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  • bone marrow donation
  • This is especially important as we see an increase in requests for the surgical bone marrow donation procedure. (stemcellsfreak.com)
  • The Human Tissue Authority (HTA) was surprised to be named as the respondent in the matter of SW earlier this year - there had been no contact or information from the applicants before the papers were served - on a matter relating to a bone marrow donation involving an individual who it was. (hta.gov.uk)
  • cancer
  • However, wiping out blood cells (healthy cells and cancer) during the transplant process also presents grave risks for the patient. (medicalxpress.com)
  • The hope is that when a patient needs a bone marrow transplant to treat cancer or another disease, we can find the cells that match, expand them and use them. (redorbit.com)
  • This led Dr Fred Appelbaum, executive director at the Seattle Cancer Care Alliance who was not involved in the study, to suggest that stem cells from bone marrow should be used in preference to those from peripheral blood. (bionews.org.uk)
  • The discovery offers hope of alternative treatments for people who would normally require bone marrow transplants to replenish their blood supply, for example those with cancer or blood disorders. (bionews.org.uk)
  • This trial was supported by the National Heart, Lung, and Blood Institute (NHLBI) and the National Cancer Institute (NCI) of the National Institutes of Health (NIH) and the NMDP. (healthcanal.com)
  • The high-dose treatment kills the cancer cells, but it also gets rid of the blood-producing cells that are left in your bone marrow. (mskcc.org)
  • The allogeneic stem cell or bone marrow transplant (BMT), which is used to treat certain types of blood cancer, may be one of the most rigorous cancer treatments. (mskcc.org)
  • The purpose of conditioning is to attack the tumor cells in the patient's bone marrow and destroy the cancer, but it also results in collateral damage to various tissues," explains physician-scientist Marcel van den Brink , who is head of MSK's Division of Hematologic Oncology and also has a lab in the Sloan Kettering Institute's Immunology Program . (mskcc.org)
  • Our transplantation experts are closely integrated with our world-class teams of blood cancer experts and transplantation immunologists. (nyp.org)
  • One of the many difficult things about pancreatic cancer is that tumors are resistant to most treatments because of their unique density and cell composition. (medicalxpress.com)
  • HACKENSACK, N.J., Oct. 2 /PRNewswire/ -- The Blood and Marrow Stem Cell Transplantation Program at the John Theurer Cancer Center at Hackensack University Medical Center is the first in the United States to receive Disease Specific Care Certification for stem cell transplantation from The Joint Commission, the nation's leading accrediting agency for hospitals and healthcare organizations. (bio-medicine.org)
  • Nearly 300 adults and children throughout the country with cancer and serious blood disorders come to the John Theurer Cancer Center each year to undergo a life-saving stem cell transplant at the program. (bio-medicine.org)
  • These designations attest to the high level of expertise offered by our Blood and Marrow Stem Cell Transplantation Program's chief, Dr. Scott Rowley, by his associate, Dr. Michele Donato, and by the entire transplantation team," says Andrew L. Pecora, M.D., chairman and executive administrative director of the John Theurer Cancer Center at Hackensack University Medical Center. (bio-medicine.org)
  • mesenchymal
  • Mesenchymal stem cells can be grown on silicone membranes with micropatterned grooves. (berkeley.edu)
  • Researchers placed mesenchymal stem cells, extracted from bone marrow, onto a silicone membrane that was stretched longitudinally once every second. (berkeley.edu)
  • Mesenchymal stem cells have the ability to turn into different types of connective tissue including bone, cartilage and muscle. (berkeley.edu)
  • In research related to the study published in the Proceedings of the National Academy of Sciences (PNAS), members of Song Li's lab have been developing vascular grafts from mesenchymal stem cells positioned in a polymer tube. (berkeley.edu)
  • In an effort to better understand the factors that affect the eventual fate of mesenchymal stem cells, the researchers designed the experiment to simulate the physical forces a cell would encounter if it were to become a blood vessel. (berkeley.edu)
