Combat staphylococcal infectionsStaphylococciMethicillin-resistAnti-staphylococcalNosocomial infectionsImmunityAureus infectionBloodstream infectionsOsteomyelitisVirulence factorsAbscessesScalded skin synIsolatesPneumoniaPathogenesisSymptomsStaph bacteriaInhibitoryToxicIncidencePathogenicMeningitisPathogensComplicationsBacteriaVancomycinPreventionMurineAntibiotic therapySkinHuman infectionsInvasiveDefinitionTherapeuticDistinguishAntimicrobialOccurProteinHealthcareBoneSurgical site
- Immunotherapeutic strategies to combat staphylococcal infections. (nih.gov)
- Although a few novel antibiotics have been recently introduced into clinical practice, the search for alternative strategies to efficiently combat staphylococcal infections is urgently demanded to decrease the enormous burden caused by pathogenic staphylococci. (nih.gov)
- Taken together, these investigations will provide preclinical evidence for the therapeutic use of small molecule C5aR antagonists in man to combat staphylococcal infections. (grantome.com)
- Antibiotic-resistant staphylococci are the leading cause of nosocomial infections in many hospitals around the world. (nih.gov)
- Staphylococci are among the most important human pathogens and a major cause of morbidity and mortality worldwide, causing septicaemia, pneumonia, endocarditis, osteomyelitis and post-operative infections. (frontiersin.org)
- Among staphylococci, Staphylococcus aureus is regarded as the most virulent species, while S. epidermidis, once considered harmless, is emerging as an important agent of nosocomial infections, particularly in association with indwelling medical devices. (frontiersin.org)
- Nevertheless, infections due to staphylococci have remained a serious therapeutic problem. (annals.org)
- Infection (PJI) caused by methicillin-susceptible and methicillin-resistant staphylococci will be included and followed during 2 years. (bioportfolio.com)
- Staphylococci also cause skin, surgical site, and wound infections, some of which are resistant to most antibiotics. (dmoztools.net)
- Problematically, Methicillin-resistant Staphylococcus aureus (MRSA) has become a major cause of hospital-acquired infections, and is being, MRSA has also been recognized with increasing frequency in community-acquired infections. (wikipedia.org)
- Treatment outcomes for serious infections caused by methicillin-resistant Staphylococcus aureus with reduced vancomycin susceptibility. (monashhealth.org)
- Some staph bacteria such as MRSA (methicillin-resistant Staphylococcus aureus) are resistant to certain antibiotics, making infections harder to treat. (premilife.com)
- During the past several years, infections with methicillin-resistant Staphylococcus aureus strains (MRSA) have become increasingly prevalent in the US and worldwide. (grantome.com)
- Studies have suggested the reduced effectiveness of vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections with high vancomycin minimum inhibitory concentrations. (bioportfolio.com)
- In particular, immunological strategies based on vaccine development or therapeutic antibodies may significantly enhance the efficiency of anti-staphylococcal therapy. (nih.gov)
- Moreover, the pronounced capacity of PSMs to kill human neutrophils after phagocytosis might explain failures in the development of anti-staphylococcal vaccines. (nih.gov)
- Here, we discuss recent progress made in our understanding of the biochemical and genetic properties of PSMs and their role in S. aureus pathogenesis, and suggest potential avenues to target PSMs for the development of anti-staphylococcal drugs. (nih.gov)
- They are the leading cause of primary infections originating in hospitals (nosocomial infections) in the United States . (encyclopedia.com)
- In conclusion, this Research Topic focuses on the role of staphylococcal virulence factors in adhesion, invasion and biofilm formation on one hand and on their interaction with innate immunity on the other. (frontiersin.org)
- Is there any immunity after staphylococcal infection? (healthtap.com)
- Thank you for sharing this Infection and Immunity article. (asm.org)
- Message Body (Your Name) thought you would be interested in this article in Infection and Immunity. (asm.org)
- Any S. aureus infection can cause the staphylococcal scalded skin syndrome, a cutaneous reaction to exotoxin absorbed into the bloodstream. (wikipedia.org)
- In this study, we show the clinical and anatomopathological data of a patient infected with dengue, who subsequently died of acute multi-organic failure related to Staphylococcus aureus infection. (ajtmh.org)
- In Aim 1 we will establish a model of S. aureus infection using the humanized mouse line and determine the efficacy of blocking toxin binding to the C5aR with small molecule antagonists. (grantome.com)
- Patients who completed 18 months of mupirocin or developed new (recurrent) S. aureus infection. (clinicaltrials.gov)
- This pathogen is an important cause of skin and skin and soft tissue infection (SSTI), pneumonia, and bloodstream infections. (clinicalpainadvisor.com)
- Administration of vancomycin to treat bloodstream infections requires intravenous delivery. (ama-assn.org)
