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  • patients undergoing
  • In fact, early attempts to decrease treatment related mortality in chronic myelogenous leukemia (CML) patients undergoing allogeneic BMT by T-cell depletion of the graft resulted in an unacceptably high rate of relapse suggesting that alloreactivity in the donor graft accounted for a significant portion of the cure rate in this disease. (knowcancer.com)
  • myeloid
  • However, counting CD34+ mononuclear cells may overestimate myeloid blasts in bone marrow smears due to hematogones (B lymphocyte precursors) and CD34+ megakaryocytes. (wikipedia.org)
  • Procedure
  • PBSCT is now a much more common procedure than its bone marrow harvest equivalent, this is in-part due to the ease and less invasive nature of the procedure. (wikipedia.org)
  • precursors
  • These cells have often been called neuroblasts in an effort to delineate them as precursors to neurons and glial cells. (wikipedia.org)
  • Finally, recent data suggest CD34 may also play a more selective role in chemokine-dependent migration of eosinophils and dendritic cell precursors. (wikipedia.org)
  • myocardial
  • Among several clinical trials that have reported that adult stem-cell therapy is safe and effective, powerful effects have been reported from only a few laboratories, infarcts as well as heart failure not arising from myocardial infarction. (wikipedia.org)
  • engraftment
  • The end points of this study are engraftment, degree of donor-host chimerism, incidence of acute and chronic GVHD, transplant related morbidity and mortality, disease free survival, as well as overall survival, and overall level and persistence of progeny of gene modified cells. (knowcancer.com)
  • Hematology
  • As Head of Hematology at the British Columbia Cancer Agency and the University of British Columbia for 18 years (1985-2003) he engineered the building of one of the first and largest bone marrow transplant programs in Canada. (wikipedia.org)
  • In 2006 Eaves retired as required by provincial law at that time, becoming Professor Emeritus of Hematology and spending more time on several companies he founded to further the fields of cellular therapy and regenerative medicine - STEMCELL Technologies, STEMSOFT Software Inc. and Malachite Management Inc. These companies continue to grow under his leadership and by 2016, STEMCELL had over 900 employees making Canada's largest biotechnology company. (wikipedia.org)
  • clinical
  • You may have the opportunity to participate in a clinical trial studying new, safer methods of preparing for, receiving, and recovering from a bone marrow transplant. (nyp.org)
  • In 1995, Hackensack was part of a large clinical study sponsored by National Cancer Institute to study the use of bone marrow transplantation to treat women with advanced breast cancer. (wikipedia.org)
  • As of 2008 clinical research at the University of Minnesota has included a bone marrow transplant to a 2-year-old child who is one of 2 brothers with EB. (wikipedia.org)
  • Clinical and animal studies have been conducted into the use of stem cells in cases of spinal cord injury. (wikipedia.org)
  • CD34
  • CD34) progenitors and total cells than bone marrow. (knowcancer.com)
  • CD34 is also an important adhesion molecule and is required for T cells to enter lymph nodes. (wikipedia.org)
  • Conversely, under other circumstances CD34 has been shown to act as molecular "Teflon" and block mast cell, eosinophil and dendritic cell precursor adhesion, and to facilitate opening of vascular lumina. (wikipedia.org)
  • Regardless of its mode of action, under all circumstances CD34, and its relatives podocalyxin and endoglycan, facilitates cell migration. (wikipedia.org)
  • spleen
  • In the late 1940s, University of Chicago researcher Dr. Leon Jacobson discovered that he could save a mouse, whose bone marrow and spleen had been destroyed with radiation, by transplanting healthy spleen tissue from another mouse. (uchospitals.edu)
  • granulocyte colony
  • Granulocyte-colony stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream. (wikipedia.org)
  • somatic
  • Hela cells and human fibroblast-derived iPS cells showed high telomerase activity while Muse was at nearly the same level as that in somatic cells such as fibroblasts (these data are shown without running control for the telomerase activity, the comparison is not scientific thought). (wikipedia.org)
  • In contrast, genes related to cell cycle progression and tumorigenicity in Muse cells were at the same level as those in somatic cells, while the same genes were very high in ES and iPS cells. (wikipedia.org)
  • Embryonic cell lines and autologous embryonic stem cells generated through somatic cell nuclear transfer or dedifferentiation have also been proposed as promising candidates for future therapies. (wikipedia.org)
