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SqualeneSqualene MonooxygenaseFarnesyl-Diphosphate FarnesyltransferaseTricarboxylic AcidsLanosterolMevalonic AcidSterolsSebumOxygenasesIntramolecular TransferasesErgosterolFarnesolPolyisoprenyl PhosphatesLovastatinHydroxymethylglutaryl CoA ReductasesTriterpenesAllylamineGeranylgeranyl-Diphosphate GeranylgeranyltransferaseCholesterolBicyclo Compounds, HeterocyclicOxazepinesChromatography, Thin LayerPhytosterolsBenzophenonesStigmasterolCyclizationCholestanesBicyclo CompoundsGeranyltranstransferaseSitosterolsAcetatesQuinuclidinesNaphthalenesStramenopilesTelluriumEncyclopedias as Topic
EpoxidaseDifferentially expressed genesMonooxygenaseAntibodyEnzymeInhibitionFattyTerbinafineLipidCholesterolTranscriptomicsPerformed gene expressionFunctionalBiologicalHumanActivityDirectlyIdentifyAnalysisFatty acidFDFT1ProteinSymbolAdenocarcinomaEnzymesEncodeViralPrevalenceNasopharyngeal carcinomaPancreaticAccessionPathwayGenome-wideAntigenDiseasesPrognosisProteinsVitroInduceMechanismsDataIdentificationActivationOriginalRoleDevelopmentStudyValuesTargetPageExpression profilesShowCells
Epoxidase15
  • Squalene monooxygenase (also called squalene epoxidase) is a eukaryotic enzyme that uses NADPH and diatomic oxygen to oxidize squalene to 2,3-oxidosqualene (squalene epoxide). (wikipedia.org)
  • Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway. (wikipedia.org)
  • In humans, squalene epoxidase is encoded by the SQLE gene. (wikipedia.org)
  • Several eukaryote genomes lack a squalene monooxygenase encoding gene, but instead encode an alternative squalene epoxidase that performs the same task. (wikipedia.org)
  • The alternative squalene epoxidase belongs to the fatty acid hydroxylase superfamily and obtains electrons from cytochrome b5. (wikipedia.org)
  • Inhibitors of squalene epoxidase have found application mainly as antifungal drugs: butenafine naftifine terbinafine Since squalene epoxidase is on the biosynthetic pathway leading to cholesterol, inhibitors of this enzyme may also find application in treatment of hypercholesterolemia. (wikipedia.org)
  • In baker's yeast (Saccharomyces cerevisiae), squalene epoxidase is localized to both the endoplasmic reticulum and lipid droplets. (wikipedia.org)
  • Squalene epoxidase also catalyzes the formation of diepoxysqualene (DOS). (wikipedia.org)
  • SQLE, squalene epoxidase enzyme. (cdc.gov)
  • Du Y, Rokavec M, Hermeking H. Squalene epoxidase/SQLE is a candidate target for treatment of colorectal cancers with p53 mutation and elevated c- MYC expression. (ijbs.com)
  • In a bioinformatics screen we identified Squalene epoxidase/SQLE as a candidate therapeutic target that appeared to be especially relevant for cell survival in CRCs, which display elevated c-MYC expression and loss of p53 function. (ijbs.com)
  • Terbinafine hydrochloride is a synthetic allylamine whose mechanism of action consists of inhibiting the enzyme squalene epoxidase that participates in the first stage of ergosterol synthesis, interfering with fungal membrane function. (bvsalud.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Squalene Epoxidase (SQLE) in Tissue homogenates, cell lysates and other biological fluids. (noveoninc.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Squalene Epoxidase (SQLE) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (noveoninc.com)
  • Description: A sandwich ELISA kit for detection of Squalene Epoxidase from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (noveoninc.com)
Differentially expressed genes2
  • 600 genes differentially expressed during Leber congenital amaurosis_Retina_GSE3249 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. (maayanlab.cloud)
  • The transcriptomic findings exhibited that the differentially expressed genes of fungus after rosmarinic acid intervention were mainly enriched in the carbon metabolism pathway, while the proteomic findings suggested that rosmarinic acid could inhibit the average growth of Trichophyton mentagrophytes by interfering with the expression of enolase in the glycolysis pathway. (biomedcentral.com)
Monooxygenase3
