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  • cleavage
  • WIDER IMPLICATIONS OF THE FINDINGS: Our results provide functional data that can help explain the high aneuploidy rates seen in human cleavage-stage embryos and suggest that this is due to their unusual cell cycle control. (vub.be)
  • time-lapse
  • PARTICIPANT/MATERIALS, SETTING, METHODS: We cultured human preimplantation embryos overnight in a time-lapse imaging system, in control or in a nocodazole-containing medium that prevents the formation of a proper mitotic spindle. (vub.be)
  • cells
  • The FISH data suggest that in compacted Day-4 embryos, approximately one in six cells started a polyploid new cell cycle rather than to go in apoptosis after the failure to maintain the SAC-mediated M-phase arrest. (vub.be)
  • placenta
  • 1 ] is that on further study, it became evident that one of the X-linked genes, Rhox5 / Pem (reproductive homeobox 5/placenta and embryos gene), was apparently being expressed in females preferentially from their paternal X chromosome, which is preferentially inactivated in the preimplantation embryo. (biomedcentral.com)
  • It is proposed that human decidua contains a population of stem cells that are responsible for the proliferation ability during the process of embryo implantation and placenta formation and that factors in the crosstalk between the decidua and chorion may mediate decidual stem cell. (ebscohost.com)
  • bovine
  • In vitro production of embryos alters levels of insulin-like growth factor-II messenger ribonucleic acid in bovine fetuses 63 days after transfer. (publish.csiro.au)
  • 1986
  • The first edition of Manipulating the Mouse Embryo appeared in 1986 as an outgrowth of Cold Spring Harbor Laboratory courses on the molecular embryology of the mouse held in the early 1980s, and authors of the first two editions included Brigid Hogan, Rosa Beddington, Frank Costantini, and Liz Lacy. (cshlpress.com)
  • genetic
  • 2016. Unraveling the association between genetic integrity and metabolic activity in pre-implantation stage embryos. . (ncbs.res.in)
  • Several letters to the editor about single embryo transfer, stem cells in ovaries and preimplantation genetic screening (PGS) are presented. (ebscohost.com)
  • These findings have important implications both for routine IVF and preimplantation genetic diagnosis. (springer.com)
  • Preimplantation genetic diagnosis (PGD) aims to help couples with heritable genetic disorders to avoid the birth of diseased offspring or the recurrence of loss of conception. (springer.com)
  • A distinctive form of PGD, commonly referred to as preimplantation genetic diagnosis for aneuploidy screening (PGD-AS) or PGS, was tailored to help couples who have normal karyotypes but are burdened with fertility problems due to advanced maternal age, recurrent miscarriage, recurrent implantation failure or severe male factor infertility. (springer.com)
  • mechanisms
  • Using wildtype or engineered stem cell lines, researchers may use this technique to uncover the various mechanisms or treatments that may affect early brain infection and resulting microcephaly in Zika virus-infected embryos. (jove.com)
  • nutrient
  • The inner cell mass is extracted from the embryo and cultured in a nutrient rich environment in a Petri dish in order to create stem cell lines. (spusa.org)
  • human
  • We now have an experimental system that provides us with routine access to stages of the human life cycle that were previously out of reach to experimentation. (biologists.org)
  • Focuses on private research concerning the cloning of human embryos, and resulting pressure on the United States Congress from medical and religious interest groups. (ebscohost.com)
  • Discusses the controversy over research on stem cells taken from human embryos in the United States. (ebscohost.com)
  • structures
  • Atg16L1 localizes to the outer surface of the pre-autophagosomal structures, and dissociates from fully formed (mature) autophagosomes. (biochemsoctrans.org)
  • Thus Atg16L1-positive vesicles represent pre-autophagosomal structures. (biochemsoctrans.org)
  • LC3-II is specifically targeted to elongating pre-autophagosomal structures and then remains on mature autophagosomes, until after fusion with lysosomes. (biochemsoctrans.org)
  • mosaic
  • Two embryos only were aneuploid (non-mosaic) throughout but, after excluding those showing chaotic division, 30% were considered to be chromosomal mosaics. (springer.com)
  • cell
  • From the first cell division on, the two-cell stage, one uses the term embryo. (cpma.ch)
  • MICRO-ePORE™ was designed for a range of applications including generation of CRISPR/Cas9 mediated knock-in mice with large insertions by microinjection into two-cell stage embryos with high viability.7 The MICRO-ePORE™ has delivered accurate microinjection of morpholino oligomers (anti-sense "knockdown") in zebrafish tails. (wpiinc.com)
  • whereas
  • The occurrence of chaotically dividing embryos was strongly patient-related, i.e. some patients had 'chaotic' embryos in repeated cycles, whereas other patients were completely free of this type of anomaly. (springer.com)
  • Despite maternal immune recognition of the conceptus as evidenced by alloantibodies, unlike for conventional allografts, the immune response is spared, cytotoxic effectors being downregulated or suppressed, whereas several cytokinic responses, including inflammatory ones, are used or even provoked for their preimplantation or later on 'immunotrophic' effects. (els.net)
  • important
  • The chapters comprising this book have been selected and edited with the aim of providing an up-to-date and comprehensive account of the most important aspects of vertebrate gamets and embryos as revealed by the integration of several different submicroscopic methods. (springer.com)