EosinophilsPeripheral blood eosinophiliaNitric oxideSerumEosinophilicInfiltratesClinicalLarvaeResponse to corticosteroidsSpecimensBiomarkersDiagnosisNairPatient'sGene expressionAssayCough productivePersistentInflammationPeriostinChronicParagonimusTuberculosisPatientsPatientExpectorationSymptomsMildMalignantCytokinesRespiratoryBloodReactiveDiagnosticTissueExaminationOccurPositiveProcedureChestMolecularAnalysisFeverSevere asthma
Eosinophils14
- In this article, the term eosinophilia is defined as an increase in peripheral blood eosinophils to more than 600 cells per microliter (μL) of blood. (medscape.com)
- They were more symptomatic with higher exhaled nitric oxide fraction ( F eNO ) and blood and sputum eosinophils, but not serum IgE or periostin. (ersjournals.com)
- John Brennan, director of McMaster's Biointerfaces Institute, and Parameswaran Nair, a respirologist at the St. Joseph's-based Firestone Institute for Respiratory Health, led the creation of a new rapid test that can quickly and accurately identify white blood cells known as eosinophils, even when they are present in complex biological samples such as sputum, by tracking their protein signatures. (medicalxpress.com)
- Previous research at the Firestone Institute, led by the late Professor Freddy Hargreave, had pioneered another technique to enumerate eosinophils in sputum to guide asthma treatment," says Professor Nair, who is a respiratory physician at St. Joe's and a Professor of Medicine at McMaster University. (medicalxpress.com)
- Routine blood tests revealed an eosinophilia of 9×10 9 eosinophils per L and a C-reactive protein concentration of 106 mg⋅L −1 . (ersjournals.com)
- No eosinophils on admission, later developed eosinophilia. (libsyn.com)
- 20 eosinophils/mm 2 ) eosinophilia, sputum analysis is technically difficult, and patients with asthma do not routinely have a bronchoscopy. (medscape.com)
- Serum eosinophils are routinely obtained, but they fluctuate over time and a clear threshold for "eosinophilia" has not been defined. (medscape.com)
- It is however unknown whether clinical differences between patients with eosinophilic and non-eosinophilic asthma are reflected by differential cell surface expression patterns of neutrophils and eosinophils in blood compared to sputum. (biomedcentral.com)
- Eosinophils and neutrophils from blood and sputum were analysed by flow cytometry for expression of activation and degranulation markers. (biomedcentral.com)
- 3% sputum eosinophils) were characterised by increased ACQ scores and blood eosinophil counts. (biomedcentral.com)
- Both sputum neutrophils and eosinophils displayed a highly activated and degranulated phenotype compared to cells obtained from blood. (biomedcentral.com)
- More specifically, degranulation of all granule types was detected in sputum neutrophils and eosinophils, combined with an increased expression of the activation markers (activated) Mac-1, Programmed Death-Ligand 1 (PD-L1) and a decreased expression of L-selectin. (biomedcentral.com)
- CD69 expression was only increased on sputum eosinophils. (biomedcentral.com)
Peripheral blood eosinophilia3
- The Sensitivity and Specificity of Peripheral Blood Eosinophilia To Predict Sputum Eosinophilia in COPD Subjects. (ox.ac.uk)
- The other differential diagnoses can all present with peripheral blood eosinophilia and radiographic changes. (ersjournals.com)
- Peripheral blood eosinophilia. (msdmanuals.com)
Nitric oxide1
- On the other hand, a subgroup of patients with COPD shows reversibility of airway obstruction associated with increased exhaled nitric oxide (NO) and sputum eosinophilia. (pneumon.org)
Serum6
- T2-high severe asthma can be predicted to some extent from raised levels of F eNO , blood and sputum eosinophil counts, but serum IgE or serum periostin were poor predictors. (ersjournals.com)
- PURPOSE: The data on the differences between sputum autoantibodies (Sp-Abs) and serum autoantibodies (Se-Abs) in reflection of autoimmune responses to lungs is still lacking. (koreamed.org)
- Methods: At inclusion, 64 patients were evaluated for phenotypic traits, sputum and blood eosinophilia, exhaled NO, serum cytokines and chemokines, total serum IgE, lung function (LF), and airway hyper-responsiveness (AHR). (uzh.ch)
- Serum IL-5 and IL-13 were the two best, followed by EDN as separators of high vs low blood eosinophilia. (uzh.ch)
- Conclusion: Serum IL-5 and IL-13 are reliable biomarkers for the blood eosinophilia asthma phenotype. (uzh.ch)
- 76% of sputum counts, and serum neutrophils are not strongly correlated with airway counts. (medscape.com)
Eosinophilic3
- Acute eosinophilic pneumonia is not a likely differential diagnosis as typically this presents with a normal blood eosinophil count but sputum or BAL eosinophilia. (ersjournals.com)
- The main finding is that granulocytes are highly activated and degranulated in sputum and that expression profiles of activation and degranulation markers on sputum granulocytes were similar for patients with eosinophilic and non-eosinophilic asthma. (biomedcentral.com)
