Loading...
  • infect
  • The polymorphic immunodominant molecule (PIM) is expressed by two stages of the parasite: the sporozoite, which is inoculated by the tick to infect mammalian lymphocytes, and the schizont, the established intralymphocytic stage. (cgiar.org)
  • lymphocytes
  • The results suggest that at least two sporozoite molecules, PIM and the previously described p67, are involved in the entry of T. parva into mammalian lymphocytes. (cgiar.org)
  • appears
  • This reduction appears to be due to blocking of sporozoite attachment by binding of the MAb to several regions of PIM. (cgiar.org)
  • anti-sporozoite
  • are presented: "Polyclonal B-lymphocyte activation and sensitization of erythrocytes by IgG in human malaria: relevance to the development of anaemia in a holoendemic area in Northwestern Brazil" (Memorias do Instituto Oswaldo Cruz (1986) 1 (supplement II) 169-176) and "Can malaria associated polyclonal B-lymphocyte activation interfere with the development of anti-sporozoite specific immunity? (eurekamag.com)
  • oocyst
  • The phenotypes detectable by cytological methods in the oocyst some 10 d after the critical period of activity suggests key roles of the LAPs or LAP-dependent processes in the regulation of the cell cycle, possibly in the regulation of cytoplasm-to-nuclear ratio, and, importantly, in the events of cytokinesis at sporozoite formation. (nih.gov)
  • Earlier stage oocysts that occur in the mosquito midgut may or may not develop into sporozoites, and oocyst rates are regarded as epidemiologically less informative as a measure of the potential of particular mosquito species to transmit malaria. (biomedcentral.com)
  • transgenic
  • We transferred 2 × 105 nonactivated OT-I (CD8) and OT-II (CD4) T cells each into mice, and 24 h later, immunized the recipient animals with 10,000 irradiated normal or transgenic OVA sporozoites (Fig. 5). (nih.gov)
  • motility
  • Scoring sporozoite motility. (biomedsearch.com)
  • Using pharmacological activators and inhibitors, we have concluded that gliding motility is initiated when albumin interacts with the surface of the sporozoite and that this leads to a signal transduction cascade within the sporozoite, including the elevation of intracellular cAMP, the modulation of sporozoite motility by Ca 2+ and the release of microneme proteins. (pubmedcentralcanada.ca)
  • infectious
  • In previous studies, crossing Δpblap1 gametocytes (pblap1−) with wt gametocytes (pblap1+) to form heterokaryotic (pblap1+/pblap1−) oocysts rescued the lethal Δpblap1 phenotype, and produced Δpblap1 sporozoites that were infectious to mice . (nih.gov)
  • injection
  • It has always been assumed that sporozoites rapidly exit the injection site, making their interactions with the host at this site, brief and difficult to study. (wiley.com)
  • We then performed sub-inoculation experiments which confirmed these findings and showed that the pattern of sporozoite exit from the injection site resembles a slow trickle. (wiley.com)
  • Initiation
  • We show that sporozoite latency is an active process controlled by a eukaryotic initiation factor-2α (eIF2α) kinase (IK2) and a phosphatase. (gla.ac.uk)
  • intravenous
  • Last, we found that drainage of approximately 20% of the sporozoite inoculum to the lymphatics is associated with a significant enlargement of the draining lymph node, a response not observed after intravenous inoculation. (wiley.com)
  • protective
  • In this study, we present data on safety and protective efficacy using sporozoites with deletions of two genes, that is the newly identified b9 and slarp , which govern independent and critical processes for successful liver-stage development. (elifesciences.org)
  • humans
  • Indeed, sub-inoculation experiments in humans have demonstrated that sporozoites appear in the circulation even while the infected mosquito is feeding ( Fairley, 1947 ). (wiley.com)