Stem cell biology molecular progenitor satellite cell. Medical search. Frequent questions

Endothelial progenitor cells (EPCs) are one of the main focuses of this field. (wikipedia.org)
They are valuable cells because they directly precede endothelial cells, but have characteristics of stem cells. (wikipedia.org)
Angioblasts or endothelial progenitor cells (EPC). (wikipedia.org)
6- Differentiation of iPSCs into cardiomyocytes and endothelial cells for disease modeling and screening. (uh.edu)
Her biological study spans a wide range of topics, including Progenitor cell, CD34, Endothelial stem cell and Molecular biology. (research.com)
Two groups of resident progenitors, the skeletal muscle satellite cells (SCs) and vascular endothelium (VE)/vascular endothelial progenitors (VEPs), have been considered to be putative cell sources for ectopic lesions of heterotopic ossification due to their reported multipotent characteristics. (uconn.edu)

Scientists at the University of Pennsylvania School of Veterinary Medicine have found a new wrinkle in the developmental biology dogma that cell differentiation occurs irreversibly as stem cells give rise to increasingly specialized types of offspring cells. (innovations-report.com)
Our work identifying the human segmentation clock represents an important milestone in understanding human developmental biology. (nature.com)
It thus would require a comprehensive understanding of developmental biology and a development of new approaches to activate the critical players to rejuvenate the self-repair mechanism in the elder or under chronic injury condition. (biomedcentral.com)

Cellular and molecular regulation of muscle regeneration. (scielo.br)
Satellite cells are essential for skeletal muscle regeneration:the cell on the edge returns centre stage. (scielo.br)
Muscle regeneration is characterised by a well-timed network of different cell types providing an environment that allows the activation of muscle stem cells, called satellite cells (SCs) to regenerate the damaged tissue. (usz.ch)
Master thesis projects are available to better understand the role of microRNAs in this process using mouse models for muscle regeneration and work with primary muscle cells from mice and humans. (usz.ch)
The main interest of Dr. Darabi's lab is to use pluripotent stem cells for skeletal muscle regeneration in muscular dystrophies and muscle injuries. (uh.edu)
Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration. (research.com)
In 2009 beginning of 2010 we have focused on investigating what factors human embryonic stem cells (hESCs) may produce that enhance regeneration and if those factors have any effects by themselves on regeneration. (ca.gov)
Finally, our data suggest that muscle stem cells either do not accumulate DNA damage with age or can efficiently repair such damage, when activated for tissue regeneration. (ca.gov)
Directional cell migration is a critical process underlying morphogenesis and post-natal tissue regeneration. (crick.ac.uk)
During embryonic myogenesis, migration of skeletal myogenic progenitors is essential to generate the anlagen of limbs, diaphragm and tongue, whereas in post-natal skeletal muscles, migration of muscle satellite (stem) cells towards regions of injury is necessary for repair and regeneration of muscle fibres. (crick.ac.uk)
Here, we review mechanisms of myogenic stem/progenitor cell migration during skeletal muscle development and post-natal regeneration. (crick.ac.uk)
Mitochondrial peptides contain an immaculate blend of cellular peptides, predominantly specific to mitochondria, extracted to ensure rapid cell regeneration and restoration of normal function. (mcamcyprus.org)
Remarkably type 2 cytokine signaling is also required in FAPs but not myeloid cells for quick clearance of necrotic debris a process that is necessary for timely and total regeneration of BV-6 cells. (scienceexhibitions.org)
2008 In addition to satellite cells recent studies have recognized an important part for fibro/adipogenic progenitors (FAPs) in muscle mass regeneration and its fatty degeneration (Joe et al. (scienceexhibitions.org)
In a number of species cells regeneration is associated with the presence of the molecular signature for type 2 innate immune response such as alternatively triggered (M2) macrophages and eosinophils (Allen and Wynn 2011 Palm et al. (scienceexhibitions.org)
Following postdoctoral fellowships at the Center for Genomic Regulation (Barcelona, Spain) and the University of Colorado-Boulder, Dr. Doles moved to Mayo Clinic in 2016, where he leads a basic science research lab focused on stem cells, tissue regeneration, and multi-organ wasting. (jove.com)
Mechanisms regulating cardiomyocyte cell cycle arrest are of great interest partly because reversing this process could provide a way to stimulate cardiac regeneration after injury [ 17 ]. (springer.com)

Assessment of the myogenic stem cell compartment following transplantation of pax3/pax7-induced embryonic stem cell-derived progenitors. (uh.edu)
Transplantation of myogenic stem cells possesses great potential for long-term repair of dystrophic muscle. (biomedcentral.com)

