Stem cell embryonic stem clone cells. Medical search. Frequent questions

Therapeutic cloning, which creates embryonic stem cells . (medlineplus.gov)
Therapeutic Use of Cloning: Osmangazi Tu. (yildiz.edu.tr)
There are important problems in the therapeutic use of cloning which increase with the more advanced differentiation of somatic cells. (yildiz.edu.tr)
Kuldip S. Sidhu , " Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials Bench-to-Bedside ", Bentham Science Publishers (2012). (benthamscience.com)
Embryonic stem cells (ESCs) can grow infinitely and give rise to all types of cells in human body, thus of tremendous therapeutic potentials for a variety of diseases, such as Parkinson's disease, spinal cord injury, and diabetes. (benthamscience.com)
Under such circumstances, the idea of "therapeutic cloning" was proposed, indicating the generation of ESCs from SCNT embryos for therapeutic purpose. (benthamscience.com)
With Hwang discredited, both the field of therapeutic cloning and the public's trust in science have suffered a serious setback. (nature.com)
A well-respected medical ethicist from one of Canada's leading universities says Canada must not legalize embryonic cloning for any purpose, including therapeutic purposes. (catholicnewsagency.com)
The reader benefits from the scholar's clear explanation about embryonic stem-cell research and therapeutic cloning. (catholicnewsagency.com)
In therapeutic cloning, the blastocyst is not transferred to a womb. (eurostemcell.org)
Another long-term hope for therapeutic cloning is that it could be used to generate cells that are genetically identical to a patient. (eurostemcell.org)
To date, no human embryonic stem cell lines have been derived using therapeutic cloning, so both these possibilities remain very much in the future. (eurostemcell.org)
An Australian ban on therapeutic cloning was lifted in December 2006 after a long debate in Federal parliament. (bioedge.org)
Yet, human embryonic stem cell research has thus far been unsuccessful in the quest to develop any therapeutic treatments. (all.org)
5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)
Therapeutic cloning possesses enormous potential for revolutionizing medical and thera- peutic techniques. (who.int)
This is therapeutic cloning. (who.int)
This cell then has therapeutic cloning: the global the capacity to divide and grow into an exact replica of the original from whom the debate somatic cell was taken. (who.int)
With this background information as a foundation, we then discuss each of the key questions in relation to the upcoming therapeutic trial and critically assess if the time is ripe for clinical translation of parthenogenetic stem cell technology in Parkinson's disease. (lu.se)

Depending on the source, stem cells can be classified into two broad categories i.e. embryonic stem cells that are derived from embryos and non-embryonic stem cells that are derived from adult and fetal tissues. (benthamscience.com)
However, the derivation of human NT-ESCs goes with the destruction of clone embryos, leading to fierce ethical disputes. (benthamscience.com)
In January 2006, Hwang's home research institution, Seoul National University, delivered a damning report about Hwang's work on cloned human embryos, concluding it was all based on fraudulent data. (nature.com)
The MIT Technology Review reported that the researchers in Portland, Oregon, edited the DNA of a large number of one-cell embryos, specifically targeting genes associated with inherited diseases in those embryos. (cnn.com)
The Australian government has issued its first license for cloning human embryos to obtain embryonic stem cells. (bioedge.org)
Chinese scientists have successfully created chimeric embryos containing a combination of human and pig cells. (bioedge.org)
It is further speculated that those who support human embryonic stem cell research are also seeking human embryos for the purposes of human cloning. (all.org)
Some prohibit only cloning for reproductive purposes and allow the creation of cloned human embryos for research, whereas others prohibit the creation of cloned embryos for any purpose. (who.int)
The stem cells suits human needs, does not cause harm and can be obtained from both adult and fetal does not conflict with religious beliefs, it has tissues, umbilical cord and early embryos. (who.int)
Unicellular for those cells that are derived from human organisms are primed to replicate (clone) pre-embryos, which seem to have a high themselves by nature. (who.int)

Okamoto K, Okazawa H, Okuda A, Sakai M, Muramatsu M, Hamada H. A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. (bdbiosciences.com)

