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  • genes
  • These genes, and others triggering osteoblastic differentiation, are selectively downregulated during enforced HSC mobilization or beta3 adrenoreceptor activation. (nih.gov)
  • Expression of pluripotency genes and triploblastic differentiation are self-renewable over generations. (wikipedia.org)
  • The expression 'pattern' of genes related to pluripotency in Muse cells was almost the same as that in ES and iPS cells, while the expression 'level' was much higher in ES and iPS cells and that in Muse cells. (wikipedia.org)
  • In contrast, genes related to cell cycle progression and tumorigenicity in Muse cells were at the same level as those in somatic cells, while the same genes were very high in ES and iPS cells. (wikipedia.org)
  • B cell development is divided into several successive steps as judged by surface markers and rearrangement of immunoglobin genes. (pnas.org)
  • miR-15 and miR-16 genes are often deleted or expressed at reduced levels in B cell chronic lymphocytic leukemias (CLL), suggesting that these miRNAs might be tumor-suppressor genes ( 25 - 27 ). (pnas.org)
  • Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells. (wikipedia.org)
  • Below is a list of genes/protein products that can be used to identify various types of stem cells, or functional assays that do the same. (wikipedia.org)
  • maturation
  • Enforced expression of the ABCG2 cDNA resulted in a robust SP phenotype and a reduction in hematopoietic maturation. (wiley.com)
  • citation needed] It is important for proliferation during certain stages of B-cell maturation, T and NK cell survival, development and homeostasis. (wikipedia.org)
  • One example is the transformation of iris cells to lens cells in the process of maturation and transformation of retinal pigment epithelium cells into the neural retina during regeneration in adult newt eyes. (wikipedia.org)
  • The fact that transdetermination (change of the path of differentiation) often occurs for a group of cells rather than single cells shows that it is induced rather than part of maturation. (wikipedia.org)
  • functional
  • Thus, by direct effect on progenitor cells and through activation and remodeling of the supporting hematopoietic microenvironment, DLE may contribute a robust innate immune response by promoting the emerging lymphopoiesis of functional CD11c + NK cells in a partially TLR-related manner. (hindawi.com)
  • Treatment of mice with DNA methylation inhibitors will reveal the functional consequences on hematopoietic progenitors and the resulting changes in methylation patterns. (grantome.com)
  • By analyzing the phenotypic and functional consequences of Dnmt3 loss in HSCs, we will provide the first detailed portrait of the role of Dnmt3s in any adult cell type. (grantome.com)
  • Stem cells can also be identified by functional assays. (wikipedia.org)
  • a donor's healthy bone marrow reintroduces functional stem cells to replace the cells lost in the host's body during treatment. (wikipedia.org)
  • regenerative
  • We believe that knowledge of the molecular and cellular regulation of HSCs will contribute to improved methods to direct these processes to expand hematopoietic stem cells (HSCs), develop pharmaceuticals to treat leukemia and other hematological disorders, and improve methods of bone marrow transplantation (BMT), gene therapy, and regenerative medicine. (cancer.gov)
  • Types of stem cells used for cardiac regenerative therapy. (hindawi.com)
  • In 2006 Eaves retired as required by provincial law at that time, becoming Professor Emeritus of Hematology and spending more time on several companies he founded to further the fields of cellular therapy and regenerative medicine - STEMCELL Technologies, STEMSOFT Software Inc. and Malachite Management Inc. These companies continue to grow under his leadership and by 2016, STEMCELL had over 900 employees making Canada's largest biotechnology company. (wikipedia.org)
  • Marrow nucleated cells are used every day in regenerative orthopedics. (wikipedia.org)
  • Some of the biomedical approaches within the field of regenerative medicine may involve the use of stem cells. (wikipedia.org)
  • primitive
  • Using a semiquantitative reverse transcription-polymerase chain reaction, one of the ATP-binding cassette (ABC) transporters, the breast cancer resistance protein (Bcrp) or ABC transporter G2 (ABCG2), was found to be highly expressed in SP cells as well as other primitive HSCs and to sharply drop with hematopoietic differentiation. (wiley.com)
  • Further, EPC colony-forming assay of BM-Lin − /Sca-1 + (BM-LS) cells exhibited a conversion from the predominant primitive EPC colony production at P12 to the definitive EPC colony at P17. (arvojournals.org)
  • Moreover, the definitive EPC colony cells intravitreally injected into OIR significantly abrogated pathologic versus primitive vascular growth. (arvojournals.org)
  • GATA1 is essential for normal primitive and definitive erythropoiesis and is expressed at high levels in erythroid cells, mast cells, and megakaryocytes. (wikipedia.org)
  • The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. (wikipedia.org)
  • somatic
  • These results uncover an unprecedented partnership between two distinct somatic stem-cell types and are indicative of a unique niche in the bone marrow made of heterotypic stem-cell pairs. (nih.gov)
  • Hela cells and human fibroblast-derived iPS cells showed high telomerase activity while Muse was at nearly the same level as that in somatic cells such as fibroblasts (these data are shown without running control for the telomerase activity, the comparison is not scientific thought). (wikipedia.org)
  • Progenitors are obtained by so-called direct reprogramming or directed differentiation and are also called induced somatic stem cells. (wikipedia.org)
  • Induced totipotent cells can be obtained by reprogramming somatic cells with somatic-cell nuclear transfer (SCNT). (wikipedia.org)
  • The process involves sucking out the nucleus of a somatic (body) cell and injecting it into an oocyte that has had its nucleus removed Using an approach based on the protocol outlined by Tachibana et al. (wikipedia.org)
  • extracellular
  • The cells, which are long and thin, are widely dispersed and the adjacent extracellular matrix is populated by a few reticular fibrils but is devoid of the other types of collagen fibrils. (wikipedia.org)
  • survival
  • We characterized the effect of transplanted donor mononuclear cells on relapse- and event-free survival after allogeneic bone marrow transplantation (BMT). (cancernetwork.com)
  • Recipients of larger numbers of DC2 cells had significantly lower event-free survival, a lower incidence of chronic graft-vs-host disease, and an increased incidence of relapse. (cancernetwork.com)
  • 1-A number of factors, including patient disease status, age, conditioning regimen, and (for allogeneic recipients) type of graft-vs-host disease prophylaxis, influence the probability of survival after transplantation. (cancernetwork.com)
  • Binding results in a cascade of signals important for T-cell development within the thymus and survival within the periphery. (wikipedia.org)
  • regulate
  • We have found that proteins, which alter the structure of DNA (DNA methyltransferases) can help regulate the ability of these blood forming stem cells to make blood. (grantome.com)
  • Understanding how these proteins regulate stem cells and blood production may improve bone marrow transplantation and lend insight into development of myelodysplastic syndromes. (grantome.com)
  • It must balance enormous production needs (more than 500 billion blood cells are produced every day) with the need to precisely regulate the number of each blood cell type in the circulation. (wikipedia.org)
  • Stem-cell niche refers to a microenvironment, within the specific anatomic location where stem cells are found, which interacts with stem cells to regulate cell fate. (wikipedia.org)
  • proteins
  • Inhibitors of DNA Binding (Id) Proteins in Normal Hematopoietic Development. (cancer.gov)
  • It is believed that the molecular distinction between symmetric and asymmetric divisions lies in differential segregation of cell membrane proteins (such as receptors) between the daughter cells. (wikipedia.org)