  • The canonical squalene monooxygenase is a flavoprotein monooxygenase. (wikipedia.org)
  • Squalene monooxygenase differs from other flavin monooxygenases in that the oxygen is inserted into the substrate as an epoxide rather than as a hydroxyl group. (wikipedia.org)
  • Description: Quantitative sandwich ELISA for measuring Human Squalene monooxygenase (SQLE) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (noveoninc.com)
Antibody1
  • There are currently no images for SQLE Antibody (NBP2-98542B). (novusbio.com)
Enzyme2
  • SQLE is a rate-limiting enzyme in the cholesterol synthesis. (ijbs.com)
  • Description: Enzyme-linked immunosorbent assay kit for quantification of Human Squalene synthase in samples from serum, plasma, tissue homogenates and other biological fluids. (noveoninc.com)
Inhibition1
  • Inhibition of SQLE decreased viability of CRC cells. (ijbs.com)
Fatty4
  • The significant module (royal blue) identified was associated with TC, TG and non-HDL-C. GO and KEGG enrichment analyses revealed that the genes in the royal blue module were associated with carbon metabolism, steroid biosynthesis, fatty acid metabolism and biosynthesis pathways of unsaturated fatty acids. (biomedcentral.com)
  • Quantitative real time PCR, and -in a second animal experiment- intestinal fatty acid oxidation measurements confirmed significant gene expression differences and showed in a dose-dependent manner significant changes at biological functional level. (biomedcentral.com)
  • We show that marine n-3 fatty acids regulate small intestinal gene expression and increase fatty acid oxidation. (biomedcentral.com)
  • We hypothesized that, using long-term dietary intervention studies, dietary fatty acid composition may modulate gene expression and lipid metabolism in the intestine, and that especially EPA and DHA may stimulate expression of genes involved in lipid catabolism. (biomedcentral.com)
Terbinafine1
  • The transcription factor AP4/TFAP4 directly induced SQLE expression and cholesterol levels, whereas inactivation of AP4 resulted in decreased SQLE expression and caused resistance to Terbinafine, an inhibitor of SQLE. (ijbs.com)
Lipid2
  • The main biological process affected based on gene expression analysis was lipid metabolism. (biomedcentral.com)
  • Furthermore, no major changes in the expression of lipid metabolism genes were observed in the colon. (biomedcentral.com)
Cholesterol2
  • SQLE and SCD are related to hyperlipidaemia, and SQLE/SCD may be new targets for cholesterol-lowering or triglyceride-lowering therapy, respectively. (biomedcentral.com)
  • Here, we show that p53 supresses SQLE expression, cholesterol levels, and cell viability via the induction of miR-205 , which directly targets SQLE . (ijbs.com)
Transcriptomics1
  • Comparison of real-time PCR and transcriptomics results showed that the trends of gene expression in glycolytic, carbon metabolism and glutathione metabolic pathways were identical. (biomedcentral.com)
Performed gene expression1
  • To examine this, we performed gene expression analysis of the mouse small intestine and colon, using whole genome oligonucleotide arrays and validation experiments using quantitative real time PCR (qRT-PCR). (biomedcentral.com)
Functional1
  • Gene co-expression network-based methods have been widely used in processing microarray data and have especially been used to identify meaningful functional modules [ 18 , 19 ]. (biomedcentral.com)
Biological1
  • Here, we assessed gene expression changes induced by DHA and EPA in the wildtype C57BL/6J murine small intestine using whole genome microarrays and functionally characterized the most prominent biological process. (biomedcentral.com)
Human1
  • Produced in rabbits immunized with E. coli-derived Human SQLE fragment. (novusbio.com)
Activity1
  • Altogether, our results demonstrate that SQLE represents a vulnerability for CRCs with p53 inactivation and elevated c-MYC activity. (ijbs.com)
Directly1
  • Furthermore, c-MYC induced SQLE expression directly and via its target gene AP4 . (ijbs.com)
Identify2
  • Microarray analysis might serve as a novel and practical approach to identify susceptibility genes associated with HLP [ 15 ]. (biomedcentral.com)
