• It's also known as celiac sprue, nontropical sprue, or gluten-sensitive enteropathy. (webmd.com)
  • These conditions include tropical sprue, and nontropical sprue (idiopathic steatorrhea, gluten-induced enteropathy). (drugs.com)
  • It may be possible to treat the underlying disease by surgical correction of anatomic lesions leading to small bowel bacterial overgrowth, expulsion of fish tapeworm, discontinuation of drugs leading to vitamin malabsorption (see Drug/Laboratory Test Interactions ), use of a gluten-free diet in nontropical sprue, or administration of antibiotics in tropical sprue. (nih.gov)
  • Lo A, Guelrud M, Essenfeld H, Bonis P. Classification of villous atrophy with enhanced magnification endoscopy in patients with celiac disease and tropical sprue. (medscape.com)
  • MATERIAL: 94 patients, aged more than 12 years, presenting with Chronic diarrhoea and malabsorption syndrome were analyzed by clinical presentation, endoscopic and histopathological examination.The spectrum of disease in these patients and features differentiating celiac disease and tropical sprue are reported here. (bvsalud.org)
  • Coeliac disease (also known as coeliac sprue or gluten sensitive enteropathy), has similar symptoms to tropical sprue, with the flattening of the villi and small intestine inflammation and is caused by an autoimmune disorder in genetically susceptible individuals triggered by ingested gluten. (wikipedia.org)
  • Environmental enteropathy is a less severe, subclinical condition similar to tropical sprue. (wikipedia.org)
  • Brown et al compared the histologic changes found in tropical sprue with those occurring in gluten-sensitive enteropathy, a condition for which tropical sprue is often mistaken. (medscape.com)
  • The study, which involved 12 patients with tropical sprue and 150 cases of gluten-sensitive enteropathy, identified no complete villous blunting in the duodenal mucosa of the tropical sprue patients, although partial blunting occurred in 75% of them. (medscape.com)
  • If villous atrophy persists or the initial diagnosis of celiac disease was not confirmed, consider other causes of villous atrophy, including common variable immunodeficiency, autoimmune enteropathy, tropical sprue and medication-induced enteropathy. (gastro.org)
  • Tropical sprue (TS) is a syndrome characterized by acute or chronic diarrhea, weight loss, and malabsorption of nutrients. (medscape.com)
  • [ 1 ] The first description of tropical sprue is attributed to William Hillary's 1759 account of his observations of chronic diarrhea while in Barbados. (medscape.com)
  • Tropical malabsorption and tropical diarrhea. (medscape.com)
  • Persistent TD also has been associated with tropical sprue and Brainerd diarrhea. (cdc.gov)
  • Whipple's disease, tropical sprue, and eosinophilic gastroenteritis are some of the rare conditions that can lead to malabsorption diarrhea. (gi.org)
  • noun (2) Definition of sprue (Entry 2 of 2) 1 : a disease of tropical regions that is of unknown cause and is characterized by fatty diarrhea and malabsorption of nutrients. (draftlessig.org)
  • Inflammatory bowel disease must be differentiated from other diseases that present with abdominal pain , fever and diarrhea which include appendicitis , diverticulitis , Whipple's disease , mesenteric ischemia , Tropical sprue , hepatitis and spontaneous bacterial peritonitis . (wikidoc.org)
  • A link between small intestinal bacterial overgrowth and tropical sprue has been proposed to be involved in the aetiology of post-infectious irritable bowel syndrome (IBS). (wikipedia.org)
  • Intestinal immunologic dysfunction, including deficiencies in secretory immunoglobulin A (IgA), may predispose people to malabsorption and bacterial colonization, so tropical sprue may be triggered in susceptible individuals following an acute enteric infection. (wikipedia.org)
  • As no study on PI-IBS has rigorously excluded tropical sprue by appropriate investigations, including small intestinal biopsy, the frequency of tropical sprue among patients with PI-IBS is not known. (nih.gov)
  • The exact causative factor of tropical sprue is unknown, but an intestinal microbial infection is believed to be the initiating insult. (medscape.com)
  • Enterotoxigenic intestinal bacteria in tropical sprue. (medscape.com)
  • Patients with tropical sprue were older and more often normal duodenal epithelium. (bvsalud.org)
