AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
AdenocarcinomaAdenocarcinoma, MucinousLung NeoplasmsPancreatic NeoplasmsEsophageal NeoplasmsAdenocarcinoma, PapillaryBarrett EsophagusCarcinoma, Pancreatic DuctalStomach NeoplasmsAdenocarcinoma, Bronchiolo-AlveolarCardiaImmunohistochemistryTumor Markers, BiologicalColonic NeoplasmsEsophagogastric JunctionCell Line, TumorNeoplasm StagingPrognosisGene Expression Regulation, NeoplasticKeratin-7Carcinoma, Squamous CellEndometrial NeoplasmsNeoplasms, Multiple PrimaryPrecancerous ConditionsTumor Cells, CulturedIntestinal NeoplasmsProstatic NeoplasmsMammary Neoplasms, ExperimentalNeoplasm InvasivenessCarcinoma, Signet Ring CellDuodenal NeoplasmsCarcinoma, EndometrioidAdenocarcinoma, Clear CellAntineoplastic AgentsCecal NeoplasmsImmunoenzyme TechniquesMetaplasiaColorectal NeoplasmsNeoplasmsRectal NeoplasmsNeoplasm TransplantationGenes, rasNeoplasm MetastasisAmpulla of VaterCommon Bile Duct NeoplasmsAdenomaTissue Array AnalysisKeratin-20DNA, NeoplasmSurvival RateIleal NeoplasmsNeoplasm ProteinsMice, NudePancreaticoduodenectomyCarcinoma, Non-Small-Cell LungCarcinoma, Acinar CellTreatment OutcomeLymphatic MetastasisRetrospective StudiesDisease ProgressionJejunal NeoplasmsCarcinoembryonic AntigenCarcinoma, AdenosquamousSurvival AnalysisEsophagusMutationRNA, MessengerAntigens, NeoplasmReceptor, Epidermal Growth FactorNeoplasms, ExperimentalPancreatectomyBiopsyReverse Transcriptase Polymerase Chain ReactionGastrectomyKaplan-Meier EstimateFatal OutcomeCarcinoma in SituCell ProliferationParanasal Sinus NeoplasmsDeoxycytidineOvarian NeoplasmsGastrointestinal NeoplasmsTime FactorsUterine Cervical NeoplasmsGene Expression ProfilingTumor Suppressor Protein p53MucinsPancreatic DuctsAntineoplastic Combined Chemotherapy ProtocolsAppendiceal NeoplasmsCell Transformation, NeoplasticGallbladder NeoplasmsKeratinsFluorouracilTomography, X-Ray ComputedPolymerase Chain ReactionApoptosisCarcinomaTransplantation, HeterologousSigmoid Neoplasms
CarcinomaCellGastric CancerHigh-grade squamous intraepithelial lesionNSCLCIntraepithelial lesionLower anogenital squamous terminologyMalignantEpithelialLesionMetastaticInvasiveCancersCervicalDysphagiaPancreaticLiquidsPatientsCarcinomasPapillaryMucosaEpitheliumBiopsyLUADAtypicalUncommonEndometrialEsophagusTumoursMetaplasiaNeoplasmsTransitionIncidenceCancerSignificantlyTissue
Carcinoma41
Cell10
  • Preclinical studies have shown that alisertib, an oral, selective inhibitor of Aurora kinase A, results in mitotic defects and induces cell death, and preliminary antitumor activity has been observed in phase I clinical trials of both hematologic and solid tumors. (aacrjournals.org)
  • Two hundred forty-nine patients with breast cancer, small cell lung cancer (SCLC), non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), or gastroesophageal adenocarcinoma, each of whom had received previous cytotoxic treatments, were enrolled, and the proportion of patients with an objective response was determined as the primary endpoint. (aacrjournals.org)
  • Safety and activity of alisertib, an investigational aurora kinase A inhibitor, in patients with breast cancer, small-cell lung cancer, non-small-cell lung cancer, head and neck squamous-cell carcinoma, and gastro-oesophageal adenocarcinoma: a five-arm phase 2 study. (aacrjournals.org)
  • The TROP-2-directed antibody-drug conjugate datopotamab deruxtecan may significantly improve progression-free survival in patients with metastatic non-small cell lung cancer (NSCLC), especially in patients with non-squamous cell tumors, according to new findings simultaneously published by Ahn et. (ascopost.com)
  • The remaining 44% were composed of carcinomas not otherwise specified and a variety of uncommon tumors: large cell, clear cell, solid, bronchoalveolar, adenosquamous, epithelial hemangioendothelioma, oat cell, carcinoid, small cell and mucinous histological types. (biomedcentral.com)
  • In rare cases, the papillomas may turn into cancerous tumors or squamous cell carcinomas . (vetinfo.com)