And the other technique, which produces " induced pluripotent stem cells ," skips the step that requires a human egg cell, so some people find it less fraught, ethically. (usf.edu)
Induced pluripotent stem cells, another types of pluripotent stem cells derived from any tissue by reprogramming and are the homologous source of stem cells. (benthamscience.com)
Right now, the hottest area in stem cell biology is that of induced pluripotent stem cells, or iPS cells, which have the ability to develop into several different tissue types. (cbc-network.org)
Boiani M, Schöler HR. Regulatory networks in embryo-derived pluripotent stem cells. (bdbiosciences.com)

Audience member on the Jewish perspective on stem cell research: "A fetus is a fetus is a fetus until it becomes a lawyer. (kottke.org)
A chronology of Woo Suk Hwang's stem-cell research. (nature.com)
Culver signed legislation easing limits on types of stem cell research in Iowa. (wikipedia.org)
While allowing for further research, it prohibits reproductive cloning of humans," according to National Public Radio. (wikipedia.org)
In addition, Culver proposed spending $12.5 million to establish a stem cell research center at the University of Iowa. (wikipedia.org)
Its new frontier is embryonic stem-cell and human cloning research. (lifenews.com)
Scientists, many of whom are sold on utilitarian-based ethical analysis, try to downplay the issue of human life in stem-cell research. (catholicnewsagency.com)
And yet, all of us would be appalled at the idea of terminating their lives so we could harvest their tissues or organs in order to save others," she says, in reference to the common utilitarian argument that embryonic stem-cell research is valid in an effort to find cures that could save people's lives. (catholicnewsagency.com)
What is cloning, and what does it have to do with stem cell research? (eurostemcell.org)
This form of cloning is unrelated to stem cell research. (eurostemcell.org)
Remember, this is the research which takes and adult skin cell and then turns the stem cells back to an "embryonic" like state. (cbc-network.org)
Keep in mind, this is ethical adult stem cell research, which is in human clinical trials, helping patients NOW. (cbc-network.org)
Unlike *yawn* embryonic stem cell and cloning research which has produced zip to date. (cbc-network.org)
Stem cell research. (masterfile.com)
The papers made fantastic claims about embryonic stem cell research studies that turned out to be false. (lifenews.com)
In handling fraudulent stem-cell research articles, journal editors went above and beyond existing procedures to try and verify the findings, but in today's competitive publishing environment, more stringent, less trusting safeguards are now essential,' the committe said, according to a Science statement LifeNews.com obtained. (lifenews.com)
Hwang has since started a new animal cloning lab and hopes to continue the kind of research that led to the creation of Snuppy, the first cloned dog. (lifenews.com)
Shoukhrat Mitalipov, director of the Oregon Health & Science University's Center for Embryonic Cell and Gene Therapy, reportedly led the new research. (cnn.com)
In 2007, a research team led by Mitalipov announced they created t he first cloned monkey embryo and extracted stem cells from it. (cnn.com)
The director of the lobby group Australians for Ethical Stem Cell Research, David van Gend, criticised the issuing of the licence. (bioedge.org)
He said cloning research was no longer necessary because of recent advances in stem cell science. (bioedge.org)
The state of Illinois has passed a law allowing human embryonic stem cell research, but banning human cloning. (bioedge.org)
Stem cell research has limitless potential to help cure devastating diseases, from Parkinson's to diabetes and even many forms of cancer," said Governor Rod Blagojevich. (bioedge.org)