- Therefore, we conclude that clinical differences between eosinophilic and non-eosinophilic asthma patients are most likely not reflected by differences in granulocyte activation in sputum. (biomedcentral.com)
Infiltrates1
- Which of the following is not a likely differential diagnosis for chest radiograph infiltrates and blood eosinophilia? (ersjournals.com)
Clinical4
- Measurement of sputum eosinophilia has been proposed for clinical use in the diagnosis of asthma. (cmaj.ca)
- Differential cell count in induced sputum is of clinical relevance in phenotyping airway inflammation. (ersjournals.com)
- Relevant clinical guidelines incorporate the use of induced sputum for the monitoring of asthma. (ersjournals.com)
- Induction and processing of sputum samples in a standardised manner is a key component to provide valuable information for clinical decision making [ 9 - 14 ]. (ersjournals.com)
Larvae1
- If the number of larvae passing through the lung is significant, pneumonitis and eosinophilia can be seen (also known as Loeffler syndrome). (statpearls.com)
Response to corticosteroids2
- Gone are the days when eosinophilia equals atopy/allergy, which corresponds to excellent response to corticosteroids. (medscape.com)
- Some studies have shown that sputum eosinophilia can predict a positive response to corticosteroids treatment in stable COPD or can be used to titrate maintenance steroid treatment. (gridblock.top)
Specimens2
Biomarkers1
- Background: Molecular biomarkers that identify the phenotype of blood eosinophilia were evaluated in adult asthmatics, and their relationship with clinically significant asthma outcomes was assessed. (uzh.ch)
Diagnosis4
- Induced sputum and sputum cell count analysis is a test for the diagnosis of various respiratory diseases. (koreamed.org)
- Based on the suspected diagnosis, why were no eggs found in the sputum? (med-chem.com)
- Although this case represents the possibility of several conditions, in other patients the diagnosis can be confirmed by the presence of typical Paragonimus in stool, sputum, or BALs (see below). (med-chem.com)
- Helbig G. Advances in the diagnosis and treatment of eosinophilia. (medscape.com)
Nair1
- A rapid test to detect eosinophilia would help clinicians make decisions about using drugs such as steroids or new biologics for patients with severe asthma and other lung diseases associated with eosinophilia, such as severe cough, and COPD, says Nair. (medicalxpress.com)
Patient's1
Gene expression2
- Sputum IL-4, IL-5 and IL-13 protein levels did not correlate with gene expression. (ersjournals.com)
- This study aimed to identify EA-related biological pathways by analyzing genome-wide gene expression profiles in sputum cells. (koreamed.org)
Assay1
- M. Monsur Ali et al, A Rapid Sputum‐based Lateral Flow Assay for Airway Eosinophilia using an RNA‐cleaving DNAzyme Selected for Eosinophil Peroxidase, Angewandte Chemie International Edition (2023). (medicalxpress.com)
Cough productive2
- 55 yo woman, who initially presented to our outpatient clinic 4 months ago with a 1 year history of cough productive of whitish sputum, sometimes with streaks of blood, mainly in the mornings. (uab.edu)
- On migration of flukes into the lungs, patients can experience fevers, cough productive of brownish sputum, and occasionally hemoptysis as early signs of chronic pulmonary infection. (logicalimages.com)
Persistent1
- We aimed to evaluate factors associated with persistent sputum positivity. (koreamed.org)
Inflammation1
- Eosinophil differential count in induced sputum is a recommended, evidence-based mode of assessing airway inflammation in asthma and its use is incorporated into the relevant guidelines. (ersjournals.com)
Periostin1
- Periostin did not identify blood or sputum eosinophilia, even after stratification for total IgE, and did not correlate with IL-5, IL-13, eotaxin, or EDN. (uzh.ch)
Chronic3
- Chronic productive cough with purulent sputum is a reason for concern in children and is not usually a symptom of asthma. (cdc.gov)
- For further information readers are advised to use additional sources of information, such as the task force report [ 3 - 8 ], the ERS website for video-based educational material on sputum induction and the material from the ERS School course on Monitoring of Asthma, Chronic Obstructive Pulmonary Disease (COPD) and Other Airway Diseases ( www.ersnet.org/education/courses/item/4559-monitoring-of-asthma-copd-a-other-airway-diseases.html ). (ersjournals.com)
- Up to 75% of people with chronic strongyloidiasis have mild peripheral eosinophilia or elevated IgE levels. (cdc.gov)
Paragonimus1
Tuberculosis2
- PURPOSE: To assess the usefulness of flexible bronchoscopy in patients with suspected pulmonary tuberculosis (PTB) who have difficulty in sputum expectoration. (koreamed.org)
- A 4-mo regimen of isoniazid and rifampin is acceptable therapy for adults who have active tuberculosis and who are sputum-smear and culture negative, if there is little possibility of drug resistance (see Section 1 above). (cdc.gov)
Patients3
