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  • ASCT
  • It is important to consider the possibility of a future ASCT at the time of diagnosis because stem cells have to be collected and frozen early in the disease course even if the initial treatment plan involves ASCT for treatment after a myeloma recurrence. (toweroncology.com)
  • Clinical
  • Lamivudine (100 mg die) achieved a complete clinical recovery and HBV-DNA clearance from blood within 8 weeks. (wiley.com)
  • Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters. (springermedizin.de)
  • Gonadal maldevelopment as risk factor for germ cell cancer: towards a clinical decision model. (mdedge.com)
  • CT detection of retroperitoneal lymph node metastases in patients with clinical stage I testicular nonseminomatous germ cell cancer: assessment of size and distribution criteria. (mdedge.com)
  • 12. Nicolai N, Pizzocaro G. A surveillance study of clinical stage I nonseminomatous germ cell tumors of the testis: 10-year followup. (mdedge.com)
  • To date, clinical responses have been observed by using vaccines targeting HER-2/neu protein, human telomerase reverse transcriptase, carcinoembryonic antigen, and carbohydrate antigen given after stem cell rescue. (aacrjournals.org)
  • HSCT
  • Overall survival in the RCT was reported not statistically significantly different between autologous HSCT following HDCT versus SDCT. (bmj.com)
  • Conclusions Overall survival in patients with locally advanced or metastatic NRSTS was not statistically different after autologous HSCT following HDCT compared with SDCT in a single RCT with a total of 83 patients. (bmj.com)
  • Therefore, HLA-matched unrelated HSCT, HLAmismatched related HSCT, and unrelated cord blood transplantation have been investigated. (go.jp)
  • One-antigen mismatched related HSCT can be performed without T-cell depletion, but the outcome has been somewhat inferior to HSCT from an HLA-matched sibling or HSCT from an HLA-allele-matched unrelated donor. (go.jp)
  • Two- or three-antigen mismatched related HSCT without ex vivo T-cell depletion has been investigated in Japan using a variety of strategies including in vivo T-cell depletion using anti-thymocyte globulin or alemtuzumab, and its safety has become close to that of HLA-matched HSCT. (go.jp)
  • However, the appropriate choice of these strategies as well as the difference in HSCT outcome with cord blood transplantation has not been clarified. (go.jp)
  • neuropathy
  • Peripheral neuropathy is the dominant and frequently presenting feature in patients with POEMS. (renalandurologynews.com)
  • Some may present with known history of a specific monoclonal gammopathy, while in others, boney lesions of osteomyeloma or other evidence of a plasma cell dyscrasia are detected during workup for POEMS in patients with neuropathy. (renalandurologynews.com)
  • Although some consider multicentric CD with peripheral neuropathy to be a distinct entity, a history of CD and neuropathy, should prompt and extensive endocrinologic, dermatologic, and pulmonary evaluation to exclude POEMS. (renalandurologynews.com)
  • POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes) syndrome is a rare cause of demyelinating neuropathy with monoclonal plasma cell proliferation, and POEMS neuropathy is usually chronically progressive. (bmj.com)
  • progenitor
  • An important gene associated with Gastric Leiomyosarcoma is PDGFRA (Platelet Derived Growth Factor Receptor Alpha), and among its related pathways/superpathways are B Cell Development Pathways and Cardiac Progenitor Differentiation . (malacards.org)
  • clonal plasma cell
  • Multiple myeloma is a clonal plasma cell malignancy that accounts for slightly more than 10% of all hematologic cancers. (bloodjournal.org)
  • 1 , 2 It usually evolves from an asymptomatic premalignant stage of clonal plasma cell proliferation termed "monoclonal gammopathy of undetermined significance" (MGUS). (bloodjournal.org)
  • The definition of active MM relies on clinicopathological criteria that require evidence of end-organ damage attributable to the underlying clonal plasma cell disorder. (bloodjournal.org)
  • In immunoglobulin light chain (AL) amyloidosis, amyloid fibril deposits derived from immunoglobulin light chains produced by a clonal plasma cell dyscrasia accumulate in tissues and damage vital organs. (bloodjournal.org)
  • lymphomas
  • Pathologically, AIDS-related lymphomas comprise a narrow spectrum of histologic types consisting almost exclusively of B-cell tumors of aggressive type. (cigna.com)
  • polyneuropathy
  • POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) is a paraneoplastic syndrome that is associated with an underlying plasma cell dyscrasia. (renalandurologynews.com)
  • It is defined as the combination of a plasma-cell proliferative disorder (typically myeloma), polyneuropathy, and effects on many other organ systems. (lymphedemapeople.com)
  • Since there is no single diagnostic test for the diagnosis of POEMS syndrome, the diagnosis is typically based on the presence of polyneuropathy associated with monoclonal plasma cell disorders presenting with the distinct symptoms described above. (biomedcentral.com)
  • radiation
  • Acupuncture, a complementary therapy used in symptom management,[ 1 , 2 , 3 , 4 ] is used clinically to manage cancer-related symptoms, treat side effects induced by chemotherapy or radiation therapy, boost blood cell count, and enhance lymphocyte and natural killer (NK) cell activity. (healthlinkbc.ca)
  • Holmium Ho 166 DOTMP may deliver radiation directly to cancer cells and cause less damage to normal tissue. (clinicaltrials.gov)
  • Determine the radiation absorbed dose of holmium Ho 166 DOTMP to the kidney in patients with multiple myeloma, based on whole body gamma camera image data for comparison with that obtained using an ICRP mathematical model. (clinicaltrials.gov)