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  • deuterium
  • The deuterium-labelled and the unlabelled form of the drug to be investigated were simultaneously infused in 10 min. (biomedsearch.com)
  • The mean distribution and elimination half-lives were 8.4 +/- 5.9 min and 96 +/- 26 min for lidocaine, 9.2 +/- 7.0 min and 98 +/- 27 min for deuterium-labelled lidocaine, 15.3 +/- 9.9 min and 111 +/- 32 min for bupivacaine, and 15.2 +/- 10.9 min and 109 +/- 31 min for deuterium-labelled bupivacaine, respectively. (biomedsearch.com)
  • The mean volumes of the central compartment and mean steady state volumes of distribution were: lidocaine 37 +/- 151 and 97 +/- 201, deuterium-labelled lidocaine 39 +/- 161 and 98 +/- 181, bupivacaine 27 +/- 111 and 66 +/- 231 and deuterium-labelled bupivacaine 28 +/- 121, and 65 +/- 221, respectively. (biomedsearch.com)
  • This is an analyte form where some or all of its stable (non-dissociable) hydrogens are switched to deuterium atoms, carbon-12 atoms are switched for carbon-13 atoms, or nitrogen-14 atoms are switched for nitrogen-15 atoms. (chromatographyonline.com)
  • Deuterium labelled version of aminooxy-biotin is useful aldehyde reactive agent for labeling abasic sites in damaged DNA. (syninnova.com)
  • Silodosin-d 6 β-D-glucuronide is a deuterium labelled analog of Silodosin β-D-glucuronide and a metabolite of Silodosin, which is an α1a-adrenoceptor antagonist used in treatment of benign prostatic hypertophy. (syninnova.com)
  • vitro
  • The advantage of metabolic labeling over in vitro tagging techniques is that the heavy and unlabeled samples are mixed before sample preparation, preventing variability between preparations from distorting the final quantitation results. (isotope.com)
  • Yeast
  • The combination of 15 N/ 13 C stable isotope labelling (SIL) and LC-MS/MS revealed a total of 52 modifications in RNA from E. coli and yeast, including 10 previously undescribed modifications. (rsc.org)
  • respectively
  • Liver was the most efficient, brain the least, and the labeling efficiency were 96.34%±0.90% and 92.62%±1.98% respectively. (nih.gov)
  • Using a two-label system incorporating [ 13 C 3 15 N 1 ]-nicotinamide and [ 13 C 11 ]-tryptophan, we quantify the relative contribution of salvage and de novo NAD synthesis, respectively, in S. cerevisiae and HepG2 human hepatocellular carcinoma cells under basal conditions. (rsc.org)
  • Study
  • In this study we calculated approximate rate constants for over 500 phosphorylation sites based on labeling progress curves. (umd.edu)
  • techniques
  • Hippocampal neurogenesis is enhanced by different classes of antidepressants, but screening for neurogenic actions of novel antidepressants has been inefficient because of limitations of 5-bromo-2′-deoxyuridine labeling techniques. (aspetjournals.org)