  • The primary focus of the trial is to establish the safety and tolerability of FF-10832 in combination with KEYTRUDA in patients with advanced solid tumors, and evaluate its preliminary efficacy in non-small cell lung cancer (NSCLC)* 2 and urothelial cancer (UC)* 3 patients who have progressed after standard therapy, including immune checkpoint inhibitor therapy. (fujifilm.com)
  • Cervical squamous cell cancer. (aiom.it)
  • In squamous epithelia, this is defined as continuous strong nuclear, or nuclear plus cytoplasmic, staining of the basal cell layer with extension upward involving at least one-third of the epithelial thickness. (cancer.org.au)
  • The diagnosis of squamous cell dysplasia is concordant with previously cited rates. (bvsalud.org)
Gastric Cancer1
  • Aidexi is indicated for the treatment of locally advanced or metastatic gastric cancer (including gastroesophageal junction adenocarcinoma) with HER2 over-expression in patients who have received at least two types of systemic chemotherapy. (pharmaceutical-technology.com)
High-grade squamous intraepithelial lesion2
  • The lower anogenital squamous terminology (LAST), an acronym for LAST, incorporates the low- and high-grade squamous intraepithelial lesion (HSIL) terminology. (cytojournal.com)
  • Intraepithelial lesion, including 1 high-grade squamous intraepithelial lesion and 1 SMILE, was found. (techscience.com)
NSCLC2
  • In contrast, only one (4%) of 23 patients with NSCLC, four (9%) of 45 patients with HNSCC, and four (9%) of 47 patients with gastroesophageal adenocarcinoma achieved partial responses. (aacrjournals.org)
  • As the most predominant subtype of NSCLC, lung adenocarcinoma (LUAD) accounts for approximately 50% of the total lung cancers [ 3 ]. (biomedcentral.com)
Intraepithelial lesion1
  • No benefit of addition of other biomarkers like p63 or ki67 is found in problem-solving in differentiation of HSIL from mimics or low-grade squamous intraepithelial lesion. (cytojournal.com)
Lower anogenital squamous terminology1
  • To address this problem and to improve communication between the specialties, the Lower Anogenital Squamous Terminology (LAST) Standardization Project for HPV-Associated Lesions was convened, including five major working groups. (cancer.org.au)
Malignant4
  • Both desmoplasia and metaplasia were frequent findings in benign and malignant neoplasms, but they were more frequent among complex tubular adenocarcinomas: 38 percent presented desmoplasia, 57 percent cartilaginous metaplasia and 28 percent bone metaplasia. (bvsalud.org)
  • Accordingly, there is an unmet need for targeting of solid tumor cells for the treatment of malignant diseases that will show an affinity for cancer cells, deliver therapeutic payloads that inhibit proliferation and/or destroy cancerous tumor cells without inhibiting and/or destroying normal cells. (justia.com)
  • Albeit difficult, preoperative diagnosis of malignant ECFs impacts treatment since it requires en-bloc resection plus chemotherapy. (eurorad.org)
  • The sebaceous adenocarcinomas are malignant and are red, ulcerated and solid. (vetinfo.com)
Epithelial1
  • HPV-related squamous disease reflects a unified epithelial biology. (cancer.org.au)
Lesion1
  • 5. According to the evaluation criteria for the efficacy of solid tumors (RECIST v1.1 version), there should be at least one imaging measurable lesion. (who.int)
Metastatic1
  • Patients with HIV and a confirmed solid tumor, either metastatic or unresectable, and patients with Kaposi sarcoma (KS) were eligible for the study. (eatg.org)
Invasive2
  • Spread through air spaces (STAS) is a recently-recognized invasive pattern of lung cancer defined as 'micropapillary clusters, solid nests or single cells beyond the edge of the tumor into air spaces. (esmo.org)
  • A two-tiered nomenclature system has been accepted for non-invasive HPV associated squamous proliferations of cervix and lower anogenital tract. (cancer.org.au)
Cancers5
  • SCT-1000 is under development for the prevention of human Papillomavirus (HPV) associated cancers such as genital wart, cervical cancer, anal cancer, head and neck cancer, vaginal cancer, adenocarcinoma and vulvar cancer. (pharmaceutical-technology.com)
  • and RC28 molecule to treat WAMD (wet age-related macular degeneration) and multiple solid cancers. (pharmaceutical-technology.com)
