Spontaneous animal model. Medical search. Frequent questions

Spontaneous electrical activity in neonate rats of either sex was analyzed through a ventral craniotomy in mechanically ventilated pups to carry out patch clamp and multi-electrode electrophysiology recordings in the medial region of the superior olivary complex (SOC) between birth (postnatal day 0, P0) and P12. (frontiersin.org)
This study draws a parallel between the rare spontaneous regression of human brain tumors and the C6 spheroid implantation in rats. (uni-wuerzburg.de)
In the present work, we describe the effects of dopamine depletion after the administration of 6-hidroxidopamine (6-OHDA) into the substantia nigra pars compacta of male rats submitted to the pilocarpine model of epilepsy. (scielo.br)
Non-Status Epilepticus female rats show seizure-like behaviors in the chronic phase of Pilocarpine experimental model. (scielo.br)
2023. A review on experimental surgical models and anesthetic protocols of heart failure in rats. (awionline.org)
Diabetic GK rats and control animals were randomly assigned to receive E4 or vehicle by intravitreal injection. (molvis.org)
In the inguinal adipose depot, expression of uncoupling protein-1 was detected in Lou/C but not in Wistar rats, in keeping with a higher expression of peroxisome proliferator-activated receptor-gamma coactivator-1 in these animals. (unige.ch)

Although different factors are taken into account to choose the type of anesthetic, few studies have addressed its potential effects on in vivo spontaneous neuronal activity. (frontiersin.org)
This evidence comes from laboratory models of AD, as well as living patients, showcasing the potential of neuronal excitability changes as a biomarker for early detection of AD. (nature.com)
Electroencephalographic recordings from the developing human brain are characterized by spontaneous neuronal bursts, the most common of which is the delta brush. (elifesciences.org)
The primary function of the orexin system, i.e. the orexins, their receptors and associated neuronal circuitries, perhaps is to increase spontaneous physical activity and food intake, thereby promoting an increase in energy expenditure. (researchgate.net)
Thus, by applying genetically modified or kindled animals [9] it may be possible to discover new AEDs that inhibit the neuronal hypersynchronization leading to an ictal event, without interfering with normal neuronal excitability [10]. (jle.com)
Background: Increased spontaneous neuronal activity is thought to underlie the pathological changes in tinnitus. (cdc.gov)

T Maze Spontaneous Alternation is a behavioral test for measuring exploratory behavior in animals, especially rodent models for CNS disorders. (stanford.edu)
For example, the light/dark paradigm is based on a conflict between the innate aversion to brightly illuminated areas and the spontaneous exploratory activity. (neurofit.com)
2023. Making a case for the free exploratory paradigm: Animal welfare-friendly assays that enhance heterozygosity and ecological validity. (awionline.org)

The Y-maze is usually employed to assess hippocampal-dependent spatial memory by measuring the spontaneous alternation behaviour in a Y-maze. (lu.se)

In general terms, epileptic discharge, seizure-like behaviors in the chronic phase of Pilocarpine experimental model, sudden unexpected death in epilepsy and consequently epileptic seizures have been associated with an imbalance between excitation and inhibition in specific brain circuitries ( Bozzi and Borrelli, 2013 BOZZI, Y. and BORRELLI, E., 2013. (scielo.br)
Interneuron replacement has been used in animal models to modify plasticity, prevent spontaneous epileptic seizures, ameliorate hemiparkinsonian motor symptoms, and prevent PCP-induced cognitive deficits. (ca.gov)

These beneficial biological properties have been extensively studied in humans and animal models, both in vitro and in vivo . (hindawi.com)
An in vivo arteriovenous malformation model in swine: preliminary feasibility and natural history study. (ajnr.org)
PURPOSE To assess the feasibility, natural history, and preliminary physiologic validation of creating an in vivo arteriovenous malformation model in swine. (ajnr.org)
Moreover, The use of animals as surrogate rine host, can provide a platform for animal models for tumour viruses in hosts for the study of human tu- in vivo infection. (who.int)

Reports of spontaneous regression and tumour infiltration with T-lymphocytes makes melanoma candidate for immunotherapies. (mdpi.com)

Spontaneous bacterial peritonitis (SBP) is an acute bacterial infection of ascitic fluid. (medscape.com)
Our data show that dopamine may play an important role on seizure severity in the pilo's model acute period, which seems to be due to dopamine inhibitory action on motor expression of seizure. (scielo.br)
Therefore, purpose of this study was to assess acute electrophysiologic effects of caffeine and taurine, two of the main ingredients of energy drinks, in an experimental whole-heart model. (researchgate.net)
Acute phase physiologic characterization of four models was also performed, using intravascular pressure and Doppler blood flow velocity measurements. (ajnr.org)