- In children, these systemic (affecting the whole body) or disseminated infections frequently affect the ends of the long bones of the arms or legs, causing a bone infection called osteomyelitis. (encyclopedia.com)
- The systematic use of genome-sequence databases, gene expression technology, x-ray crystallography and animal studies have increased our appreciation of the structure and function of these virulence factors and mechanisms underlying host-staphylococcal interactions. (frontiersin.org)
- Pathogenic strains often promote infections by producing virulence factors such as potent protein toxins, and the expression of a cell-surface protein that binds and inactivates antibodies. (wikipedia.org)
- Staphylococcal (staph) infections are communicable infections caused by staph organisms and often characterized by the formation of abscesses. (encyclopedia.com)
- Staph skin infections often produce pus-filled pockets (abscesses) located just beneath the surface of the skin or deep within the body. (encyclopedia.com)
- Most of these abscesses eventually burst, and pus leaking onto the skin can cause new infections. (encyclopedia.com)
- Although S. aureus is not always pathogenic (and can commonly be found existing as a commensal), it is a common cause of skin infections including abscesses, respiratory infections such as sinusitis, and food poisoning. (wikipedia.org)
- Learn to identify and treat common skin infections caused by the staph bacteria, including impetigo, boils, and abscesses. (dmoztools.net)
- Rare in adults and most common in newborns and other children under the age of five, scalded skin syndrome originates with a localized skin infection. (encyclopedia.com)
- Several bullous lesions affected his hands and feet (Figure 1 ) without formal argument for a necrotizing fasciitis or a staphylococcal scalded skin syndrome. (hindawi.com)
- The emergence of methicillin- and vancomycin- resistance among clinical isolates of S. aureus has made treatment of staphylococcal infections difficult and has revived research on vaccination and other strategies to prevent and treat staphylococcal infections especially in patients who are at high risk. (frontiersin.org)
- While virtually all staphylococcal strains carry ?HL, the PVL is increasingly associated with severe necrotizing pneumonia, with alarming susceptibility among non-immunocompromised individuals. (grantome.com)
- PSMs have multiple roles in staphylococcal pathogenesis, causing lysis of red and white blood cells, stimulating inflammatory responses and contributing to biofilm development and the dissemination of biofilm-associated infections. (nih.gov)
- First, our knowledge of S. aureus pathogenesis in humans is rather preliminary and it is difficult to predict how animal data will equate to human infection. (frontiersin.org)
- The symptoms of a Staph Infection include a collection of pus, such as a boil or furuncle, or abscess. (wikipedia.org)
- What are the symptoms of staphylococcal infection? (healthtap.com)
- Which are the symptoms of localized staphylococcal infections? (healthtap.com)
- Staphylococcal or Staph bacteria cause several diseases. (dmoztools.net)
- They demonstrated weak in vitro  inhibitory activity against S. aureus , but several had potent antibacterial activity against S. aureus  in an in vivo  murine wound infection model. (peptide.com)
- We retained the diagnosis of puffy hand syndrome revealed by a severe staphylococcal infection with toxic involvement mimicking a four limbs cellulitis. (hindawi.com)
- So, we concluded it as a puffy hand syndrome revealed by a severe staphylococcal infection with toxic involvement. (hindawi.com)
- We investigated the ability of staphylococcal enterotoxins A and B, exfoliative toxins A and B, and toxic shock syndrome toxin 1 to activate macrophages. (asm.org)
- Staphylococcal enterotoxin A, toxic shock syndrome toxin 1, and both exfoliative toxins triggered C3HeB/FeJ macrophages to secrete tumor necrosis factor alpha, but enterotoxin B induced only marginal amounts of tumor necrosis factor. (asm.org)
- It is generally believed that the incidence of staphylococcal infection has increased since the introduction of antimicrobials, although only a few studies to document this impression have appeared in the literature. (annals.org)
- Infants with lower gestational age and birth weight had a higher incidence of CoNS infection. (pubmedcentralcanada.ca)
- More than 30 staphylococcal species are pathogenic. (mhmedical.com)
- Dr. Lawrence Zumo reports on this form of bacterial meningitis infection often linked to neurosurgery, trauma, and compromised immune system. (dmoztools.net)
- Through regular cleansing of hands, healthcare workers (HCWs) reduce the risk to transmitting nosocomial pathogens between patients and thus reduce the risk of exogenously-acquired infection. (biomedcentral.com)
- Staphylococcus epidermidis ( S. epidermidis ) has emerged as one of the leading pathogens of biomaterial-related infections. (utu.fi)
- pathogens in infections primarily associated with prosthetic devices. (mhmedical.com)
- One of the most common complications arising from AlloDerm hernia patches is staphylococcal infection. (hernia-patchlawsuit.com)
