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Cell Line Cell Membrane HeLa Cells COS Cells Cell Line, Tumor Cells, Cultured Tumor Cells, Cultured CHO Cells Cytoplasm Cell Nucleus HEK293 Cells Liver Fibroblasts Oocytes

Organisms15

Helix (Snails)Escherichia coli Spiroplasma Cattle Saccharomyces cerevisiae Cricetinae Mice, Inbred C57BL Mice, Knockout Rabbits HIV-1 Rats, Sprague-Dawley Xenopus laevis Cercopithecus aethiops Chickens Mice, Transgenic

Diseases2

alpha 1-Antitrypsin Deficiency Genomic Instability

Chemicals and Drugs101

alpha 1-Antitrypsin Recombinant Proteins Peptides Receptors, Adrenergic, alpha Hypoxia-Inducible Factor 1, alpha Subunit DNA Peptide Fragments Intracellular Calcium-Sensing Proteins Bacterial Proteins Solutions Recombinant Fusion Proteins Proteins Ligands Membrane Proteins Transcription Factors DNA-Binding Proteins alpha7 Nicotinic Acetylcholine Receptor Macromolecular Substances Protein Subunits Amino Acids Bacteriorhodopsins Escherichia coli Proteins Cysteine Integrin alpha3beta1 Integrin alpha4 Integrin alpha6 Integrin alpha5beta1 DNA Primers Carrier Proteins Integrin alpha4beta1 Interleukin-1alpha Disulfides Receptors, Adrenergic, alpha-1 Integrin alpha2beta1 Integrin alpha1beta1 Tryptophan Integrin alpha5 Micelles DNA, Complementary Receptors, Adrenergic, alpha-2 Integrin alpha6beta1 Nuclear Proteins Integrins Integrin alpha6beta4 Lipid Bilayers Integrin alpha1 Integrin alpha Chains RNA, Messenger Saccharomyces cerevisiae Proteins Receptors, Nicotinic Integrin alpha3 RNA-Binding Proteins Adrenergic alpha-Agonists Epitopes Collagen PPAR alpha Dinoprost Trypsin RNA Adrenergic alpha-Antagonists Water Hepatocyte Nuclear Factor 1-alpha alpha 1-Antichymotrypsin Tumor Necrosis Factor-alpha Transforming Growth Factor alpha Fungal Proteins Guanidine Apolipoproteins Viral Proteins Phosphoproteins Adrenergic alpha-1 Receptor Antagonists Alanine alpha Karyopherins GTP-Binding Proteins Nerve Tissue Proteins Protein Isoforms Prazosin Mutant Proteins Solvents 6-Ketoprostaglandin F1 alpha Isoenzymes Oligonucleotides Cross-Linking Reagents Calcium Trifluoroethanol Glycine Antibodies, Monoclonal Clonidine Proline Interleukin-1 Trans-Activators RNA, Small Interfering Urea Yohimbine Salts GTP-Binding Protein alpha Subunits, Gi-Go Enzyme Inhibitors Proteasome Endopeptidase Complex Adrenergic alpha-2 Receptor Agonists Peptide Elongation Factor 1 Sodium-Potassium-Exchanging ATPase

Analytical, Diagnostic and Therapeutic Techniques and Equipment43

Models, Molecular Drug Stability Enzyme Stability Crystallography, X-Ray Circular Dichroism Mutagenesis, Site-Directed Magnetic Resonance Spectroscopy Nuclear Magnetic Resonance, Biomolecular Sequence Alignment Amino Acid Substitution Cloning, Molecular Cryoelectron Microscopy Protein Denaturation Models, Chemical Transfection Spectrometry, Fluorescence Electrophoresis, Polyacrylamide Gel Models, Biological Crystallography Spectrophotometry, Ultraviolet Spectrophotometry, Infrared Crystallization Spectroscopy, Fourier Transform Infrared X-Ray Diffraction Alpha Rhythm Microscopy, Electron DNA Mutational Analysis Chromatography, Gel Blotting, Western Sequence Analysis, Protein Calorimetry, Differential Scanning Molecular Dynamics Simulation Protein Engineering Protein Unfolding Reverse Transcriptase Polymerase Chain Reaction Binding, Competitive Polymerase Chain Reaction Chromatography, High Pressure Liquid Drug Storage Immunoblotting Blotting, Northern Immunohistochemistry Calorimetry

