• At least two populations of epithelial stem/progenitor cells give rise to the lung anlage, comprising the laryngo-tracheal complex versus the distal lung below the first bronchial bifurcation. (nih.gov)
  • Residual pools of adult stem cells are hypothesized to be the source of lung regeneration and repair. (nih.gov)
  • Alternatively, exogenous stem/progenitor cells can be delivered into the lung either intravenously, intratracheally, or by direct injection. (nih.gov)
  • Sources of exogenous stem/progenitor cells that are currently under evaluation in the context of acute lung injury repair include embryonic stem cells, bone marrow- or fat-derived mesenchymal stem cells, circulating endothelial progenitors, and, recently, amniotic fluid stem/progenitor cells. (nih.gov)
  • This study aimed at elucidating the effect of major non-THC phytocannabinoids on the fate of adult neural stem progenitor cells (NSPCs), which are an essential component of brain function in health as well as in pathology. (nih.gov)
  • Therapeutic potentials of mesenchymal stem cells (MSCs) depend largely on their ability to secrete cytokines or factors that modulate immune response, enhance cell survival, and induce neovascularization in the target tissues. (hindawi.com)
  • We studied the secretome profile of gestational tissue-derived MSCs and their effects on functions of endothelial progenitor cells (EPCs), another angiogenic cell type that plays an important role during the neovascularization. (hindawi.com)
  • Mesenchymal stem cells (MSCs) are multipotent stem/progenitor cells which can differentiate to several mesodermal derivatives and possess an ability to secrete factors involved in neovascularization and immunomodulation [ 1 , 2 ]. (hindawi.com)
  • However, recent studies have demonstrated that other angiogenic cells called endothelial progenitor cells (EPCs) also play an important role during the formation of new vessels through the process of vasculogenesis [ 7 - 9 ]. (hindawi.com)
  • Also making up a part of the hematopoietic system are short-term repopulating progenitor cells, which give rise to lineage-specific cell types. (stemcell.com)
  • Collectively, these are referred to as hematopoietic stem and progenitor cells (HSPCs). (stemcell.com)
  • The colony-forming unit (CFU) assay is a clonal, in vitro culture assay that measures the growth and frequency of functionally viable HSPCs by assessing the proliferation and differentiation of individual progenitor cells, resulting in the formation of discrete colonies in a semi-solid methylcellulose medium (such as MethoCult™ ) when supplemented with appropriate cytokines. (stemcell.com)
  • Colonies derived from different types of progenitor cells are classified and counted based on morphological and phenotypic criteria. (stemcell.com)
  • CD34 is the most commonly used cell surface marker to identify human HSPCs as it is expressed on HSCs, in addition to both multipotent and more differentiated progenitor cells of individual blood cell lineages. (stemcell.com)
  • Here, we show that conditional knockout of Mef2c in nestin-expressing neural stem/progenitor cells (NSCs) impaired neuronal differentiation in vivo, resulting in aberrant compaction and smaller somal size. (ca.gov)
  • Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
  • Mesenchymal stem/progenitor cells (MSC/MPC) are found in many tissues and fluids including bone marrow, adipose tissues, muscle, synovial membranes, synovial fluid, and blood. (scirp.org)
  • Hart, D. (2014) Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
  • Borlongan, C.V., Glover, L.E., Tajiri, N., Kaneko, Y. and Freeman, T.B. (2011) The Great Migration of Bone Marrow-Derived Stem Cells towards the Ischemic Brain: Therapeutic Implications for Stroke and Other Neurological Disorders. (scirp.org)
  • Ando, W., Heard, B., Nakamura, N., Frank, C.B. and Hart, D.A. (2012) Ovine Synovial Membrane-Derived Mescenchymal Progenitor Cells Retain the Phenotype of the Original Tissue That Was Exposed to in Vivo Inflammation: Evidence for a Suppressed Chondrogenic Differentiation Potential of the Cells. (scirp.org)
  • Batsali, A.K., Kastrinaki, M.C., Papadaki, H.A. and Pontikoglou, C. (2013) Mesenchymal Stem Cells Derived from Wharton's Jelly of the Umbilical Cord: Biological Properties and Emerging Clinical Applications. (scirp.org)
  • Stem cells rely on extracellular signals produced by the niche, which dictate their ability to self-renew, expand and differentiate. (karger.com)
  • It is essential to have sensitive and reproducible methods of either quantifying or isolating these stem cells and progenitors to understand their intrinsic properties and how extrinsic signals regulate their development. (karger.com)
  • However, stem cells are difficult to distinguish from multipotential progenitors, which may look and act like them. (karger.com)
  • 00:39 police is these are hematopoietic stem cells. (yale.edu)
  • 02:14 progenitors that make red blood cells. (yale.edu)
  • During human forebrain development, neural progenitor cells (NPCs) in the ventricular zone (VZ) undergo asymmetric cell divisions to produce a self-renewed progenitor cell, maintaining the potential to go through additional rounds of cell divisions, and differentiating daughter cells, populating the developing cortex. (elifesciences.org)
  • During human brain development, neural progenitor cells (NPCs) undergo two modes of cell division. (elifesciences.org)
  • The developmental strategies used by progenitor cells to allow a safe journey from their induction place towards the site of terminal differentiation are still poorly understood. (elifesciences.org)
  • The remaining delaminated cells follow the movement of apically attached progenitors by a protrusion-dependent cell-cell contact mechanism, avoiding sequestration by the adjacent endoderm, ensuring their collective fate and allocation at the site of differentiation. (elifesciences.org)
  • These early progenitor cells often travel long distances from their induction site to the site of terminal differentiation, making them vulnerable to environmental cues and movement of neighbouring tissues. (elifesciences.org)
  • Several embryonic tissues and organs originate from small sets of progenitor cells. (elifesciences.org)
  • Despite the importance of the developmental pathways followed by these small groups of progenitor cells and their impact on the physiology of the organism, we still know little about the set of developmental strategies that progenitor cells deploy in vivo to overcome the challenges imposed by the environment as they travel to the site of terminal differentiation. (elifesciences.org)
  • Notch activation in human CD34+ hematopoietic stem/progenitor cells (HSPCs) by treatment with Delta1 ligand has enabled clinically relevant ex vivo expansion of short-term HSPCs. (confex.com)
  • However, sustained engraftment of the expanded cells was not observed after transplantation, suggesting ineffective expansion of hematopoietic stem cells with long-term repopulating activity (LTR-HSCs). (confex.com)
  • Most clusters could be computationally assigned to a defined hematopoietic subpopulation, including progenitor cells (clusters 0 to 4) and a single transcriptionally defined HSC population (cluster 5). (confex.com)
  • Second, compared to BM, extramedullary hematopoietic stem cells/multipotent progenitors (HSCs/MPPs) from the spleen, PB, and mobilized PB to have a shared transcriptional profile and a higher abundance of lineage-primed subsets. (physiciansweekly.com)