  • Next we compared gene expression profiles of Foxp3+ Treg subsets (+) of different maturity (24lo, 24int, 24hi) and could identify a set of genes that were specifically up or downregulated in Foxp3+ Tregs, but not in Foxp3- conventional T cells, in a maturation-dependent manner. (gsea-msigdb.org)
Analysis2
  • Weighted gene co-expression network (WGCNA) analysis was used to analyse the gene expression profile, and the royal blue module was considered to have the highest correlation. (biomedcentral.com)
  • Weighted gene co-expression network analysis (WGCNA) is one of the most effective methods of gene co-expression network analysis. (biomedcentral.com)
Fatty acid1
  • This phenotype was associated with molecular signatures of increased hepatic de novo lipogenesis (DNL) via activation of sterol regulatory element-binding protein 1 (SREBP1) and concomitant upregulation of the expression of key genes in both fatty acid and triglyceride metabolism. (biomedcentral.com)
FDFT11
  • In this study, we sought to explore the function of seven important enzymes(MSMO1, EBP, HMGCS1, IDI2, DHCR7, FDFT1, and SQLE) involved in cholesterol biosynthesis especially SQLE in PDAC therapy. (researchsquare.com)
Protein3
  • Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)
  • Our data clearly reflect such tumor promotion, showing that deregulation of key proteins involved in apoptosis (BCL2-related protein A1 and Fas apoptotic inhibitory molecule), cell cycle checkpoints (AKIP, SCYL1, and NIN), and metastasis (matrix metalloproteinase 1) is closely correlated with the levels of EBV gene expression in NPC. (gsea-msigdb.org)
  • with Pubmed ID, gene symbol/accession number and parasite interacting protein. (polygenicpathways.co.uk)
Symbol1
  • Approved gene symbol with link to HUGO Gene Nomenclature Committee. (nih.gov)
Adenocarcinoma2
  • 4. Development and Validation of an Inflammatory Response-Related Gene Signature for Predicting the Prognosis of Pancreatic Adenocarcinoma. (nih.gov)
  • 11. Using ESTIMATE algorithm to establish an 8-mRNA signature prognosis prediction system and identify immunocyte infiltration-related genes in Pancreatic adenocarcinoma. (nih.gov)
Enzymes1
  • We demonstrated that downregulation of those enzymes especially SQLE significantly suppressed PDAC cells survival. (researchsquare.com)
Encode1
  • Methods: We used two congenic mouse models that differ at the Ahr gene and encode AHRs with a 10-fold difference in signaling activity. (nih.gov)
Viral1
  • Expression levels of six viral genes (EBNA1, EBNA2, EBNA3A, EBNA3B, LMP1, and LMP2A) were correlated among themselves and strongly inversely correlated with the expression of a large subset of host genes. (gsea-msigdb.org)
Prevalence2
  • B) Prevalence of substitution points in the gene encoding SQLE. (cdc.gov)
  • Jensen Lab generated fractional counting score for the prevalence of this gene in Pubmed articles. (nih.gov)
Nasopharyngeal carcinoma2
  • Genes up-regulated in nasopharyngeal carcinoma (NPC) positive for LMP1 [GeneID=9260] , a latent gene of Epstein-Barr virus (EBV). (gsea-msigdb.org)
  • To identify the molecular mechanisms by which EBV-associated epithelial cancers are maintained, we measured the expression of essentially all human genes and all latent EBV genes in a collection of 31 laser-captured, microdissected nasopharyngeal carcinoma (NPC) tissue samples and 10 normal nasopharyngeal tissues. (gsea-msigdb.org)
Pancreatic1
  • SQLE was upregulated in PDAC cell lines, and the elevated level of SQLE is correlated with poor prognosis in pancreatic cancer samples. (researchsquare.com)
Accession1
  • Gene symbols, accession ids and various other target identifiers. (nih.gov)
Pathway1
  • Currently, there are 205 genes in SZGR 2.0 (with evidence in schizophrenia) that are present at this pathway. (uth.edu)
Genome-wide1
  • We determined the hepatic, statin-related gene signature from genome-wide transcriptomic profiling in severely obese patients with varying degrees of glucose tolerance and cardio-metabolic comorbidities. (biomedcentral.com)
Antigen1