Some research found that progenitor cells were mobile and that these progenitor cells could move through the body and migrate towards the tissue where they are needed. (wikipedia.org)
Both miRNAs and siRNAs need to be delivered into the target tissue or cell in order to activate the desired therapeutic effect," Muthiah Manoharan, Ph.D., senior vp, drug discovery, Alnylam Pharmaceuticals, explained. (genengnews.com)
Tissue-engineering and cell-based therapies, two prominent branches of Regenerative Medicine, are considered as the most suitable techniques to repair the tissue damage. (sciepub.com)
Our work is at the stage of understanding the molecular mechanisms by which the aging of the regenerative potential of organ stem cells can be reversed by particular human embryonic factors that are capable of neutralizing the affects of aged niches on tissue regenerative capacity. (ca.gov)
Thus, the use of hESC-produced pro-regenerative factors for boosting the regenerative capacity of organ stem cells is likely to yield healthy, young tissue. (ca.gov)
Although functional organ stem cells persist in the old, tissue damage invariably overwhelms tissue repair, ultimately causing the demise of an organism. (ca.gov)
In regenerative biology, the overarching goal is to rebuild degenerating or absent tissue with a patient's own cells. (uconn.edu)
Here, we focus on identifying and characterizing tissue resident progenitors. (uconn.edu)
In this regard, we have concentrated on the tissue resident adult progenitors in skeletal muscle and specifically, their role in soft tissue associated heterotopic ossification. (uconn.edu)
Tissue stem cells live in their organ niches where they represent a minute cell population. (ca.gov)
Traditional cell-screening techniques such as FACS and MACS are better suited for large numbers of cells isolated from bulk tissue and cannot easily screen stem or progenitor cells from minute populations found in their physiological niches. (ca.gov)
Previous molecular characterizations of mammary stem cells (MaSC) have utilized fluorescence-activated cell sorting or in vitro cultivation of cells from enzymatically dissociated tissue to enrich for MaSC. (frontiersin.org)
How is the tissue specificity of immune cells generated and how is it affected by environmental influences, plasticity and the tissue microenvironment? (mdc-berlin.de)
In both processes, rapid proliferation gives rise to new tissue, cell fate has to be specified within that tissue, and distinct positional identities have to be established to generate a properly patterned structure. (frontiersin.org)
Whole-amount staining is a powerful technique for macrophage characterization within the 3D environment of the adipose tissue, enabling the visualization of different macrophage populations and their interaction with other cells within their in vivo niche. (bvsalud.org)

To determine their possible roles in tissues and satellite cells in vitro, their expression pattern was examined in tissues from 40-day-old chickens and in satellite cells from the breast muscles of 1-week-old and 2-week-old chickens using RT-PCR and immunocytochemistry analyses. (scielo.br)
Skoglund G, Lainé J, Darabi R , Fournier E, Perlingeiro R, Tabti N. Physiological and ultrastructural features of human induced pluripotent and embryonic stem cell-derived skeletal myocytes in vitro. (uh.edu)
Since only small numbers of cells are obtainable from the patient, it requires expansion of cells in vitro . (sciepub.com)
Nevertheless, these primary cells grow slowly in vitro and lose their general characteristics during prolonged culturing period. (sciepub.com)
Furthermore, we decisively prove through in vitro clonal assays that the majority of these mesenchymal progenitors are capable of multilineage differentiation, contributing to spontaneously forming adipogenic and fibrocyte-like cells, and to BMP-induced osteogenic cells. (uconn.edu)
Here we show that human PSM cells derived in vitro-as well as those of the mouse 4 -recapitulate the oscillations of the segmentation clock. (nature.com)
Single-cell RNA sequencing reveals that mouse and human PSM cells in vitro follow a developmental trajectory similar to that of mouse PSM in vivo. (nature.com)
Fig. 1: Recapitulation of the mouse and human segmentation clocks in vitro by differentiation of pluripotent stem cells towards PSM fate. (nature.com)
In vivo , the identification of macrophage phenotype is complicated since macrophages are obviously exposed to a microenvironment that is more complex respect to cell culture conditions, and they display characteristics that do not conform to the in vitro defined phenotypic categories. (hindawi.com)

A new tumor model, combining human embryonic stem cells (ESC) and tumor cells, develops abundant human vessels. (nih.gov)

Intermediate progenitor cells formed in the subventricular zone. (wikipedia.org)

One of the cell types involved in the regenerative stem cell niche are fibro/adipogenic progenitors (FAPs). (usz.ch)
Instead, we identify a novel mesenchymal cell type located in the interstitial space of skeletal muscle that harnesses robust in vivo chondrogenic, osteogenic and adipogenic capabilities. (uconn.edu)

Bone marrow stromal cells found in the epidermis and make up 10% of progenitor cells. (wikipedia.org)
Her Cell biology research is multidisciplinary, relying on both Dendritic cell, Interferon gamma, Interleukin 12, Bone marrow and Transplantation. (research.com)
The various areas that Anne Galy examines in her Stem cell study include Fanconi anemia, Bone marrow and Lymphocyte. (research.com)
The concepts of her Cancer research study are interwoven with issues in Bone marrow failure, FANCA, Stem cell, Bone marrow and In vivo. (research.com)
Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny. (sciepub.com)

