Key Points Hif-2α-dependent signaling is dispensable for steady-state multilineage hematopoiesis. (ox.ac.uk)
In vivo, Nlrp10 signaling is dispensable during steady state but becomes functional during autoinflammation in antagonizing mucosal damage. (biomed.news)
HSCs4
Definitive hematopoiesis - multipotent HSCs appear (occurs through the majority of human lifetime). (wikipedia.org)
HSCs are thought to be a reserve population residing in a deeply quiescent ("dormant") state that protects them from metabolic and proliferative stress. (digs-bb.de)
We first review the existing literature describing FAO in HSCs under steady-state hematopoiesis. (jax.org)
Next, we describe the models used to examine HSCs under stress conditions, and, finally, we describe how infection causes a shift toward FAO in HSCs and the impact of using this pathway on emergency hematopoiesis. (jax.org)
Adult2
Similar to tissue-resident macrophages, mast cells are of dual ontogeny and are generated during both fetal and adult ("definitive") hematopoiesis. (digs-bb.de)
Studies using radiation chimeras and parabiotic mice demonstrated that monocytes only populate tissue-resident macrophages in a few organs during steady-state conditions in adult mice. (musculoskeletalkey.com)
Fetal1
There are 2 types of hematopoiesis that occur in humans: Primitive hematopoiesis - blood stem cells differentiate into only a few specialized blood lineages (typically isolated to early fetal development). (wikipedia.org)
Differentiation6
Hematopoiesis involves a series of differentiation steps from one progenitor cell to a more committed cell type, forming the recognizable tree seen in the adjacent diagram. (wikipedia.org)
This study demonstrates that MAPCs can be cultivated as aggregates in an undifferentiated state for at least 16 days, as levels of a number of transcripts, including Oct4, remained similar, Oct4 protein was unchanged, and differentiation to neural progenitor, endothelial cell and hepatocyte like cells was retained. (bvsalud.org)
To investigate the proliferation and differentiation of hematopoietic stem and progenitor cells in their physiologic environment, we use state-of-the-art mouse models. (digs-bb.de)
However, it is not known if this coherent mode of action between miRNAs and the transcriptional program is maintained in non-steady state situations like cell differentiation. (smallrna-bioinformatics.eu)
Moreover, pseudo-time analysis demonstrates that miRNA-mediated regulation acts in concert with the transcriptional regulation of their targets in the continuum of non-steady states of differentiation occurring in hematopoiesis. (smallrna-bioinformatics.eu)
In both cases, we observe a coherent mode of action between miRNA and transcriptional program, as it was described for steady state situations, except that now pseudo-time analysis allows us to see that one program dominates more than other depending on how far along the differentiation path the cell is. (smallrna-bioinformatics.eu)
Progenitors2
CD49d blockade by natalizumab in patients with multiple sclerosis affects steady-state hematopoiesis and mobilizes progenitors with a distinct phenotype and function. (jamanetwork.com)
Lee and colleagues investigated the role of the intestinal microbiota in steady-state hematopoieisis, demonstrating that microbiota-derived DNA circulates to the bone marrow, where uptake by mononuclear cells leads to inflammatory cytokine production favoring myeloid-cell maturation of hematopoietic progenitors. (ashpublications.org)
Metabolic1
Metabolic regulation of hematopoiesis is dynamically regulated under steady-state and stress conditions. (jax.org)
Definitive1
Definitive hematopoiesis then occurs later in the aorta-gonad-mesonephros (AGM), a region of embryonic mesoderm that develops into the ventral wall of the dorsal aorta, at E10.5 in mice and 4wpc (4 weeks post-conception) in humans. (wikipedia.org)
HSPCs2
Hematopoietic stem and progenitor cells (HSPCs) sustain life-long hematopoiesis and are first detected in the embryo by transplantation at embryonic day 10.5 (E10.5). (qmul.ac.uk)
To begin, unlike continuously dividing BM HSPCs, they observed no evidence of significant continuing hematopoiesis in extramedullary tissues at a steady-state, although they did find enhanced splenic HSPC proliferative output during stress erythropoiesis. (physiciansweekly.com)
Primitive2
Primitive hematopoiesis is first found in the blood islands (Pander's islands) of the yolk sac at E7.5 (embryonic day 7.5) in mice and 30dpc (30 days post-conception) in humans. (wikipedia.org)
Although steady-state conditions revealed no increase in primitive cell proliferation in p21-null mice, a significantly larger fraction of quiescent neural precursors was activated in the hippocampus and subventricular zone after brain ischemia. (rupress.org)
Commensal2
The intestinal mucosa establishes state of hypo-responsiveness against commensal bacteria and of active readiness against pathogens. (nature.com)
