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  • nonalcoholic
  • Nonalcoholic fatty liver disease is a common condition associated with metabolic syndrome. (aafp.org)
  • Although treatment of metabolic syndrome with statins, metformin (Glucophage), glitazone medications, and lifestyle changes may improve histologic and physiologic endpoints in patients with nonalcoholic fatty liver disease, use of these medications is not recommended solely as a treatment for this disease. (aafp.org)
  • infiltration
  • It is the most common cause of elevated liver enzymes in U.S. adults, and is diagnosed after ruling out other causes of steatosis (fatty infiltration of liver), particularly infectious hepatitis and alcohol abuse. (aafp.org)
  • adipose
  • Whereas liver-specific 11β-HSD1 KO mice developed a full Cushingoid phenotype, adipose-specific 11β-HSD1 KO mice were protected from hepatic steatosis and circulating fatty acid excess. (pnas.org)
  • These data challenge our current view of GC action, demonstrating 11β-HSD1, particularly in adipose tissue, is key to the development of the adverse metabolic profile associated with circulating GC excess, offering 11β-HSD1 inhibition as a previously unidentified approach to treat Cushing syndrome. (pnas.org)
  • M2-type ATMs predominate in lean mice, whereas obesity induces the accumulation of M1-type ATMs with high expression of TNF-α, IL-6, and inducible nitric oxide synthase (iNOS), leading to a proinflammatory environment in white adipose tissue (WAT). (diabetesjournals.org)
  • Although BMI and waist circumference (WC) have traditionally been used as proxies for obesity, recent studies have suggested that abdominal visceral adipose tissue (VAT) area measured by CT might be a better indicator than BMI or WC for the risk of developing colorectal neoplasm [ 5 - 7 ]. (irjournal.org)
  • obese
  • Multiple cognitive domains are affected by metabolic syndrome in adults and in obese adolescents, with volume losses in the hippocampus and frontal lobe, affecting executive function. (mdpi.com)
  • In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY). (labome.org)
  • basal
  • Cachexia is characterized by increased muscle protein degradation, elevated basal metabolic rate and total energy expenditure, and either no change or reduction in FM . (deepdyve.com)
  • patients
  • characterize carotid atherosclerotic lesions in patients with metabolic syndrome. (sld.cu)
  • a prospective descriptive study was conducted of 128 patients with a clinical diagnosis of metabolic syndrome. (sld.cu)
  • Patients with metabolic syndrome have a higher likelihood of fatty liver disease and are at greater risk of having progressive liver disease. (apollohospitals.com)
  • 5 ) identify a syndrome characterized by the association of fatty liver and lobular hepatitis and chronically elevated alanine aminotransferase plasma levels in patients with negligible alcohol intake. (diabetesjournals.org)
  • A consequence of this is the progressive increase in the number of patients undergoing surgery related to medical complications of obesity-in particular weight loss (bariatric), cardiac, and orthopaedic surgery. (asahq.org)
  • In patients with familial hypobetalipoproteinaemia (FHBL), hepatic steatosis is a direct consequence of impaired hepatic VLDL excretion, independently of metabolic derangements. (springer.com)
  • ¹H-MRS showed moderate to severe hepatic steatosis in patients with FHBL. (springer.com)
  • Loss of weight in cancer patients cannot be easily reversed by standard nutritional interventions and treatment directed at normalizing underlying metabolic abnormalities is critical in order to utilize nutrients effectively . (deepdyve.com)
  • lipid
  • The liver plays a central role in lipid metabolism, importing serum free fatty acids and manufacturing, storing and exporting lipids and lipoproteins. (cmaj.ca)
  • Expert consensus definition of cancer cachexia highlights metabolic abnormalities resulting in altered glucose, lipid, and protein metabolism . (deepdyve.com)
  • ultrasonography
  • Carotid echo-Doppler was performed to describe intima media thickness, location and type of atheromatous plaques, stenosis degree and atherogenic index, followed by liver ultrasonography for steatosis and details about its extent. (sld.cu)
  • Overweight
  • To develop an internationally acceptable definition of child overweight and obesity , specifying the measurement, the reference population, and the age and sex specific cut off points. (labome.org)
  • fatty acid
  • Like the hypothalamus, we have shown that skeletal muscle also becomes resistant to leptin in obesity ( 14 , 15 ), which is characterized by an impaired ability of leptin to increase fatty acid oxidation via the AMP-activated protein kinase (AMPK) ( 16 ). (diabetesjournals.org)
  • pancreas
  • However, the discovery that clock genes can regulate circadian rhythmicity in vitro in other central as well as peripheral tissues, including those involved in nutrient homeostasis (e.g., mediobasal hypothalamus, liver, muscle, and pancreas), indicates that circadian and metabolic processes are linked at multiple levels ( 4 - 9 ). (sciencemag.org)
  • diet-induced
  • SOCS3 heterozygous mice ( 12 ) or those with SOCS3 deleted in hypothalamic neurons ( 13 ) have reduced appetite and are protected from development of diet-induced obesity attributable to enhanced hypothalamic leptin sensitivity within proopiomelanocortin-expressing neurons ( 11 ). (diabetesjournals.org)