AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
IsoniazidAntitubercular AgentsRifampinMycobacterium tuberculosisPyrazinamideEthambutolAntibiotics, AntitubercularDrug StabilityTuberculosis, Multidrug-ResistantTuberculosisTuberculosis, PulmonaryProtein StabilityEthionamideEnzyme StabilityStreptomycinRNA StabilityAminosalicylic AcidsMicrobial Sensitivity TestsAminosalicylic AcidDrug Resistance, BacterialIsonicotinic AcidsCatalaseBacterial ProteinsMycobacteriumThioacetazoneMycolic AcidsDrug Resistance, Multiple, BacterialLatent TuberculosisMutationDrug Resistance, MicrobialMycobacteriophagesDrug Therapy, CombinationAza CompoundsSputumTuberculin TestMycobacterium smegmatisOxidoreductasesArylamine N-AcetyltransferaseClofazimineRifamycinsHydrazinesMolecular Sequence DataColony Count, MicrobialTime FactorsTemperatureProtein DenaturationThermodynamics
RifampicinRifampinMycobacteriumRifapentineFormulationAssayMetabolic StabilitySynthesisBiologicalPowderChemical stabilitySimultaneousDoseIntermediateTreatmentConstantSlightlyActivityActiveSensitiveDrugHighAnalysisEthambutolRifampicin and isoniazidResistanceAnti-tuberculosisEthanolTuberculosisAmikacinKatGCompoundsDrugsMethodsHeat stabilityStudiesInfluence
Rifampicin2
  • Isoniazid and rifampicin have been prequalified by WHO according to WHO's Procedure for assessing the acceptability, in principle, of active pharmaceutical ingredients for use in in pharmaceutical products (WHO Technical Report Series No. 953, 2009, Annex 4). (who.int)
  • The analysis revealed that mutations in the genes rpoB (rifampicin), katG (isoniazid), inhA -promoter (isoniazid), rpsL (streptomycin) and embB (ethambutol) were responsible for the majority of resistance observed. (biomedcentral.com)
Rifampin2
  • 2 of the most po- ics of MDR/XDR TB by using strains from the most recent tent TB drugs, rifampin and isoniazid) occurred in 2007 (2002) nationwide drug-resistance survey in Japan, an in- ( 1 ). (cdc.gov)
  • For instance, while many studies observed the association of BL with multidrug resistant TB (MDR-TB-resistance to at least isoniazid and rifampin) as in Indonesia, Iran, Pakistan, and Georgia, some studies showed no such association [ 4 , 6 , 7 ]. (hindawi.com)
Mycobacterium2
Rifapentine5
  • The Committee noted that WHO recommends tuberculosis preventive treatment regimens including rifapentine in combination with isoniazid as a weekly dose for 3 months (3HP) or a daily regimen for 1 month (1HP). (essentialmeds.org)
  • The Committee noted that both rifapentine and isoniazid as single agents have been included as antituberculosis medicines on the core list of the EML for several years and that the effectiveness and potential harms of the two medicines are expected to be similar for the single-pill formulations and the fixed-dose combination. (essentialmeds.org)
  • Therefore, the availability of rifapentine and isoniazid in a fixed-dose combination tablet would reduce the pill burden substantially and improve adherence to treatment. (essentialmeds.org)
  • The Expert Committee therefore recommended adding the fixed-dose combination of isoniazid and rifapentine to the core list of the EML and EMLc for tuberculosis preventive treatment for use in line with dosing recommendations in WHO guidelines. (essentialmeds.org)
  • Single ingredient formulations of rifapentine and isoniazid are currently included on the EML. (essentialmeds.org)
Formulation1
  • This paper is organized as follows: section 2, presents model formulation, model analysis is carried sections 3 (reproduction numbers, existence of equilibria) and 4 (stability analysis). (ommegaonline.org)
Assay1
  • A stability-indicating assay method has been developed to quantify glycopyrrolate in an oral liquid dosage form. (ijpc.com)
Metabolic Stability1
  • While direct repurposing of haloperidol as an anti-TB agent is unlikely due to its neurotoxicity, this study reveals potential approaches to modifying this chemical scaffold to minimize toxicity and improve metabolic stability, while preserving potent Eis inhibition. (cdc.gov)
Synthesis1
  • New isoniazid based compounds and their transition metal complexes (cobalt (II), copper (II), nickel (II) and zinc (II)) were produced using microwave synthesis technique. (fortunepublish.com)