  • Solid tumors, also known as solid cancers, is an abnormal growth of cells that do not contain liquid or cysts. (kingscollegehospitaldubai.com)
  • Fifteen patients had KS, 12 had other solid tumors, and 9 had cancers where PD-1 agents had shown efficacy. (eatg.org)
  • Fujifilm is focused on the development of liposomes/LNPs to meet unmet medical needs, including hard-to-treat cancers such as advanced solid tumors," said Junji Okada, general manager of pharmaceutical products division, FUJIFILM Corporation. (fujifilm.com)
Cervical1
  • Webs --- Usually squamous mucosal protrusion into the esophageal lumen, especially anterior cervical esophagus behind the cricoid area. (wikipedia.org)
Dysphagia5
  • If there is dysphagia to both solids and liquids, then it is most likely a motility problem. (wikipedia.org)
  • If there is dysphagia initially to solids but progresses to also involve liquids, then it is most likely a mechanical obstruction. (wikipedia.org)
  • Peptic stricture is a progressive mechanical dysphagia, meaning patients will complain of initial intolerance to solids followed by inability to tolerate liquids. (wikipedia.org)
  • Rings cause intermittent mechanical dysphagia, meaning patients will usually present with transient discomfort and regurgitation while swallowing solids and then liquids, depending on the constriction of the ring. (wikipedia.org)
  • Patients usually complain of dysphagia to both solids and liquids. (wikipedia.org)
Pancreatic2
  • Patients with pancreatic adenocarcinoma must have progressed during or after first-line therapy of FOLFIRINOX/ mFOLFIRINOX, gemcitabine/nab-paclitaxel unless deemed ineligible by the treating investigator to receive chemotherapy-based regimens due to prior comorbidities. (ucbraid.org)
  • Pancreatic adenocarcinoma. (aiom.it)
Liquids1
  • The condition results from impeded transport of liquids, solids, or both from the pharynx to the stomach. (msdmanuals.com)
Patients12
  • Adenocarcinoma is the most prevalent in the US and is associated with patients with chronic GERD who have developed Barrett's esophagus (intestinal metaplasia of esophageal mucosa). (wikipedia.org)
  • This study is primarily designed to assess the safety and tolerability of AZD4547 at increasing doses in patients with advanced solid malignancies and for whom no standard medication options are available. (astrazenecaclinicaltrials.com)
  • The safety and activity of alisertib was evaluated in patients with relapsed or refractory solid tumors. (aacrjournals.org)
  • Melichar and colleagues report the results of a phase II study evaluating the safety and activity of alisertib in patients with one of five predefined types of advanced refractory or relapsed solid tumors characterized by high Aurora kinase A expression. (aacrjournals.org)
  • Although additional work is needed to understand the differential activity of alisertib among solid tumors and to identify predictive markers of response, these findings demonstrate the antitumor activity of this inhibitor in patients with advanced breast cancer and SCLC and support future clinical trials of alisertib in combination with other therapeutic agents. (aacrjournals.org)
  • The prognosis and survival of lung adenocarcinoma (LUAD) patients are still not promising despite recent breakthroughs in treatment. (biomedcentral.com)
  • Patients with colorectal adenocarcinoma must have progressed during or after their first two lines of therapy, including FOLFOX ± Avastin and FOLFIRI ± Avastin, unless deemed ineligible by the treating investigator to receive chemotherapy-based regimens due to prior comorbidities. (ucbraid.org)
  • Information on STAS and preoperative CT were availablen 327 patients with resected lung adenocarcinomas. (esmo.org)
  • Among the 327 patients with resected adenocarcinoma, 191 (58.4%) were positive for STAS. (esmo.org)
  • TOKYO―FUJIFILM Corporation (President and CEO, Representative Director: Teiichi Goto) today announced that it has begun implementation of a phase 2a study in the U.S. to evaluate safety, tolerability, and preliminary efficacy of FF-10832, a liposomal drug candidate, in combination therapy with Merck & Co., Inc., Rahway, N.J., U.S.A.'s anti-PD-1 therapy KEYTRUDA® (pembrolizumab) for patients with advanced solid tumors. (fujifilm.com)