  • Stem-cell therapy has become controversial following developments such as the ability of scientists to isolate and culture embryonic stem cells, to create stem cells using somatic cell nuclear transfer and their use of techniques to create induced pluripotent stem cells. (wikipedia.org)
  • embryonic
  • Can be isolated as cells positive for SSEA-3, a well known human embryonic stem cell marker. (wikipedia.org)
  • Neuroepithelial cells of the ectoderm begin multiplying rapidly and fold in forming the neural plate, which invaginates during the fourth week of embryonic growth and forms the neural tube. (wikipedia.org)
  • Neuroepithelial cells give rise to radial glial cells early on during embryonic development. (wikipedia.org)
  • severe
  • [ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)
  • In 2014, the European Medicines Agency recommended approval of limbal stem cells for people with severe limbal stem cell deficiency due to burns in the eye. (wikipedia.org)
  • Stems cells are being studied in those with severe heart disease. (wikipedia.org)
  • pluripotent
  • A muse cell (multi-lineage differentiating stress enduring cell) is a endogenous non-tumorigenic pluripotent stem cell. (wikipedia.org)
  • Pluripotent stem cells, which can generate various kinds of the cells representative of all three germ layers have the ability to self-renew. (wikipedia.org)
  • Pluripotent stem cells can be directly obtained from normal human mesenchymal tissues without using artificial manipulations such as gene introduction. (wikipedia.org)
  • Therefore, Muse cells are double positive for pluripotent and mesenchymal stem cell markers. (wikipedia.org)
  • These gene expression pattern and level may explain why Muse cells are pluripotent but without tumorigenic activity. (wikipedia.org)
  • diseases
  • Our transplant programs offer access to highly innovative cellular treatment protocols including gene therapeutic approaches (for sickle cell disease) or cellular immunotherapy for treatment or prevention of viral diseases. (nyp.org)
  • The Department has unique knowledge and experience in care of patients with pulmonary hypertension, cystic fibrosis, interstitial lung diseases and the patients before and after lung transplantation. (bookinghealth.com)
  • Andrew Louis Pecora (born 1957) is an American hematologist and oncologist who has been involved in the research on the use of stem cells and oncolytic viruses to treat diseases, including cancer. (wikipedia.org)
  • Research is underway to develop various sources for stem cells, and to apply stem-cell treatments for neurodegenerative diseases and conditions such as diabetes, heart disease, and other conditions. (wikipedia.org)
  • The paracrine soluble factors produced by stem cells, known as the stem cell secretome, has been found to be the predominant mechanism by which stem cell-based therapies mediate their effects in degenerative, auto-immune and inflammatory diseases. (wikipedia.org)
  • Injection of CD34+ hematopoietic Stem Cells has been clinically applied to treat various diseases including Spinal Cord Injury, Liver Cirrhosis and Peripheral Vascular disease. (wikipedia.org)
  • Cancer
  • Relapse remains the biggest challenge for cancer patients who have undergone stem cell transplantation. (uchospitals.edu)
  • In a study from the United States, long-term survivors of pediatric bone marrow transplantation followed in the Bone Marrow Transplant Survivors Study were compared with survivors of childhood cancer treated without bone marrow transplant from the Childhood Cancer Survivor Study. (medscape.com)
  • Our scientists are developing new approaches to lower your risk of treatment-related complications and to reduce the chance that your cancer will come back after transplantation. (nyp.org)
  • In 2002, Pecora was an investigator in a study of PV701, a virus that selectively attacks cancer cells. (wikipedia.org)
  • This false appearance of increase in cancer cells was confirmed by a later trial of the same oncolytic virus and also in Onyx 015, an oncolytic adenovirus. (wikipedia.org)
  • Autologous stem-cell transplantation entry in the public domain NCI Dictionary of Cancer Terms ScienceDaily Report University of Louisville. (wikipedia.org)
  • During his medical training he was greatly influenced by Dr. Ross Langley, a research-oriented hematologist who suggested that Eaves do a PhD at the Princess Margaret Hospital in Toronto where Dr. Robert Bruce was collaborating with Drs. James Till and Ernest McCulloch (Lasker Award) on how different types of cancer chemotherapeutic agents killed tumour stem cells while sparing normal stem cells. (wikipedia.org)
  • tissues
  • Combining two-photon microscopy with fluorescent tracers, we successfully visualized the engrafted tissues at the single cell level in live mice over several months. (jove.com)