  • The ability to genetically manipulate hematopoietic stem and progenitor cells (HSPCs) in particular has significantly advanced our understanding of the mechanisms that regulate hematopoiesis and is contributing to the development of novel cellular therapies. (stemcell.com)
  • Additionally, edited CD34 + cells can be further cultured in conditions stimulating lineage-specific differentiation by combining StemSpan™ media with expansion supplements designed for the expansion and differentiation of progenitors to erythroid, myeloid, megakaryocyte, natural killer (NK), or T cell lineages. (stemcell.com)
  • Formation of new myonuclei required for efficient muscle hypertrophy relies on prior activation and proliferation of muscle stem cells (MuSCs). (mdc-berlin.de)
  • Hematopoietic stem cells (HSC) give rise to all types of blood lineages, including red blood cells (RBC). (lu.se)
  • Hematopoietic stem/progenitor cells (HSPC) are known to be functionally diverse in terms of their self-renewal potential and lineage output. (lu.se)
  • Researchers identify the origin of endothelial cells that constitute the vascular niche for hematopoietic stem and progenitor cells in zebrafish. (go.jp)
  • Endothelial cells (ECs) line blood vessels and can serve as specialized vascular niches for hematopoietic stem and progenitor cells (HSPCs), a special environment where HSPCs reside and self-renew. (go.jp)
  • They also serve as specialized vascular niches that provide instructive signals to tissue-specific stem cells or parenchymal cells for tissue formation and repair. (go.jp)
  • They found that islet1 -expressing cells are the progenitors of the venous ECs that constitute the majority of the HSPC niche (Figure 1A). (go.jp)
  • Stem Cells Translational Medicine. (ed.ac.uk)
  • In an effort to develop cell therapy-based strategies for progressive MS, we investigated the pre-clinical efficacy of bone marrow mesenchymal stem cell-derived neural progenitors (MSC-NPs) as an autologous source of stem cells. (listlabs.com)
  • Intrathecal injection of MSC-NPs correlated with reduced immune cell infiltration, reduced area of demyelination, and increased number of endogenous nestin-positive progenitor cells in EAE mice. (listlabs.com)
  • Hematopoietic stem cells (HSCs) reside in association with bone marrow (BM) sinusoidal vessels in vivo, but the function of BM endothelial cells (ECs) in regulating hematopoiesis is unclear. (duke.edu)
  • BALB/c mice were treated with total body irradiation (TBI) and then infused with C57Bl6-derived endothelial progenitor cells (EPCs) to augment endogenous BM EC activity. (duke.edu)
  • Neural Progenitor Cells Derived from XCL-1 DCXp-GFP are a neuronal lineage reporter cell line that can be used in neuronal differentiation and drug screening. (atcc.org)
  • To download a certificate of analysis for Neural Progenitor Cells Derived from XCL-1 DCXp-GFP ( ACS-5005 ), enter the lot number exactly as it appears on your product label or packing slip. (atcc.org)
  • The certificate of analysis for that lot of Neural Progenitor Cells Derived from XCL-1 DCXp-GFP ( ACS-5005 ) is not currently available online. (atcc.org)
  • In this study, we compared two frequently used digestion methods and three sets of frequently used surface markers for their efficiency in enriching mammary stem and progenitor cells in two commonly used mouse strains, C57BL/6J and FVB. (springeropen.com)
  • CD24/CD29) for enriching mammary stem and progenitor cells. (springeropen.com)
  • To address some of these shared obstacles by new investigators in this field, we compared two frequently used digestion methods and three sets of frequently used surface markers for their efficiency in enriching mammary stem and progenitor cells in two commonly used mouse strains, C57BL/6J and FVB. (springeropen.com)
  • Furthermore, the percentage of basal cells characterized with EpCAM + CD49f hi , the fraction highly enriched with mammary stem cells, was significantly lower with the fast digestion method (0.5 ± 0.1 % of total cells, Mean ± SE, n = 3) when compared with the slow digestion protocol (8.0 ± 0.8 %, P = 0.016, paired t test) using mammary tissues from the same mice (Fig. 1 a). (springeropen.com)
  • Astrocytes are generated from neural stem cells (NSCs) during late embryonic and early postnatal stages. (nature.com)
  • The key difference between hematopoietic stem cells and progenitor cells is, Think of the hematopoietic stem cell as the ultimate multitasker. (thenoveldifference.com)
  • Hematopoietic stem cells have a unique superpower - they can transform into many different cell types. (thenoveldifference.com)
  • On the other hand, progenitor cells are like specialists. (thenoveldifference.com)
  • They are descendants of hematopoietic stem cells, and they have a specific function. (thenoveldifference.com)
  • Hematopoietic stem cells are the all-in-one package, while progenitor cells are like specialists who focus on their specific roles. (thenoveldifference.com)
  • Hematopoietic stem cells (HSCs) are a type of multipotent stem cell found primarily in the bone marrow and, to a lesser extent, in peripheral blood. (thenoveldifference.com)
  • Hematopoietic stem cells have the unique capacity to continuously self-renew and maintain a pool of stem cells for the lifelong production of blood cells. (thenoveldifference.com)
  • Hematopoietic stem cells give rise to progenitor cells, which, in turn, differentiate into specific blood cell lineages. (thenoveldifference.com)
  • The bone marrow serves as the primary residence for hematopoietic stem cells. (thenoveldifference.com)
  • Hematopoietic stem cells are widely used in medical treatments, particularly in bone marrow transplantation for individuals with hematological disorders like leukemia or aplastic anemia. (thenoveldifference.com)
  • Hematopoietic stem cells are pivotal in maintaining the body's blood cell supply, and their versatility makes them invaluable in both medical treatments and scientific research related to blood disorders and regenerative medicine. (thenoveldifference.com)
  • What are Progenitor Cells? (thenoveldifference.com)
  • Progenitor cells, also known as precursor cells, are a type of cell that falls somewhere between stem cells and fully differentiated, specialized cells in terms of their differentiation potential. (thenoveldifference.com)
  • Progenitor cells are more specialized than stem cells. (thenoveldifference.com)
  • They have already committed to a particular differentiation pathway, meaning they are destined to become a specific type of cell, such as a red blood cell, white blood cell, or platelet in the case of hematopoietic progenitor cells. (thenoveldifference.com)
  • While progenitor cells can divide and replicate, their proliferation potential is more restricted compared to stem cells. (thenoveldifference.com)
  • They produce a defined number of specialized cells and do not have the same capacity for self-renewal as stem cells. (thenoveldifference.com)
  • Progenitor cells play a crucial role in tissue repair and regeneration. (thenoveldifference.com)
  • Progenitor cells are often located within specific tissues, close to where they will ultimately function. (thenoveldifference.com)
  • For example, hematopoietic progenitor cells are found in the bone marrow, as this is where blood cell production occurs. (thenoveldifference.com)