The exploitation of the spontaneous paradigm is based on the natural preference and/or aversion of mice. (neurofit.com)
TSEs are characterized by the accumulation in the central nervous system and, less often, in lymphoid tissues of TSE-associated prion protein (PrP TSE ), a conformational variant of a normal host cellular prion protein (PrP C ). PrP C is a nonessential protein but, at least in mice and cows, must be expressed by animals susceptible to TSE infection. (cdc.gov)
To propose an alternative model of hepatic encephalopathy (HE) in mice, resembling the human features of the disease. (wjgnet.com)
2023. Longitudinal home-cage automated assessment of climbing behavior shows sexual dimorphism and aging-related decrease in C57BL/6J healthy mice and allows early detection of motor impairment in the N171-82Q mouse model of Huntington's disease. (awionline.org)
Monitoring the activity of mice within their home cage is proving to be a powerful tool for revealing subtle and early-onset phenotypes in mouse models. (awionline.org)
Using bioluminescence to image gene expression and spontaneous behavior in freely moving mice. (awionline.org)
2022. Simultaneous assessment of spontaneous cage activity and voluntary wheel running in group-housed mice. (awionline.org)
Modified Handling for Mice: Handling mice by gripping the base of the tail has been shown to negatively impact animal welfare by increasing anxiety and aversion to handling. (awionline.org)
As with immunocompetent animal models, these mice can also be used for both heterotopic and orthotopic tumor models. (uclahealth.org)
To address the question of specificity for the allele encoding the Na V 1.4-R669H variant as a cause of HypoPP and to produce a model system in which to characterize functional defects of the mutant channel and susceptibility to paralysis, we generated knockin mice carrying the ortholog of the gene encoding the Na V 1.4-R669H variant (referred to herein as R669H mice). (jci.org)

Susceptibility to pilocarpine-induced status epilepticus (SE), as well as spontaneous and recurrent seizures (SRSs) frequency during the chronic period of the model were determined. (scielo.br)
The induction of status epilepticus (SE) and kindling represent two animal paradigms in the preclinical evaluation of AEDs. (jle.com)

For this reason, the infect humans, this virus can infect cordance between humans and ex- question about tumour site concor- several other species - including perimental animals. (who.int)
Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
For other human tumour virus- primate species are related to the hu- tween data in humans and in experi- es, the use of humanized severe man tumour viruses, the incidence of mental animals is not obvious. (who.int)

At postnatal day 1, the pups that survived were subjected to a battery of neurobehavioral tests developed specifically for these animals, and the tests were videotaped and scored in a masked manner. (jneurosci.org)
Most previous studies have employed models of cerebral hypoxia-ischemia in postnatal animals. (jneurosci.org)

The CD31 stains showed that there is no statistically significant difference between immunocompetent and deficient animals. (uni-wuerzburg.de)

In recent years, different lines of genetically manipulated mouse models were used to study how modulation of the cochlear pacemaker affects the maturation of central auditory neurons and synapses. (frontiersin.org)
We found that 48-72 hours after cardiac arrest, thalamocortical neurons demonstrate significantly elevated firing rates both during spontaneous activity and in response to whisker deflections. (cdc.gov)

Crowding is a validated animal model reproducing naturalistic psychosocial stress, whose consequences on gut physiology remain unexplored. (nih.gov)
[ 6 , 7 ] We don't know whether the animal and physiology models translate to actual patient care, and therefore we still don't know whether APRV is the right choice for our critical care patients. (medscape.com)

Spontaneous" tumor animal models, which simulate the occurrence of tumors in the general human population, are readily available as are many other transgenic strains. (uclahealth.org)

Newborn pups of hypoxic groups displayed significant impairment in multiple tests of spontaneous locomotion, reflex motor activity, and the coordination of suck and swallow. (jneurosci.org)
Under normal conditions, primary afferents show little if any spontaneous activity. (asra.com)
This ongoing input is believed to provide the source of the afferent activity that leads to spontaneous on going sensation. (asra.com)
Single unit recording from the afferent axon has indicated that the origin of the spontaneous activity in the afferent arises from the neuroma and from the dorsal root ganglia of the injured axon. (asra.com)
This increased ionic conductance may result in the increase in spontaneous activity that develops in a sprouting axon. (asra.com)
Small animal models are frequently used to improve our understanding of the molecular and biological signaling pathways underlying the beneficial effects of physical activity and exercise. (awionline.org)
Laetrile has shown little anticancer activity in animal studies and no anticancer activity in human clinical trials. (cancer.gov)

Promote novel clinical trial design using simulation, new statistical models, and novel animal models/animal model alternatives. (fda.gov)

The NIH Animal Genetic Resource received the B6 Nude Spontaneous mutant model in 1980. (taconic.com)

this includes the potential for producing xenograft models of bio-banked human samples and allograft models of bio-banked mouse samples. (uclahealth.org)

similarly colitis can be induced by genetic modification, cell transfer, spontaneous inflammation and chemical agents. (intechopen.com)

High concentrations of methylprednisolone (0.32 mg/mL) accelerated growth and attenuated spontaneous apoptosis of Exserohilum rostratum in vitro. (johnshopkins.edu)