  • The researchers placed a single layer of mesenchymal stem cells onto a membrane with microgrooves to resemble the patterns formed in blood vessels by collagen fibers. (berkeley.edu)
  • OBJECTIVE To investigate the feasibility of employing double transplantations of autologous bone marrow mesenchymal stem cells (BMSC) and umbilical cord mesenchymal stem cells (UMSC) in the treatment of progressive muscular dystrophy (PMD). (semanticscholar.org)
  • CXCL12 production by early mesenchymal progenitors is required for haemoatopoietic stem-cell maintenance. (todaytopics.com)
  • Background: In recent years we have successfully adopted an in vitro hepatogenic differentiation of mesenchymal stem cells (MSCs). (ac.ir)
  • 2007. Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes. (ac.ir)
  • 2000.Mesenchymal progenitor cells in human umbilical cord blood. (ac.ir)
  • The role of albumin and PPAR-╬▒in differentiation- dependent change of fattyacid profile during differentiation of mesenchymal stem cells to hepatocyte-likecells. (ac.ir)
  • HSCs
  • The engineered protein maintains the expanded HSCs in a stem-like state -- meaning, they will not differentiate into specialized blood cell types before they are transplanted in the recipient's bone marrow. (redorbit.com)
  • Because of these issues of extracting donor bone marrow, there have been a number of attempts to expand HSCs that have focused on the transcription factor HOXB4, which stimulates HSCs to make copies of themselves. (redorbit.com)
  • In adult mammals, hematopoietic stem cells (HSCs) reside in the bone marrow (BM) and are maintained in a quiescent and undifferentiated state through adhesive interactions with specialized microenvironmental niches. (bloodjournal.org)
  • Here, we show that HSCs adhere to JAM-B expressed by BM stromal cells in a JAM-C dependent manner. (bloodjournal.org)
  • The interaction regulates the interplay between HSCs and BM stromal cells as illustrated by the decreased pool of quiescent HSCs observed in jam-b deficient mice. (bloodjournal.org)
  • 10 Recently, expression of several JAM family members, such as JAM-A, JAM-C, JAM4, or ESAM, has been reported in hematopoietic stem cells (HSCs), although a function for these proteins in hematopoiesis remains unknown. (bloodjournal.org)
  • In adult mammals, HSCs are rare cells mainly located in the bone marrow (BM) and able to generate all mature blood cells. (bloodjournal.org)
  • chronic
  • Chronic lymphocytic leukemia (CLL) and prolymphocytic leukemia, in complete or partial remission, Mantle cell lymphoma, relapsed Hodgkin's and non-Hodgkin's lymphoma. (knowcancer.com)
  • adult
  • It also suggests that adult blood stem cells could be frozen and banked for future expansion and use -- which is not currently possible. (redorbit.com)
  • Our work demonstrates that we can overcome a major technical hurdle in the expansion of adult blood stem cells, making it possible, for the first time, to produce them on an industrial scale," says the study's senior investigator, Dr. Pengbo Zhou, professor of pathology and laboratory medicine at Weill Cornell. (redorbit.com)
  • BERKELEY - When stretched, a type of adult stem cell taken from bone marrow can be nudged towards becoming the type of tissue found in blood vessels, according to a new study by bioengineers at the University of California, Berkeley. (berkeley.edu)
  • Embryonic stem cells have the advantage of being able to turn into any kind of body tissue and of being easier to work with in the lab, though that flexibility comes with controversy and ethical questions not found in research on adult stem cells. (berkeley.edu)
  • De Bari C, Dell'Accio F, Tylzanowski P, Luyten FP.2001.Multipotentmesenchymal stem cells from adult human synovial membrane. (ac.ir)
  • Robin Roberts with Sergio Giralt, Chief of the Adult Bone Marrow Transplant Service. (mskcc.org)
  • We meet to celebrate the success you've had in this journey and to acknowledge all the people who helped you to have that success," Sergio A. Giralt , Chief of the Adult Bone Marrow Transplant Service, told those gathered. (mskcc.org)
  • lymphoma
  • And when leukemia, certain types of lymphoma, or injury from chemo and radiation destroys blood stem cells, a transplant offers a fresh replacement. (medicalxpress.com)
  • NewYork-Presbyterian offers bone marrow and stem cell transplantation for people with hematological malignancies (e.g., leukemia, lymphoma, multiple myeloma, myelodysplastic syndromes (MDS)) for myeloproliferative disorders such as myelofibrosis, for AL-amyloidosis, and for non-malignant blood disorders such as severe aplastic anemia and sickle cell anemia (SCA). (nyp.org)