  • Progenitor cells are being explored for various therapeutic applications, including tissue engineering and regenerative medicine. (thenoveldifference.com)
  • Progenitor cells are partially specialized cells that serve as intermediaries between stem cells and fully differentiated cells. (thenoveldifference.com)
  • However, when the liver is severely damaged or hepatocyte proliferation is greatly inhibited, liver stem/progenitor cells (LSPCs) will contribute to the liver regeneration process. (ijbs.com)
  • In addition to the restoration of the liver parenchymal tissue by hepatocytes or/and LSPCs, or in some cases bone marrow (BM) derived cells, such as hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs), the wound healing after injury in terms of angiopoiesis by liver sinusoidal endothelial cells (LSECs) or/and sinusoidal endothelial progenitor cells (SEPCs) is another important aspect taking place during regeneration. (ijbs.com)
  • To conclude, liver regeneration can be mainly divided into three distinct restoring levels according to the cause and severity of injury: hepatocyte dominant regeneration, LSPCs mediated regeneration, extrahepatic stem cells participative regeneration. (ijbs.com)
  • In this review, we focus on the recent findings of liver regeneration, especially on those related to stem/progenitor cells (SPCs)-mediated regeneration and their potential clinical applications and challenges. (ijbs.com)
  • Megakaryocyte-erythroid progenitor cells, among other blood cells, are generated as a result of hematopoiesis, which occurs in the bone marrow. (wikipedia.org)
  • Hematopoietic stem cells can differentiate into one of two progenitor cells: the common lymphoid progenitor and the common myeloid progenitor. (wikipedia.org)
  • Megakaryocyte/erythrocyte progenitor cells must commit to becoming either platelet-producing megakaryocytes via megakaryopoiesis or erythrocyte-producing erythroblasts via erythropoiesis. (wikipedia.org)
  • Most of the blood cells produced in the bone marrow during hematopoiesis come from megakaryocyte/erythrocyte progenitor cells. (wikipedia.org)
  • Evaluating Interaction of Cord Blood Hematopoietic Stem/Progenitor Cells with Functionally Integrated Three-Dimensional Microenvironments. (wakehealth.edu)
  • Stem Cells Transl Med. (wakehealth.edu)
  • Human pluripotent stem cells, with their ability to proliferate indefinitely and to differentiate into virtually all cell types of the human body, provide a novel resource to study human development and to implement relevant disease models. (mdpi.com)
  • Here, we employed a human pancreatic differentiation platform complemented with an shRNA screen in human pluripotent stem cells (PSCs) to identify potential drivers of early endoderm and pancreatic development. (mdpi.com)
  • After centrifugation the cell pellet was treated for analysis of CD117+ cells using flowcytometry, once small percentage of CD117+cells were identified the cells were prepared for differentiation and that was carried out using specific growth factors including BMP4, BMP7, FGF2, and retinoic acid, providing the niche to the stem cells for differentiation towards nephron progenitors which was confirmed by protein expression of Wilms Tumor-1 (WT1) using immunofluorescence analysis. (org.pk)
  • We successfully isolated small percentage of CD117+ cells in amniotic fluid followed by in vitro expansion and differentiation towards nephron progenitor cells (NPCs) using well defined media and growth factors, initially differentiated cells were spindle shaped and showed fibroblastic appearance later at stage of nephron progenitors it attained the shape of rounded big clusters, differentiated cells stained positive for WT1 and negative for cluster of differentiation (CD117). (org.pk)
  • Therefore, confirming the successful isolation and differentiation of amniotic fluid stem cells towards nephron progenitors. (org.pk)
  • To the best of our knowledge this is the first study from the country on the use of Amniotic fluid stem cells and their differentiation towards nephron progenitors that can be used as substitution source of cell therapy for exploration of renal diseases at cellular and molecular level and potential regenerative medicine applications. (org.pk)
  • Jabeen H, Wahid M, AinUddin JA, Mustafa F. Differentiation of CD117+ Amniotic Fluid Stem Cells towards Nephron Progenitors. (org.pk)
  • Gcells are conditioned to work with an enriched suspension of progenitor cells that can efficiently aid tissue repair process. (issca.us)
  • MSCs also possess subpopulations that are stem-like nature commonly referred to as "side population" (SP) they have been found out to be enriched in over 1000-fold of progenitor cells and multipotent stem cells and as well exist in tissues and tumors. (issca.us)
  • This discovery was in an in vitro and in vivo experiment when Dental Pulp Stem Cells (DPSCs) showed capability to differentiate into osteoblasts and built a woven bone by forming an Extracellular Matrix (ECM) secreted by the osteoblasts. (issca.us)
  • The experiment drew results on the both the quality and quantity of the matrix formed by the DPSCs in the in vivo and in vitro experiment using Stem cells and accompanying biomaterials. (issca.us)
  • Thus proved that dental pulp holds potentialities of therapeutic strength and a rich source of progenitor/autologous cells that can be used to aid healing processes even applicable to regeneration of craniofacial bones. (issca.us)
  • Patients with Wiskott-Aldrich syndrome (WAS) lacking a human leukocyte antigen-matched donor may benefit from gene therapy through the provision of gene-corrected, autologous hematopoietic stem/progenitor cells. (ucl.ac.uk)
  • Negative regulatory factors inhibit the proliferation of haematopoietic stem cells thus protecting them from differentiation pressures. (st-andrews.ac.uk)
  • Haematopoietic stem cells were induced into cell cycle by in vivo administration of either 2 Gy-γ-irradiation or the two cytotoxic drugs, cytosine arabinoside (Ara-C) (100 mg/kg i.p.) or 5 flourouracil (5 FU) (150 mg/kg i.v). Bone marrow cells were sampled and incubated in vitro for up to 24 hours. (st-andrews.ac.uk)
  • Liver stem/progenitor cells have the potential to differentiate to form hepatocytes or cholangiocytes. (elsevierpure.com)
  • Adult stem/progenitor cells were isolated from the liver of mice with chemically induced liver injury. (elsevierpure.com)
  • Inhibition of autophagy promoted hepatic differentiation in the stem/progenitor cells. (elsevierpure.com)
  • Our findings indicated that promoting amino acid sensitivity of the mTOR pathway is dependent on p62 accumulated by inhibition of autophagy and that this process plays an important role in the hepatic differentiation of stem/progenitor cells. (elsevierpure.com)
  • The existence of adult pancreatic progenitor cells has been debated. (bepress.com)
  • While some favor the concept of facultative progenitors involved in homeostasis and repair, neither a location nor markers for such cells have been defined. (bepress.com)
  • Cardiac progenitor/stem cells in adult hearts represent an attractive therapeutic target for heart regeneration, though (inter)-relationships among reported cells remain obscure. (ox.ac.uk)
  • Using single-cell qRT-PCR and clonal analyses, here we define four subpopulations of cardiac progenitor/stem cells in adult mouse myocardium all sharing stem cell antigen-1 (Sca1), based on side population (SP) phenotype, PECAM-1 (CD31) and platelet-derived growth factor receptor-α (PDGFRα) expression. (ox.ac.uk)