A 9 page research paper that presents an overview of stem cell research that looks at possible benefits, but primarily focuses on the issues being debated and the biological realities involved, before arguing a stance regarding US guidelines on this topic, which favors loosening restrictions on this valuable line of research. (echeat.com)
Egg harvesting and Embryonic Stem-cell Research Pose Serious Threat to Women's Health A congressional hearing last Thursday raised awareness on the risks to women's health and fertility by in vitro fertilization (IVF), human cloning, embryonic stem-cell. (physiciansforlife.org)
Adult Stem Cells Taken from Human Fat Tissue Used to Treat Heart Failure Sweden Company Wants To Start First Stem Cell Research Factory Leading Scientist Charges Colleagues With "Misleading" Public British Stem Cell Researcher: Benefits of. (physiciansforlife.org)
No harm comes to the person whose stem cells are obtained for research in such a fashion. (all.org)
There are those in the government and scientific community who say more money must be spent on human embryonic stem cell research because it holds the most promise for helping people with conditions such as Alzheimer's disease. (all.org)
Alzheimer's researcher Ned Potter said, however, that human embryonic stem cell research would not help the Alzheimer's patient at all. (all.org)
Contrary to the impression many people have, research involving human embryonic stem cells is not new. (all.org)
Therefore, it is speculated that those who support human embryonic stem cell research are clamoring loudly for taxpayer dollars because private companies know human embryonic stem cell research is neither worth their time nor their money. (all.org)
On the other hand, research involving adult stem cells has not only been around for a long time, it has also been used successfully for decades! (all.org)
While stem cell research and human cloning are complex topics, the facts are readily available. (all.org)
And the MSM (mainstream media), who remain desperately committed to push embryonic stem cell research despite its failures, dangers, and immoral foundations, may soon be reeling at the fall of one of their heroes. (blogspot.com)
embryonic stem cell research has not had a good year. (blogspot.com)
A Korean television station whose investigative report was the nail in the coffin that prompted human cloning scientist Hwang Woo-suk to admit he lied about egg donations his researchers made says he may have lied about the results of his research as well. (blogspot.com)
However, Korean television station MBC has conducted interviews with an unnamed member of Hwang's research team who says the cells were never cloned successfully. (blogspot.com)
Such is the fate of two entire fields of academia intertwined in the current issue of human embryonic stem cell research. (lifeissues.net)
See Irving, "Human Embryonic Stem Cell Research: Are official positions based on scientific fraud? (lifeissues.net)
Great Iranian Muslim scholars netics, stem cell research, and organ trans- laid huge emphasis on teaching and practis- plantation are some of the medical issues ing ethics. (who.int)
Although many species produce clonal offspring in this fashion, Dolly, the lamb born in 1996 at a research institute in Scotland, was the first asexually produced mammalian clone. (who.int)
Somatic-cell nuclear transfer, the technique by which Dolly was created, was first used 40 years ago in research with tadpoles and frogs. (who.int)
This paper outlines the debates prompted through a reproduction mechanism involv- by progress in cloning research, with special ing male and female germ cells. (who.int)
Below you can see some examples of the infrastructure for research on genes and cells, available for researchers at Lund University. (lu.se)
Recent news of an impending clinical cell transplantation trial in Parkinson's disease using parthenogenetic stem cells as a source of donor tissue have raised hopes in the patient community and sparked discussion in the research community. (lu.se)

