AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
Carcinoma, Squamous CellCarcinoma, Basal CellLung NeoplasmsKeratins, Type IICarcinomaCarcinoma, Non-Small-Cell LungSkin NeoplasmsNeoplasms, Squamous CellCarcinoma, Small CellAdenocarcinomaHead and Neck NeoplasmsBasal Cell Nevus SyndromeTumor Markers, BiologicalCarcinoma, HepatocellularGene Expression Regulation, NeoplasticMouth NeoplasmsImmunohistochemistryPrognosisSmall Cell Lung CarcinomaCarcinoma, Renal CellEsophageal NeoplasmsNeoplasm ProteinsEyelid NeoplasmsCarcinoma in SituCell Line, TumorNeoplasm StagingCarcinoma, Lewis LungTumor Cells, CulturedGene AmplificationLungCarcinoma, Large CellMohs SurgeryFacial NeoplasmsNeoplasm InvasivenessCarcinoma, Transitional CellCarcinoma, PapillaryLaryngeal NeoplasmsAntineoplastic AgentsReceptor, Fibroblast Growth Factor, Type 1Tongue NeoplasmsKeratosis, ActinicKeratosisLiver NeoplasmsLymphatic MetastasisDNA, NeoplasmKeratoacanthomaCarcinoma, Merkel CellMice, NudeCarcinoma, NeuroendocrineRNA, MessengerCarcinoma, AdenosquamousImmunoenzyme TechniquesRetrospective StudiesNeoplasm Recurrence, LocalCarcinoma, BronchogenicSurvival AnalysisSurvival RateCarcinoma, Ductal, BreastBowen's DiseaseKidney NeoplasmsCisplatinTreatment OutcomeAntigens, NeoplasmNeoplasm MetastasisTumor Suppressor Protein p53Reverse Transcriptase Polymerase Chain ReactionPrecancerous ConditionsNeoplasms, Multiple PrimaryOropharyngeal NeoplasmsNeoplasm TransplantationUterine Cervical NeoplasmsCell ProliferationCarcinoma, BasosquamousSkinApoptosisLoss of HeterozygosityKeratinsChromosomes, Human, Pair 3SunlightReceptor, Epidermal Growth FactorMutationNeoplasms, Basal CellCarcinoma, VerrucousCarcinoma, Adenoid CysticDermoscopyBiopsyDisease ProgressionCombined Modality TherapyGenes, p53Vulvar NeoplasmsKeratinocytesCase-Control StudiesCell DivisionKeratosis, SeborrheicAntineoplastic Combined Chemotherapy ProtocolsFollow-Up StudiesPapillomavirus InfectionsBreast NeoplasmsPapillomaviridaeTime Factors
MelanomaRenal Cell CarcCancersCutaneousTumorsCancerMerkel Cell CarcLesionsNeuroendocrineTumorSubtypeHead and neckMetastaticDifferentiationSituDiagnosisNSCLCNeoplasmsAdenocarcinomaMucosalPatientsPulmonaryGrowthsOxidative stressProliferationSkin'sPancreasMalignanciesSurvivalKeratinocyteClinicalExposureRegimenMalignancyEpidermisLiverTissueBreastBiopsyInvasiveGeneticPrognosisOrgansPoorlyPropensityTypically
Melanoma10
Renal Cell Carc3
  • Compared to other kidney cancers, the clear cell type of renal cell carcinoma tends to be more aggressive and spread faster. (healthyskinworld.com)
  • If are suspected to have clear cell renal cell carcinoma, your doctor will use imaging scans such as X-rays, CT or MRI to look at the size of the tumor. (healthyskinworld.com)
  • This study is being performed as a single-arm open-label study in order to rapidly provide information on the potential benefits of the combination of pembrolizumab and lenvatinib in participants with previously untreated advanced/metastatic non-clear cell renal cell carcinoma. (survivornet.com)
Cancers14
  • Among the most dominant bladder subtypes, one was remarkably similar to lung adenocarcinomas and another was similar to head and neck squamous-cell cancers. (g2intelligence.com)
  • In this study, the breast basal-like subtype exhibited similarities between lung squamous cell carcinoma and serous ovarian cancers. (g2intelligence.com)
  • The typical verrucous or ulcerative cutaneous lesions of blastomycosis may mimic skin cancers, such as basal cell carcinoma and squamous cell carcinoma. (medscape.com)
  • The association between arsenic exposure and urinary bladder cancers, typically transitional cell carcinomas, has been observed in the same endemic areas of the world where skin cancer populations have been identified. (cdc.gov)
  • Squamous cell cancer accounts for about 20 percent of skin cancers, according to the American Cancer Society. (baptisthealth.net)
  • Each year there are more new cases of skin cancer than the combined incidence of cancers of the breast, prostate, lung and colon. (baptisthealth.net)
  • The occurrence of lung cancer was strongly related to age, with 84% of new lung cancers in males and 80% in females diagnosed in those aged 60 and over. (copdx.org.au)
  • Smoking is the largest single cause of lung cancer, responsible for 90% of lung cancers in males and 65% of lung cancers in females in Australia. (copdx.org.au)
  • Unlike many other cancers, including those originating in the lung, pancreas, and stomach, only a small minority of those affected will actually die of the disease, though it can be disfiguring. (medicalxpress.com)
  • Cigarette smoke exerts inflammatory and suppressive effects on immune cells, alters mucosal immunity and promotes autoimmunity, resulting in oral cancers [ 10 ]. (biomedcentral.com)
  • Common examples include prostate, breast, and lung cancers. (amazingposting.com)