Research on regenerative medicine has focused on progenitor cells, and stem cells, because their cellular senescence contributes largely to the process of aging. (wikipedia.org)
The natural aging of cells, called their cellular senescence, is one of the main contributors to aging on an organismal level. (wikipedia.org)
Cellular and molecular mechanisms regulating skeletal muscle development. (scielo.br)
Her studies deal with areas such as Cellular differentiation, CD40, Antigen-presenting cell, Dendritic cell and Interleukin 12 as well as Cell biology. (research.com)
Cytoskeleton, U-93631 which is a network of interconnected filaments of different types, connects the cell membrane with underlying sub-cellular components. (globaltechbiz.com)
The nucleus is the largest organelle among sub-cellular components, demonstrating solid-elastic behavior [4], and it is typically stiffer than the cell itself [5]. (globaltechbiz.com)
These primitive-like cells hold promise as an autologous cell source for regenerative treatments and importantly, afford us the opportunity to begin to understand seemingly normal cellular processes in pathological contexts. (uconn.edu)
If asymmetric segregation of centrosomes occurs in NPCs of the developing human brain, which depends on unique molecular regulators and species-specific cellular composition, remains unknown. (elifesciences.org)
Asymmetric divisions result in two daughter cells with different fates and cellular behaviour: one daughter remains in the VZ and retains the ability to self-renew, comparable to the mother cell. (elifesciences.org)
Cell therapy is a regenerative biomedical treatment based on the combination of peptides, amino acids, proteins, growth factors, transcription factors and hormones derived from cellular tissues with the aim of biochemical, metabolic and immunological modulation as well as cellular restoration. (mcamcyprus.org)
Cellular Peptides Nano in aesthetic range designed with the highest quality peptides molecules and cellular extracts prepared from precursor stem cells. (mcamcyprus.org)

During the last several years, his lab has developed novel methods for multi-lineage differentiation of pluripotent stem cells for cell therapy in mice models of muscular dystrophies and injuries. (uh.edu)

The proliferation and differentiation of satellite cells are regulated by a number of extracellular signals ( Wang & Rudnicki, 2012 Wang YX, Rudnicki MA. (scielo.br)
Osathanon T, Bespinyowong K, Arksornnukit M, Takahashi H, Pavasant P. "Human osteoblast-like cell spreading and proliferation on Ti-6Al-7Nb surfaces of varying roughness. (sciepub.com)
Khadra M, Lyngstadaas SP, Haanaes HR, Mustafa K. "Effect of laser therapy on attachment, proliferation and differentiation of human osteoblast-like cells cultured on titanium implant material. (sciepub.com)
Enriched expression of genes in LRECb was associated with stem cell attributes and identified WNT, TGF-β, and MAPK pathways of self renewal and proliferation. (frontiersin.org)
During rapid mammary growth in the mouse, label retaining epithelial cells (LREC) appear to retain label by asymmetric distribution of DNA strands, as evidenced by a rapid proliferation index of the LREC ( Smith, 2005 ). (frontiersin.org)
During periods of low mammary proliferation, quiescence of the stem cell population may account for retention of label. (frontiersin.org)
Intro The regenerative response of skeletal muscle mass to ICAM4 injury is dependent within the quiescent populace of skeletal muscle mass stem cells termed the satellite cells which reside beneath the basal lamina of each myofiber (Brack and Rando 2012 Wang and Rudnicki 2012 Upon injury these quiescent satellite cells become triggered and undergo proliferation providing rise to myogenic progenitors (MPs) that ultimately differentiate into mature myofibers. (scienceexhibitions.org)
2008 For instance autocrine Notch signaling regulates the activation and proliferation of satellite cells (Bjornson et al. (scienceexhibitions.org)
However, diprotin A, a positive modulator of CXCR4-SDF-1 binding, significantly enhanced engraftment and stimulated sustained proliferation of donor cells in vivo . (biomedcentral.com)
Diprotin A stimulation of CXCR4, however, significantly increased the number of canine dystrophin-positive muscle fibers and canine-derived satellite cells by enhancing donor cell proliferation. (biomedcentral.com)

While this paper is more focused on mechanisms, the area of wound healing is one of the most promising in the cell therapy space. (ipscell.com)
Additionally, our data in progress suggest that muscle and brain age by similar molecular mechanisms and thus, therapeutic strategies for rejuvenating muscle repair might be applicable to the restoration of neurogenesis in aged brain. (ca.gov)
The MDC is devoted to understanding the molecular basis of health and disease, with a focus on disease mechanisms at a system-wide level and the translation of findings into clinical applications. (mdc-berlin.de)
Dr. Bosinger is defining the molecular mechanisms of virus pathogenesis through application of next-gen RNA sequencing to studies of HIV and SARS-CoV-2 infection in non-human primates. (emory.edu)

Dr. Jason Doles (pronouns He/Him/His) is an Associate Professor in the Department of Biochemistry and Molecular Biology at Mayo Clinic. (jove.com)