In the 18 years since researchers cloned a sheep, scientists have found another way to produce cloned human cell lines. (usf.edu)
Researchers hope to use these cells to grow healthy tissue to replace injured or diseased tissues in the human body. (medlineplus.gov)
The new legislation allows medical researchers to create embryonic stem cells through cloning. (wikipedia.org)
The stem cells could be studied in the laboratory to help researchers understand what goes wrong in diseases like these. (eurostemcell.org)
A six-person review committee consisting of stem cell researchers, an editor from the journal Nature, and members of the Science editorial boad determined that the editors of Science followed the correct review procedures at the time the papers were published. (lifenews.com)
hero" is the right word for how Hwang Woo-suk is revered by the media -- and by a large section of the Korean public who have bought into the false promises of embryonic stem cell and cloning researchers. (blogspot.com)
Such "guidelines" will ensure that stem cell researchers are not treated poorly as was Hwang when he was eventually found guilty of falsifying his data. (lifeissues.net)

Eighteen years ago, scientists in Scotland took the nuclear DNA from the cell of an adult sheep and put it into another sheep's egg cell that had been emptied of its own nucleus. (usf.edu)
So ideally scientists would like to be able to extract DNA from the cells of older people - not just cells from infants - to create therapies for adult diseases. (usf.edu)
In principle, scientists could produce a series of cell lines that would allow a close match for the majority of would-be cell recipients - just as transplant surgeons currently seek a close match for organ donors. (usf.edu)
Scientists produced embryonic stem cells from the DNA of one person combined with a human donor egg. (technologyreview.com)
"PrimeGen , based in Irvine, California, says that its scientists have converted specialised adult human cells back to a seemingly embryonic state - using methods that are much less likely to trigger cancer than those deployed previously. (cbc-network.org)
The company also claims to be able to produce reprogrammed cells faster and much more efficiently than other scientists. (cbc-network.org)
Umbilical Cord Blood Storage Company Sees Growth Umbilical Cord Stem Cell Storage Resources Arkansas House Votes to Create Umbilical Cord Stem Cell Bank Scientists Claim They Discovered Molecule That Might Help Embryonic Stem Cells Grow US Senate Vote for. (physiciansforlife.org)
1. Cloning is an umbrella term traditionally used by scientists to describe different processes for duplicating biological material. (who.int)
For instance, he wonders-just an intellectual puzzle, he assures me, that he would never want to do-What would happen if scientists injected human stem cells into a monkey embryo? (discovermagazine.com)
Scientists were initially interested in somatic-cell nuclear transfer as a means of determining whether genes remain functional even after most of them have been switched off as the cells in a developing organism assume their specialized functions as blood cells, muscle cells, and so forth. (who.int)
The con- is removed and replaced by a nucleus of cept of human cloning has long been in the another cell type, the stem cell will then imagination of many scientists, scholars and be reprogrammed to produce the product fiction writers [ 1 ]. (who.int)

After many divisions in culture, this single cell forms a blastocyst (an early stage embryo with about 100 cells) with almost identical DNA to the original donor who provided the adult cell - a genetic clone. (eurostemcell.org)
To produce Dolly, the cloned blastocyst was transferred into the womb of a recipient ewe, where it developed and when born quickly became the world's most famous lamb. (eurostemcell.org)
Instead, embryonic stem cells are isolated from the cloned blastocyst. (eurostemcell.org)

Cloning describes the processes used to create an exact genetic replica of another cell, tissue or organism. (medlineplus.gov)
Embryonic stem cells can then be harvested from the cloned embryo and used to create new cells and organs for the original organism. (kottke.org)
These stem cells are genetically matched to the donor organism, holding promise for studying genetic disease. (eurostemcell.org)
The science fiction definition of "clone" suggests that the cloned organism would be an exact genetic copy of another creature-human or beast-created in the laboratory by any of a number of means. (all.org)
There are differences-so much so that despite the "exact copy" claim, the cloned organism is actually unique genetically. (all.org)
A clone is an organism that is a genetic copy of an existing one. (who.int)

He'd like to see a library of cells created with those carefully chosen genes. (usf.edu)
The fact that the DNA of a fully differentiated (adult) cell could be stimulated to revert to a condition comparable to that of a newly fertilized egg and to repeat the process of embryonic development demonstrates that all the genes in differentiated cells retain their functional capacity, although only a few are active. (who.int)
explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)
Below is a non-exhaustive list of in-house infrastructures that are categorized into three overarching themes: bio-imaging, proteins, genes & cells and other resources. (lu.se)
In addition to infrastructures for bioimaging, protein and genes & cells, we also provide other resources e.g., databases, networks and specialized labs. (lu.se)

Dolly, the first mammal to be genetically cloned from adult cells, poses for the camera in 1997 at the Roslin Institute in Edinburgh, Scotland. (usf.edu)
WHA50.37 of 1997 argues that human cloning is ethically unacceptable and contrary to human integrity and morality. (who.int)
He stayed on to earn his Ph.D. in molecular biology at Cambridge, training under the legendary geneticist John Gurdon, whose breakthroughs in the 1950s and 1960s were key to the experiments performed by Ian Wilmut, a Gurdon student who cloned Dolly the sheep in 1997. (discovermagazine.com)
General Assembly the following year,3 and the World Medical Association's Resolution on Cloning, endorsed in 1997, have confronted the issue but lack binding legal force. (who.int)