  • Eight out of 10 lung cancers are due to tobacco smoke. (medicinenet.com)
  • Lung cancers are classified as either small cell or non-small cell cancers. (medicinenet.com)
  • Different skin cancers start in different cells of the skin. (limamemorial.org)
Cutaneous7
  • Libtayo, a monoclonal antibody, has previously been approved to treat metastatic cutaneous squamous cell carcinoma, advanced basal cell carcinoma, and patients with advanced non-small-cell lung cancer whose tumors have high PD-L1 expression. (biospace.com)
  • Separately, cemiplimab is also approved for use in advanced cutaneous squamous cell carcinoma (CSCC) and basal cell carcinoma (BCC). (medscape.com)
  • Cutaneous squamous cell cancer refers to squamous cell cancer that develops in the skin. (tataaig.com)
  • Merkel cell carcinoma is a rare cutaneous malignancy with an estimated incidence of 1 in 200,000. (pediagenosis.com)
  • Merkel cell carcinoma is derived from a specialized cutaneous nerve ending. (pediagenosis.com)
  • Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma. (kaiserpermanente.org)
  • Cemiplimab, a PD-1 antibody, is approved for treatment of advanced cutaneous squamous cell carcinoma and has shown clinical activity as monotherapy in first-line non-small-cell lung cancer. (elsevierpure.com)
Tumors10
  • As patients with uncommon lung tumor variants, including tumors composed of mixtures of histological subtypes, tend to be excluded from clinical trials, the most efficacious treatment regimen(s) for basaloid squamous cell carcinoma remain unknown. (wikipedia.org)
  • Stages I and II), the decreased survival could be attributable to earlier distant metastasis appearing during the natural history of these tumors, as compared to other squamous cell carcinomas and NSCLCs in general. (wikipedia.org)
  • More than half of human malignant tumors harbor TP53 gene mutations, most of which are point mutations within the DNA-binding domain of TP53, resulting in mutant p53 (mutp53) protein stabilization and accumulation in the cell and enhanced tumor progression. (researchsquare.com)
  • The types of skin tumors found include either Bowen's disease, squamous cell carcinomas, basal cell carcinomas, or combined lesions (9-11). (cdc.gov)
  • Lung tumors from arsenic are often associated with occupational exposure, such as smelters or agricultur e workers, and occur from inhalation (12). (cdc.gov)
  • These cells may form tumors, which are lumps of tissue. (cancer.gov)
  • This virus has been isolated from a high percentage of Merkel cell tumors, but not from all of them. (pediagenosis.com)
  • Tumors or cancer of the LUNG. (lookformedical.com)
  • As a result, the virus causes skin cells to make a protein that turns off the genes that normally suppress the growth of tumors . (clevelandclinic.org)
  • Tumors from Merkel cell carcinoma typically appear on sun-exposed areas of skin. (clevelandclinic.org)
Cancer87
  • Basaloid squamous cell carcinoma (Bas-SqCC) is an uncommon histological variant of lung cancer composed of cells exhibiting cytological and tissue architectural features of both squamous cell lung carcinoma and basal cell carcinoma. (wikipedia.org)
  • Lung cancer is a large and exceptionally heterogeneous family of malignancies. (wikipedia.org)
  • As a variant of SqCC, it is considered a non-small cell lung cancer (NSCLC). (wikipedia.org)
  • CIS is a fully malignant lesion, but by definition, the cancer cells have not yet invaded beyond the tissue delimiting their original site of genesis. (wikipedia.org)
  • citation needed] Like other forms of lung cancer, Bas-SqCC is ultimately diagnosed after a pathologist examines a tumor sample containing viable malignant cells and tissue under a light microscope and identifies certain particular characteristics. (wikipedia.org)
  • The true incidence and prevalence of basaloid squamous cell lung carcinoma remains unknown, but this form of lung cancer is considered relatively uncommon. (wikipedia.org)
  • Basaloid carcinomas of the lung - like nearly all recognized variants of lung cancer - are highly associated with tobacco smoking. (wikipedia.org)
  • Researchers are calling for adoption of a molecular-based classification system of cancer rather than the current tissue-of-origin methods, according to a study published Aug. 14 in Cell. (g2intelligence.com)
  • This confirms previously established differences between breast cancer subtypes (basal-like and luminal). (g2intelligence.com)
  • The company is hoping BNT111, which used a fixed combination of mRNA-encoded, tumor-associated antigens to target the cancer cells, will demonstrate the same kind of success as the COVID-19 vaccine. (biospace.com)
  • Pulmonary blastomycosis may resemble lung cancer, and blastomycosis osteomyelitis may resemble bony metastasis. (medscape.com)