- A localized staph infection is confined to a ring of dead and dying white blood cells and bacteria. (encyclopedia.com)
- Staphylococcus is a form of bacteria that can cause a wide range of infections, some of which can pose a serious risk to the health of an affected individual. (hernia-patchlawsuit.com)
- The majority of infections resulting from hernia repair are caused by the staphylococcus bacteria. (hernia-patchlawsuit.com)
- Following lung infection with PVL+ Staph (USA300), hC5aR-KI mice fail to clear the bacteria as efficiently as wild type animals, and their bronchoalveolar lavage fluid contains significantly elevated inflammatory cells. (grantome.com)
- In fact, because vancomycin has poor gastrointestinal absorption, the only infection it can effectively treat orally is Clostridium difficile . (ama-assn.org)
- 1 year of age, the Centers for Disease Control and Prevention defines CoNS infection as the presence of clinical sepsis (e.g., hyperthermia, hypothermia, apnea, or bradycardia) and isolation of CoNS organisms, either cultured from two or more blood cultures drawn on separate occasions or obtained from at least one blood culture in a patient with an intravascular line, where the physician begins appropriate antimicrobial therapy. (pubmedcentralcanada.ca)
- Murine macrophage activation by staphylococcal exotoxins. (asm.org)
- The receptors for human C5a anaphylatoxin, C5aR and C5L2, were recently shown to act as binding sites for both PVL and ?HL/HlgCB, and we hypothesize that small molecule antagonists of the C5a receptor will be useful in treating staphylococcal infections as an adjunct to antibiotic therapy. (grantome.com)
- Based on this finding, we hypothesize that small molecule antagonists of the C5a receptor will be useful in treating Staphylococcal infections as an adjunct to antibiotic therapy. (grantome.com)
- S. aureus commonly causes infections in the skin and soft tissue, bones, joints, and the respiratory system. (clinicalpainadvisor.com)
- S. epidermidis, a coagulase-negative staphylococcus species, is a commensal of the skin, but can cause severe infections in immune-suppressed patients and those with central venous catheters. (wikipedia.org)
- How can one diagnose staphylococcal skin infection? (healthtap.com)
- Which staphylococcal skin infection is considered the most serious? (healthtap.com)
- Skin infections are the most common. (premilife.com)
- Anyone can get a staph skin infection. (premilife.com)
- Most staph skin infections are easily treated with antibiotics or by draining the infection. (premilife.com)
- Prophylactic measures against skin infections are essential. (hindawi.com)
- This organism is responsible for both nosocomial and community-based infections that range from relatively minor skin and soft tissue infections primarily to life-threatening systemic infections. (mhmedical.com)
- Additionally, it can cause various skin and soft tissue infections, particularly when skin or mucosal barriers have been breached. (wikipedia.org)
- S. aureus infections can spread through contact with pus from an infected wound, skin-to-skin contact with an infected person, and contact with objects used by an infected person such as towels, sheets, clothing, or athletic equipment. (wikipedia.org)
- In recent years, several other staphylococcal species have been implicated in human infections, notably S. lugdunensis, S. schleiferi, and S. caprae. (wikipedia.org)
- Staphylococcus aureus  is a virulent pathogen that is responsible for a wide range of superficial and invasive infections. (peptide.com)
- What is the definition or description of: Staphylococcal infection? (healthtap.com)
- In summary, these anuran peptides are promising as novel therapeutic agents for treating infections from a clinically resistant pathogen. (peptide.com)
- 12 The common objective of these various definitions is to distinguish CoNS infection from CoNS contaminant. (pubmedcentralcanada.ca)
- Antimicrobial peptides (AMPs) from natural resources offer potential as new treatments against Staphylococcal infections. (peptide.com)
- A mild fever and/or an increase in the number of infection-fighting white blood cells may occur. (encyclopedia.com)
- The mecA gene, which is found in staphylococcal cassette chromosome SCC mec , codes for penicillin-binding protein (PBP) 2A, and this confers resistance to beta-lactam and non-beta-lactam antibiotics. (clinicalpainadvisor.com)
- 11 Some investigators have defined CoNS infection as either two positive blood cultures drawn within two days of each other or one positive blood culture and observed elevated C-reactive protein within two days of the CoNS positive culture. (pubmedcentralcanada.ca)
- Hand hygiene is generally considered to be the most important measure that can be applied to prevent the spread of healthcare-associated infection (HAI). (biomedcentral.com)
- 68 Ga-DOTA-Siglec-9 PET detected inflammation induced by S. epidermidis and S. aureus catheter-related bone infections (SUV ratio +58.1% and +41.7%, respectively). (utu.fi)
- It also is a frequent cause of surgical site and to a lesser degree, endovascular infections. (clinicalpainadvisor.com)