2. Over the years, the international community has tried without success to build a consensus on an international convention against the reproductive cloning of human beings. (who.int)
3. Creating awareness among ministries of health in the African Region will provide them with critical and relevant information on the reproductive cloning of human beings and its implications to the health status of the general population. (who.int)
7. The WHO Regional Committee for Africa is invited to review this document for information and guidance concerning reproductive cloning of human beings. (who.int)
3. Media reports on nuclear transfer are usually about one form, reproductive nuclear transfer, also known as reproductive cloning of human beings . (who.int)
Elaboration of an international convention against reproductive cloning of human beings has been under consideration in the United Nations since December 2001 when the subject was included in the agenda of the fifty- sixth session as a supplementary agenda item at the request of France and Germany. (who.int)

Using tooth Pulp Cells ill SCNT increased the first cleavage rates compared with adult somatic Cells, leading to a higher rate of DNA reprogramming and increased production of an identical embryonic stem cells (ESCs) line. (yildiz.edu.tr)
These Outcomes are promising for regenerative medicine ill the therapy of diabetes mellitus, and clarification of the importance of selecting appropriate adult somatic cells in deriving identical ESC lines is also a significant step. (yildiz.edu.tr)
In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)

The resulting egg was implanted in the womb of a third sheep, and the result was Dolly, the first clone of a mammal. (usf.edu)
The most famous clone was a Scottish sheep named Dolly. (medlineplus.gov)
Cloning, or somatic cell nuclear transfer (SCNT), is the technique used to produce Dolly the sheep, the first animal to be produced as a genetic copy of another adult. (eurostemcell.org)

Writing in the journal Cell Stem Cell , they say they started with nuclear DNA extracted from the skin cells of a middle-age man and injected it into human eggs donated by four women. (usf.edu)
This Study presents the first use in somatic cell nuclear transfer (SCNT) of tooth Pulp cells containing progenitor cells that resemble the nonaging embryonic connective tissue in adults. (yildiz.edu.tr)
Mouse nuclear transfer embryonic stem cells (NT-ESCs) were first established in 2000, and then proved to be able to differentiate either in vivo or in vitro, and give rise to individual tissues through germ line transmission or tetraploid complementation. (benthamscience.com)
For example, stem cells could be generated using the nuclear transfer process described above, with the donor adult cell coming from a patient with diabetes or Alzheimer's. (eurostemcell.org)
2. Nuclear transfer is a technique used to duplicate genetic material by creating an embryo through the transfer and fusion of a diploid cell in an enucleated female oocyte.2 Cloning has a broader meaning than nuclear transfer as it also involves gene replication and natural or induced embryo splitting (see Annex 1). (who.int)
체세포 핵 치환 (Somatic-cell nuclear transfer, SCNT)은 난자 의 핵 을 제거한 후에, 체세포 의 핵을 이식하여 복제 를 하는 기술을 말한다. (wikipedia.org)
if it implants and the pregnancy goes to term, the resulting individual will carry the same nuclear genetic material as the donor of the adult somatic cell. (who.int)
However, an animal created through this technique would not be a precise genetic copy of the source of its nuclear DNA because each clone derives a small amount of its DNA from the mitochondria of the egg (which lie outside the nucleus) rather than from the donor of cell nucleus. (who.int)
In neu- fatal neurologic disease of horses and sheep, owes rons, sometimes in glia cells, acidophilic intra- its name to the town Borna in Saxony, Germany, nuclear inclusion bodies, called Joest-Degen inclu- where a large number of horses died during an sion bodies, are occasionally found. (cdc.gov)

The other paper claimed Hwang's team successfully cloned a human embryo to be killed for her stem cells. (lifenews.com)

Do our only cloned primates come from the lab of Woo Suk Hwang's colleague? (nature.com)
Last year, Hwang's team said it successfully cloned a human embryo from embryonic stem cells. (blogspot.com)
According to MBC, the scientist "maintains that Hwang's team fabricated data because in reality it failed to clone a somatic cell and instead used a frozen embryo from the hospital to make stem cells. (blogspot.com)

For pediatric patients with refractory cytopenia, certain cytogenetic abnormalities, or malignant transformation, hematopoietic stem cell transplantation (HSCT) from a matched related or unrelated donor early in the course of the disease is the treatment of choice. (medscape.com)
MDS is rare in childhood and may have a rapidly progressive course with an extremely poor prognosis without hematopoietic stem cell transplantation (HSCT). (medscape.com)