  • While in lung cancer, IRS-1 has been confirmed to suppress tumor metastasis ( 11 ). (spandidos-publications.com)
  • Large-scale analysis of human genomics showed that the frequency of p53 mutations is high in certain types of cancer, such as basal breast cancer (88%), pancreatic cancer (41%), lung squamous cell carcinoma (84%), and high-grade serous ovarian cancer (as high as 96%) 7, 8 . (researchsquare.com)
  • Findings for colorectal cancer and esophageal squamous cell carcinoma remained compatible with causality in sensitivity analyses for violations of assumptions. (duke.edu)
  • INTERPRETATION: The PUFA biosynthesis pathway may be an intervention target for prevention of colorectal cancer and esophageal squamous cell carcinoma but with potential for increased risk of inflammatory bowel disease. (duke.edu)
  • The purpose of this study is to determine whether a 12-week, home-based, virtually supervised exercise intervention is feasible and improves various health outcomes among individuals with advanced lung cancer receiving immunotherapy. (dana-farber.org)
  • Histologically diagnosed with metastatic Non-small cell lung cancer (NSCLC). (dana-farber.org)
  • Patients with ALK fusion-positive lung cancer, BRAFV600E-mutant colorectal cancer, KRASG12D-mutant ovarian cancer, and ROS1 fusion-positive pancreatic cancer who previously developed targeted therapy resistance were treated with PF-07284892 on the first dose level of a first-in-human clinical trial. (bvsalud.org)
  • BACKGROUND: Standard platinum-based therapy for ovarian cancer is inefficient against ovarian clear cell carcinoma (OCCC). (bvsalud.org)
  • They are among the 2-3 million people diagnosed with skin cancer globally each year, many with basal cell lesions emerging on their face due to years of sun exposure. (baptisthealth.net)
  • While basal cell cancer is rarely fatal, it can be very disfiguring if left untreated. (baptisthealth.net)
  • Merkel cell carcinoma (MCC) is a rare, aggressive, and often fatal neuroendocrine skin cancer. (medscape.com)
  • Lung cancer is a serious health problem in Australia ( Cancer Council Australia 2004 ). (copdx.org.au)
  • In 2007, in Australia, lung cancer was the fourth most commonly diagnosed cancer in both males and females (excluding basal and squamous cell carcinoma of the skin), with a total of 9,703 diagnosed ( AIHW & Cancer Australia 2011 ).Lung cancer is the leading cause of cancer deaths for both sexes. (copdx.org.au)
  • Between 1982 and 2007, the incidence rate of lung cancer decreased in males by 32%, but increased in females by 72%, reflecting historical differences in smoking behaviour. (copdx.org.au)
  • The risk of lung cancer in people who have pre-existing lung disease has been studied using case-control studies, which found an increased risk of lung cancer in people with bronchitis and emphysema, even after correcting for the smoking history. (copdx.org.au)
  • A cohort study of 2,507 patients with COPD followed for 60 months found an incidence of lung cancer of 16.7 per 1000 patient years. (copdx.org.au)
  • During the first year of followup, the Standardised Incidence Ratio (SIR) for any cancer was 3.1 (95%CI 3.0-3.2), and lung cancer 8.5 (95%CI 8.2-8.8). (copdx.org.au)
  • The cumulative risks for lung cancer in this COPD cohort after 1, 5 and 10 years were 1.8% (95% CI 1.7 to 1.9%), 3.6% (95% CI 3.6 to 3.7%) and 4.9% (4.9 to 5.0%) respectively (Kornum 2012) [evidence level III-2]. (copdx.org.au)
  • During the longitudinal follow-up of the COPDGene Study [an average follow-up of 5.7 years (+/-1.87 years)], a total of 169 subjects diagnosed with lung cancer were matched (for age, race, sex, smoking status, average smoking pack-years and years since quitting smoking) against 671 control subjects with no reported lung cancer diagnosis. (copdx.org.au)
  • Characteristics associated with a future risk of lung cancer included airflow obstruction as measured by FEV 1 /FVC, history of exacerbations in the previous year and the presence of visual emphysema. (copdx.org.au)
  • Research has suggested a mechanism for the association, through identification of single-nucleotide polymorphisms (SNPs) on chromosome 15 in the nicotinic acetylcholine receptor subunit genes (CHRNA3 and CHRNA5) that are associated with smoking behaviour and with an increased risk of lung cancer and COPD ( Bierut 2010 ). (copdx.org.au)
  • The SNPs on chromosome 15 appear to have an independent effect on disease risk, as if you incorporate the smoking history into the statistical analyses, the genetic variants continue to contribute to lung cancer risk above and beyond the smoking behaviour ( Bierut 2010 ). (copdx.org.au)
  • The results can confirm a cancer diagnosis and determine whether its the clear cell subtype. (healthyskinworld.com)
  • A dividing breast cancer cell. (cancer.gov)
