have discovered a common process in the development of late-stage, small cell cancers of the prostate and lung. (medicalxpress.com)
The key finding: Prostate and lung cells have very different patterns of gene expression when they're healthy, but almost identical patterns when they transform into small cell cancers. (medicalxpress.com)
They found that the pattern of gene expression in PARCB-SCNC cells was extremely similar to those of both prostate and lung small cell cancers. (medicalxpress.com)

The non-invasive in situ MPM imaging analysis in this study is valuable because it enables longitudinal, 3D analysis of the structural and functional status of thick, opaque scaffolds as they interact with stem cells and are being degraded. (rsc.org)
Balafkan N, Mostafavi M, Siller R, Liang KX, Sullivan G, Bindoff LA. A method for differentiating human induced pluripotent stem cells toward functional cardiomyocytes in 96-well microplates. (uib.no)
molecular, structural and functional neuroimaging, and neuroengineering. (usc.edu)
Mostajeran M, Wetterling F, Blixt FW, Edvinsson L, Ansar S. Acute mitogen-activated protein kinase 1/2 inhibition improves functional recovery and vascular changes after ischaemic stroke in rat-monitored by 9.4 T magnetic resonance imaging. (lu.se)

Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC-exosomes) attenuate AD-like symptoms by reducing multiple inflammatory cytokine levels. (mdpi.com)
AChR antibodies show a complex interaction with human skeletal muscle cells in a transcriptomic study. (uib.no)
The doctoral student did this by recreating 258 flexible protein regions in test tubes - both "healthy" variants as well as disease-related ones - and then adding human cell extracts. (eurekalert.org)
The present study was performed to evaluate the extracts of Cimicifugae Rhizoma on the morphology and viability of human stem cells derived from gingiva. (spandidos-publications.com)
The aim of the present study was to evaluate the effects of extracts of Cimicifugae Rhizoma on the morphology and viability of human stem cells derived from gingiva. (spandidos-publications.com)
When those cells grew in the mice, they displayed unique features of human small cell neuroendocrine carcinomas. (medicalxpress.com)
The similarities between the PARCB-SCNC cancers and human small cell prostate cancer samples were extraordinary," Witte said. (medicalxpress.com)
King BC, Kulak K, Krus U, Rosberg R, Golec E, Zhang E, O'Connell D, Renström E, Blom AM. Complement component C3 is highly expressed in human pancreatic islets and protects against beta-cell death via ATG16L1 interaction. (lu.se)
Most DEGs were expressed in human β-cells based on single-cell RNA-sequencing data. (lu.se)
Overall, we identified molecular alterations in human pancreatic islets contributing to β-cell dysfunction in T2D pathophysiology. (lu.se)

Welcome to the Cell and Gene Therapy Core Facility at Lund University. (lu.se)
At our facility, we are passionate about fostering a collaborative environment where scientists can explore the frontiers of cell and gene therapy. (lu.se)

MDS may involve one, two, or all three myeloid hematopoiesis cell lineages-erythrocytic, granulocytic, megakaryocytic-depending on the subtype and stage of the disease. (medscape.com)

Dr. Contag is a founding member, and past president of the Society for Molecular Imaging (now part of WMIS) and recent past president and a Fellow of WMIS. (msu.edu)

My research continues to focus on stem cells and osteoblasts and in particular 3D cell culture models and microenvironments. (nottingham.ac.uk)
In this case, the research team used the cells to study neurodevelopmental abnormalities in schizophrenia . (bbrfoundation.org)
The images also can be acquired using commercially available OCT systems, making the technique available to a broader research community. (wustl.edu)
The research suggests that different types of small cell tumors evolve similarly, even when they come from different organs. (medicalxpress.com)
BBA - Molecular Cell Research, Under revision. (lu.se)

CytoCore, Inc. (formerly Molecular Diagnostics, Inc. (kaloramainformation.com)
The advent of molecular diagnostics has further improved the specificity of Fanconi anemia diagnosis. (medscape.com)

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Gene therapy2

Myeloid1

WMIS1

Research5

Diagnostics2