Phenomena and Processes80

Protein Structure, Secondary Amino Acid Sequence Protein Conformation Protein Structure, Tertiary Protein Stability Binding Sites Protein Binding Protein Folding Enzyme Stability Sequence Homology, Amino Acid Base Sequence Mutation RNA Stability Dimerization Structure-Activity Relationship Thermodynamics Hydrogen Bonding Kinetics Protein Structure, Quaternary Hydrophobic and Hydrophilic Interactions Nucleic Acid Conformation Amino Acid Motifs Temperature Amino Acid Substitution Static Electricity Conserved Sequence Hydrogen-Ion Concentration Protein Denaturation Mutagenesis Catalytic Domain Transfection Transcription, Genetic Protein Multimerization Signal Transduction Molecular Conformation Point Mutation Substrate Specificity Protein Interaction Domains and Motifs Molecular Structure Sequence Deletion Catalysis Crystallization Biophysical Phenomena Gene Expression Regulation X-Ray Diffraction Time Factors Hot Temperature Molecular Weight Protein Transport Alpha Rhythm Plasmids Phosphorylation Dose-Response Relationship, Drug Gene Expression Consensus Sequence Promoter Regions, Genetic Algorithms Base Pairing Molecular Dynamics Simulation Genomic Instability Protein Unfolding Enzyme Activation Phenotype Binding, Competitive Solubility Evolution, Molecular Protein Biosynthesis Hydrolysis Protein Processing, Post-Translational Transcriptional Activation Up-Regulation Structural Homology, Protein Mutation, Missense Down-Regulation Half-Life Species Specificity Cell Differentiation Cell Hypoxia Transition Temperature Physicochemical Phenomena

Disciplines and Occupations5

Crystallography Biophysics Computational Biology Immunohistochemistry Chemistry, Physical

Technology, Industry, Agriculture2

Models, Structural Lipid Bilayers

Information Science8

Molecular Sequence Data Amino Acid Sequence Base Sequence Computer Simulation Models, Structural Algorithms Molecular Dynamics Simulation Software

Health Care2

Temperature Hot Temperature

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Protein Structure, Secondary Molecular Sequence Data Models, Molecular Amino Acid Sequence Protein Conformation Helix (Snails)Drug Stability Protein Structure, Tertiary Protein Stability Binding Sites Protein Binding Protein Folding Enzyme Stability Crystallography, X-Ray Sequence Homology, Amino Acid Circular Dichroism Base Sequence Mutation Mutagenesis, Site-Directed Magnetic Resonance Spectroscopy alpha 1-Antitrypsin Nuclear Magnetic Resonance, Biomolecular Sequence Alignment RNA Stability Dimerization Structure-Activity Relationship Recombinant Proteins Escherichia coli Peptides Thermodynamics Hydrogen Bonding Kinetics Protein Structure, Quaternary Receptors, Adrenergic, alpha Hydrophobic and Hydrophilic Interactions Hypoxia-Inducible Factor 1, alpha Subunit Nucleic Acid Conformation DNA Amino Acid Motifs Peptide Fragments Temperature Amino Acid Substitution Static Electricity Intracellular Calcium-Sensing Proteins Bacterial Proteins Solutions Recombinant Fusion Proteins Proteins Cloning, Molecular Ligands Cryoelectron Microscopy Membrane Proteins Conserved Sequence Transcription Factors Hydrogen-Ion Concentration Cell Line Protein Denaturation DNA-Binding Proteins Mutagenesis alpha7 Nicotinic Acetylcholine Receptor Macromolecular Substances Catalytic Domain Cell Membrane Models, Chemical Protein Subunits Transfection Spiroplasma Amino Acids Bacteriorhodopsins Escherichia coli Proteins Cysteine Spectrometry, Fluorescence Integrin alpha3beta1 Transcription, Genetic Protein Multimerization Cattle Integrin alpha4 Signal Transduction Integrin alpha6 Integrin alpha5beta1 Electrophoresis, Polyacrylamide Gel Computer Simulation Molecular Conformation DNA Primers Carrier Proteins Integrin alpha4beta1 Point Mutation Models, Biological HeLa Cells Models, Structural Substrate Specificity Interleukin-1alpha Protein Interaction Domains and Motifs Disulfides Receptors, Adrenergic, alpha-1 Crystallography Integrin alpha2beta1 Integrin alpha1beta1 Molecular Structure Tryptophan

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