• In particular, immunological strategies based on vaccine development or therapeutic antibodies may significantly enhance the efficiency of anti-staphylococcal therapy. (nih.gov)
  • Moreover, the pronounced capacity of PSMs to kill human neutrophils after phagocytosis might explain failures in the development of anti-staphylococcal vaccines. (nih.gov)
  • Here, we discuss recent progress made in our understanding of the biochemical and genetic properties of PSMs and their role in S. aureus pathogenesis, and suggest potential avenues to target PSMs for the development of anti-staphylococcal drugs. (nih.gov)
  • The systematic use of genome-sequence databases, gene expression technology, x-ray crystallography and animal studies have increased our appreciation of the structure and function of these virulence factors and mechanisms underlying host-staphylococcal interactions. (frontiersin.org)
  • Pathogenic strains often promote infections by producing virulence factors such as potent protein toxins, and the expression of a cell-surface protein that binds and inactivates antibodies. (wikipedia.org)
  • Rare in adults and most common in newborns and other children under the age of five, scalded skin syndrome originates with a localized skin infection. (encyclopedia.com)
  • Several bullous lesions affected his hands and feet (Figure 1 ) without formal argument for a necrotizing fasciitis or a staphylococcal scalded skin syndrome. (hindawi.com)
  • While virtually all staphylococcal strains carry ?HL, the PVL is increasingly associated with severe necrotizing pneumonia, with alarming susceptibility among non-immunocompromised individuals. (grantome.com)
  • Dr. Lawrence Zumo reports on this form of bacterial meningitis infection often linked to neurosurgery, trauma, and compromised immune system. (dmoztools.net)
  • In fact, because vancomycin has poor gastrointestinal absorption, the only infection it can effectively treat orally is Clostridium difficile . (ama-assn.org)
  • 1 year of age, the Centers for Disease Control and Prevention defines CoNS infection as the presence of clinical sepsis (e.g., hyperthermia, hypothermia, apnea, or bradycardia) and isolation of CoNS organisms, either cultured from two or more blood cultures drawn on separate occasions or obtained from at least one blood culture in a patient with an intravascular line, where the physician begins appropriate antimicrobial therapy. (pubmedcentralcanada.ca)
  • The receptors for human C5a anaphylatoxin, C5aR and C5L2, were recently shown to act as binding sites for both PVL and ?HL/HlgCB, and we hypothesize that small molecule antagonists of the C5a receptor will be useful in treating staphylococcal infections as an adjunct to antibiotic therapy. (grantome.com)
  • Based on this finding, we hypothesize that small molecule antagonists of the C5a receptor will be useful in treating Staphylococcal infections as an adjunct to antibiotic therapy. (grantome.com)
  • In summary, these anuran peptides are promising as novel therapeutic agents for treating infections from a clinically resistant pathogen. (peptide.com)
  • Antimicrobial peptides (AMPs) from natural resources offer potential as new treatments against Staphylococcal infections. (peptide.com)
  • The mecA gene, which is found in staphylococcal cassette chromosome SCC mec , codes for penicillin-binding protein (PBP) 2A, and this confers resistance to beta-lactam and non-beta-lactam antibiotics. (clinicalpainadvisor.com)
  • 11 Some investigators have defined CoNS infection as either two positive blood cultures drawn within two days of each other or one positive blood culture and observed elevated C-reactive protein within two days of the CoNS positive culture. (pubmedcentralcanada.ca)
  • Hand hygiene is generally considered to be the most important measure that can be applied to prevent the spread of healthcare-associated infection (HAI). (biomedcentral.com)
  • 68 Ga-DOTA-Siglec-9 PET detected inflammation induced by S. epidermidis and S. aureus catheter-related bone infections (SUV ratio +58.1% and +41.7%, respectively). (utu.fi)