Nanog and transcriptional networks in embryonic stem cell pluripotency. (bdbiosciences.com)
In terminally differentiated cell fate is coupled to appropriate regulation of the alternative cells, transcriptional networks must be stable and irreversible, pathways. (lu.se)

Thus, the clone would be genetically identical to the nucleus donor only if the egg came from the same donor or from her maternal line. (who.int)
Beyond this scientific interest, the commercial concern in animal cloning focuses on replicating large numbers of genetically identical animals, especially those derived from a progenitor that has been modified genetically. (who.int)

These cells were named Osmangazi Turk Identical ESCs since this was the first use in SCNT of tooth pulp cells to demonstrate a decrease in glucose levels following administration of these cells. (yildiz.edu.tr)

Stem cells are not specialized and the process of their specialization is called differentiation. (benthamscience.com)
Genetic abnormalities associated with MDS block differentiation of hematopoietic stem and progenitor cells. (medscape.com)
Aim: To detect the expression of molecules associated with Notch signaling pathway in stem cells from human exfoliated deciduous teeth (SHED) cultured in specific differentiation medium, namely, keratinocyte growth medium (KGM). (bvsalud.org)
Notch-1, Jagged-1, Jagged-2, and stem cell marker Nanog are expressed in SHED cultured in KGM which may be involved in the differentiation into epithelial-like cells in human dental pulp tissues. (bvsalud.org)
Since the Notch signaling pathway molecules play an important role in differentiation of epithelial cells, it is important to identify the presence of notch signaling molecules in SHED during the process of cell differentiation. (bvsalud.org)
The Notch signaling pathway provides important intercellular signaling mechanisms essential for cell fate specification and it regulates differentiation and proliferation of stem or progenitor cells by para-inducing effects 3-4 . (bvsalud.org)
Notch signaling pathway is also involved in the regulation of epithelial cell differentiation in various tissues 5-6 . (bvsalud.org)
Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)
Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)

Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. (bdbiosciences.com)
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. (bdbiosciences.com)
RNA was reverse-transcribed to obtain the cDNA and then proceeded with PCR using specific primers for the Notch signaling pathway molecules (Notch1, Jagged-1, Jagged-2 and, Hes1) as well as stem cell marker (Nanog). (bvsalud.org)

SOX2 is an intronless gene encoding a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. (thermofisher.com)

The South Korean stem-cell researcher Woo Suk Hwang has been at the centre of one of the largest investigations of scientific fraud in living memory. (nature.com)
Perhaps the most widely publicized retractions were those surrounding the now-discredited stem cell researcher Woo Suk Hwang, formerly of Seoul National University in South Korea, after proposing that he had cloned human embryonic stem cells. (scientificamerican.com)

This mouse egg (top) is being injected with genetic material from an adult cell to ultimately create an embryo - and, eventually, embryonic stem cells. (usf.edu)
They repeated the process - this time starting with the genetic material extracted from the skin cells of a much older man. (usf.edu)
The copied material, which has the same genetic makeup as the original, is referred to as a clone. (medlineplus.gov)
Genetic match for the patient - you use their skin cells. (cbc-network.org)
Most natural cloning occurs in those species that produce their descendants asexually, that is, without combining the male and female genetic material. (who.int)

The term applies not only to entire organisms but also to copies of molecules (such as DNA) and cells. (who.int)
Our facilities provide the opportunity to study molecules, cells, organs and entire organisms. (lu.se)

The following product was used in this experiment: SOX2 (Embryonic Stem Cell Marker) Recombinant Rabbit Monoclonal Antibody (SOX2/4267R) from Thermo Fisher Scientific, catalog # 6657-RBM7-P1. (thermofisher.com)
However, SOX2 is expressed in a high percentage of lung squamous cell carcinomas and has been shown to be an independent favorable prognostic marker. (thermofisher.com)
The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)

The study of biology of stem cells is the hallmark of the recent emerging field of regenerative medicine and medical biotechnology. (benthamscience.com)
Nature Cell Biology. (bdbiosciences.com)
Based on the physical characteristics of the sample, biobanks can be classified into several categories, such as tissue biobanks, cell biology banks, and blood biobanks. (technavio.com)
One of the greatest controversies triggered tissue, a stem cell encoding for heart tissue by the rapid pace of evolution in biology, will eventually develop into heart tissue particularly in genomics and biotechnology, and so on. (who.int)
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. (lu.se)
Our facilities provide the opportunity to study protein structure, molecular probes and drug design, system biology and molecular interactions in cells and tissues. (lu.se)

