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  • Grb2
  • The deduced protein of 368 aa contains a central α-helical region and a C-terminal Src homology 3 (SH3) domain most similar to the C-terminal SH3 domain found in the Grb2/Sem-5/Drk family of genes. (hku.hk)
  • We now report that tau can bind to SH3 domains derived from the p85α subunit of phosphatidylinositol 3-kinase, phospholipase Cγ1, and the N-terminal (but not the C-terminal) SH3 of Grb2 as well as to the kinases Fyn, cSrc, and Fgr. (edu.au)
  • We purified 150kDa protein bound to Ash/Grb2 from bovine brain, and isolated its cDNA.P150 was found to have homology with synaptojanin. (nii.ac.jp)
  • gene
  • The diphtheria toxin repressor (DtxR) regulates the expression of several iron-sensitive genes in Corynebacterium diphtheriae , including the iron-response protein genes ( irp ), a heme oxygenase, and the diphtheria toxin gene ( tox ) ( 1 - 3 ). (pnas.org)
  • The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. (nih.gov)
  • Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. (nih.gov)
  • sevenless , a cell-specific homeotic gene of Drosophila , encodes a putative transmembrane receptor with a tyrosine kinase domain. (springer.com)
  • mutant
  • For the yeast two-hybrid assay against various PDZ domains, wild-type and mutant (the last amino acid V to A) KIF1Bα (amino acids 1083-1150) in pBHA were used. (jneurosci.org)
  • regulation
  • A limited number of mutations in the C-terminal domain ( 12 ) or the linker region ( 13 ) affect repressor activity, but the structural nature of this regulation by the C-terminal domain has been obscure. (pnas.org)
  • mutations
  • PLCG2 C2 domain mutations co-occur with BTK and PLCG2 resistance mutations in chronic lymphocytic leukemia undergoing ibrutinib treatment. (nih.gov)
  • residues
  • The solution structure of the C-terminal domain, consisting of residues N130-L226 plus a 13-residue N-terminal extension, has been determined by using NMR spectroscopy. (pnas.org)
  • Residues before A147 are highly mobile and adopt a random coil conformation, but residues A147-L226 form a single structured domain consisting of five β-strands and three helices arranged into a partially orthogonal, two-sheet β-barrel, similar to the structure observed in the crystalline Co 2+ complex of full-length DtxR. (pnas.org)
  • From the sequential assignment of resonances in heteronuclear NMR spectra of a recombinant C-terminal domain (residues N130-L226), we have shown that this isolated domain contains five β-strands and three helices ( 14 ). (pnas.org)
  • NMR chemical shift perturbation studies demonstrate that a synthetic peptide corresponding to this internal ligand interacts with specific amino acid residues in the C-terminal domain. (pnas.org)
  • Here we report the crystal structure of KorB-C, the C-terminal domain of KorB comprising residues 297-358. (mdc-berlin.de)
  • yeast
  • These findings support a role for the SH3 domain in Myo5p localization and function in budding yeast. (rupress.org)
  • localization
  • Thus, the SH3 domain of Myo5p contributes to but is not sufficient for localization of Myo5p either to patches or to sites of polarized cell growth. (rupress.org)
  • Sequence
  • The detailed analysis of the dimer interface and a chemical cross-linking study suggest that the C-terminal domain is responsible for stabilizing the dimeric form of KorB in solution to facilitate binding to the palindromic operator sequence. (mdc-berlin.de)
  • mechanism
  • In the present study, we investigate the mechanism for the protein kinase A (PKA)-mediated activation of C-terminal Src kinase (Csk). (biochemj.org)
  • actin
  • Deletion of the tail homology 2 (TH2) domain, previously implicated in ATP-insensitive actin binding, has no detectable effect on Myo5p function. (rupress.org)
  • The first step, assembly of Myo5p patches, is dependent upon F-actin, and the second step, polarization of actin patches, requiresVrp1p and the SH3 domain of Myo5p. (rupress.org)
  • Present
  • The protein regulates the expression of plasmid genes whose products are involved in replication, transfer, and stable inheritance of RP4 by binding to palindromic 13-bp DNA sequences (5′-TTTAGC(G/C)GCTAAA-3′) present 12 times in the 60-kb plasmid. (mdc-berlin.de)
  • The present study aims to show PSD-95 distribution in 3 dimensions. (nih.gov)
  • dimerization
  • The N-terminal domain is structurally well-defined and is responsible for Fe 2+ binding, dimerization, and DNA binding. (pnas.org)
  • found
  • However, the short inserts found in neuron-specific isoforms of Src prevented the binding of tau. (edu.au)
  • We found that PIP_2 bound to histon H_1 and H_3 and determined the binding sites. (nii.ac.jp)
  • function
  • The results of this study, combined with previous x-ray studies of intact DtxR, provide insights into a possible biological function of the C-terminal domain in regulating repressor activity. (pnas.org)
  • site
  • The extra Val codon is attached to the 3'-end of the ORF, because a Pme I site (GTTTAAAC) is tagged at the 3' end of the ORF instead of the stop codon. (or.jp)
  • study
  • Title: A molecular dynamics study of the binary complexes of APP, JIP1, and the cargo binding domain of KLC. (nih.gov)