  • Using Stem Cells for Stroke Recovery? (stemcellmagic.com)
  • These data suggest that fetal HSCs minimally contribute to the generation of progenitors and functional blood cells before birth. (elsevierpure.com)
  • The colonic epithelial turnover is driven by crypt-base stem cells that express the R-spondin receptor Lgr5. (nature.com)
  • The majority of epithelial cells are therefore short-lived, in contrast to a limited number of long-lived stem cells in the base of the crypts. (nature.com)
  • Lgr5 is a well-established marker of these basal stem cells in the gastrointestinal tract 1 and lineage tracing experiments have demonstrated that Lgr5 + cells give rise to clonal cell populations establishing entire colonic crypts 2 . (nature.com)
  • While Lgr5 + cells are long-lived and act as stem cells during homeostatic conditions, experimental models have demonstrated that Lgr5 + stem cells per se are not essential for maintaining epithelial integrity 3 . (nature.com)
  • This has been studied mainly in the small intestine, where different cell types such as enterocyte progenitors 4 , more differentiated secretory Bmi1 + cells 3 , or even fully differentiated Paneth cells can repopulate crypts upon injury. (nature.com)
  • Rspo proteins are secreted and can stabilize the effects of Wnt ligands by preventing ubiquitination and turnover of the Wnt receptor frizzled 9 , thereby dictating the size of the Lgr5 + stem cell pool by regulating self-renewal of Lgr5 + cells 10 . (nature.com)
  • In preclinical and clinical studies, progenitor cell therapy (cord blood and mesenchymal stem cells) has shown promise in reversing the underlying pathology of SNHL, the loss of cochlear sensory hair cells. (intechopen.com)
  • By transducing two genes (c-MYC and BCL-XL) into iPS cells and ES cells, a research team has succeeded in producing erythrocyte progenitor cells with almost unlimited ability to replicate in vitro, which they then differentiated successfully into mature erythrocytes. (sciencedaily.com)
  • Erythrocytes are produced in the body by progressive evolution of hematopoietic stem cells into hematopoietic progenitor cells and then erythroblasts. (sciencedaily.com)
  • During the differentiation process from hematopoietic progenitor cells, chromosomes in the cell nucleus aggregate and the cell becomes a mature erythrocyte by subsequently losing this nucleus (enucleation). (sciencedaily.com)
  • Hematopoietic progenitor cells, however, still have self-replication ability, and if the factors involved in this self-replication could be identified, it might become possible to induce virtually unlimited replication of progenitor cells. (sciencedaily.com)
  • The research showed that an increase in the expression of the c-MYC gene led to an enhancement of the replication ability of erythrocyte progenitor cells. (sciencedaily.com)
  • It was also found that the expression of the BCL-XL gene was higher during the maturation process of erythrocyte progenitor cells than during their replication process. (sciencedaily.com)
  • As the c-MYC gene and BCL-XL gene are present within erythrocyte progenitor cells, methods that make use of them actually mimic the body's own system and can therefore be thought of as safer with a view to future clinical application than the previously developed systems for large-scale erythrocyte production using oncogene-derived from Human papillomavirus that are not normally expressed in the human body. (sciencedaily.com)
  • The review presents literature data on embryogenesis, physiological and reparative thyroid gland (TG) regeneration in the postnatal period in terms of substantiating the presence of stem/progenitor cells in its tissue. (genescells.ru)
  • The data concerning genetic and protein markers of thyroid stem cells, as well as markers of their thyroid differentiation, are systematized. (genescells.ru)
  • Unresolved problems and perspectives of the use of thyroid stem/progenitor cells in tissue engineering are discussed. (genescells.ru)
  • Fierabracci A. Identifying thyroid stem/progenitor cells: advances and limitations. (genescells.ru)
  • The Emerging Cell Biology of Thyroid Stem Cells. (genescells.ru)
  • Kimura S. Thyroid Regeneration: How Stem Cells Play a Role? (genescells.ru)
  • Lin R.Y. New insights into thyroid stem cells. (genescells.ru)
  • Thyroid stem cells-danger or resource? (genescells.ru)
  • Generation of functional thyroid from embryonic stem cells. (genescells.ru)
  • Ma R., Latif R., Davies T.F. Thyroid follicle formation and thyroglobulin expression in multipotent endodermal stem cells. (genescells.ru)
  • Ma R., Latif R., Davies T.F. Human embryonic stem cells form functional thyroid follicles. (genescells.ru)
  • Hematopoietic stem/progenitor cells (HSPCs), which can be found in little numbers in hematopoietic tissues, can differentiate into most hematopoietic lineages and self-renew to keep up their undifferentiated phenotype. (hiv-proteases.com)
  • Desk 1 The radiosensitivity from the hematopoietic myeloid progenitor cells. (hiv-proteases.com)
  • Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
  • Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
  • Over the past decade, the identification of stem-like cells as drivers of tumor initiation, recurrence, and metastasis spread in a variety of human cancers had a tremendous impact in basic and translational cancer research. (hindawi.com)
  • Advances in this field point to a more complex model of tumor development than previously envisioned, in which the stem-like phenotype may be dynamically acquired by cancer cells. (hindawi.com)
  • Understanding how cancer stem cells affect tumor heterogeneity, the contribution of resident stem and progenitor cells to the tumor niche, and the search for true cancer stem cell markers are other examples of scientific challenges in this fast-growing research area. (hindawi.com)
  • We invite investigators to submit original research as well as review articles addressing recent advancements in our understanding of stem cells in cancer. (hindawi.com)
  • Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
  • The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
  • The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
  • Victoria Ptasinski defended her Ph.D. thesis 'Alveolar Progenitor Cells in Lung Damage and Regeneration in Pulmonary Fibrosis' on Monday, November 27, 2023. (lu.se)
  • During vertebrate embryogenesis , fetal hematopoietic stem and progenitor cells (HSPCs) exhibit expansion and differentiation properties in a supportive hematopoietic niche. (bvsalud.org)
  • In addition, there is considerable interest in delineating the mechanisms by which stem cells survive radiation exposure and promote tissue regeneration. (cdc.gov)
  • In this study, we isolated stable radioresistant acinar progenitor cells from the submaxillary gland of the Sprague Dawley rat. (cdc.gov)
  • Progenitor cells are characterized as c-Kithigh/alpha-amylase+ and are resistant to X rays (=5 Gy).We further isolated a radiosensitive acinar counterpart, characterized as c-Kitlow/alpha-amylase+, which is effectively killed by exposure to 2 Gy X ray of radiation. (cdc.gov)
  • Phosphopeptides with homology to the treacle protein (TCOF1) were disproportionately increased in progenitor cells, compared to their radiosensitive counterparts. (cdc.gov)