  • Tropical sprue is a gastrointestinal disease that results in malabsorption of nutrients and water. (osmosis.org)
  • Tropical sprue is a condition that affects the small intestine and is characterized by malabsorption of nutrients, particularly vitamin B12 and folate. (osmosis.org)
  • The symptoms of tropical sprue are: Diarrhoea Steatorrhoea or fatty stool (often foul-smelling and whitish in colour) Indigestion Cramps Weight loss and malnutrition Fatigue Left untreated, nutrient and vitamin deficiencies may develop in patients with tropical sprue. (wikipedia.org)
  • These deficiencies may have these symptoms: Vitamin A deficiency: hyperkeratosis or skin scales Vitamin B12 and folic acid deficiencies: anaemia, numbness, and tingling sensation Vitamin D and calcium deficiencies: spasm, bone pain, muscle weakness Vitamin K deficiency: bruises The cause of tropical sprue is not known. (wikipedia.org)
  • Diagnosis of tropical sprue can be complicated because many diseases have similar symptoms. (wikipedia.org)
  • Tropical sprue is suspected in people who live in or have visited areas where the disease is endemic and who have megaloblastic anemia and symptoms of malabsorption. (msdmanuals.com)
  • Dutta AK, Chacko A, Avinash B. Suboptimal performance of IgG anti-tissue transglutaminase in the diagnosis of celiac disease in a tropical country. (medscape.com)
  • Small-bowel series and enteroclysis are the preferred radiographic examinations for the diagnosis of celiac sprue. (medscape.com)
  • Complications of tropical sprue include anemia, malnutrition, and vitamin deficiency. (medscape.com)
  • Tropical Sprue and Malnutrition in West Bengal. (medscape.com)
  • However, up to 25% of patients may not have enough findings for a confident diagnosis, and a small percentage of patients may have multiple findings that are radiographically suggestive of celiac sprue with negative biopsy results. (medscape.com)
  • The investigators also found that in the appropriate clinical context, tropical sprue is indicated by involvement of the terminal ileum, with greater inflammation and villous blunting than in the duodenum, and by the presence, in the lamina propria, of a conspicuous eosinophil infiltrate. (medscape.com)
  • However, following acute infectious gastroenteritis, patients can also develop post-infectious malabsorption syndrome (PI-MAS), popularly known as tropical sprue. (nih.gov)
  • Hormone enteroglucagon and motilin levels are elevated in patients with tropical sprue. (medscape.com)
  • Prognosis is generally good for patients with tropical sprue. (medscape.com)
  • Unlike in celiac disease, anti-tissue transglutaminase antibody (tTG) and anti-endomysial antibody (EMA) are negative in patients with tropical sprue. (msdmanuals.com)
  • Radiographic findings of celiac sprue are present in virtually all patients in the clinically active phase of the disease. (medscape.com)
  • In patients with a dilated pancreatic duct, a Roux-en-Y side-to-side pancreaticojejunostomy is indicated. (medscape.com)
  • Treatment for tropical sprue typically involves using antibiotics to reduce bacterial overgrowth, and nutrition replacement to deal with specific deficiencies like folate and Vitamin B12. (osmosis.org)
  • The use of folic acid and vitamin B12 in the treatment of tropical sprue was promoted in the late 1940s by Dr. Tom Spies of the University of Alabama, while conducting his research in Cuba and Puerto Rico. (wikipedia.org)
  • For example, although tropical sprue is commonly reported in Puerto Rico and the Dominican Republic, it is not reported in Jamaica. (medscape.com)
  • Twenty-seven individual studies on various aspects of tropical sprue were published in the Puerto Rico Journal of Public Health and Tropical Medicine from 1925 to 1949. (bvsalud.org)
  • Tropical sprue is a malabsorption disease commonly found in tropical regions, marked with abnormal flattening of the villi and inflammation of the lining of the small intestine. (wikipedia.org)
  • Just like the other " sprue " diseases, like celiac sprue which is more often known as celiac disease , in tropical sprue the villi of the small intestine become flattened, but the exact cause isn't known. (osmosis.org)
  • Tropical sprue is associated with deficiencies of vitamins absorbed in the proximal and distal small bowel and most commonly affects long-term travelers to tropical areas, as the name implies. (cdc.gov)