  • Imaging using confocal/two-photon hybrid microscopy enables simultaneous high resolution assessment of uniquely marked cells and their progeny in conjunction with structural components of the tissues. (jove.com)
  • Volumetric analyses over large areas reveal that spectrally coded HSPC-derived cells can be detected non-invasively in various intact tissues, including the bone marrow (BM), for extensive periods of time following transplantation. (jove.com)
  • However, with regard to 42 strains thus far produced , none showed expression in the hematopoietic tissues, except one strain in which LacZ expression was observed in osteoblast cells. (nii.ac.jp)
  • A category of rare and aggressive haematologic tumors co-expressing CD4 and CD56 antigens in the absence of any specific myeloid, B-, T-lymphoid or natural killer (NK) lineage markers is classified as blastic plasmacytoid dendritic cell neoplasms (BPDCN) according to the most recent 2008 WHO classification of tumours of haematopoietic and lymphoid tissues (1). (czytelniamedyczna.pl)
  • Another kind of cell-the pluripotent stem cell of mouse teratocarcinomas-was found to give rise to normal tissues in adult chimeras after injection into the mouse blastocyst. (thefreedictionary.com)
  • All the differentiated tissues in the tumor arise from pluripotent stem cells known as embryonal carcinoma (EC) cells. (thefreedictionary.com)
  • When embryonal carcinoma cells are injected into a genetically marked host blastocyst, they continue to divide and participate in normal development, and give rise to fully differentiated cells in all tissues of the adult, including skin, muscle, nerve, kidney, and blood. (thefreedictionary.com)
  • The presence of CD34 on non-hematopoietic cells in various tissues has been linked to progenitor and adult stem cell phenotypes. (wikipedia.org)
  • For years, the concept of harvesting stem cells and re-implanting them into one's own body to regenerate organs and tissues has been embraced and researched in animal models. (wikipedia.org)
  • The diagnosis of CLL is based on the demonstration of an abnormal population of B lymphocytes in the blood, bone marrow, or tissues that display an unusual but characteristic pattern of molecules on the cell surface. (wikipedia.org)
  • Mesenchymal stem cells have the capacity to become any type of fully developed cell, which can contribute to replacing muscle tissues or internal organs. (wikipedia.org)
  • cancer
  • The donated stem cells may replace the patient's immune system and help destroy any remaining cancer cells (graft-versus-tumor effect). (clinicaltrials.gov)
  • Doctors evaluate the results of various blood tests to confirm that new blood cells are being produced and that the cancer has not returned. (stemcellcordblood.net)
  • The study has currently met its primary end point and is now recruiting patients to be treated at the RD expansion cohort of selected tumor types, specifically: endometrial adenocarcinomas, neuroendocrine tumors, and small-cell lung cancer (SCLC). (careacross.com)
  • A new study using cryoablation to decrease pain for patients who have cancer metastases in the bone is now underway throughout Emory Healthcare . (advancingyourhealth.org)
  • Emory interventional radiologists freeze tumors in order to kill cancer cells in contact with the bone and reduce the size of the tumor. (advancingyourhealth.org)
  • Sorafenib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the cancer. (clinicaltrials.gov)
  • Cutaneous T cell lymphoma (CTCL) is a class of non-Hodgkin lymphoma, which is a type of cancer of the immune system. (wikipedia.org)
  • However, the cited gene changes can go awry in plasma cells by, for example, placing a gene that ordinarily controls cell growth adjacent to the normally highly active antibody gene promotor thereby creating a cancer-causing oncogene or, more commonly, by forming extra chromosomes (see trisomy) or chromosomes that have deleted or repetitive sections, any of which such changes may promote malignancy in more complex and less well understood ways. (wikipedia.org)
  • Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). (wikipedia.org)
  • Malignancy
  • However, in the past a number of different terms were used for BPDCN due to their uncommon immunophenotypic, histopathological and clinical features, including blastic NK leukemia/lymphoma, histiocytic lymphoma or histiocytic associated hematologic malignancy, cutaneous a granular CD4+ CD56+ hematodermic neoplasm and NK-cell lymphoma or myelo-monocytic precursor - related lymphoma (5-12). (czytelniamedyczna.pl)
  • Experimental chimeras have been used to study a number of biological questions, including the origin and fate of cell lineages during embryonic development, immunological self-tolerance, tumor susceptibility, and the nature of malignancy. (thefreedictionary.com)
  • The lack of the normal distribution of these B cells is one basis for demonstrating clonality, the key element for establishing a diagnosis of any B cell malignancy (B cell non-Hodgkin lymphoma). (wikipedia.org)
