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  • phospholipase
  • PI(4,5)P 2 is also important in NK cell signaling by acting as the substrate for phospholipase C (PLC), which hydrolyzes PI(4,5)P 2 into diacylglycerol (DAG), to activate PKC and inositol 1,4,5-trisphosphate [I(1,4,5)P 3 ] which triggers release of intracellular Ca 2+ stores. (frontiersin.org)
  • Endothelial
  • PNETs are characterized by being remarkably vascular and expressing several growth factors, including vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), insulin-like growth factor 1 (IGF-1), basic fibroblast growth factor (bFGF), and transforming growth factor (TGF)-α and TGF-β. (aacrjournals.org)
  • acute monocyti
  • To investigate the effect of CD300F stimulation on TLR signaling, the human acute monocytic leukemia cell line THP-1 was treated with CD300F-specific mAbs or two synthetic peptides that represented the ITIM-like domains of CD300F. (jimmunol.org)
  • tumor
  • Although GEPNETs represent less than 2% of all gastrointestinal cancers, they constitute the second most prevalent advanced tumor of the gastrointestinal tract after colorectal cancer ( 1 ). (aacrjournals.org)
  • Akt and SHP-1 are DC-intrinsic checkpoints for tumor immunity. (stanford.edu)
  • found
  • However, the short inserts found in neuron-specific isoforms of Src prevented the binding of tau. (edu.au)
  • Abl interactor 1 has been found to form a complex with EPS8 and SOS1, and is thought to be involved in the transduction of signals from Ras to Rac. (wikipedia.org)
  • function
  • Studies addressing SHP-1 function in DCs have typically been performed using the motheaten ( me/me ) and motheaten viable ( me v /me v ) mouse strains, which are spontaneously arising SHP-1-deficient strains. (jimmunol.org)
  • survival
  • Inhibiting SHP-1 in DCs enhanced proinflammatory cytokines, IL-6, IL-12, and IL-1β production, promoted survival, and increased DC migration to draining lymph nodes. (jimmunol.org)
  • human
  • The thyroid cancer is a rare oncological entity, representing no more than 1% of all human malignant neoplasms. (hindawi.com)
  • The thyroid cancer (TC) is a rare oncological entity, representing no more than 1% of all human malignant neoplasms. (hindawi.com)
  • cell
  • Epithelial Src homology region 2 domain-containing phosphatase-1 restrains intestinal growth, secretory cell differentiation, and tumorigenesis. (nih.gov)
  • Figure
  • ATC, approximately representing 2%, is the most aggressive form of TC, while PLT and PST are very rare (Figure 1 ). (hindawi.com)
  • In this work we focus on myosin II, for which multiple crystallographic studies 5 show that the differences between M* and M** structural states are limited to three areas, as illustrated in Figure 1 . (wiley.com)
  • activity
  • HIV-1 enhances mTORC1 activity and repositions lysosomes to the periphery by co-opting Rag GTPases. (nih.gov)
  • results
  • In fact, the data collected at the Surveillance Epidemiology and End-Results Cancer Registries program (SEER) [ 1 ] indicate an annual average prevalence of thyroid carcinoma (TCa) of 6.6/100.000 (9.5 and 3.5/100.000 for women and men, resp. (hindawi.com)
  • type
  • Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. (antibodies-online.cn)