• CRISPR/Cas9-mediated double knockout of SRPK1 and SRPK2 in a nasopharyngeal carcinoma cell line. (cellosaurus.org)
  • Three mammalian SRPKs - SRPK1, SRPK2, and SRPK3 - relay information between environmental cues and gene expression by regulating SR protein phosphorylation 1,2 . (biologists.com)
  • Furthermore, SRPK1 and SRPK2 mediated phosphorylation of RNF12 stimulates its ubiquitylation activity in vitro . (biologists.com)
  • The small-molecule SRPIN340 is an SRPK inhibitor that is highly selective for SRPK1 (Ki = 0.89 mM) and SRPK2. (cellsignal.jp)
  • Inhibition of SRPK1 and SRPK2 by SRPIN340 reduces SRp75 protein phosphorylation, leading to suppressed Sindbis virus propagation and reduced HIV production (2). (cellsignal.jp)
  • For example, down-regulation or chemical inhibition of SRPK1 effectively blocks angiogenesis by changing the RNA splicing patterns 4 . (biologists.com)
  • These preclinical studies demonstrate that SCO-101 sensitizes SN38-resistant colon cancer cells to SN38 through two different mechanisms of actions e.g. inhibition of the SRPK1 kinase and degradation of the ABCG2/BCRP drug efflux pump. (scandiononcology.com)
  • An ATP-competitive, serine/arginine-rich protein kinase (SRPK)-specific inhibitor (Ki = 0.89 µM for SRPK1). (biovisi.com)
  • SRPK1 inhibitors (e.g. (wikipedia.org)
  • Development of novel anti-angiogenic SRPK1 inhibitors" (PDF). (wikipedia.org)
  • Cell viability assays with two different SRPK1 inhibitors demonstrated that this kinase is involved in re-sensitization to SN38. (scandiononcology.com)
  • Serine/arginine-Rich Splicing Factor (SRSF) protein kinase-1 SRPK1 is an enzyme that in humans is encoded by the SRPK1 gene. (wikipedia.org)
  • Genetic analysis of sinonasal undifferentiated carcinoma discovers recurrent SWI/SNF alterations and a novel PGAP3-SRPK1 fusion gene. (cdc.gov)
  • SRPK1 activates (phosphorylates) VEGF splicing factor. (wikipedia.org)
  • EXN 407 inhibits serine/arginine-protein kinase 1 (SRPK1), which enables production of the form of VEGF that stimulates blood vessel formation. (nottinghamtechventures.com)
  • A kinase screen revealed that the kinase SRPK1 was inhibited by SCO-101 and the importance of SRPK1 activity in re-sensitization of SN38 resistant colon cancer cells was investigated by two different synthetic SRPK1 inhbitors. (scandiononcology.com)
  • Chapters 3 and 4 detail the investigation of a phenylcarboxamide scaffold, previously shown to inhibit SRPK1. (edu.au)
  • In the current work, they found SRPK1 & 2 deletions and SRPK3 variants in patients suffering from intellectual disabilities. (biologists.com)
  • SRPK1 has been shown to interact with: ASF/SF2 and SNRP70. (wikipedia.org)
  • Serine/arginine-Rich Splicing Factor (SRSF) protein kinase-1 SRPK1 is an enzyme that in humans is encoded by the SRPK1 gene. (wikipedia.org)
  • 1. Serine-Arginine Protein Kinase 1 (SRPK1): a systematic review of its multimodal role in oncogenesis. (nih.gov)
  • 2. Serine-Arginine Protein Kinase 1 (SRPK1) as a Prognostic Factor and Potential Therapeutic Target in Cancer: Current Evidence and Future Perspectives. (nih.gov)
  • 7. Inhibition of serine/arginine-rich protein kinase-1 (SRPK1) prevents cholangiocarcinoma cells induced angiogenesis. (nih.gov)
  • 15. Human papillomavirus type 1 E1^E4 protein is a potent inhibitor of the serine-arginine (SR) protein kinase SRPK1 and inhibits phosphorylation of host SR proteins and of the viral transcription and replication regulator E2. (nih.gov)