14 , 16 However, under steady-state conditions, lack of TLR signaling in MyD88 −/− mice results in more intestinal IgA production compared with that in WT mice after colonization with commensal bacteria, which has been considered as a mechanism functionally compensating for innate immune deficiency in the clearance of invading microbiota. (nature.com)
Contribution1
Mouse models for fate mapping and proliferation tracking allow investigating the contribution of HSC to native hematopoiesis. (digs-bb.de)
Mice1
Under steady-state conditions, mice without MiR144 or MiR451 can just about produce enough red blood cells, but if you challenge them, by chemically inducing anaemia, most of them don't survive, because in those conditions you just can't live with inefficient red blood cell formation" O'Carroll explains. (embl.org)
Fundamental1
The model was able to recapitulate the fundamental steady-state features of haematopoiesis and simulate the re-establishment of steady-state conditions after haemorrhage and bone marrow transplantation. (lu.se)
Functional1
Recent lineage tracing analyses revealed MPPs to be major functional contributors to steady-state hematopoiesis. (thekanglab.org)
Proliferation1
Using our fate mapping and proliferation reporter mouse models, we recently investigated how native hematopoiesis responds to systemic inflammation or blood loss (Munz et al. (digs-bb.de)
Conditions2
Steady-state dynamics are governed by cell division and commitment rates as well as by population sizes, while feedback components guarantee the restoration of steady-state conditions. (lu.se)
While being much smaller compartments than MPP4 at steady-state, MPP2 and MPP3 are transiently expanded in regenerative conditions and are essential for rebuilding the myeloid lineage. (thekanglab.org)
Goals1
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. (lu.se)
Divide2
A combination of literature data, a novel divide et impera approach for steady-state calculations and stochastic optimization allowed one to reduce possible configurations of the system. (lu.se)
At steady-state, HSC infrequently divide and slowly but continuously spawn rapidly dividing progenitor cells. (digs-bb.de)
Process called1
A very high number of different types of blood cells must be generated daily through a process called haematopoiesis in order to meet the physiological requirements of the organism. (lu.se)
Maintenance2
As these cells are short-lived, there needs to be a steady turnover of new blood cells and the maintenance of an HSC pool. (wikipedia.org)
G-CSF plays an important role in defense against infection, in inflammation and repair, and in the maintenance of steady state hematopoiesis. (rndsystems.com)
Blood4
The pioneering work of Till and McCulloch in 1961 experimentally confirmed the development of blood cells from a single precursor hematopoietic stem cell (HSC), creating the framework for the field of hematopoiesis to be studied over the following decades. (wikipedia.org)
Our goal is to understand how blood formation proceeds in mammals, which factors govern and control this and how dysregulation of hematopoiesis leads to disease. (digs-bb.de)
A lot of the effort of blood cell formation, or haematopoiesis, goes into just keeping enough red blood cells in circulation" says Dónal O'Carroll, who led the work at EMBL Monterotondo: "We've identified two molecules that help to do so, and which are essential in challenging situations. (embl.org)
Overview of the hematopoietic blood cell production process (image created by Sigward Söderström and Helene Johansson, Örebro University Hospital, Sweden), which is growth factor-dependent and strictly regulated to maintain steady-state blood levels. (boule.com)
Role1
In this thesis, the role of HOXB4 in hematopoiesis is explored through gain-of-function and lack-of-function approaches. (dissertations.se)
Cells1
Here we identify two stage-specific enhancers: the proximal enhancer mediates the constitutive CCL5 expression during the steady state, while the distal enhancer located 1.35 Mb from the promoter induces CCL5 expression in activated cells. (nature.com)
University1
1 Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Guangzhou, China. (jci.org)
We are investigating native hematopoiesis following mutations that either reduce genome replication fidelity or predispose to leukemia development. (digs-bb.de)
Factors1
The aims of the study were to determine if hepcidin is associated with severity of steady-state anemia in SCD and to investigate factors associated with hepcidin and anemia in SCD. (ox.ac.uk)
Levels1
Decreased Hepcidin Levels Are Associated with Low Steady-state Hemoglobin in Children With Sickle Cell Disease in Tanzania. (ox.ac.uk)
Environment1
Many pathological states can arise from disturbances in this niche environment, highlighting its importance in maintaining hematopoiesis. (wikipedia.org)
Analysis1
For the analysis and modeling of our experimental data, we collaborate with theoretical scientists to achieve a more quantitative interpretation of native haematopoiesis. (digs-bb.de)
Population1
Single-cell RNA-seq unmasked the existence of two subsets within the LT-HSC population that was apparent upon stimulation but not steady-state. (biorxiv.org)