  • The prognosis for tropical sprue may be excellent after treatment. (wikipedia.org)
  • Tropical sprue (hematoxylin-eosin [H&E], original magnification ×10). (medscape.com)
  • Once diagnosed, tropical sprue can be treated by a course of the antibiotic tetracycline or sulphamethoxazole/trimethoprim (co-trimoxazole) for 3 to 6 months. (wikipedia.org)
  • As both IBS, particularly the subset probably associated with SIBO, and tropical sprue improve with antibiotic treatment, we provide evidence and an explanatory model to support a link among these disorders. (nih.gov)
  • Our current understanding of tropical sprue is that it is a malabsorption syndrome that responds to treatment with folic acid and a broad spectra antibiotic. (bvsalud.org)
  • Over the years my research interests and publications involved bile acid metabolism in tropical sprue, regulation of gastric secretion of Pepsinogen and Intrinsic Factor, Vitamin B12 absorption, and Laser-Induced Fluorescence Spectroscopy in the detection of dysplasia in the colon. (yale.edu)
  • Tropical sprue is a rare acquired disease, probably of infectious etiology, characterized by malabsorption and megaloblastic anemia. (msdmanuals.com)
  • A recognized complication of celiac sprue and can occur when the body's ability to fight infectious diseases is compromised or entirely absent. (sils.com.sg)
  • One of the speakers was Raman Velayudhan, PhD, the unit head of the WHO's Global Program on the Control of Neglected Tropical Diseases for coordinating the dengue and arbovirus initiatives. (medscape.com)
  • Tropical sprue occurs in geographically limited areas. (medscape.com)
  • Tropical sprue occurs in both epidemic and endemic forms, primarily in Southeast Asia and the Caribbean. (medscape.com)
  • Tropical sprue occurs chiefly in the Caribbean, southern India, and Southeast Asia, affecting both natives and visitors. (msdmanuals.com)
  • Preventive measures for visitors to tropical areas where the condition exists include steps to reduce the likelihood of gastroenteritis. (wikipedia.org)
  • Common findings in celiac sprue include dilatation of the small intestine lumen, intussusception, hypersecretion, segmentation, a mosaic pattern, and jejunoileal fold-pattern reversal. (medscape.com)
  • This article summarizes significant findings, presented chronologically, and speculates on the direction of future investigations into tropical sprue. (bvsalud.org)
  • A diameter of sprue base should be 1 to 2 times bigger than the thickness, if the thickness is not enough. (draftlessig.org)
  • Tropical sprue is common in the Caribbean, Central and South America, and India and southeast Asia. (wikipedia.org)
  • The biggest clue is that tropical sprue seems to mostly affect individuals living in the the tropical regions of the world, like the Caribbean, India, and Southeast Asia. (osmosis.org)
  • Although etiology is unclear, tropical sprue is thought to result from chronic infection of the small bowel by toxigenic strains of coliform bacteria. (msdmanuals.com)
  • Tropical sprue is a well documented condition with a special geographical distribution. (bmj.com)
  • Sprue, nontropical: This condition results from an immune (allergic) reaction to gluten, a protein found in wheat and related grains and present in many foods that we eat. (draftlessig.org)
  • When multiple findings of sprue are present on small-bowel follow-though or enteroclysis, the diagnosis is fairly specific. (medscape.com)
  • The most common small bowel disease in the U.S. is celiac disease, also called celiac sprue. (gi.org)
  • Sprue causes impaired absorption and digestion of nutrients through the small intestine. (draftlessig.org)
  • Tropical sprue is largely limited to within about 30 degrees north and south of the equator. (wikipedia.org)
  • Other conditions which can resemble tropical sprue need to be differentiated. (wikipedia.org)
  • Tropical sprue was responsible for one-sixth of all casualties sustained by the Allied forces in India and Southeast Asia during World War II. (wikipedia.org)
  • Tropical sprue appears to be declining globally. (medscape.com)
  • One unusual feature is that tropical sprue appears to be limited to certain geographic areas, even within the tropics. (medscape.com)
  • The incidence of tropical sprue appears to have declined dramatically over the past 2 decades. (cdc.gov)