- Given the broad spectrum of conditions linked to eosinophilia, this article emphasizes the diagnostic considerations that clinicians may want to focus on in patients with eosinophilia. (medscape.com)
- For patients without spontaneous sputum production lower airway secretions can be sampled by sputum induction. (ersjournals.com)
- SIENA was a prospective study to determine if patients with low sputum eosinophil levels benefit from inhaled glucocorticoids and/or an alternative treatment with a LAMA. (nih.gov)
Patient3
- BACKGROUND: Non-conversion of sputum smear and culture prolongs the infectivity of the patient and has been associated with unfavorable outcomes. (koreamed.org)
- The presence of high or low expression of MCP-1, eotaxin, and IL-8 identified two separate blood eosinophilia patient clusters linked to asthma severity. (uzh.ch)
- C) LFD images obtained from positive and negative patient sputum samples without added SDS. (medicalxpress.com)
Expectoration1
- Sputum induction is conducted by inhalation of nebulised sterile saline solution (isotonic or hypertonic) followed by coughing and expectoration of airway secretions. (ersjournals.com)
Symptoms1
- however, upon their withdrawal, the symptoms and esophageal eosinophilia recurred. (curehunter.com)
Mild1
Malignant1
- Samples sent for analysis demonstrated a marked eosinophilia, no malignant cells and no growth on routine culture. (ersjournals.com)
Cytokines1
- Thus, eosinophilia can be triggered via these 3 eosinophilopoietic cytokines by increased eosinophil production, by eosinophil longevity, or by a combination of these. (medscape.com)
Respiratory3
- This showed a high number of respiratory epithelial cells with reactive changes but no eosinophilia in the lavage fluid. (ersjournals.com)
- Nevertheless, respiratory infection presenting purulent sputum can exacerbate asthma in children previously diagnosed with asthma. (cdc.gov)
- Therefore, a task force was set up by the European Respiratory Society (ERS) and it published its recommendations for standardisation of sputum induction and processing in 2002 [ 3 - 8 ]. (ersjournals.com)
Blood3
- Results: Lung function, asthma control, and monocyte chemotactic protein-1 (MCP-1) were identified as the most important distinguisher and blood eosinophilia as second most important identifier in principal component analysis. (uzh.ch)
- A robust relationship was observed between blood eosinophilia and IL-5, IL-13, and eosinophil-derived neurotoxin (EDN), which stayed consistent after 6 weeks. (uzh.ch)
- She had no significant history of medical problems, other than a lingering cough and occasional blood-tinged sputum. (med-chem.com)
Reactive3
- Primary eosinophilia is not a reactive phenomenon and can be described as either clonal or idiopathic in nature. (medscape.com)
- If reactive causes are ruled out and no underlying clonal origin is proven, the eosinophilia is described as idiopathic. (medscape.com)
- Secondary eosinophilia is a reactive phenomenon driven by eosinophilopoietic cytokine release by nonmyeloid cells. (medscape.com)
Diagnostic2
- Saw serpiginous trail on diagnostic agar plate of sputum sample. (libsyn.com)
- Sputum analysis has been used as a diagnostic technique for centuries, and reports on sputum in different diseases, containing important aspects of sample processing, were published more than a century ago [ 1 ]. (ersjournals.com)
Tissue1
- An increase in tissue eosinophilia may be seen with or without concurrent peripheral eosinophilia. (medscape.com)
Examination1
- Bronchoscopic and cytological examination of the sputum were not significant. (med-chem.com)
Occur1
- Urticaria and eosinophilia may also occur in this early phase. (logicalimages.com)
Positive2
- NC: negative control (buffer alone), N6: EOS negative sputum sample, P5: EOS positive sputum sample. (medicalxpress.com)
- N6: EOS negative sputum sample, P5: EOS positive sputum sample showing lack of a test line. (medicalxpress.com)
Procedure1
- Resuscitation equipment should be available in the place where the sputum induction is undertaken and a physician should be available to supervise the procedure, which can be carried out by an experienced technician. (ersjournals.com)
Chest1
- Two months prior to her initial presentation to us she was prescribed 6 months of 4-drug TB therapy because of the hemoptysis and an abnormal chest x-ray [Image A] even though she had 3 negative sputa for acid-fast bacilli. (uab.edu)
Molecular1
- If an underlying molecular or cytogenetic abnormality can be identified, the eosinophilia can be designated as a clonal disorder. (medscape.com)
Analysis1
- Summary Sputum induction is a relatively non-invasive mode of airway sampling that provides an opportunity for analysis of cellular components and infective agents, including bacteria and viruses, together with fluid-phase constituents. (ersjournals.com)
Fever1
- A 34 year old female was admitted to the hospital with complaints of fever, fatigue, generalized myalgia, abdominal pain, and a slightly elevated eosinophilia. (med-chem.com)