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  • pathway
  • Xanthatin inhibits corneal neovascularization by inhibiting the VEGFR2-mediated STAT3/PI3K/Akt signaling pathway. (abcam.cn)
  • A Novel Tumor-promoting Mechanism of IL6 and the Therapeutic Efficacy of Tocilizumab: Hypoxia-induced IL6 Is a Potent Autophagy Initiator in Glioblastoma via the p-STAT3-MIR155-3p-CREBRF Pathway. (abcam.co.jp)
  • This mHJV can be an essential aspect in the iron regulatory pathway of hepcidin manifestation and represents itsconnection to BMP-SMAD pathway. (research-matters.net)
  • pathways
  • Hepcidin production is mainly regulated at transcriptional level by several signalling pathways . (pubmedcentralcanada.ca)
  • Hereditary defects of the proteins involved in hepcidin regulatory pathways are responsible for the different forms of Hereditary Hemochromatosis (HH, OMIM#235200) , . (pubmedcentralcanada.ca)
  • Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis. (abcam.co.jp)
  • synthesis
  • Our findings suggest that the deregulation of hepcidin synthesis in the liver may be one of the underlying mechanisms of iron overload observed in ALD. (grantome.com)
  • We conducted a proof-of-concept study to assess the effect of curcuma on hepcidin synthesis in human. (archives-ouvertes.fr)
  • In vitro study showed that THAL sera down-regulated, HFE -HH and C-NAFLD sera up-regulated hepcidin synthesis. (pubmedcentralcanada.ca)
  • Thalassemia syndromes (OMIM #613985) and other anemias with ineffective erythropoiesis are characterised by marked reduction of hepcidin synthesis caused by a still unidentified erythroid signal , . (pubmedcentralcanada.ca)
  • phosphorylation
  • STAT3 is definitely controlled by Janus kinases (JAK) via phosphorylation of a conserved tyrosine residue near the C-terminus . (neuroart2006.com)
  • Both the tyrosine phosphorylation and DNA-binding activity of the transcription element, STAT3 101917-30-0 manufacture offers been demonstrated to become activated by ceramide in a JAK-dependent manner in cultured fibroblast cells . (neuroart2006.com)
  • Anemia
  • Obesity increased hepcidin levels and was associated with diminished response to oral iron therapy in childhood iron deficiency anemia. (biomedcentral.com)
  • agonists
  • Hepcidin/Fpn-mediated transcription is anti-inflammatory and can reduce toxicity due to activation of TLR by agonists such as LPS, turpentine, and poly(I:C). (pubmedcentralcanada.ca)
  • These data led us to suggest that therapeutics that could increase hepcidin levels or act as hepcidin agonists might help treat the abnormal iron absorption in individuals with β-thalassemia and related disorders. (jci.org)
  • genes
  • The changes in transcript levels for half of these genes were a direct effect of hepcidin, as shown by cycloheximide insensitivity, and dependent on the presence of Stat3. (pubmedcentralcanada.ca)
  • Here we demonstrate that activation of Jak2, through binding of hepcidin to Fpn, results in Stat3-mediated transcriptional activation of a large number of genes. (pubmedcentralcanada.ca)
  • transcript
  • Hepcidin-mediated transcriptional changes modulated LPS-induced transcription in both cultured macrophages and in vivo mouse models, as demonstrated by suppression of IL-6 and TNF-α transcript and secreted protein. (pubmedcentralcanada.ca)
  • We found that treatment with the isoflavone, genistein, from 28-52 hours postfertilization in zebrafish embryos enhanced Hepcidin transcript levels, as assessed by whole-mount in situ hybridization and quantitative real-time reverse-transcriptase polymerase chain reaction. (edu.au)
  • adipose
  • In overly obese individuals undergoing bariatric surgery, a relationship between adipose tissue-derived IL-6, and elevated hepcidin appearance in adipose cells offers been demonstrated . (neuroart2006.com)
  • liver
  • We have demonstrated that alcohol-induced oxidative stress down-regulates hepcidin transcription without causing changes in liver histology or an increase in triglycerides. (grantome.com)
  • Hepcidin is a circulatory peptide synthesized in the liver. (grantome.com)
  • Thus, alcohol may compromise this protective mechanism of hepcidin, which may have implications for alcoholic liver disease (ALD). (grantome.com)
  • The peptide hormone hepcidin is produced in the liver and promotes hypoferremia by simulating degradation of the iron channel ferroportin, thus reducing both the uptake of dietary iron and the release of iron into the bloodstream by the macrophages that recycle red blood cells. (sciencemag.org)
  • vivo
  • Target specificity, in vivo pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma. (abcam.co.jp)
  • infection
  • In infection hepcidin hides iron in its shops from bacteria which have high-affinity iron-binding siderophores for retrieving iron from hosts transferrin and utilizing it for their optimum growth and fat burning capacity. (research-matters.net)
  • endogenous
  • Endogenous stimulants of Hepcidin transcription include bone morphogenic protein 6 (BMP6) and interleukin-6 (IL-6) by effects on mothers against decapentaplegic homolog (Smad)4 or signal transducer and activator of transcription (Stat)3, respectively. (edu.au)
  • erythropoiesis
  • These observations led us to hypothesize that more iron is absorbed in β-thalassemia than is required for erythropoiesis and that increasing the concentration of hepcidin in the body of such patients might be therapeutic, limiting iron overload. (jci.org)
  • In this manner, hepcidin limits iron recycling and absorption, thereby controlling body iron stores and the availability of iron for erythropoiesis. (jci.org)