  • Anti-PD-1 or PD-L1 antibodies alone or in combination with CTLA-4 were shown to induce objective responses in approximately 10% to 20% of patients with gastric and gastroesophageal adenocarcinoma in small nonrandomized trials. (medscape.com)
  • In a phase II study of pembrolizumab in patients with microsatellite-high (MSI-H) solid tumors, the objective response rate was 39.6% (95% CI = 31.7% to 47.9%), including 7.4% complete responses (CRs) and 32.2% partial responses (PRs). (medscape.com)
Carcinomas2
  • Macroscopically, ulcerative carcinomas are poorly-differentiated adenocarcinomas, which invade deeply into the stomach wall. (poznayka.org)
  • Microscopically, fungating or polypoid carcinomas are well-differentiated adenocarcinomas, commonly papillary type. (poznayka.org)
Papillary1
  • 1. Adenocarcinoma: papillary, mucoid, trabecular (well-differentiated). (poznayka.org)
Mucosa2
  • The endocervix is lined by columnar mucinous epithelium and in continuity with vaginal mucosa, the ectocervix is lined by squamous epithelium. (cytojournal.com)
  • The sections show a squamous mucosa with focal moderate atypia of the squamous cells, keratinization and easily identified mitotic figures. (librepathology.org)
Epithelium1
  • The region where there is a transition from squamous to columnar epithelium in cervix is transformation zone. (cytojournal.com)
Biopsy1
LUAD1
  • However, we are rarely aware of its diagnostic, progressive and prognostic performance in lung adenocarcinoma (LUAD). (ijbs.com)
Atypical2
  • The atypical cells are partially covered by benign squamous cells, and there is a very sharp transition between the cells with atypia and those without. (librepathology.org)
  • The atypical squamous cells extend into the subepithelial tissue in irregularly shaped nests and cords. (librepathology.org)
Uncommon1
  • Our results suggest a similar distribution, but with a possibly lower proportion of adenocarcinomas, and a higher number of uncommon lung cancer types. (biomedcentral.com)
Endometrial1
  • Rarely, adenocarcinomas arise within endometrial polyps. (slideserve.com)
Esophagus1
Tumours4
  • In solid tumours, hypoxia is a common phenomenon. (bmj.com)
  • Understanding the regulation of apoptosis during hypoxia and the mechanisms of resistance to apoptosis might lead to more specific treatments for solid tumours. (bmj.com)
  • Hypoxia is a common phenomenon in solid tumours because impaired vascular function results in an inadequate blood supply. (bmj.com)
  • This chapter exposed adults, with a shorter laten onal solid tumours, are observed as summarizes the literature that docu cy period from the time of exposure tumours of adult life in conventional ments this high susceptibility of the to the carcinogen until the appear rodents. (who.int)
Metaplasia1
  • Tanto a desmoplasia como a metaplasia foi um achado freqüente nas neoplasias benignas e malignas, mas foram mais freqüentes entre os adenocarcinomas tubulares compostos: 38% apresentaram desmoplasia, 57% metaplasia cartilaginosa e 28% metaplasia óssea. (bvsalud.org)
Neoplasms1
Transition1
  • 1 cm, abrupt "shouldering" transition, lost mural stratification, soft-tissue attenuation or solid MRI signal intensity, irregular serosal nodularity, regional adenopathy [10-11]. (eurorad.org)
Incidence1
Cancer2
  • FF-10832 is a liposomal formulation which encapsulates gemcitabine* 1 , an approved anti-cancer agent indicated for the treatment of a variety of solid tumors. (fujifilm.com)
  • Gastric adenocarcinoma is the second leading cause of cancer death worldwide, following lung cancer. (medscape.com)
Significantly1
  • A univariable analysis demonstrated that STAS-positive adenocarcinomas were significantly associated with a larger radiological tumor diameter (P = 0.02), the presence of vascular convergence (P (esmo.org)
Tissue1
  • Laparotomic en-bloc resection of ileal mass, anterior abdominal wall and subcutaneous tissue involved by enterocutaneous fistulas and a segment of transverse colon was performed (post-surgical status shown in Fig. 2a, b). (eurorad.org)