  • Cancer is a disease in which some of the body's cells grow uncontrollably and spread to other parts of the body. (cancer.gov)
  • Cancer can start almost anywhere in the human body, which is made up of trillions of cells. (cancer.gov)
  • Cancer cells differ from normal cells in many ways. (cancer.gov)
  • trick the immune system into helping cancer cells stay alive and grow. (cancer.gov)
  • For instance, some cancer cells convince immune cells to protect the tumor instead of attacking it. (cancer.gov)
  • Some cancer cells have double the normal number of chromosomes. (cancer.gov)
  • In addition, some cancer cells make energy from nutrients in a different way than most normal cells. (cancer.gov)
  • This lets cancer cells grow more quickly. (cancer.gov)
  • Many times, cancer cells rely so heavily on these abnormal behaviors that they can't survive without them. (cancer.gov)
  • Researchers have taken advantage of this fact, developing therapies that target the abnormal features of cancer cells. (cancer.gov)
  • Cancer is a genetic disease-that is, it is caused by changes to genes that control the way our cells function, especially how they grow and divide. (cancer.gov)
  • Cancer is a disease caused when cells divide uncontrollably and spread into surrounding tissues. (cancer.gov)
  • In normal cells, tumor suppressor genes prevent cancer by slowing or stopping cell growth. (cancer.gov)
  • DNA changes that inactivate tumor suppressor genes can lead to uncontrolled cell growth and cancer. (cancer.gov)
  • A new approval from the US Food and Drug Administration (FDA) expands the use of the immunotherapy PD-1 inhibitor cemiplimab-rwlc (Libtayo) for patients with non-small cell lung cancer (NSCLC). (medscape.com)
  • However, another lung cancer expert questioned the new approval. (medscape.com)
  • Skin cancer develops when skin cells multiply and expand in an unchecked, disorderly manner. (tataaig.com)
  • This cluster of cells could either be malignant, which, if not identified and managed at the early stage of skin cancer, could spread to surrounding tissue or other parts of your body. (tataaig.com)
  • This is where basal cell cancer starts. (tataaig.com)
  • The American Cancer Society (ACS) estimates that basal cell carcinoma makes up about 80% of all skin carcinoma. (tataaig.com)
  • The cells that provide your skin pigment, known as melanocytes, give rise to this particular cancer. (tataaig.com)
  • 1,3 Malignant squamous differentiation is characteristic of the squamous cell carcinoma (SCCA) subtype of non-small cell lung cancer (NSCLC). (roche.com)
  • Cancer is group of diseases that involves abnormal cell growth, where some of the body's cells become abnormal and begins to divide too rapidly. (grouploop.org)
  • Previously, we used to sort cancer types based on where in the body they occurred or how the cancer cells looked in a microscope. (grouploop.org)
  • Malign tumours can invade nearby tissue, and it is also possible for cancer cells to break off and be transported to distant parts of the body where they become the starting point for new tumours. (grouploop.org)
  • Both the blood system and the lymph system are known pathways for cancer cells. (grouploop.org)
  • One important difference between cancer cells and normal cells is that cancer cells are less specialized. (grouploop.org)
  • Cancer cells work differently and they also continue to divide in an uncontrolled fashion. (grouploop.org)
  • It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA . (lookformedical.com)
  • 3.Patient has a concurrent malignancy or malignancy within 3 years of randomization, with the exception of adequately treated, basal or squamous cell skin carcinoma, non-melanomatous skin cancer or curatively resected cervical cancer. (who.int)
  • The scientific community divides cancer into several different types, primarily based on the origin of the abnormal cell growth. (amazingposting.com)
  • Cancer is not a singular disease but rather an array of conditions characterized by unregulated cell growth. (amazingposting.com)
  • Carcinomas are the most common type of cancer, forming in the skin or tissues that line the internal organs. (amazingposting.com)
  • This cancer affects the basal cells, which line the skin's lowest layer. (amazingposting.com)
  • This cancer originates from glandular cells that are present in different organs. (amazingposting.com)
  • This is a slow-growing cancer affecting lymphoid cells, predominantly seen in adults. (amazingposting.com)
  • Affecting the myeloid cells, this cancer tends to progress slowly compared to its acute counterpart. (amazingposting.com)
  • This cancer has a characteristic presence of Reed-Sternberg cells, affecting the lymph nodes and sometimes other organs. (amazingposting.com)
  • Lung cancer kills more men and women than any other form of cancer. (medicinenet.com)
