• The emergence of methicillin- and vancomycin- resistance among clinical isolates of S. aureus has made treatment of staphylococcal infections difficult and has revived research on vaccination and other strategies to prevent and treat staphylococcal infections especially in patients who are at high risk. (frontiersin.org)
  • Finally, a deeper evaluation of the role of neutrophils and macrophages subtypes as well as their cooperation in promoting extravasation and activation of neutrophils and a better knowledge of the function of cytokines and T cells in promoting staphylococcal killing represent a critical step for planning of clinical trials and future vaccine development. (frontiersin.org)
  • Management of infection is a major clinical problem. (springeropen.com)
  • The systematic use of genome-sequence databases, gene expression technology, x-ray crystallography and animal studies have increased our appreciation of the structure and function of these virulence factors and mechanisms underlying host-staphylococcal interactions. (frontiersin.org)
  • In conclusion, this Research Topic focuses on the role of staphylococcal virulence factors in adhesion, invasion and biofilm formation on one hand and on their interaction with innate immunity on the other. (frontiersin.org)
  • Invasive infections are more serious and usually treated in hospital with antibiotic injections. (your.md)
  • Rare in adults and most common in newborns and other children under the age of five, scalded skin syndrome originates with a localized skin infection. (encyclopedia.com)
  • Several bullous lesions affected his hands and feet (Figure 1 ) without formal argument for a necrotizing fasciitis or a staphylococcal scalded skin syndrome. (hindawi.com)
  • Any S. aureus infection can cause the staphylococcal scalded skin syndrome, a cutaneous reaction to exotoxin absorbed into the bloodstream. (wikipedia.org)
  • Staphylococcal scalded skin syndrome (SSSS), which usually affects children less than five years old or rarely, adults with kidney failure. (bestonlinemd.com)
  • Severity of staphylococcal scalded skin syndrome varies from a few blisters localized to the site of infection to a severe exfoliation affecting almost the entire body. (medscape.com)
  • Two types of staphylococcal scalded skin syndrome are thought to exist: a localized form, in which there is only patchy involvement of the epidermis, and a generalized form, in which significant areas of are involved, remote from the initial site of infection. (medscape.com)
  • [ 3 , 4 , 5 ] The relative quantity of DG-1 in the skin differs with age and may partially explain the increased frequency of staphylococcal scalded skin syndrome in children younger than 5 years. (medscape.com)
  • The decrease in frequency of staphylococcal scalded skin syndrome (SSSS) in adults is thought to be explained by the presence of antibodies specific for exotoxins and also improved renal clearance of toxins that are produced. (medscape.com)
  • Initial studies suggested that phage lytic group II S aureus (subtypes 3A, 3B, 3C, 55 and 71) were solely responsible for exfoliative toxin production, but it is now known that all phage groups are able to produce exfoliative toxin and cause staphylococcal scalded skin syndrome. (medscape.com)
  • Staphylococcal scalded skin syndrome differs from bullous impetigo . (medscape.com)
  • In staphylococcal scalded skin syndrome, the exfoliative toxins are spread hematogenously from a localized source potentially causing epidermal damage at distant sites. (medscape.com)
  • Staphylococcal scalded skin syndrome differs from the more severe toxic epidermal necrolysis (TEN) , in that the cleavage site in staphylococcal scalded skin syndrome is intraepidermal, as opposed to TEN, which involves necrosis of the full epidermal layer (at the level of the basement membrane). (medscape.com)
  • Staphylococcal scalded skin syndrome (SSSS) is most common in children and neonates. (medscape.com)
  • Staphylococcal scalded skin syndrome is rarer in adults, but it has been described in adults with renal failure, immunologic deficiency, and other chronic illness. (medscape.com)
  • Daptomycin is a phosphatidylglycerol specific, calcium dependent membrane-active antibiotic that has been approved for the treatment of Gram-positive infections. (bioportfolio.com)
  • Due to widespread antibiotic resistance, it is better to prevent staphylococcal infections where possible. (bestonlinemd.com)
  • How to treat internal infections using a naturally occurring powerful antibiotic with a proven success rate. (aspeneducationgroup.com)
  • The receptors for human C5a anaphylatoxin, C5aR and C5L2, were recently shown to act as binding sites for both PVL and ?HL/HlgCB, and we hypothesize that small molecule antagonists of the C5a receptor will be useful in treating staphylococcal infections as an adjunct to antibiotic therapy. (grantome.com)
  • Based on this finding, we hypothesize that small molecule antagonists of the C5a receptor will be useful in treating Staphylococcal infections as an adjunct to antibiotic therapy. (grantome.com)
  • Skin infections are usually mild and can be treated using antibiotic tablets or creams. (your.md)
  • Invasive infections are more serious and usually treated in hospital with antibiotic injections. (your.md)
  • These findings hold implication for the development of therapeutics in treating antibiotic-resistant S. aureus infection. (jimmunol.org)
  • Immunotherapeutic strategies to combat staphylococcal infections. (nih.gov)
  • Taken together, these investigations will provide preclinical evidence for the therapeutic use of small molecule C5aR antagonists in man to combat staphylococcal infections. (grantome.com)
  • It is generally believed that the incidence of staphylococcal infection has increased since the introduction of antimicrobials, although only a few studies to document this impression have appeared in the literature. (annals.org)
  • Overall incidence is higher in developing countries and wherever the incidence of staphylococcal infections is higher. (medscape.com)
  • Periprosthetic joint infections (PJI) cause significant morbidity and a considerable claim on the health care resource utilization. (biomedcentral.com)
  • 68 Ga-DOTA-Siglec-9 PET detected inflammation induced by S. epidermidis and S. aureus catheter-related bone infections (SUV ratio +58.1% and +41.7%, respectively). (utu.fi)
  • PET/CT imaging with novel 68 Ga-DOTA-Siglec-9 tracer was able to detect inflammatory tissue response induced by catheter implantation and staphylococcal infections. (utu.fi)
  • The third experiment (Study III) demonstrated that positron emission tomography (PET) imaging with the novel 68Ga labelled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) CD33 related sialic-acid immunoglobulin like lectins (Siglec-9) tracer was able to detect inflammatory response to S. epidermidis and S. aureus peri-implant infections in an intraosseous polytetrafluoroethylene catheter model. (utupub.fi)
  • [ 8 ] Some recent reports show an increase in hospitalizations and prescriptions for staphylococcal disease, including SSSS, in England. (medscape.com)