  • Silencing of TCOF1 expression (shRNA) radiosensitized progenitor cells, a response conserved in human cells with TCOF1 knockdown. (cdc.gov)
  • Collectively, these observations indicate that radiation resistance is an intrinsic property of c-Kithigh salivary gland progenitor cells. (cdc.gov)
  • Since human salivary gland stem cells with c-Kit expression are believed to have enhanced regenerative potencies, our model system provides a stable platform to investigate molecular features associated with c-Kit expression that may contribute to protection or stabilization of the stem cell niche. (cdc.gov)
  • Similarly, destruction of neonatally abundant pluripotent stem cells would likely have a more pervasive outcome than destruction of The value of incorporating immunologic appeared more severe and/or persistent when single lineages or differentiated cells that pre- data for the toxicologic assessment of drugs, the exposure occurred perinatally when com- dominate in adults. (cdc.gov)
  • Early fate decisions in hematopoietic stem and progenitor cells. (lu.se)
  • Progenitor stem cells found in the testicles. (bvsalud.org)
  • 2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)
  • 1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)
  • Mesenchymal Stem Cells (MSCs) can be isolated from several body tissues, including dental tissues. (bvsalud.org)
  • The aim of this paper is to provide a review about current and future materials for scaffolds to carry stem cells in tissue engineering in Dentistry, especially for bone tissue repair. (bvsalud.org)
  • Stem cells from dental tissues have a real potential in Advanced Therapies. (bvsalud.org)
  • The combination of inductive scaffold materials with stem cells might optimize the approaches for bone regeneration. (bvsalud.org)
  • The potential therapeutic use of stem cells has been broadly researched in recent years. (bvsalud.org)
  • The ability to restore cells and tissue function without the need of immunosuppressive drugs and without the concern for tissue compatibility makes Mesenchymal Stem Cells (MSCs, usual acronym) a strong promise for the future. (bvsalud.org)
  • Until now, several progenitor cells derived from dental tissues have been isolated and characterized ( table I ). (bvsalud.org)
  • Stem cells derived from dental tissues are isolated from specialized tissues and have a strong ability to give rise to other cell lines, but with a different potential of bone marrow stem cells 16 . (bvsalud.org)
  • For stem cells to be used in tissue engineering a scaffold is essential to provide the necessary support for the transport of nutrients, oxygen and the elimination of metabolic waste 30 , promoting a conducive environment for cell growth and differentiation. (bvsalud.org)
  • Stem cells are classified into two main: embryonic stem cells, which are found in the embryos and adult stem cells, found in adult tissues. (bvsalud.org)
  • Embryonic stem cells are present only in the early stages of development and are able to generate any cell type (Pluripotent Stem Cells). (bvsalud.org)
  • Adult stem cells are found in differentiated tissues and are able to generate specialized cells in some types of tissues (Multipotent Stem Cells). (bvsalud.org)
  • The stem cells from exfoliated deciduous teeth (SHEDs) have a great potential for therapeutic use because of its differentiation capability and its easy access, since the collection is performed at the physiological exfoliation stage of the deciduous teeth. (bvsalud.org)
  • A potentially pre-clinical aspect of this thesis is detailed in paper №4 where I describe a robust protocol for the generation of functional mesDA neurons from human embryonic stem cells that are functional in a rat model of PD. (lu.se)
  • Exercise enhances the proliferation of neural stem cells and neurite growth and survival of neuronal progenitor cells in dentate gyrus of middle-aged mice. (bvsalud.org)
  • ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)
  • The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)
  • Myelodysplastic syndrome (MDS) in childhood encompasses a diverse group of bone marrow disorders that share a common clonal defect of stem cells and that result in ineffective hematopoiesis with dysplastic changes in the marrow. (medscape.com)
  • Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. (ca.gov)
  • When faced with these environmental hazards, progenitors may deviate from their correct pathway or change their potential, leading to a reduction in the pool of progenitors available for later stages of differentiation. (elifesciences.org)
  • The team visualized endothelial differentiation step-by-step from the endoderm to the HSPC niche-constituting ECs via islet1+ endothelial progenitors by live imaging-based lineage tracing. (go.jp)
  • MSC-NPs consist of a subpopulation of bone marrow MSCs with neural progenitor and immunoregulatory properties, and a reduced capacity for mesodermal differentiation, suggesting that this cell population may be appropriate for clinical application in the CNS. (listlabs.com)
  • Hepatic differentiation was assessed based on increased albumin and hepatocyte nuclear factor 4α, as hepatocyte markers, and decreased cytokeratin 19 and SOX9, as stem/progenitor cell markers. (elsevierpure.com)
  • Self-renewal and differentiation are tightly controlled to maintain haematopoietic stem cell (HSC) homeostasis in the adult bone marrow 1,2 . (elsevierpure.com)
  • Rare hematopoietic stem and progenitor cell (HSPC) pools outside the bone marrow (BM) contribute to blood formation under stress and illness, but their functions are unknown. (physiciansweekly.com)
  • Hypoxia lessened the cellular stress response in both progenitors and HSCs, but the mitigation was more apparent in the HSC population (Fig. C, grey plots), and decreased apoptosis was observed only within the HSC-enriched cluster 5 (Fig. D). These findings are consistent with several reports indicating that HSCs are more vulnerable to strong ER stress than downstream progenitors due to their lower protein folding capacity. (confex.com)
  • Here we used in vivo genetic tracing in mice to analyse the formation of HSCs and progenitors from intra-arterial haematopoietic clusters, which contain HSC precursors and express the transcription factor hepatic leukaemia factor (HLF). (elsevierpure.com)
  • Through kinetic study, we observed the simultaneous formation of HSCs and defined progenitors-previously regarded as descendants of HSCs 5 -from the HLF + precursor population, followed by prompt formation of the hierarchical haematopoietic population structure in the fetal liver in an HSC-independent manner. (elsevierpure.com)
  • Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis" Cell Stem Cell Vol. 18 Iss. (bepress.com)
  • Signals that regulate epithelial regeneration upon stem cell injury are largely unknown. (nature.com)
  • C) We have identified that islet1 + endothelial progenitors originate from endoderm and finally differentiate into posterior venous ECs in a process dependent on Bmp-Smad signaling, requiring Npas4l-Etsrp function. (go.jp)
  • This scholarly research reveals that X-irradiation can boost continual intracellular ROS in human being Compact disc34+ HSPCs, which may not really derive from mitochondrial ROS because of mitochondrial dysfunction, and indicates that substantial DNA double-strand damage may decrease the stem cell function critically. (hiv-proteases.com)