  • The page also collects GeneMedi's different modalities and formats products for SQLE in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. (genemedi.net)
Diseases2
  • 600 genes differentially expressed during Leber congenital amaurosis_Retina_GSE3249 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. (maayanlab.cloud)
  • With GeneMedi's target-insight database-GM ITD database, the SQLE target is also connected to human indications/diseases/conditions/MOA. (genemedi.net)
Prognosis1
  • 17. Ferroptosis regulators, especially SQLE, play an important role in prognosis, progression and immune environment of breast cancer. (nih.gov)
Proteins1
Vitro1
  • A novel liver-specific Pxr knockout mouse model was also generated to determine the contribution of hepatic PXR signaling to efavirenz-elicited dyslipidemia and hepatic steatosis.We found that efavirenz is a potent PXR-selective agonist that can efficiently activate PXR and induce its target gene expression in vitro and in vivo. (nih.gov)
Induce1
  • The AHR is a nuclear receptor/transcription factor that is best known for responding to environmental toxicant exposures to induce a battery of xenobiotic-metabolizing genes. (nih.gov)
Mechanisms2
  • In addition to transcriptional regulation mediated by hypoxia-inducible factors, HIFs, other epigenetic mechanisms of gene regulation, such as histone modifications and DNA methylation, are utilized under hypoxia. (biomedcentral.com)
  • However, other mechanisms regulating expression of Tet1 genes remain largely unknown. (biomedcentral.com)
Data1
  • Mechanistically, GSEA analysis with RNA-seq data revealed that SQLE silencing negatively mediated mTORC1 and TNFα/NF-κB signaling pathways. (researchsquare.com)
Identification1
Activation1
  • A DNL gene activation profile in response to statins is associated with insulin resistance and the diabetic status of the patients. (biomedcentral.com)
Original1
  • Search results: The pahtway p3218 has 311 genes in the original annotation. (uth.edu)
Role3
  • These findings demonstrate that TET1 serves as a transcription co-activator to regulate hypoxia-responsive gene expression and EMT, in addition to its role in demethylating 5mC. (biomedcentral.com)
  • The set of genes that was regulated by TET1 under hypoxia and their role in hypoxia-induced EMT were delineated. (biomedcentral.com)
  • These results provide a fresh insight into regulation of hypoxia-responsive gene expression by TET1 and further expand the role of TET1. (biomedcentral.com)
Development2
  • Pre-made anti-SQLE monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). (genemedi.net)
  • The anti-SQLE mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. (genemedi.net)
Study2
  • Model organisms have been used in the study of SQLE function. (wikipedia.org)
  • This study demonstrated that SQLE is a novel target for PDAC therapy. (researchsquare.com)
Values1
  • Expression level and prognostic values of SQLE were evaluated by western blot and Kaplan-Meier analysis. (researchsquare.com)
Target3
  • Total count of NCBI Gene Reference Into Function hits for target listed in parenthesis, and summary table with links to publications per PMID with the specific text in article that includes the reported target. (nih.gov)
  • Number of Gene Ontology (GO) annotations for this target, consisting of the sum of GO Functions and GO Processes. (nih.gov)
  • It's the GeneMedi's summary page for Target/Biomarker Introduction of SQLE. (genemedi.net)
Page1
  • Because the gene page contains a lot of information, it takes on average 3-5 seconds to load. (uth.edu)
Expression profiles1
  • Global gene expression profiles clearly distinguished tumors from normal healthy epithelium. (gsea-msigdb.org)
Show1
Cells3
  • The influence of SQLE knockdown by shRNA in PDAC cells was assessed by Transwell, colony formation and cell cycle analysis. (researchsquare.com)
  • SQLE knockdown could significantly inhibit the proliferation and migration of PDAC cells. (researchsquare.com)
  • Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 4 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 4 h. (gsea-msigdb.org)