  • Nonmelanoma skin cancer (NMSC) includes basal cell carcinoma and squamous cell carcinoma. (limamemorial.org)
  • Skin cancer is cancer that starts in the skin cells. (limamemorial.org)
  • Merkel cell carcinoma is a rare but aggressive type of skin cancer that can be life-threatening. (clevelandclinic.org)
  • Merkel cell carcinoma is a very rare type of skin cancer , affecting approximately 3,000 Americans every year. (clevelandclinic.org)
  • Merkel cell cancer. (clevelandclinic.org)
  • UV rays from sun exposure or artificial light sources like tanning beds cause most types of skin cancer, including Merkel cell carcinoma. (clevelandclinic.org)
  • Merkel cell carcinoma is an aggressive cancer that spreads quickly to other parts of your body. (clevelandclinic.org)
  • A major epidemiological study on environmental tobacco smoke has been completed and revealed a significant dose-response relationship between passive smoking (at home or at the workplace) and lung cancer. (who.int)
  • Squamous cell carcinoma is cancer that begins in the squamous cells of the skin. (msdmanuals.com)
  • Squamous cell carcinoma is cancer of these cells. (msdmanuals.com)
  • Basal Cell Carcinoma Basal cell carcinoma, the most common skin cancer, originates in certain cells of the outer layer of the skin (epidermis). (msdmanuals.com)
  • However, people who have had more sun exposure to their skin have a higher risk of developing squamous cell skin cancer. (msdmanuals.com)
  • The incidence of keratinocyte cancer (basal cell and squamous cell carcinomas of the skin) is 17-fold lower in Singapore than the UK, despite Singapore receiving 2-3 times more ultraviolet (UV) radiation. (cdc.gov)
Merkel Cell Carc24
Lesions5
  • Both basaloid and squamous cell carcinomas have been shown to arise from pre-malignant lesions of dysplasia in the airways of the lung. (wikipedia.org)
  • All 13 cases of atypical squamous lesions (including one case of bronchial squamous dysplasia) were negative with the 8G7G3/1 antibody, but 6/13 cases of squamous carcinoma/dysplasia showed positive nuclear labelling with the SP141 antibody in the same tissue biopsy. (edu.au)
  • CK5 is expressed in the basal epithelium of the lung and its overexpression is an indicator of malignant squamous differentiation in pulmonary lesions. (roche.com)
  • 9,10 Thus, detection of CK5 in prostatic basal cells with anti-Cytokeratin 5/6 (D5/16B4) antibody may be used to aid in the differentiation of benign and malignant prostate lesions. (roche.com)
  • The term organoid nevus may be used to emphasize the admixture of epidermal cells often evident in individual lesions of epidermal nevi. (medscape.com)
Neuroendocrine3
  • Among other pulmonary malignancies, the main differential diagnoses in suspected cases of Bas-SqCC include the high-grade neuroendocrine carcinomas, such as small cell carcinoma and large cell neuroendocrine carcinoma. (wikipedia.org)
  • The cells are a type of neuroendocrine cell that has both nervous system and endocrine system functions. (clevelandclinic.org)
  • Neuroendocrine carcinoma of the skin. (clevelandclinic.org)
Tumor21
  • In the third revision of the World Health Organization lung tumor typing and classification scheme, published in 1999, basaloid variants of both squamous cell lung carcinoma (SqCC) and large cell lung carcinoma (LCLC) were recognized as distinct entities. (wikipedia.org)
  • This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. (cancerindex.org)
  • In this study, we found a negative correlation of IRS-1 expression with tumor metastasis both in human tissue samples and in cell lines. (spandidos-publications.com)
  • However, recently Houghton et al ( 7 ) showed increased cell proliferation after silencing of IRS1 gene expression in A549 cells suggesting tumor suppression potential. (spandidos-publications.com)
  • Loss of E-cadherin, not only results in loss of adherens junctions between neighbor cells resulting in dissemination of cells from the original tumor, but also results in releasing its cytoplasmic binding with β-catenin. (spandidos-publications.com)
  • However, due to the lack of specific autophagy receptors and the insufficient level of autophagy in tumor cells, targeted degradation of mutp53 by nanomaterials via the autophagy pathway has not been reported. (researchsquare.com)
  • The NRs specifically bind mutp53 in tumor cells via mutp53-binding peptide (MBP). (researchsquare.com)
  • The tumor suppressor p53, encoded by the TP53 gene, is an important tumor transcription factor that serves to maintain cell homeostasis by regulating cell cycle arrest and cell death in response to a variety of stress signals 1-4 . (researchsquare.com)
  • Secondary objectives include progression-free survival (PFS), changes in circulating tumor cells (CTC) and exploration of genomic alterations. (bvsalud.org)