  • MEPs derive from the common myeloid progenitor lineage. (wikipedia.org)
  • Figure 1 Rays doseCresponse curves of PF-04691502 human being umbilical myeloid hematopoietic progenitors. (hiv-proteases.com)
  • The full total amount of myeloid hematopoietic progenitors produced in both ethnicities was examined by calculating the full total cell amounts and colony amounts in the ethnicities at each incubation period. (hiv-proteases.com)
  • Table 2 The full total amounts of myeloid hematopoietic progenitors produced in liquid lifestyle. (hiv-proteases.com)
  • Desk 3 The structure ratios of myeloid hematopoietic progenitors in comparison to CFU-GM. (hiv-proteases.com)
  • The present results clearly demonstrate that ECs originating from the endoderm via islet1 + endothelial progenitors play a specialized role in forming a functional vascular HSPC niche (Figure 1C). (go.jp)
  • Their structure includes a Mesenchymal stem cell (MSCs), multi potent in nature and offer supportive, therapeutic and trophic functions. (issca.us)
  • This rubric exemplifies the utility of this cross-platform resource for deconvoluting the complexity of tran- scriptional programs controlling stem/progenitor cell fate in hematopoiesis. (lu.se)
  • Strategies to enhance endogenous alveolar epithelial repair could include protection of epithelial progenitors from injury and/or stimulation of endogenous progenitor cell function. (nih.gov)
  • These observations suggest that MSC-NPs may influence the rate of repair through effects on endogenous progenitors in the spinal cord. (listlabs.com)
  • Progenitors of the zebrafish laterality organ originate from the superficial epithelial enveloping layer by an apical constriction process of cell delamination. (elifesciences.org)
  • A single-cell resolution developmental atlas of hematopoietic stem and progenitor cell expansion in zebrafish. (bvsalud.org)
  • Here we demonstrate that interstitial mesenchymal progenitors respond to mechanical load and stimulate MuSC proliferation in a surgical mouse model of increased muscle load. (mdc-berlin.de)
  • Mechanistically, transcriptional activation of Yes-associated protein 1 (Yap1)/transcriptional coactivator with PDZ-binding motif (Taz) in mesenchymal progenitors results in local production of thrombospondin-1 (Thbs1), which, in turn, drives MuSC proliferation through CD47 signaling. (mdc-berlin.de)
  • One of the negative regulators of stem cell proliferation is the tetrapeptide Acetyl-Seryl-Aspartyl-Lysyl-Proline (AcSDKP). (st-andrews.ac.uk)
  • Murine mammary stem/progenitor cell isolation: Different method matters? (springeropen.com)
  • Murine mammary stem/progenitor cell isolation has been routinely used in many laboratories, yet direct comparison among different methods is lacking. (springeropen.com)
  • Murine mammary stem/progenitor cell isolation has been routinely used in many laboratories since the first two reports of mammary stem cell isolation in 2006 (Shackleton et al. (springeropen.com)
  • PDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium. (ox.ac.uk)
  • We have shown that in the stomach, stem cell homeostasis is regulated by Wnt and Rspo secreted by stromal myofibroblasts 11 . (nature.com)
  • Scholars@Duke publication: Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo. (duke.edu)
  • By genetically manipulating EVI1 expression, we were able to alter HSC and progenitor output from precursors in vivo. (elsevierpure.com)
  • Here, we uncovered a mechanism of progenitor cell allocation that stems from an incomplete process of epithelial delamination that allows progenitors to coordinate their movement with adjacent extra-embryonic tissues. (elifesciences.org)
  • During this process, progenitors retain long-lasting apical contacts that enable the epithelial layer to pull a subset of progenitors on their way to the vegetal pole. (elifesciences.org)
  • Hart, D.A. (2014) Why Mesenchymal Stem Cell/Progenitor Cell Heterogeneity in Specific Environments? (scirp.org)
  • Li, L. and Jiang, J. (2011) Regulatory Factors of Mesenchymal Stem Cell Migration into Injured Tissues and Their Signal Transduction Mechanisms. (scirp.org)
  • Stem cell-independent pathways during development thus offer a rational strategy for the rapid and simultaneous growth of tissues and stem cell pools. (elsevierpure.com)
  • Progenitor cell therapy may also allow functional reorganization of the auditory pathways including primary auditory cortex (Heschl's gyrus). (intechopen.com)
  • Using a novel, recombination-induced tag exchange-based genetic tool to birthdate and track the segregation of centrosomes over multiple cell divisions in human embryonic stem cell-derived regionalised forebrain organoids, we show the preferential inheritance of the older mother centrosome towards self-renewed NPCs. (elifesciences.org)
  • CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
  • Here, we will review the role of endothelial progenitor cells and of supporting proangiogenic cells and their products, principally in humans, as diagnostic and therapeutic agents for wound repair and tissue regeneration. (ox.ac.uk)
  • Circulating endothelial progenitor cells (EPCs) are increased in conditions associated with ischaemia and can potentially support angiogenesis and vasculogenesis. (bmj.com)
  • Endothelial progenitor cells (EPCs) 7 reside in the bone marrow and are found to some extent in the peripheral blood. (bmj.com)
  • Penn State researchers have recently developed small molecule-based methods of using human pluripotent stem cells (hPSCs) as a source to generate pancreatic progenitors (PPs) and insulin-producing beta cells for disease modeling and treatment of type 1 diabetes (T1D). (psu.edu)
  • For patients with depleted marrow HSPC reserves who may not respond well to EPAG treatment, de novo generation of HSPCs through induced pluripotent stem cells (iPSCs) offers a promising alternative. (nih.gov)
  • Her lab is interested in understanding the molecular mechanisms controlling lineage-specific differentiation of pluripotent stem cells, and applying this information to generate tissue-specific stem/progenitor cells endowed with in vivo regenerative potential. (stemcellpodcast.com)
  • NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells. (harvard.edu)
  • Although the regenerative potential of adult skeletal muscle is maintained by satellite cells, other stem/progenitor cell populations also reside in skeletal muscle. (nih.gov)
  • Adult tendon stem/progenitor cells (TSPCs) are essential for tendon maintenance, regeneration, and repair, yet they become susceptible to senescence with age, impairing the self-healing capacity of tendons. (sens.org)
  • Aging of tissue-resident adult stem/progenitor cells and their pathological consequences. (nih.gov)
  • The fascinating discovery of tissue-resident adult stem/progenitor cells in recent years led to an explosion of interest in the development of novel stem cell-based therapies for improving the regenerative capacity of these endogenous immature cells or transplanted cells for the repair of damaged and diseased tissues. (nih.gov)
  • In counterbalance, a growing body of evidence has revealed that the changes in phenotypic and functional properties of human adult stem/progenitor cells may occur during chronological aging and have severe pathological consequences. (nih.gov)