Obtaining stem cells from fatty tissue, bone marrow, or the umbilical cord after the birth of a baby, on the other hand, may be done ethically. (all.org)
WHA50.37, which states "the use of cloning for the replication of human individuals is ethically unacceptable and contrary to human integrity and morality. (who.int)

Previously, Mitalipov and his colleagues reported the first success in cloning human stem cells in 2013, successfully reprogramming human skin cells back to their embryonic state. (cnn.com)

Specificity Comments: SOX2 is required for stem cell maintenance in the central nervous system, and it also regulates gene expression in the stomach. (thermofisher.com)
An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct 3/4 expression. (thermofisher.com)
Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells. (bdbiosciences.com)

1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)

In Alzheimer's, it is the degeneration of the nerve cells that cause the problem because they lose their ability to connect with each other. (all.org)

Cloning takes "old cells" back in time, creating identical young cells. (kottke.org)
The term "clone", from the Greek word for twig, denotes a group of identical entities. (who.int)
In sexual reproduction, clones are created when a fertilized egg splits to produce identical (monozygous) twins with identical genomes. (who.int)

Apparently distinct mechanisms of de novo lumen formation observed in vitro - in three-dimensional cultures of endothelial and Madin-Darby canine kidney (MDCK) cells - and in vivo - in zebrafish vasculature, Caenorhabditis elegans excretory cells and the Drosophila melanogaster trachea - in fact share many common features. (bvsalud.org)

It also means that finally getting the sheep technology to work with cells from adult humans may not turn out to be a turning point for this technology, after all. (usf.edu)
In most countries, it is illegal to attempt reproductive cloning in humans. (eurostemcell.org)
See "Review of Critical Article: Cobbe, 'Why the apparent haste to clone humans? (lifeissues.net)
2002). In humans, SSEA4 is expressed by building the nervous system but also for their prospec- nonneural cells such as the erythrocytes (Kannagi et al. (lu.se)

And with a bit of coaxing, these cells could, theoretically, be prodded to turn into any sort of human cell - nerve, heart, liver and pancreas, for example. (usf.edu)

Immunohisto- have been used for positive selection of NSCs from em- chemistry on human embryonic central nervous system bryonic mice (Nagato et al. (lu.se)

Dolly's birth set off a huge outpouring of ethical concern - along with hope that the same techniques, applied to human cells, could be used to treat myriad diseases. (usf.edu)
Cloning technology, however, is perceived as having the potential for reproductive cloning, which raises serious ethical and moral concerns. (who.int)

South Korean professor and cloning pioneer Hwang Woo-suk, is in yet more trouble. (blogspot.com)

The present report gives an overview of the terms and methods used in cloning and summarizes the debates in the General Assembly. (who.int)

Reproductive cloning versus germ cell (egg, ovum). (who.int)
HN - 2008 BX - Von Ebner's Glands MH - Cumulus Cells UI - D054885 MN - A05.360.319.114.630.535.200.500 MN - A06.407.312.497.535.300.500 MN - A11.436.300.500 MS - The granulosa cells of the cumulus oophorus which surround the OVUM in the GRAAFIAN FOLLICLE. (bvsalud.org)

The "stem cell theory of cancer" states that a subpopulation of cells with stem cell-like properties plays a central role in the formation, sustainment, spread, and drug resistant characteristics of malignant tumors. (medscape.com)
Recent studies have isolated distinct cell populations from infantile hemangiomas that display properties equivalent to aberrant progenitor cells, suggesting that, in addition to malignant tumors, benign tumors may also contain a stem cell-like component. (medscape.com)
These findings provide supporting evidence that enrichment for proteins involved in pluripotency is not restricted solely to malignant tumors as is suggested by the "stem cell theory of cancer", but additionally extends to common benign vascular tumors such as hemangiomas. (medscape.com)