  • The tumor suppressor p53 responds to a number of extrinsic and intrinsic tension indicators to result in many mobile applications, including cell-cycle arrest, apoptosis, inhibition of angiogenesis/metastasis, and DNA restoration (13C16). (immune-source.com)
  • The mechanism of action of abatacept is fundamentally different from that of other biologic DMARD, such as tumor necrosis factor (TNF) antagonists or B cell-depleting agents. (jrheum.org)
  • An expert, called a pathologist, will study cells from the sample under the microscope to see what kind of tumor it is. (healthyskinworld.com)
  • Even within the same tumor, different cells may have different genetic changes. (cancer.gov)
  • Treatment regimen for Squamous cell carcinoma is intended for controlling the primary tumor and dealing with the concern for metastasis. (petmoo.com)
  • The tumor promoting Merkel cell polyomavirus has been implicated in its pathogenesis. (pediagenosis.com)
  • The tumor is composed of small, uni- formly shaped, basophilic-staining cells. (pediagenosis.com)
  • It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
  • A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane. (lookformedical.com)
  • A cell line derived from cultured tumor cells. (lookformedical.com)
  • To the best of our knowledge, this is the first study considering oxidative activity of both serum and tissue specimens in human basal cell carcinoma (BCC), which is the most common tumor in the world. (scirp.org)
  • Basal cell carcinoma (BCC) is the most common tumor in light skin people [1]. (scirp.org)
Subtype2
  • The aim of this study was to identify valuable biomarkers by searching the candidate molecules that contribute to lung adenocarcinoma pathogenesis, especially KC subtype. (cancerindex.org)
  • REG4, an important regulator of gastro-intestinal carcinogenesis, was highly expressed in KRAS mutant lung adenocarcinoma with low expression of TTF-1 (KC subtype). (cancerindex.org)
Head and neck1
Metastatic1
  • Eligible patients (aged ≥18 years and with an Eastern Cooperative Oncology Group performance status of 0 or 1) with a histologically confirmed diagnosis of metastatic basal cell carcinoma (group 1) or locally advanced basal cell carcinoma (group 2) who had progressed on or were intolerant to previous HHI therapy were enrolled. (elsevierpure.com)
Differentiation9
  • In the case of Bas-SqCC, it is essential that both evidence of squamous differentiation (i.e., intercellular bridges, production of keratin, tonofilament bundles) and basaloid architecture (i.e. prominent peripheral palisading of cell nuclei, organoid/lobular structures) are identified to make a correct diagnosis. (wikipedia.org)
  • Insulin receptor substrate 1 (IRS-1) is an adaptor protein that integrates multiple transmembrane signals from growth factors and hormones, to regulate cell growth, survival, differentiation and metabolism ( 4 ). (spandidos-publications.com)
  • They are invasive, the unregulated proliferation of epidermal prickle-squamous cell layers that also show keratinocytic differentiation. (petmoo.com)
  • This study aimed to find out more candidate miRNA-mRNA pairs involved in the osteogenic differentiation of MC3T3-E1 cells. (frontiersin.org)
  • An MC3T3-E1-based microarray dataset (accessioned as GSE46400) downloaded from the Gene Expression Omnibus included MC3T3-E1 cells with or without 14-day osteoblast differentiation osteoblast induction. (frontiersin.org)
  • The MC3T3-E1 cells were cultured and incubated in the osteogenic differentiation medium for 14 days. (frontiersin.org)
  • There were 7 overlapped miRNA-mRNA pairs identified during osteogenic differentiation of MC3T3-E1 cells, including mmu-miR-204-5p-Arhgap11a, mmu-miR-211-5p-Arhgap11a, mmu-miR-24-3p-H2afx, mmu-miR-3470b-Chek2, mmu-miR-3470b-Dlgap5, mmu-miR-466b-3p-Chek1, and mmu-miR-466c-3p-Chek1. (frontiersin.org)
  • The Arhgap11a, H2afx, Chek2, Dlgap5, and Chek1 were hub genes downregulated in MC3T3-E1 cells after osteogenic differentiation, verified by RT-qPCR results. (frontiersin.org)
  • Our study characterizes miR-211-5p targeting Arhgap11a promotes the osteogenic differentiation of MC3T3-E1 cells, which provides novel targets to promote the osteogenesis process during bone repair. (frontiersin.org)
Situ1
  • After continued exposure to tobacco smoke or other carcinogenic stimuli, cells in areas of severe dysplasia can suffer additional genetic damage that results in progression to a basaloid or squamous cell carcinoma in situ (CIS). (wikipedia.org)
Diagnosis7
  • The relevance of this genetic diagnosis for lung transplant management has not been examined. (ersjournals.com)
  • The significance of the genetic diagnosis of telomerase-mediated pulmonary fibrosis to lung transplant management has not been examined. (ersjournals.com)