  • Especially, intense oxidative and metabolic stress and chronic inflammation, enhanced telomere attrition and defects in DNA repair mechanisms may lead to severe DNA damages and genomic instability in adult stem/progenitor cells with advancing age that may in turn trigger their replicative senescence and/or programmed cell death. (nih.gov)
  • This age-associated decline in the regenerative capacity and number of functional adult stem/progenitor cells may increase the risk to develop certain diseases. (nih.gov)
  • Therefore, the rescue or replacement of aged and dysfunctional endogenous adult stem/progenitor cells or molecular targeting of their malignant counterpart, cancer stem/progenitor cells may constitute potential anti-aging and cancer therapies. (nih.gov)
  • This view has been radically changed due to the discovery of resident cardiac stem and progenitor cells in the adult mammalian heart. (imrpress.com)
  • Most likely, the different putative adult cardiac stem and progenitor cells represent different developmental and/or physiological stages of a unique resident adult cardiac stem cell. (imrpress.com)
  • Scientists have been actively pursuing the study of these cells, known as neural progenitor cells, since they were first spotted in the adult human brain several years ago. (nih.gov)
  • It's amazingly cool that we can dial adult cells all the way back to embryonic-like stem cells, but there are a lot of issues that still need to be addressed before iPS cells can be used to treat patients," said Evan Y. Snyder, M.D., Ph.D., director of Sanford-Burnham's Stem Cells and Regenerative Biology Program and corresponding author of the study. (sbpdiscovery.org)
  • Finally, we studied the adult human brain for the presence of progenitor cells with migratory characteristics. (5dok.org)
  • Despite advances in ex vivo expansion of cord blood-derived hematopoietic stem/progenitor cells (CB-HSPC), challenges still remain regarding the ability to obtain, from a single unit, sufficient numbers of cells to treat an adolescent or adult patient. (nih.gov)
  • A better understanding of the origin, biology and physiology of the myocardial stem and progenitor cells will impact the development of regenerative medicine as an effective therapy for heart disease and failure. (imrpress.com)
  • The Laboratory of Regenerative Therapies for Inherited Blood Disorders, led by Dr. Andre Larochelle, is investigating novel strategies and stem cell concepts that can help advance the translational regenerative field, with a focus on inherited disorders affecting blood-forming hematopoietic stem cells (HSCs). (nih.gov)
  • The program aims to harness the regenerative potential of hematopoietic stem cells (HSCs), which are the cornerstone of the body's blood-forming system. (nih.gov)
  • Dr. Rita Perlingeiro is the Lillehei Professor in Stem Cell and Regenerative Cardiovascular Medicine at the Lillehei Heart Institute. (stemcellpodcast.com)
  • Lymphoid Progenitor Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Lymphoid Progenitor Cells" by people in Harvard Catalyst Profiles by year, and whether "Lymphoid Progenitor Cells" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Lymphoid Progenitor Cells" by people in Profiles. (harvard.edu)
  • Long-term lymphoid progenitors independently sustain naïve T and NK cell production in humans. (harvard.edu)
  • Conditional Immortalization of Lymphoid Progenitors via Tetracycline-Regulated LMO2 Expression. (harvard.edu)
  • Direct role of FLT3 in regulation of early lymphoid progenitors. (harvard.edu)
  • Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors. (harvard.edu)
  • Although previous studies have shown that yolk-sac-derived erythromyeloid progenitors and HSCs emerge from distinct populations of HE, it remains unknown whether the earliest lymphoid-competent progenitors, multipotent progenitors, and HSCs originate from common HE. (github.io)
  • Incubation of embryoid bodies derived from mouse embryonic stem cells with VEGF-A induces formation of VE-cadherin-positive ECs, whereas platelet-derived growth factor promotes the development of smooth muscles. (medscape.com)
  • Mature mouse ECs from embryonic stem cells contribute to neoangiogenesis [ 41 ] . (medscape.com)
  • Similarly, CD133 + angioblasts derived from human embryonic stem cells differentiate into mature human ECs and contribute to neoangiogenesis in immunocompromised mice [ 67 ] . (medscape.com)
  • Given the current restrictions on using human embryonic stem cells, therapeutic cloning for generation of transplantable human EPCs is not a viable option. (medscape.com)
  • Human embryonic stem cells (hESCs) and hESC-derived neural progenitors (NPs) may provide a number of new ways for studying and treating diseases and injuries in the brain. (5dok.org)
  • Full Text HL-96-020 HOMING DETERMINANTS IN HEMATOPOIETIC STEM/PROGENITOR CELLS NIH GUIDE, Volume 25, Number 24, July 19, 1996 RFA: HL-96-020 National Heart, Lung, and Blood Institute National Institute of Diabetes and Digestive and Kidney Diseases P.T. 34 Keywords: Biology, Cellular Immunology Letter of Intent Receipt Date: September 25, 1996 Application Receipt Date: October 25, 1996 THIS RFA USES "MODULAR GRANT" AND "JUST-IN-TIME" CONCEPTS. (nih.gov)
  • This review outlines the biology of stem/progenitor cells derived from the articular cartilage, the synovial membrane, and the synovial fluid, including their tissue distribution, function and biological characteristics. (unboundmedicine.com)
  • Global analysis of stem/progenitor cells promises brand-new insight into mechanisms that govern self-renewal and mobile potential an unresolved question of stem/progenitor cell biology. (ecolowood.com)
  • The purpose of the workshop was to discuss and identify potential areas of the auditory and vestibular systems that might be good candidates for applications being used in other reparative medicine systems, one being the potential use of stem cell biology. (nih.gov)
  • The workshop panel was composed of a diverse group of experts from auditory and vestibular systems as well as tissue engineers using aspects of stem cell biology in other reparative systems. (nih.gov)
  • Patient conditioning is a critical initial step in hematopoietic stem and progenitor cell (HSPC) transplantation procedures to enable marrow engraftment of infused cells. (nih.gov)
  • Deletion of CCR5 renders cells resistant to R5-tropic HIV-1 infection, and the potential for cure has been shown through allogeneic stem cell transplantation with naturally occurring homozygous deletion of CCR5 in donor hematopoietic stem/progenitor cells (HSPC). (ca.gov)
  • In colony forming unit (CFU) progenitor assays, ¿-irradiated HSPCs cultured with eltrombopag or TPO yielded 4- to 6-fold more CFUs than control SF groups, indicating increased HSPC survival in the presence of eltrombopag or TPO. (nih.gov)
  • Rare hematopoietic stem and progenitor cell (HSPC) pools outside the bone marrow (BM) contribute to blood production in stress and disease but remain ill-defined. (kumamoto-u.ac.jp)
  • Cite this: Therapeutic Stem and Progenitor Cell Transplantation for Organ Vascularization and Regeneration - Medscape - Jun 01, 2003. (medscape.com)
  • Fibro-adipogenic progenitor cells (FAPs) and muscle stem cells (MuSCs) play critical roles in muscle repair and regeneration. (nih.gov)
  • Mesenchymal stem/progenitor cells are promising graft cells for tissue regeneration, but the most suitable source of cells for cartilage repair remains controversial. (unboundmedicine.com)