  • tumors
  • Embryonal carcinoma cells from several sources, including spontaneous and embryo-derived tumors and cultured lines selected to carry specific mutations or even human chromosomes, have contributed to normal chimeras. (thefreedictionary.com)
  • this disorder is a form of plasma cell dyscrasia in which no myeloma protein is detected in serum or urine (at least as determined by conventional laboratory methods) of individuals who have clear evidence of an increase in clonal bone marrow plasma cells and/or evidence of clonal plasma cell-mediated tissue injury (e.g. plasmacytoma tumors). (wikipedia.org)
  • malignant
  • Plasma cell dyscrasias (also termed plasma cell disorders and plasma cell proliferative diseases) are a spectrum of progressively more severe monoclonal gammopathies in which a clone or multiple clones of pre-malignant or malignant plasma cells (sometimes in association with lymphoplasmacytoid cells or B lymphocytes) over-produce and secrete into the blood stream a myeloma protein, i.e. an abnormal monoclonal antibody or portion thereof. (wikipedia.org)
  • The overproduced Ig's, termed myeloma proteins, commonly circulate in blood, may accumulate in urine, and are the hallmarks of plasma cell dyscrasias including their most malignant forms viz. (wikipedia.org)
  • Malignant infantile osteopetrosis, also known as infantile autosomal recessive osteopetrosis or simply infantile osteopetrosis is a rare osteosclerosing type of skeletal dysplasia that typically presents in infancy and is characterized by a unique radiographic appearance of generalized hyperostosis - excessive growth of bone. (wikipedia.org)
  • Failure of remodeling of the distal femoral and proximal humeral metaphyses giving the affected bones a funnel shaped appearance known as (Erlenmeyer flask deformity) Alternating radiolucent femoral metaphyseal bands Pathologic fractures The differential diagnosis of malignant infantile osteopetrosis includes other genetic skeletal dysplasias that cause osteosclerosis. (wikipedia.org)
  • Disorders
  • They can differentiate into many cell types including bone, fat, and muscle which allow them to treat a large range of disorders. (wikipedia.org)
  • MSCs have been used to treat a variety of disorders including cardiovascular diseases, spinal cord injury, bone and cartilage repair, and autoimmune diseases. (wikipedia.org)
  • chromosomes
  • While many genes on the Y chromosome have backups (homologues) on other chromosomes, a few genes such as RBMY on the Y chromosome do not have such backups, and their effects must be compensated for to convert cells from a woman into sperm. (wikipedia.org)
  • In 2007, a patent application was filed on methods for creating human female sperm using artificial or natural Y chromosomes and testicular transplantation. (wikipedia.org)
  • 10,000
  • 10,000 cells are harvested and grown in vitro for approximately six weeks until the population reaches 10-12 million cells. (wikipedia.org)
  • Megakaryocytes usually account for 1 out of 10,000 bone marrow cells in normal people, but can increase in number nearly 10-fold during the course of certain diseases. (wikipedia.org)
  • phenotype
  • The kind of mature, fully differentiated cell phenotype and the number of those cells created though this can be influenced in three ways. (wikipedia.org)
  • hematopoiesis
  • while a numbers of key growth factors that regulates hematopoiesis have been identified and some of them are currently used for clinical purpose, how bone marrow microenvironment that presents those signals to the hematopoietic progenitors is constructed remains totally obscure. (nii.ac.jp)
  • therapy
  • When these findings are taken together, combination therapy with MNC transplantation and AM infusion may have additional or synergetic effects on therapeutic angiogenesis for the treatment of severe peripheral vascular disease. (ahajournals.org)
  • donor
  • Sometimes the transplanted cells from a donor can also make an immune response against the body's normal cells. (clinicaltrials.gov)
  • Cells of the donor strain are injected through a fine glass needle, either into the blastocoele cavity or into the center of the inner cell mass (the group of cells from which the fetus is derived). (thefreedictionary.com)
  • immune system
  • One potential roadblock to injecting a woman's cells into a man's testicles is that the man's immune system might attack and destroy the woman's cells. (wikipedia.org)
  • In usual circumstances, when foreign cells (such as cells or organs from other people, or infectious bacteria) are put into a human body, its immune system will reject such cells or organs. (wikipedia.org)
  • However, a special property of a man's testicles is that they are immune-privileged, that is, a man's immune system will not attack foreign cells (such as a woman's cells) injected into the sperm-producing part of the testicles. (wikipedia.org)