  • M1192 is a valid 2023 HCPCS code for Patients with an existing diagnosis of squamous cell carcinoma of the esophagus or just " Pt w/ dx sq cell ca of esoph " for short, used in Medical care . (hcpcs.codes)
  • Immunohistochemical detection of thyroid transcription factor-1 (TTF-1) plays an important role in the diagnosis and subclassification of non-small cell carcinomas of the lung in biopsy and some cytology samples, specifically for identification of squamous cell carcinoma (classically negative) and non-mucinous adenocarcinoma ( positive in most cases) and for discrimination between lung adenocarcinoma and pleural malignant mesothelioma (classically negative). (edu.au)
  • If the results of SP141 are assigned overriding significance, our findings further indicate that in isolation, neither negative labelling with either 8G7G3/1 or SP141 nor positive labelling with the SP141 MAb discriminates between sarcomatoid carcinoma and sarcomatoid mesothelioma, whereas positive labelling with the 8G7G3/1 MAb favours a diagnosis of sarcomatoid carcinoma. (edu.au)
  • Must have a histologically-confirmed diagnosis of non-clear cell RCC. (survivornet.com)
  • In addition, CK5 is expressed in mesothelial cells of the pulmonary pleura and is overexpressed in epithelioid malignant mesothelioma (MM). 6 CK5 is consistently absent in pulmonary ADC that confounds the diagnosis of epithelioid MM. 6,7 Thus, detection of CK5 with anti-Cytokeratin 5/6 (D5/16B4) antibody can be used to aid in the differential diagnosis of epithelioid MM from lung ADC. (roche.com)
NSCLC2
  • Like nearly all other forms of NSCLC, the prognosis of basaloid squamous cell carcinoma is quite poor. (wikipedia.org)
  • Basaloid architecture in pulmonary carcinomas has been shown to be particularly prevalent in smokers with heavy exposure, and squamous cell carcinoma has the strongest association with tobacco exposure than any other major cell type of NSCLC. (wikipedia.org)
Neoplasms3
  • Oral neoplasms typically exhibit a high rate of metastasis to local lymph nodes and the lungs. (petmoo.com)
  • CK5 is expressed in prostatic basal cells and the loss of CK5 expression is indicative of neoplasms that have breached the basal membrane. (roche.com)
  • The concept does not refer to neoplasms located in tissue composed of squamous elements. (lookformedical.com)
Adenocarcinoma5
  • REG4 is an indicator for KRAS mutant lung adenocarcinoma with TTF-1 low expression. (cancerindex.org)
  • Recent research has classified lung adenocarcinoma patients with KRAS mutation into three subtypes by co-occurring genetic events in TP53 (KP subgroup), STK11/LKB1 (KL subgroup) and CDKN2A/B inactivation plus TTF-1 low expression (KC subgroup). (cancerindex.org)
  • All 35 cases of adenocarcinoma of the lung were positive with both antibodies. (edu.au)
  • Conclusions: Our findings indicate differences in the rates of positive and negative labelling with these two antibodies, and suggest the potential for misclassification of a proportion of squamous carcinomas of the lung as adenocarcinoma, and for misdiagnosis of some sarcomatoid mesotheliomas as sarcomatoid carcinoma of the lung. (edu.au)
  • 1,8 The detection of CK5 in basal cells is a feature of normal and benign prostatic processes and the absence of CK5 is indicative of prostate adenocarcinoma. (roche.com)
Mucosal2
  • Results: Both antibodies labelled alveolar epithelium in normal lung parenchyma, but the SP141 antibody also labelled bronchial mucosal basal cells. (edu.au)
  • Squamous cells are also seen in tissues, including the mucosal surfaces and lungs. (tataaig.com)
Patients5
  • This is a tricky one because 92% of MCC patients are not immune compromised, but those with long-term T-cell dysfunction (organ transplant recipients, autoimmune disease patients receiving immune suppression, HIV patients, chronic lymphocytic leukemia patients) are at much higher risk of developing MCC, but they represent less than 10% of all cases. (medscape.com)
  • This audit utilizes explicit proof in the field of lung transplantation in CF patients and resolves all issues of pragmatic significance. (alliedacademies.org)
  • That phase 3 trial was the EMPOWER-Lung 3, conducted in 466 patients who received platinum-doublet chemotherapy and were randomly assigned in a 2:1 ratio to receive either cemiplimab 350 mg or placebo intravenously every 3 weeks. (medscape.com)
  • Here, we present the primary analysis data of cemiplimab in patients with locally advanced basal cell carcinoma after HHI therapy. (elsevierpure.com)
  • Interpretation: Cemiplimab exhibited clinically meaningful antitumour activity and an acceptable safety profile in patients with locally advanced basal cell carcinoma after HHI therapy. (elsevierpure.com)
Pulmonary2
  • Lung transplantation is the only intervention that prolongs survival in idiopathic pulmonary fibrosis (IPF). (ersjournals.com)