Human ES and iPS-Derived Myogenic Progenitors Restore Dystrophin and Improve Contractility upon Transplantation in Dystrophic Mice. (uh.edu)
Her research in Genetic enhancement intersects with topics in Hematopoietic stem cell transplantation, Cancer research, Wiskott-Aldrich syndrome and Prospective cohort study. (research.com)
Anne Galy mainly focuses on Genetic enhancement, Haematopoiesis, Viral vector, Cancer research and Hematopoietic stem cell transplantation. (research.com)
Furthermore, strategies utilised to improve migratory capacity of myogenic cells are examined in order to identify potential treatments that may be applied to future transplantation protocols. (crick.ac.uk)
In clinical practice, these involve the life-long immunosuppression of the organ transplantation patients, the creation of the supporting environment for engineered tissues in the mended organ, the unsolved issues of cell survival and differentiation of the cell-based therapy, and the selection and development of vectors for gene therapy. (biomedcentral.com)
In murine-to-murine transplantation experiments, CXCR4 expression marks a population of adult murine satellite cells with robust engraftment potential in mdx mice, and CXCR4-positive murine muscle-derived SP cells home more effectively to dystrophic muscle after intra-arterial delivery in mdx 5cv mice. (biomedcentral.com)
In this study, we used a canine-to-murine xenotransplantation model to quantitatively compare canine muscle cell engraftment, and test the most effective cell population and modulating factor in a canine model of DMD using allogeneic transplantation experiments. (biomedcentral.com)
Furthermore, the canine-to-murine xenotransplantation model accurately predicted results in canine-to-canine muscle cell transplantation. (biomedcentral.com)
We used a clinically acceptable regimen of hematopoietic stem cell transplantation to establish mixed donor/host blood cell chimerism and immune tolerance in a canine model of Duchenne muscular dystrophy ( cxmd ) [ 9 ]. (biomedcentral.com)
Intramuscular injection of donor muscle-derived cells into chimeric cxmd recipients restored dystrophin expression for at least 24 weeks in the absence of post-transplant immunosuppression, indicating that cell transplantation may be a viable therapeutic option for muscular dystrophy. (biomedcentral.com)
Yet, it remains unclear from murine transplantation experiments which cell population most effectively engrafts into diseased skeletal muscle. (biomedcentral.com)

These approaches result in the loss of all histological information pertaining to the in vivo locale of MaSC and progenitor cells. (frontiersin.org)
Novel molecular motors will also have ex vivo applications including molecular sorting and assembly of nanoelectronics in microfabricated devices. (nih.gov)
One challenge with characterizing tumor stem cells has been finding appropriate conditions for in vivo growth. (nih.gov)
We therefore propose (3) to isolate ovarian tumor stem cells and grow them in vivo using the ESC ovarian cancer model. (nih.gov)
Here we show by in vivo fate mapping that brown, but not white, fat cells arise from precursors that express Myf5, a gene previously thought to be expressed only in the myogenic lineage. (bioseek.eu)

The characterization or the defining principle of progenitor cells, in order to separate them from others, is based on the different cell markers rather than their morphological appearance. (wikipedia.org)
Wu J, Hunt SD, Xue H, Liu Y, Darabi R . Generation and Characterization of a MYF5 Reporter Human iPS Cell Line Using CRISPR/Cas9 Mediated Homologous Recombination. (uh.edu)
Insights into the biology of stem cells will be gained by confirmation and characterization of candidate MaSC markers identified in this study. (frontiersin.org)

We isolated four categories of cells from mammary epithelium of female calves: bromodeoxyuridine label retaining epithelial cells (LREC) from basal (LRECb) and embedded layers (LRECe), and epithelial control cells from basal and embedded layers. (frontiersin.org)
This dictates cycles of mammary growth, differentiation, lactation, and regression, during which mammary stem cells (MaSC) provide for the lineages of luminal and basal (myoepithelial) epithelial cells in the ducts and alveoli. (frontiersin.org)

Bober E, Franz T, Arnold HH, Gruss P, Tremblay P. Pax-3 is required for the development of limb muscles:a possible role for the migration of dermomyotomal muscle progenitor cells. (scielo.br)
Commensurate with the known truth that HuR improved the great quantity of adhesion substances VLA-4 on Th17 cells, knockout of HuR impaired splenic Th17 cell migration towards the central anxious program and abolished the condition. (globaltechbiz.com)
He has delineated the function of these molecules in diverse set of biological processes including: 1) gut and kidney formation, 2) vascular permeability, 3) mucosal inflammatory disease, 4) stem cell homing and migration, and 5) epithelial tumor progression. (ubc.ca)
Additionally, safe and efficient migration of transplanted cells is critical in cell therapies, both allogeneic and autologous. (crick.ac.uk)
One of the key reasons for this negative outcome is the limited migration of donor cells, which hinders the overall cell engraftment potential. (crick.ac.uk)
Molecular motors lie at the heart of biological processes from DNA replication to cell migration. (nih.gov)
Given the lack of access, and the dispersed nature of brain tumor cells, we explore the possibility of electric fields inducing directed tumor cell migration. (nature.com)
To further understand electrotactic migration of tumor cells, we performed RNA-sequencing for pathway discovery to identify signaling that is differentially affected by the exposure of direct-current electrical fields. (nature.com)

Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia. (scielo.br)
Matthias N, Hunt SD, Wu J, Darabi R . Skeletal muscle perfusion and stem cell delivery in muscle disorders using intra-femoral artery canulation in mice. (uh.edu)
We suspect that this phenomenon is not limited to B-cells and macrophages in mice. (innovations-report.com)
Overall, our results suggest that lack of PKCθ promotes muscle repair in dystrophic mice, supporting stem cells survival and maintenance through increased Delta-Notch signaling. (unicatt.it)
Indeed, CXCR4-positive muscle-derived side population (SP) cells home more effectively to dystrophic muscle after intra-arterial delivery in mdx 5cv mice [ 10 ]. (biomedcentral.com)

We validated the model using experimental data and used it to quantify the effects of cell components on its behavior. (globaltechbiz.com)
Additionally, many pathological ailments, such as cancer and heterotopic ossification, are believed to be the consequence of abnormal progenitor cell behavior. (uconn.edu)
This work enables a new approach for understanding stem cell behavior at a single cell levels. (ca.gov)

She combines subjects such as Myeloid, Kidney disease and Cell biology with her study of Viral vector. (research.com)
B-cells arise from a lymphoid progenitor, while macrophages come from a myeloid progenitor. (innovations-report.com)

The poor performance of stem cells in an aged organ, such as skeletal muscle, is caused by the changes in regulatory pathways such as Notch, MAPK and TGF‐β, where old differentiated tissues and blood circulation inhibit the regenerative performance of organ stem cells. (ca.gov)
While this ultimate aim is rather ambitious, the motivation to achieve these ideal clinical tissues has driven the field of stem and progenitor cell biology to unprecedented levels of scientific and public involvement. (uconn.edu)
Researchers are uncovering ever more details about the complex system of organs, tissues, and different cell types that make up the human immune system. (mdc-berlin.de)
The epidemic of obesity, closely associated with increases in diabetes, hypertension, hyperlipidemia, cancer and other disorders, has propelled a major interest in adipose cells and tissues. (bioseek.eu)
Adipose tissues contain two distinct types of fat cells, white and brown. (bioseek.eu)

Successful engraftment of gene-corrected hematopoietic stem cells in non-conditioned patients with Fanconi anemia. (research.com)
His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. (ubc.ca)

We use in parallel many technologies that have been considerably refined to identify, isolate, and characterize, specific and practically pure cell populations, critically allowing us to attribute functional outcomes of potency tests to unique cell types. (uconn.edu)
Therefore, these results establish the efficacy of diprotin A in stimulating muscle cell engraftment, and highlight the pre-clinical utility of a xenotransplantation model in assessing the relative efficacy of muscle stem cell populations. (biomedcentral.com)
In this study we investigate the properties of populations of brain cancer undergoing electrotaxis, a phenomenon whereby cells are directed to migrate under control of an electrical field. (nature.com)

Canonical Wnt signaling induces Barx2 expression in muscle progenitors and perturbation of Barx2 leads to misregulation of Wnt target genes. (edu.au)
Conversely, ectopic expression of PRDM16 in myoblasts induces their differentiation into brown fat cells. (bioseek.eu)

We use extensively, the Cre/loxP lineage tracing system to label putative plastic cell types and assess the inherent plasticity of these cells in biologically relevant mouse-chick chimeric models of developmental potency and bioassays of heterotopic ossification. (uconn.edu)
In conclusion, these data decisively establish degrees of potency for skeletal muscle resident progenitors and identify the putative cell-of-origin for the ectopic skeletal anlagen of heterotopic ossification. (uconn.edu)
Instead, we used laser microdissection to excise putative progenitor cells and control cells from their in situ locations in cryosections and characterized the molecular properties of these cells. (frontiersin.org)

It may also provide new insights into the molecular pathways that go awry in common forms of conditions such as obesity and diabetes, which represent major public health concerns [ 8 , 9 ]. (springer.com)
We find that U87 mg electrotaxis is abolished under pharmacological inhibition of PI3Kγ, mTOR, AKT and ErbB2 signaling, whereas DAOY cell electrotaxis was not attenuated by these or other pathways evaluated. (nature.com)

