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  • gyrase
  • Fluoroquinolones trap gyrase on DNA as bacteriostatic complexes from which lethal DNA breaks are released. (asm.org)
  • These data indicate that a C-8-methoxyl substituent, which facilitates attack of first-step gyrase mutants, may help make fluoroquinolones effective antituberculosis agents. (asm.org)
  • The drugs first trap gyrase or topoisomerase IV on the chromosome as fluoroquinolone-enzyme-DNA complexes in which the DNA is broken but constrained by protein. (asm.org)
  • Ocular
  • OBJETIVOS: Avaliar a suscetibilidade a fluorquinolonas dos Staphylococcus coagulase-negativo (SCoN) identificados no Laboratório de Microbiologia Ocular da UNIFESP. (unifesp.br)
  • agents
  • In an attempt to develop more effective antituberculosis agents, we have been studying the fluoroquinolones. (asm.org)
  • Fluoroquinolones (FQ) are licensed and widely indicated for use in adults, owing to the agents' broad-spectrum antibacterial activity, their extensive tissue and intracellular penetration, and their suitability for oral administration. (springer.com)
  • activity
  • Anidulafungin increases the antibacterial activity of tigecycline in polymicrobial Candida albicans/Staphylococcus aureus biofilms on intraperitoneally implanted foreign bodies. (nih.gov)
  • When lethal activity was normalized to bacteriostatic activity, the C-8-methoxyl compound was more bactericidal than its C-8-H control, while the C-8-bromo fluoroquinolone was not. (asm.org)
  • increase
  • Looking to the ecological risk of fluoroquinolones and the increase consumption in children population we think that a control program should be developed to control FQ use in children. (springer.com)
  • drug
  • While inhibition of growth is a convenient assay for drug potency, it sometimes fails to identify the most lethal fluoroquinolone ( 29 ). (asm.org)