  • Idiopathic pulmonary fibrosis (IPF) is progressive and fatal, and lung transplantation is the only therapy that has been shown to prolong survival [ 1 ], [ 2 ]. (ersjournals.com)
Growths1
  • Threatening sicknesses during the beyond 2 years are viewed as an outright contraindication to LTX, except for nonmelanoma skin growths, for example, squamous-cell and basal-cell carcinomas [ 5 ]. (alliedacademies.org)
Oxidative stress1
  • Single cells and organisms may adapt to harmful oxidative stress conditions, through stress-activated factors. (springer.com)
Proliferation4
  • Subsequently, the degradation of mutp53 by the NRs abrogated mutp53-conferred gain-of-function (GOF) phenotypes, including enhanced cell proliferation and cell migration and reduced sensitivity to cisplatin (CDDP). (researchsquare.com)
  • The PGC-like cells in Blimp1 mutant embryos didn't show the quality proliferation and migration (7). (immune-source.com)
  • Nevertheless, zero research to day possess directly defined the part of Blimp1 in regulating cell success and proliferation. (immune-source.com)
  • Notably, many lncRNAs dysregulation are associated with Oral squamous cell carcinoma (OSCC) and affect various aspects of cellular homeostasis, including proliferation, survival, migration or genomic stability. (biomedcentral.com)
Skin's1
Pancreas1
  • No significant differences were found in the survival from tumours largely refractive to therapy, e.g., carcinomas of the pancreas, lung and liver. (who.int)
Malignancies2
  • Chronic inorganic arsenic poisoning is also associated with a number of chronic medical conditions (hypertension, diabetes mellitus, and peripheral vascular disease) as well as lung, bladder, and hepatic malignancies. (medscape.com)
  • Skin malignancies include squamous and basal cell carcinomas and Bowen disease. (medscape.com)
Survival1
Keratinocyte1
Clinical1
  • These data, along with relatively high retention rates, support the longterm clinical benefit provided by selective T cell costimulation modulation. (jrheum.org)
Exposure1
Regimen1
  • Background: Before February, 2021, there was no standard treatment regimen for locally advanced basal cell carcinoma after first-line hedgehog inhibitor (HHI) therapy. (elsevierpure.com)
Malignancy1
  • Development of second malignancy (except for basal cell carcinoma or squamous cell carcinoma of the skin) that requires concurrent treatment, which would interfere with this study. (dana-farber.org)
Epidermis4
Liver2
Tissue6
  • Merkel cells, like melanocytes, are embryologically derived from the neural crest tissue. (pediagenosis.com)
  • Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Intended Use", "Value": "Anti-Cytokeratin 5/6 (D5/16B4) Mouse Monoclonal Primary Antibody is intended for laboratory use in the qualitative immunohistochemical detection of cytokeratin 5 by light microscopy in sections of formalin-fixed, paraffin-embedded tissue stained on a BenchMark IHC/ISH instrument. (roche.com)
  • Additionally, CK5 is expressed in myoepithelial cells (MECs) in normal breast tissue and benign processes. (roche.com)
  • Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. (lookformedical.com)
  • Concentration of Malondialdehide (MDA) in human basal cell carcinoma (BCC) and individually matched normal skin tissue were examined with spectrophotometery method. (scirp.org)
  • When uninflamed, they are characterized by a wall of relatively loose connective tissue, and an epithelial lining consisting of two to four layers of cuboidal cells. (bvsalud.org)
Breast2
  • CK5 is a type II CK (high molecular weight, 62 kDa) expressed in the basal and myoepithelial cells of various epithelia and glandular structures including the bronchi, prostate and breast. (roche.com)
  • An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST. (lookformedical.com)
Biopsy1
Invasive1
  • Furthermore, we found that knockdown of IRS-1 expression enhanced cell invasive potency and induced EMT in parallel with upregulation of miR-9 expression. (spandidos-publications.com)
Genetic1
Prognosis1
  • Although case numbers tend to be rather small, and the published studies statistically underpowered, much (but not all) evidence suggests that basaloid squamous cell lung carcinomas may have a somewhat worse prognosis than "conventional" (i.e. non-basaloid) squamous cell lung carcinomas. (wikipedia.org)
Organs2
  • Found in several organs, including the skin, lungs, and more, this type develops in the squamous cells, which comprise the surface of the skin and lining of organs. (amazingposting.com)
  • From there, it may spread to other parts of your body like your bones, lungs , brain or other organs. (clevelandclinic.org)
Poorly1
  • In addition, the basaloid variant of SqCC can be difficult to distinguish from other poorly differentiated squamous cell carcinomas. (wikipedia.org)
Propensity1
Typically1