Some of these transit amplifying neural progenitors migrate via rostral migratory stream to the olfactory bulb and differentiate further into specific types of neural cells. (wikipedia.org)
Boundary cap cells from the neural crest form a barrier between the cells of the central nervous system and cells of the peripheral nervous system. (wikipedia.org)
Boundary cap neural crest stem cells promote survival of mutant SOD1 motor neurons. (wikipedia.org)
During human forebrain development, neural progenitor cells (NPCs) in the ventricular zone (VZ) undergo asymmetric cell divisions to produce a self-renewed progenitor cell, maintaining the potential to go through additional rounds of cell divisions, and differentiating daughter cells, populating the developing cortex. (elifesciences.org)
During human brain development, neural progenitor cells (NPCs) undergo two modes of cell division. (elifesciences.org)

Macrophage activation has been described as a dynamic process: the same cell may initially induce proinflammatory and cytotoxic reactions and later may take part in the resolution of inflammation and wound healing [ 9 ]. (hindawi.com)
We hypothesize that ovarian cancer cells will induce human ovarian TVM expression. (nih.gov)

Upon injury, FAPs enter the cell cycle and expand to produce cytokines and deposit extracellular matrix (ECM) to enhance differentiation of SCs into muscle fibers. (usz.ch)
2010 FAPs which do not arise from your myogenic lineage are bipotential cells capable of providing rise to fibroblasts and adipocytes. (scienceexhibitions.org)
The close association of FAPs with regenerating muscle mass fibers along with their manifestation of factors that influence myogenic differentiation such as IL-6 and IGF-1 suggests that these stromal cells may perform a supportive part in myogenic differentiation (Joe et BV-6 al. (scienceexhibitions.org)

We will focus our efforts by choosing a small number of ambitious design targets, each requiring several intermediate molecular innovations and optimizations. (nih.gov)

The study incorporates disciplines such as Cell culture, Progenitor cell, CD34, Molecular biology and Transduction in addition to Haematopoiesis. (research.com)

These tumor models display varied molecular, biochemical and mutational signatures that closely mimics the clinical situation. (usz.ch)
Examples are CRISPR/Cas9-mediated mutagenesis, genetic mouse models, cell-fate-mapping, organoids and tumor explants, as well as GMP production of pharmaceuticals and many years of experience in conducting clinical studies. (mdc-berlin.de)
One of the research areas at the MDC is immunology and inflammation, which covers tumor immunology, DNA repair in B lymphocytes, the role of tumor stroma-immune cell interaction in cancers, the role of innate immune cells in gliomas and neurodegenerative diseases, and the development of immunotherapy strategies. (mdc-berlin.de)
Finally, our preliminary data suggest that the ESC-ovarian tumor model has human tumor vascular cells. (nih.gov)
Tumor vascular cells are critical for the growth of tumor stem cells, which reside within the vascular niche. (nih.gov)
We hypothesize that the ESC ovarian tumor model, with human vascular cells, will provide an ideal microenvironment to support human stem cell growth. (nih.gov)
If successful, this will create a murine tumor model that nearly completely reproduces the human tumor microenvironment with human tumor stroma, vessels and tumor stem cells. (nih.gov)

The kind of potency they have depends on the type of their "parent" stem cell and also on their niche. (wikipedia.org)

The researchers have shown that certain mouse cells retain an ability to oscillate between very distinct blood cell types - B-cells and macrophages - long after what has been commonly regarded as the point of no return. (innovations-report.com)
It s possible that by targeting this gene with drugs, we may be able to convert malignant B-cell lymphomas into much less harmful histiocytomas, tumors composed of relatively inactive macrophages. (innovations-report.com)
Previous research has demonstrated that when B-cells are transplanted from an animal into a petri dish, the cells sometimes change into macrophages. (innovations-report.com)
Moreover, the cells could continue oscillating between B-cells and macrophages indefinitely, as many times as they were relocated. (innovations-report.com)
Alternatively activated M2 macrophages comprise cells exposed to low concentrations of M-CSF in the presence of IL-4, IL-13, or IL-10. (hindawi.com)

A progenitor cell is a biological cell that can differentiate into a specific cell type. (wikipedia.org)
Progenitor cells can only differentiate into their "target" cell type. (wikipedia.org)
Inflammatory cytokines and other factors released during infections will activate haematopoietic progenitor cells to differentiate to replenish the lost resources. (wikipedia.org)

Duchenne muscular dystrophy (DMD) is a genetic disease characterized by muscle wasting and chronic inflammation, leading to impaired satellite cells (SCs) function and exhaustion of their regenerative capacity. (unicatt.it)
Furthermore, these techniques rely upon irreversible antibody binding, potentially altering cell properties, including gene expression and regenerative capacity. (ca.gov)
Using our unique platform, we have discovered a remarkable heterogeneity in both the regenerative capacity and expression of CXCR4, beta1-integrin, Sca-1, M-cadherin, Syndecan-4, and Notch-1 in freshly isolated muscle stem (satellite) cells residing on different, single myofibers and have identified a small population of Sca-1(+)/Myf5(+) myogenic satellite cells. (ca.gov)