Biological1
Powder1
  • A portion of the vehicle was added and physical and chemical stability of extemporaneous oral mixed with the powder to form a uniform paste. (chestervetclinic.com)
Chemical stability1
  • 0.1 with a long kamagra gold lifetime through high chemical stability, high capacity through a simple me-too attempt to develop the separation. (drapikowski.pl)
Simultaneous1
  • A carbon paste electrode (CPE) modified with thionine immobilized on multi-walled carbon nanotube (MWCNT), was prepared for simultaneous determination of ascorbic acid (AA) and acetaminophen (AC) in the presence of isoniazid (INZ). (sharif.edu)
Dose1
  • 10. The areas covered by this Committee are extensive and range from good manufacturing practices and regulatory guidance texts (on, for example, interchangeability of medicines, fixed-dose combination products and stability testing) to counterfeit and substandard medicines. (who.int)
Intermediate1
  • The moisture content of the blend for compression has been identified as an intermediate CQA for stability reasons. (who.int)
Treatment2
  • Mata Hari, The available page Mata Hari is admired to Information by helping zea by a great rencer for resulting on Germany's isoniazid during World War I. King Constantine I, King Constantine I of Greece is his pollution in the treatment of chlorine from Britain and France and latter fungi. (edvgruber.eu)
  • 8 ] Temporary percutaneous fixation offers reduction of nonfixed deformities of the thoracolumbar spine and confers stability until the vertebral bodies reconstitute with adequate treatment of the infection. (surgicalneurologyint.com)
Constant1
  • The stoichiometry of the reaction and the stability constant of the complex ([Fe(CN)5(INH)]3−) have been established as 1:1 and 2.10 × 103 M, respectively. (usp.ac.fj)
Slightly1
  • In vivo studies in the guinea pig showed furonazide slightly more active than isoniazid as a tuberculostatic agent. (wikipedia.org)
Activity3
  • The in vitro antibacterial activity of furonazide against Bacillus Calmette-Guerin was found to be essentially equal to that of isoniazid on an equimolar basis. (wikipedia.org)
  • This 15-fold difference in the heat stability of the rapid and slow isoforms of NAT activity was also observed in cytosols from rapid and slow acetylator livers. (cdc.gov)
  • The results show an efficient catalytic activity of the electrode for the electro-oxidation of EN, which leads to improvement of reversibility of the electrode response and lowering its overpotential by more than 100 mV. (sharif.edu)
Active1
  • Stability was defined as the Pharmaceutics, University of Oklahoma, HSC College of retention of not less than 90% of the original concentra- Pharmacy, Oklahoma City, OK 73190 and Martin A. tion of the active drug. (chestervetclinic.com)
Sensitive1
  • A carbon-paste electrode (CPE) modified with iron(II) phthalocyanine was used for the sensitive voltammetric determination of epinephrine (EN). (sharif.edu)
Drug2
  • Furonazide is a crystalline tuberculostatic drug substance with a reported melting point of 199-201.5 °C. Furonazide was first prepared in 1955 by Miyatake from isoniazid and 2-Acetylfuran by refluxing in ethanol, followed by filtration of the crystalline product. (wikipedia.org)
  • Samples (5 mL) STABILITY STUDY DESIGN pharmacists to make informed were removed initially and after 1, 2, 7, 10, 14, 28, 35 Drug selection for this study was based on the professional decisions about and 60 days. (chestervetclinic.com)
High2
  • After the end of the 30-year civil war in 2009 and attaining politicoeconomic stability, the country experienced an increase in the number of travellers/workers to and from high TB-burden countries for tourism and construction workforce. (hindawi.com)
  • The prepared electrode showed high stability and uniformity in the composite film, short response time, good reproducibility and an. (sharif.edu)
Analysis1
  • We employ traditional analytical methods of analysis to determine conditions for existence of steady states and their stability. (ommegaonline.org)
Ethambutol9
  • Rifampicin/Isoniazid/ Pyrazinamide/Ethambutol 150mg/75mg/400mg/275mg film-coated Tablets is not indicated for use in patients with clinically significant hypersensitivity to rifampicin, isoniazid, pyrazinamide and/or ethambutol or to any of the components contained in the formulation. (who.int)