  • 18. Serine-arginine protein kinase 1 (SRPK1) inhibition as a potential novel targeted therapeutic strategy in prostate cancer. (nih.gov)
  • Homo sapiens SRSF1 in complex with #Serine/threonine-protein Kinase SRPK1, contacts at 4A. (nih.gov)
  • The firm is developing small-molecule inhibitors of the serine/threonine-protein kinase SRPK1, a regulator of messenger RNA (mRNA) splicing that promotes the production of pathogenic forms of VEGF in angiogenesis-related diseases. (genengnews.com)
  • Serine/threonine-protein kinase 1 (SRPK1) phosphorylates the SRSF family protein SRSF1 thereby regulating its assembly and localization [15]. (mdm2-inhibitors.com)
  • 10. Increased expression of SRPK1 (serine/arginine-rich protein-specific kinase 1) is associated with progression and unfavorable prognosis in cervical squamous cell carcinoma. (nih.gov)
  • 14. SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors. (nih.gov)
  • 16. Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells. (nih.gov)
  • This prompted us to check the theory that MALAT1 modulates AKAP-9 appearance and function by marketing SRPK1-catalyzed SRSF1 phosphorylation in CRC cells. (mdm2-inhibitors.com)
  • Outcomes MALAT1 SRPK1 and SRSF1 type a complicated We previously discovered that MALAT1 marketed CRC development and metastasis by regulating AKAP-9 gene appearance [9]. (mdm2-inhibitors.com)
  • Because prior research demonstrated that SRPK1 interacts with SRSF1 Olanzapine and enhances SRSF1 phosphorylation [15] we also utilized RNA-IP assays to check whether SRPK1 interacts with MALAT1 in SW480 cells. (mdm2-inhibitors.com)
  • Body 1 MALAT1 interacts with SRPK1 and SRSF1 proteins To research the specificity from the relationship between SRPK1 and SRSF1 in SW480 cells we utilized Olanzapine immunofluorescent localization within SW480 cells and co-immunoprecipitation (Co-IP) from SW480 cell ingredients with anti-SRPK1 and anti-SRSF1 antibodies respectively. (mdm2-inhibitors.com)
  • We discovered that SRPK1 particularly interacts with SRSF1 (Body 1C-1D) which signifies that MALAT1 SRPK1 and SRSF1 most likely form a complicated. (mdm2-inhibitors.com)
  • Olanzapine MALAT1 promotes SRSF1 phosphorylation by regulating SRPK1 appearance and Olanzapine activity To determine whether a MALAT1-SRPK1-SRSF1 complicated features within SW80 CRC cells we evaluated the degrees of SRSF1 appearance and phosphorylation in Scramble-SW480 RNAa-MALAT1-SW480 and RNAi-MALAT1-SW480 cells. (mdm2-inhibitors.com)
  • These observations claim that MALAT1 boosts SRSF1 phosphorylation by rousing SRPK1 appearance. (mdm2-inhibitors.com)
  • Body 2 MALAT1 enhances AKAP-9 appearance by marketing SRPK1-mediated SRSF1 proteins phospholation To verify that adjustments in MALAT1-mediated SRSF1 phosphorylation was because of SRPK1 enzyme activity RNAa-MALAT1-SW480 cells had been treated using the SRPK1. (mdm2-inhibitors.com)
  • 13. MicroRNA-1296 inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting SRPK1-mediated PI3K/AKT pathway. (nih.gov)
  • SRPK1 activates (phosphorylates) VEGF splicing factor. (wikipedia.org)
  • SDS-Page: Recombinant Human SRPK1 Protein [H00006732-Q01] - 12.5% SDS-PAGE Stained with Coomassie Blue. (novusbio.com)
  • Description: A polyclonal antibody for detection of SRPK1 from Human, Mouse, Rat. (biocatnet.com)
  • 6. SRPK1 regulates RNA binding in a pre-spliceosomal complex using a catalytic bypass mechanism. (nih.gov)