Embryonic myogenic progenitor cells express CXCR4, G-protein coupled cell surface receptor, and migrate towards regions of SDF-1 expression during limb muscle development, suggesting that CXCR4/SDF-1 plays a role in muscle cell homing. (biomedcentral.com)

Her primary areas of investigation include Cell biology, Immunology, Genetic enhancement, Haematopoiesis and Virology. (research.com)
The Immunology study combines topics in areas such as Progenitor cell and Molecular biology. (research.com)
Until recently, it was believed that the various cell types of the blood are generated from stem cells in a controlled but irreversible fashion," said James Hagman, an immunology researcher at the National Jewish Medical and Research Center in Denver who was not involved in this research. (innovations-report.com)
He won multiple international invention awards for Biotechnology and holds multiple international patents in stem cells immunology & biotech. (mcamcyprus.org)

Yamaguchi DT, Huang JT, Ma D. "Regulation of gap junction intracellular communication by pH in MC3T3-E1 osteoblastic cells. (sciepub.com)
Genes expressed in LRECe revealed retention of some stem-like properties along with up-regulation of differentiation factors. (frontiersin.org)

Wu J, Matthias N, Lo J, Ortiz-Vitali JL, Shieh AW, Wang SH, Darabi R . A Myogenic Double-Reporter Human Pluripotent Stem Cell Line Allows Prospective Isolation of Skeletal Muscle Progenitors. (uh.edu)
Wu J, Hunt SD, Matthias N, Servián-Morilla E, Lo J, Jafar-Nejad H, Paradas C, Darabi R . Generation of an induced pluripotent stem cell line (CSCRMi001-A) from a patient with a new type of limb-girdle muscular dystrophy (LGMD) due to a missense mutation in POGLUT1 (Rumi). (uh.edu)
Derivation of Skeletal Myogenic Precursors from Human Pluripotent Stem Cells Using Conditional Expression of PAX7. (uh.edu)

The cell membrane is really a viscous fluid-like matter which includes several lipids, cholesterol, and inserted proteins. (globaltechbiz.com)
There he worked with Dr. Max D. Cooper (Howard Hughes Medical Institute, National Academy of Sciences) and his research focused on cell surface proteins expressed by preB cells that regulate B cell maturation and homing. (ubc.ca)
In the next reporting period we will re-confirm that the levels of candidate proteins from the 500 antibody array actually are very highly produced by hESCs and that the signals from these proteins are perceived by regenerating muscle cells. (ca.gov)

Moreover, Barx2 interacts with the core Wnt effectors β-catenin and T cell-factor 4 (TCF4), is recruited to TCF/lymphoid enhancer factor sites, and promotes recruitment of β-catenin. (edu.au)

Methods in Molecular Biology. (uh.edu)
Written in the highly successful Methods in Molecular Biology™ , chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. (dattanibookagency.in)

Isolation and culture of individual myofibers and their satellite cells from adult skeletal muscle. (scielo.br)

When skeletal muscle is injured due to physical or chemical insult, a pool of self-renewing muscle stem cells residing within the skeletal muscles, called satellite cells, can give rise to differentiated myofibers to repair injured muscle ( Charge & Rudinicki, 2004 Chargé SBP, Rudnicki MA. (scielo.br)
Sorting single satellite cells from individual myofibers reveals heterogeneity in cell-surface markers and myogenic capacity. (ca.gov)

Taken together, these data indicate that PRDM16 specifies the brown fat lineage from a progenitor that expresses myoblast markers and is not involved in white adipogenesis. (bioseek.eu)

These include generation of knock-in reporter stem cell lines to study myogenic differentiation, CRISPR/Cas9 gene targeting methods to correct mutated genes in muscular dystrophies, and using bioscaffolds, seeded with stem cells, to treat skeletal muscle injuries. (uh.edu)
Her Cell biology research is multidisciplinary, incorporating elements of Gene transfer, Transgene, Dose dependence and Immune system. (research.com)
Through gene knockout studies he has shown that these molecules act as a type of molecular "Teflon" to make cells more mobile and invasive and also facilitate chemotaxis. (ubc.ca)
High-throughput sequencing data, raw sequencing data, raw and normalized count data, and single-cell clustering assignments generated in this study have been deposited are available from NCBI Gene Expression Omnibus (GEO) accession number GSE114186 , and can be visualized at https://tinyurl.com/DiazPourquie2019 . (nature.com)

In other words, unfaithful cells that have strayed from their original identity can come to their senses and return to the original lineage," Thomas-Tikhonenko said. (innovations-report.com)