  • Plasma cells are key effector elements of the adaptive immune system. (wikipedia.org)
  • The immune system consists of specialized cells that work together to fight off bacteria, fungi and viruses. (wikipedia.org)
  • These cells include T lymphocytes (T cells), that primarily mediate the immune system, B lymphocytes (B cells) and Natural Killer cells. (wikipedia.org)
  • germ cells
  • During spermatogenesis in mammals and in Drosophila melanogaster, male germ cells develop in a series of essential developmental processes. (jove.com)
  • In addition, post-meiotic germ cells undergo a dramatic morphological reshaping process as well as a global epigenetic reconfiguration of the germ line chromatin-the histone-to-protamine switch. (jove.com)
  • They develop spontaneously from germ cells in the gonads of certain mouse strains, or from cells in early embryos transplanted to ectopic sites. (thefreedictionary.com)
  • adult T-cell l
  • There is some evidence of a relationship with human T-lymphotropic virus (HTLV) with the adult T-cell leukemia/lymphoma subtype. (wikipedia.org)
  • lymphocytes
  • Plasma cells develop from B lymphocytes which are stimulated to undergo this maturational development by T lymphocytes during the latter cells' processing of these antigens. (wikipedia.org)
  • Normal B lymphocytes consist of a stew of different antibody-producing cells, resulting in a mixture of both kappa- and lambda-expressing cells. (wikipedia.org)
  • These B cells resemble normal lymphocytes under the microscope, although slightly smaller, and are fragile when smeared onto a glass slide, giving rise to many broken cells, which are called "smudge" or "smear" cells. (wikipedia.org)
  • Antibodies
  • Tests for T cell function: skin tests for delayed-type hypersensitivity, cell responses to mitogens and allogeneic cells, cytokine production by cells Tests for B cell function: antibodies to routine immunisations and commonly acquired infections, quantification of IgG subclasses Tests for phagocyte function: reduction of nitro blue tetrazolium chloride, assays of chemotaxis, bactericidal activity. (wikipedia.org)
  • involves
  • Aggregation chimeras are produced by a technique that involves removing the zonae pellucidae from around 8-16 cell embryos of different strains of mice and pushing the morulae together so that the cells can aggregate. (thefreedictionary.com)
  • Genetic
  • Genetic combinatorial marking using lentiviral vectors encoding fluorescent proteins (FPs) enabled cell fate mapping through advanced microscopy imaging. (jove.com)
  • Creating female sperm was first raised as a possibility in a patent filed in 1991 by injecting a woman's cells into a man's testicles, though the patent focused mostly on injecting altered male cells into a man's testes (to correct genetic diseases). (wikipedia.org)
  • dendritic cell
  • Artykuł zawiera opis dwóch przypadków chorych z rozpoznaniem bardzo rzadko występujących nowotworów z blastycznych plazmacytoidalnych komórek dendrytycznych ( blastic plasmacytoid dendritic cell neoplasms - BPDCN). (czytelniamedyczna.pl)
  • In this paper we report two cases of very rare blastic plasmacytoid dendritic cell neoplasms (BPDCN). (czytelniamedyczna.pl)
  • endothelial cell
  • Background- Previous studies have shown that adrenomedullin (AM) inhibits vascular endothelial cell apoptosis and induces angiogenesis. (ahajournals.org)
  • 8 Furthermore, AM has been shown to inhibit vascular endothelial cell apoptosis and induce angiogenesis through the activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. (ahajournals.org)
  • phenotypes
  • These phenotypes were unexpectedly linked to mutations in the gene encoding a subunit of the Go-Ichi-Ni-San (GINS) complex, which is essential for DNA replication prior to cell division. (jci.org)
  • Lymphoma
  • A point-based algorithm for the diagnosis for early forms of cutaneous T cell lymphoma was proposed by The International Society for Cutaneous Lymphomas in 2005. (wikipedia.org)
  • Cutaneous T-cell lymphoma may be divided into the several subtypes. (wikipedia.org)
  • Elorac, Inc. Announces Orphan Drug Designation for Novel Topical Treatment for Pruritus in Cutaneous T-cell Lymphoma (CTCL) website Turgeon, Mary Louise (2005). (wikipedia.org)
  • Human T-cell lymphotropic virus type 1 or human T-lymphotropic virus type 1 (HTLV-I), also called the adult T-cell lymphoma virus type 1, is a retrovirus of the human T-lymphotropic virus (HTLV) family that has been implicated in several kinds of diseases including very aggressive adult T-cell lymphoma (ATL), HTLV-I-associated myelopathy, uveitis, Strongyloides stercoralis hyper-infection and some other diseases. (wikipedia.org)
  • Adult T-cell lymphoma (ATL) was discovered in 1977 in Japan. (wikipedia.org)