Risks are increased in patients with personal or family history of substance abuse (including drug or alcohol abuse or addiction) or mental illness (eg. (drugcentral.org)
Serotonin syndrome3
Serotonin syndrome, the most serious drug-related adverse effect of SSRIs, is characterized by mental status changes, neuromuscular dysfunction, and autonomic instability. (medscape.com)
Serotonin Toxicity (Serotonin Syndrome) with 5-HT3 antagonists If you thinking 'who is this, who thinks his opinion is superior to the FDA? (psychotropical.com)
Antidepressant drugs2
The FDA has issued a public health advisory that directed manufacturers of all antidepressant drugs, including SSRIs, to revise the labeling for their products to include a boxed warning and expanded warning statements alerting health care providers to an increased risk of suicidality (suicidal thinking and behavior) in children and adolescents being treated with these agents. (medscape.com)
The risk of suicidality associated with these drugs was identified based on a combined analysis of short-term (up to 4mo), placebo-controlled trials of 9 antidepressant drugs, including SSRIs, in children and adolescents with major depressive disorder (MDD), obsessive compulsive disorder (OCD), or other psychiatric disorders. (medscape.com)
Overdoses2
SSRIs have a high toxic-to-therapeutic ratio, and fatalities are uncommon with pure SSRI overdoses. (medscape.com)
It summarises in diagrammatic form the severity of serotonin-mediated symptoms caused by therapeutic doses, and overdoses, of the various different drugs, and the interactions between them, that are capable of affecting the system to a clinically significant extent in humans. (psychotropical.com)
Essentials1
Even now, in 2021, more than three decades after key research and reviews that demonstrated the essentials of the interactions relevant to serotonin toxicity, there remains a great deal of misinformation and misunderstanding both in medical and non-medical texts. (psychotropical.com)
Disorders2
Increased use of SSRIs for various neurobehavioral disorders has led to a greater clinical awareness of the syndrome. (medscape.com)
Exposure to other psychotropic drugs can result in disorders very similar to neuroleptic malignant syndrome. (medscape.com)
Pediatric3
Fluoxetine is approved by the US Food and Drug Administration (FDA) for treatment of major depressive disorder (MDD) in pediatric patients age 8 years and older, and for treatment of depression associated with bipolar I disorder in patients age 10 and older. (medscape.com)
SSRIs approved for OCD in pediatric patients include fluoxetine (for patients ≥7 years), sertraline (for patients ≥6 years), and fluvoxamine (for patients ages ≥8 years). (medscape.com)
A statement regarding whether the particular drug is approved for any pediatric indication(s) and, if so, which one(s). (medscape.com)
Antidepressants1
Safety and a favorable adverse-effect profile, as well as the lack of multiple receptor affinity associated with the tricyclic antidepressants (TCAs), have distinguished SSRIs from TCAs. (medscape.com)
These efforts in specific aimed to develop compounds an eye to bloc with cytostatic drugs in cancer patients in which transporter over-expression contributes to medical fail- ure. (janmille.ru)
Condition1
This introductory commentary outlines this complex topic: the features of the condition, the drugs that are capable of inducing it (with a genuinely evidence-based table), the patho-physiology and medical management. (psychotropical.com)
Similar1
I have published similar papers about opioids (12), mirtazapine (13) etc. and I could write similar papers about several other drugs, but life is short, and I have other things I wish to do in my retirement. (psychotropical.com)