• We found that pharmacologic inhibition of STAT3 or its selective knockout in cancer cells improved the tumor growth-inhibitory efficacy of anthracycline-based chemotherapies. (aacrjournals.org)
  • This combined effect of STAT3 inhibition/depletion and anthracyclines was only found in tumors growing on immunocompetent (not in immunodeficient) mice. (aacrjournals.org)
  • Finally, they suggest that future immunotherapeutic protocols for this type of lymphoma may need to include the inhibition of NPM/ALK and STAT3 to achieve optimal clinical efficacy. (pnas.org)
  • These observations also provide a different rationale to therapeutically target NPM/ALK and STAT3 in ALK+TCL, and suggest that NPM/ALK inhibition may become a part of future vaccination-based therapies. (pnas.org)
  • STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130. (pharmakb.com)
  • As compared with Stat3 -sufficient control tumors, Stat3 −/− cancer cells exhibited an increased infiltration by dendritic cells and cytotoxic T lymphocytes after chemotherapy. (aacrjournals.org)
  • Bioinformatic analysis and luciferase assay exhibited that ISL-1 was a novel target of p-STAT3 and p-c-jun. (nih.gov)
  • STAT3 binds to the CD274 gene promoter in vitro and in vivo , as shown in the gel electromobility shift and chromatin immunoprecipitation assays, and is required for the PD-L1 gene expression, as demonstrated by siRNA-mediated STAT3 depletion. (pnas.org)
  • Further drug resistance mechanisms analyzed study was the tumor suppressor TP53 and the epidermal growth factor receptor (EGFR). (thefreelibrary.com)
  • Using a T cell transfer model of colitis, we found that STAT3 expression in T cells was essential for the induction of both colitis and systemic inflammation. (ox.ac.uk)
  • Various ligands, including interferons and growth factors, induce activation of the JAK kinases, which induce Stat activation. (vectorbiolabs.com)
  • Despite recent data linking STAT3 with inflammatory bowel disease, exactly how it contributes to chronic intestinal inflammation is not known. (ox.ac.uk)
  • Innate immune sensors detect not only pathogen- but also host-derived factors such as nucleic acids and cause inflammatory responses. (nii.ac.jp)
  • Similar binding affinities of AKT, MEK1, MEK2, STAT3 and mTOR were calculated for honokiol (range from -9.0 [+ or -]0.01 to 7.40 [+ or -]0.01 kcal/mol) compared to corresponding control inhibitor compounds for these signal transducers. (thefreelibrary.com)
  • The endoderm sends a fibroblast growth factor (FGF) signal to specify the notocord and the mesenchyme fates. (wikipedia.org)
  • 2010). We used the opportunity presented by STAT3 mutant AD-HIES patients to examine the role of STAT3 in the 1561178-17-3 supplier generation and maintenance of lymphocyte memory. (immune-source.com)
  • C, immunohistochemical analysis for phosphorylated STAT3, Akt, and ERK (with nuclear localization) in representative specimens from xenograft human squamous cell carcinomas. (nih.gov)
  • Specifically, the team found that activated STAT3 inhibited stathmin, a protein that normally destabilizes microtubules. (newswise.com)
  • Thus, STAT3 orchestrates multiple critical aspects of T cell function in inflammation and homeostasis. (ox.ac.uk)
  • A, western blot for phosphorylated and total STAT3, Akt, and ERK in HeLa serum-starved overnight and exposed to HDMEC conditioned medium (CM), HeLa CM, or control unconditioned medium (EBM) for the indicated time points. (nih.gov)
  • Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to Human STAT3 aa 700 to the C-terminus. (abcam.com)