They play a major role in muscle cell differentiation and injury recoveries. (wikipedia.org)
Upon increasing culture times in chicken´s primary skeletal muscle satellite cells, SULF1 and SULF2 expression in 1-week-old chickens was significantly higher than in 2-week-old chickens, suggesting that sulfatases play a key role in satellite cell development. (scielo.br)
Gros J, Manceau M, Thomé V, Marcelle C. A common somitic origin for embryonic muscle progenitors and satellite cells. (scielo.br)
MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16. (scielo.br)
Satellite cells, the engines of muscle repair. (scielo.br)
Günther S, Kim J, Kostin S, Lepper C, Fan CM, Braun T. Myf5-positive satellite cells contribute to Pax7-dependent long-term maintenance of adult muscle stem cells. (scielo.br)
Matthias N, Hunt SD, Wu J, Lo J, Smith Callahan LA, Li Y, Huard J, Darabi R . Volumetric muscle loss injury repair using in situ fibrin gel cast seeded with muscle-derived stem cells (MDSCs). (uh.edu)
We confirmed that typical growth factor signaling was in fact occurring in muscle cells exposed to hESC produced factors, and that hESCs produce a TGF-beta antagonist. (ca.gov)
Skeletal muscle, a known and plentiful source of progenitor cells is commonly associated with extraskeletal pathologies such as muscular dystrophy and heterotopic ossification. (uconn.edu)
This phenotype was associated with a higher number of Pax7 positive cells in mdxθ−/− muscle compared with mdx muscle, during the progression of the disease. (unicatt.it)
Although administration of various myogenic cell types has been done intramuscularly or intravascularly, functional restoration has not been achieved yet in patients with degenerative diseases affecting multiple large muscle. (crick.ac.uk)
2009 potentially reflecting the reduced secretion of myogenic growth element IGF-1 by these cells (Wynes and Riches 2003 While these studies demonstrate a facilitative part of innate immune cells in muscle mass regrowth after injury a direct molecular link between the innate immune system and muscle mass progenitor biology remains to be founded. (scienceexhibitions.org)
We show that CXCR4 expressing cells are important for donor muscle cell engraftment, yet FACS sorted CXCR4-positive cells display decreased engraftment efficiency. (biomedcentral.com)
We used the xenotransplant model to show that CXCR4 expression on canine donor muscle cells is also important for cell engraftment, but FACS sorting for CXCR4-positive cells decreased their engraftment efficiency. (biomedcentral.com)

Thomas-Tikhonenko and colleagues found that when the cells are returned to the animal, they generate spherical B-cell lymphomas, indicating that they have changed their identity yet again. (innovations-report.com)
The intent of this extensive volume is to generate a valuable resource containing clear methodologies pertinent to current areas of investigation, rather than attempting to educate cell culturists on specific cell types or organ systems. (dattanibookagency.in)

My laboratory will design and characterize molecular motor variants using a rapid testing cycle that relies on new instrumentation for high throughput single molecule tracking and manipulation assays. (nih.gov)

A great deal more can be understood about the properties of these regenerative cells and their therapeutic potential using a single cell analysis (as compared to conventional bulk cell preparations). (ca.gov)
Being a fusion of cell therapy and mitochondrial medicine, mitochondrial organelle cell therapy includes a range of peptides that broadens the horizons of therapeutic rejuvenation and creates new opportunities for aesthetic and anti-aging practitioners. (mcamcyprus.org)

In this point of view, they can compare to adult stem cells, but progenitors are said to be in a further stage of cell differentiation. (wikipedia.org)
Many properties are shared by adult stem cells and progenitor cells. (wikipedia.org)
Together with other published results, these observations blur the concept of fixed cell types and provide new insights concerning potential uses for adult stem cells. (innovations-report.com)

The most important difference between stem cells and progenitor cells is that stem cells can replicate indefinitely, whereas progenitor cells can divide only a limited number of times. (wikipedia.org)

However, a huge number of autologous cells are required to address these practices. (sciepub.com)

As part of this project, we would now like to analyze the whole genome sequencing profiles of two adrenocortical carcinoma cell lines. (usz.ch)

Anatomy56

Organisms16

Diseases9

Chemicals and Drugs62

Analytical, Diagnostic and Therapeutic Techniques and Equipment48

Phenomena and Processes54

Disciplines and Occupations10

Technology, Industry, Agriculture3

Humanities2

Information Science4

Health Care3

Endothelial6

Developmental biology3

Regeneration17

Myogenic stem2

Tissue15

Vitro9

Embryonic stem1

Subventricular zone1

Adipogenic2

Bone marrow5

Cellular11

Differentiation of pluripotent stem1

Proliferation10

Mechanisms4

Biochemistry1

Transplantation11

Vivo5

Characterization3

Basal2

Migration8

Mice5

Behavior3

Myeloid2

Tissues5

Hematopoietic stem2

Populations3

Induces2

Putative3

Pathways2

Neural5

Induce2

FAPs3

Intermediate1

CD341

Tumor7

Niche1

Macrophages5

Differentiate3

Regenerative capacity3

Migrate1

Immunology4

Regulation2

Pluripotent3

Proteins3

Lymphoid1

Methods in Mole2

Isolation1

Myofibers2

Myoblast1

Gene4

Lineage1

Muscle14

Generate2

Assays1

Therapeutic2

Adult stem3

Indefinitely1

Autologous1

Genome1