  • Victoria Ptasinski defended her Ph.D. thesis 'Alveolar Progenitor Cells in Lung Damage and Regeneration in Pulmonary Fibrosis' on Monday, November 27, 2023. (lu.se)
  • We show that, during development, AT1 and AT2 cells arise directly from a bipotent progenitor, whereas after birth new AT1 cells derive from rare, self-renewing, long-lived, mature AT2 cells that produce slowly expanding clonal foci of alveolar renewal. (nih.gov)
  • Earlier studies suggested that the development of new neurons from progenitor cells, called neurogenesis, is disrupted in a wide range of disorders. (nih.gov)
  • The VZ progenitors produce all the GABAergic neurons and glial cells of the cerebellum, whereas the RL progenitors generate all the glutamatergic neuronal subtypes [ 13 ]. (biomedcentral.com)
  • We identified interleukin-6 (IL-6) trans-signaling as a pathway that (i) activates normal and premalignant cells, (ii) induces a proliferative stem/progenitor-like phenotype in mammary epithelial cells, and (iii) whose activation in DCCs depends on regulatory niche cells in BM. (nature.com)
  • In ALS mice, neurodegeneration is associated with the proliferative restorative attempts of ependymal stem progenitor cells (epSPCs) that normally lie in a quiescent in the spinal cord. (unimib.it)
  • This research establishes an over-all technique for isolation of somatic stem/progenitor cells and a transcriptome data source of neural progenitor cells helpful for id of causal elements of neural progenitor cell condition global dissection of epigenetic control of mobile potential aswell for developing biomarkers AG 957 or goals of brain cancer tumor stem/initiating cells for healing interventions. (ecolowood.com)
  • Such studies will undoubtedly have a major impact on our ability to identify the factors that are involved in such critical functions such as stem cell self-renewal, maintenance of progenitor cells, bone marrow and stem cell engraftment, and graft maintenance and rejection. (nih.gov)
  • Prior studies have also suggested that skeletal stem and progenitor cells (SSPCs) localize to the surrounding periosteum and serve as a major source of marrow associated SSPCs, osteoblasts, osteocytes, and adipocytes during skeletal development. (elifesciences.org)
  • CD34 is a glycosylated transmembrane protein and represents a well-established marker for human hematopoietic stem and progenitor cells in peripheral blood, bone marrow, and cord blood. (cgt.global)
  • The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
  • With the addition of a single gene, the team instructed neural progenitor cells - a type of brain cell that can generate other types of brain cells - to self-renew in a laboratory dish. (sbpdiscovery.org)
  • There has been a surge of interest in developing cell-based therapies, focused particularly on the use of mesenchymal stem/progenitor cells with or without scaffolds. (unboundmedicine.com)
  • The team envisions that this ICSP approach will also extend to progenitor cells obtained from other organs, such as heart, pancreas, or muscle, potentially accelerating the use of stem cell therapies for a broad range of diseases. (sbpdiscovery.org)
  • Here we use molecular markers, lineage tracing and clonal analysis to map alveolar progenitors throughout the mouse lifespan. (nih.gov)
  • Classical BCR-ABL-negative myeloproliferative neoplasms (MPN) are clonal disorders of hematopoietic stem cells (HSC) caused mainly by recurrent mutations in genes encoding JAK2 (JAK2), calreticulin (CALR), or the thrombopoietin receptor (MPL). (santafe.edu)
  • We measured several times per year the clonal architecture of early and late hematopoietic progenitors (84,845 measurements) and the global variant allele frequency in mature cells (409 measurements). (santafe.edu)
  • Moreover, our results show that clonal expansion of progenitor cells provides a window in which collaborating mutations can accumulate to drive disease progression. (altmetric.com)
  • Thus, we have changed from a view of the heart as a static tissue to an organ with the highest number of tissue- specific stem cell populations. (imrpress.com)
  • FACS-isolation and Culture of Fibro-Adipogenic Progenitors and Muscle Stem Cells from Unperturbed and Injured Mouse Skeletal Muscle. (nih.gov)
  • The prospective isolation of hematopoietic stem cells (HSC) from mouse and man has allowed us to learn much about their characteristics upon transplantation. (nih.gov)
  • We present proof that differential labeling of AG 957 neural progenitor cells and their progeny allows prospective purification of the two cell types whereas isolation predicated on an individual marker compromises the purity from the designed progenitor people. (ecolowood.com)
  • Outcomes A hereditary dual reporter program for neural progenitor cell isolation To get over the issue of potential progenitor reporter retention within a progeny we've devised a hereditary differential cell tagging strategy AG 957 having a progenitor cell particular promoter together with a promoter of an early on progeny to operate a vehicle. (ecolowood.com)
  • Abnormal cerebellar lobe formation, found in Jun dimerization protein 2 ( Jdp2 )-knockout (KO) mice, is related to increased antioxidant formation and a reduction in apoptotic cell death in granule cell progenitors (GCPs). (biomedcentral.com)
  • Although these data challenge fundamental beliefs, the quantitative contributions of HSC and progenitors to cell lineages could not be tracked in individual mice or persons over time. (ashpublications.org)
  • Despite this, the endothelial lineage, its origin, and the regulation of endothelial development and function either intrinsically from stem cells or extrinsically by proangiogenic supporting cells and other elements within local and specific microenvironmental niches are still not fully understood. (ox.ac.uk)
  • Second, extramedullary stem cells/multipotent progenitors (HSC/MPPs) from spleen, PB and mPB share a common transcriptional signature and increased abundance of lineage-primed subsets compared to BM. (kumamoto-u.ac.jp)
  • Neurogenesis and Proliferation of Neural Stem/Progenitor Cells Conferred by Artesunate via FOXO3a/p27Kip1 Axis in Mouse Stroke Model. (stembook.org)
  • The consequences of activating tyrosine kinase mutations for stem and progenitor cell behavior are unclear. (altmetric.com)
  • She informed the group this workshop was not the forum to discuss ethical or developmental differences regarding stem cells themselves, but rather to focus attention on identifying and assessing areas of auditory and vestibular research potentially primed for reparative applications. (nih.gov)
  • We propose that local signals regulate AT2 stem-cell activity: a signal transduced by EGFR-KRAS controls self-renewal and is hijacked during oncogenesis, whereas another signal controls reprogramming to AT1 fate. (nih.gov)
  • Neural stem and progenitor cells (NSCs) have traditionally been cultured using the neurosphere system. (stemcell.com)
  • It has been reported that NSCs cultured under adherent conditions in the presence of extracellular matrices undergo symmetrical divisions in long term cultures maintaining a more "pure" population of stem cells, as opposed to the heterogeneous population of cells present in neurospheres. (stemcell.com)
  • RNA-seq analysis shows that genes previously shown to be differentially expressed in OL progenitors are significantly enriched in RNA from Nfix(-/-) versus wild-type NSCs. (crick.ac.uk)