  • Rifampicin/Isoniazid/ Pyrazinamide/Ethambutol 150mg/75mg/400mg/275mg film-coated Tablets is not indicated in patients with acute liver disease, icterus or severe liver impairment, in patients with optic neuritis, and in patients with acute gout. (who.int)
  • Co-administration of Rifampicin/Isoniazid/ Pyrazinamide/Ethambutol 150mg/75mg/400mg/275mg film-coated Tablets with voriconazole or any HIV-protease inhibitor is contraindicated. (who.int)
  • Rifampicin/Isoniazid/ Pyrazinamide/Ethambutol 150mg/75mg/400mg/275mg film-coated Tablets are described in the Ph.Int. and USP. (who.int)
  • Rifampicin/Isoniazid/ Pyrazinamide/Ethambutol 150mg/75mg/400mg/275mg film-coated Tablets are light buff coloured biconvex capsule shaped film-coated tablets, plain on both sides. (who.int)
  • With or without food, smith ck isoniazid and ethambutol. (stonecottagegardens.com)
  • The analysis revealed that mutations in the genes rpoB (rifampicin), katG (isoniazid), inhA-promoter (isoniazid), rpsL (streptomycin) and embB (ethambutol) were responsible for the majority of resistance observed. (lshtm.ac.uk)
  • While in India, she received empiric treatment for tuberculosis and brucellosis with isoniazid, rifampin, pyrazinamide, ethambutol and injectable streptomycin. (biomedcentral.com)
  • That regimen consists of isoniazid, rifampin, pyrazinamide and ethambutol. (casestudiesforglobalhealth.org)
Rifampicin and isoniazid2
  • We used ultra-performance liquid chromatography (UPLC) methods for rifampicin and isoniazid and a microbiological assay for rifampicin, clarithromycin, amikacin, cefoxitin and linezolid. (eur.nl)
  • Rifampicin and isoniazid concentrations in Middlebrook 7H9 medium had decreased by 92% and 54% after 7 days. (eur.nl)
Resistance2
Anti-tuberculosis1
  • 1. Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid. (nih.gov)
Ethanol1
  • Furonazide is a crystalline tuberculostatic drug substance with a reported melting point of 199-201.5 °C. Furonazide was first prepared in 1955 by Miyatake from isoniazid and 2-Acetylfuran by refluxing in ethanol, followed by filtration of the crystalline product. (wikipedia.org)
Tuberculosis1
Amikacin1
  • We assessed the stability of isoniazid, rifampicin, clarithromycin, linezolid and amikacin in Middlebrook 7H9 medium and that of clarithromycin, amikacin and cefoxitin in the cation-adjusted Mueller Hinton broth. (eur.nl)
KatG1
Compounds1
  • New isoniazid based compounds and their transition metal complexes (cobalt (II), copper (II), nickel (II) and zinc (II)) were produced using microwave synthesis technique. (fortunepublish.com)
Drugs1
  • The stability of the tested drugs in relevant test media have been understudied. (eur.nl)
Methods1
  • In addition, the effect of identified candidate mutations on protein stability and interactions was assessed quantitatively with well-established computational methods. (lshtm.ac.uk)
Heat stability2
  • The second group comprises a frequently occurring amino acid substitution and a single mutation that are both located in the C-terminal domain but do not noticeably alter either enzyme activity or heat stability. (nih.gov)
  • This 15-fold difference in the heat stability of the rapid and slow isoforms of NAT activity was also observed in cytosols from rapid and slow acetylator livers. (cdc.gov)
Studies4
  • In vivo studies in the guinea pig showed furonazide slightly more active than isoniazid as a tuberculostatic agent. (wikipedia.org)
  • The author discusses the need for compounding, required studies for extemporaneous formulations (physicochemical properties, physical and chemical stability, palatability and miscellaneous) and new regulations. (ijpc.com)
  • Preclinical studies commissioned by the TB Alliance in 2002-03 and conducted by investigators at The Johns Hopkins University have found, for example, that substituting moxifloxacin for isoniazid in a mouse model system decreased the amount of time needed to eradicate TB infection by two months. (casestudiesforglobalhealth.org)
  • New stability studies tracking the changes that will resolve the enantiomers of a aldactazide neutral molecule. (sprecherschuh.net)
Influence1