Nearly all the cells in the stalled embryo had turned into brain cells, simply because a single protein had been stopped. (discovermagazine.com)

Peripheral blood mononuclear cells (PBMCs) were used to measure the enzymatic activities of citrate synthase and complexes I, II, and IV and mtDNA copy number. (bvsalud.org)

Stem cells from human exfoliated deciduous teeth (SHED) are multipotent stem cells derived from the pulp tissues of extracted deciduous teeth 1 . (bvsalud.org)

In this procedure, the nucleus of an egg cell is removed and replaced by the nucleus of a cell from another adult. (eurostemcell.org)
After being inserted into the egg, the adult cell nucleus is reprogrammed by the host cell. (eurostemcell.org)
The nucleus of an adult somatic cell (such as a skin cell) is removed and transferred to an enucleated egg, which is then stimulated with electric current or chemicals to activate cell division. (who.int)
When the nucleus of a stem cell has been the technique of cloning. (who.int)
The basic techniques of of the implanted nucleus, when it fully cloning have been known for some time, and develops. (who.int)

This event explains the presence of multiple derangements observed in the bone marrow that involve several cell lineages. (medscape.com)
As the affected cell lines continue to divide and to provide the marrow with dysplastic cells, bone marrow dysfunction becomes apparent. (medscape.com)
Myelodysplastic syndrome (MDS) in childhood encompasses a diverse group of bone marrow disorders that share a common clonal defect of stem cells and that result in ineffective hematopoiesis with dysplastic changes in the marrow. (medscape.com)

Based on discussions held by a global collaborative initiative on translation of stem cell therapy in Parkinson's disease, we have identified a set of key questions that we believe should be addressed ahead of every clinical stem cell-based transplantation trial in this disorder. (lu.se)

Stem cells are emerging as an important source of material for diseases in regenerative medicine. (benthamscience.com)
There are more than 70 diseases or conditions-including leukemia, immune system and other blood disorders, cancers, and autoimmune diseases-that respond well when adult stem cell therapy is used. (all.org)

MDS is a clonal disorder of myeloid stem cells. (medscape.com)

ESCs derived from tooth Pulp cells using this method were observed to transfer into pancreatic beta Cells using transmission electron microscopy. (yildiz.edu.tr)
For Melton's children, this imbalance is most likely an early death sentence, unless, of course, their father can discover a stem cell fix for pancreatic cells in diabetics that are inexplicably attacked by the body's immune system. (discovermagazine.com)

Although low ROS levels are beneficial to cellular stress responses for the activation of several cellular signaling pathways, abnormally elevated ROS leads to damage to cells and organs, and eventually, to cell death, thereby ROS can be either beneficial or detrimental to health 11 . (nature.com)

General Assembly the adoption of a declaration on human cloning by which Member States were called upon to prohibit all forms of human cloning inasmuch as they are incompatible with human dignity and the protection of human life. (who.int)

Aberration occurs in a stem cell that can give rise to multiple lineages. (medscape.com)
Known as mitochondrial allostatic load, this (phenomenon) occurs when mitochondria are unable to recalibrate and maintain cell homeostasis. (bvsalud.org)

Anatomy54

Organisms13

Diseases8

Chemicals and Drugs66

Analytical, Diagnostic and Therapeutic Techniques and Equipment57

Phenomena and Processes60

Disciplines and Occupations4

Technology, Industry, Agriculture1

Information Science3

Health Care1

Therapeutic19

Embryos10

Mouse embryonic cells1

Pluripotent stem4

Research45

Researchers7

Scientists11

Blastocyst3

Organism6

Genes5

19974

Reproductive cloning of hum5

Somatic cells3

Dolly3

Nuclear9

Claimed Hwang's team1

Hwang's3

Hematopoietic Stem Cell Trans2

Transcriptional networks2

Genetically2

SCNT1

Differentiation10

Nanog3

Involved in the regulation1

Researcher2

Genetic5

Organisms2

Marker4

Biology6

Ethically2

Successfully1

SOX23

Fetal1

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Identical3

Vitro1

Humans4

Human cell1

Mice1

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South Korean1

Debates1

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Mononuclear cells1

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Prohibit1

Occurs2