In addition to its role in the endogenous control of erythropoiesis, recombinant human erythropoietin (rh-EPO) has been shown to exert tissue protective properties in various experimental models. (nih.gov)
Transmissible spongiform encephalopathy (TSE) agents have contaminated human tissue-derived medical products, human blood components, and animal vaccines. (cdc.gov)
Preterm Fetal Hypoxia-Ischemia Causes Hypertonia and Motor Deficits in the Neonatal Rabbit: A Model for Human Cerebral Palsy? (jneurosci.org)
This model offers the distinct advantages that, similar to the human newborn, the newborn rabbit has immature locomotor function and the cerebral hemispheres are not fully myelinated. (jneurosci.org)
In contrast, over time after a variety of injuries to the peripheral nerve, the animal and human will often reflect the appearance of a constellation of pain events. (asra.com)
A non-invasive method of drug delivery, intranasal atomization, has shown positive results in human medicine and in some animal species. (awionline.org)
Electrical impedance tomography in diseased lungs (animal or human) showed evidence of volume shift from nondependent to dependent areas of the lung (pendelluft) during spontaneous breaths. (medscape.com)
Spontaneous animal homologues of human autoimmune blistering diseases have been identified in the last 2 decades. (medscape.com)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)

Once thought to occur only in those individuals with alcoholic cirrhosis, spontaneous bacterial peritonitis is now known to affect patients with cirrhosis from any cause. (medscape.com)
In addition, spontaneous bacterial peritonitis can occur as a complication of any disease state that produces the clinical syndrome of ascites, such as heart failure and Budd-Chiari syndrome . (medscape.com)
Although similar events in animal models are known to occur in areas of immature cortex and drive their development, their origin in humans has not yet been identified. (elifesciences.org)
The resultant increases in coronary blood flow (epicardial and subendocardial) occur in ischemic and nonischemic models and are accompanied by dose-dependent decreases in systemic blood pressure and decreases in peripheral resistance. (nih.gov)

Laboratory Animal Science Professional 10(3) (May/June), 46-47. (awionline.org)
i.e, the ability to suppress expression of experimentally induced seizures in normal laboratory animals [1, 2]. (jle.com)
La estancia postdoctoral que disfruté en el Dementia Research Laboratory (King's College, Londres), me permitió, además de desarrollar mi habilidades técnicas e intelectuales, el ponerme en contacto y comenzar colaboraciones de investigación, que se mantiene a dia de hoy. (unav.edu)

We report a rabbit model of in utero placental insufficiency, in which hypertonia is accompanied by marked abnormalities in motor control. (jneurosci.org)

These findings provide a unique behavioral model to define mechanisms and sequelae of perinatal brain injury from antenatal hypoxia-ischemia. (jneurosci.org)
The lack of a suitable fetal animal model that reproduces the motor deficits of CP has hampered definition of these mechanisms. (jneurosci.org)
The mechanisms underlying this spontaneous pain and the miscoding of low threshold afferent input are not completely understood. (asra.com)

Transmissible spongiform encephalopathies (TSEs or prion diseases) are a heterogeneous group of fatal neurodegenerative diseases that affect animals and humans. (cdc.gov)
A unifying model for timing of walking onset in humans and other mammals. (lu.se)

Spontaneous bacterial peritonitis occurs in both children and adults and is a well-known and ominous complication in patients with cirrhosis. (medscape.com)

The notable resemblance of these findings with those in some IBS patients, support the potential interest and translational validity of this experimental model for the research of stress-sensitive intestinal disorders, particularly IBS. (nih.gov)
Since the hippocampus is one of main structures in the development of this experimental model of epilepsy, the dopamine levels in this region were also determined after drug administration. (scielo.br)

The present study investigates the time course of an experimental tumor disease either by tumor remission or neurological deterioration of the animal, in the orthotopic C6 glioma spheroid implantation model. (uni-wuerzburg.de)
One result of MRI and histological examinations was a larger maximum tumorsize in the thymectomy group (31 % The present study investigates the time course of an experimental tumor disease either by tumor remission or neurological deterioration of the animal, in the orthotopic C6 glioma spheroid implantation model. (uni-wuerzburg.de)

We will continue our investigation of rodent-derived interneuron transplantation to obtain relevant preclinical data for dose response, safety and efficacy in animal models. (ca.gov)

Many other animal species may also be "pied" or piebald including, but not limited to, birds and squirrels. (wikipedia.org)

Results of function analysis using murine SS models have elucidated that Th1, Th2, and Th17 cells are of great significance in the occurrence and development of SS, which play roles in regulating the differentiation, amplification, and functions of self-reactive T and B cells [ 7 - 9 ]. (hindawi.com)

Patients with cirrhosis who develop spontaneous bacterial peritonitis in the face of septic shock are at high risk of mortality. (medscape.com)
Typically, a significant mortality was observed or the animals recovered completely and neurobehavioral deficits were difficult to elicit ( Wright and Rang, 1990 ). (jneurosci.org)

Longitudinal studies on mouse models related to Alzheimer disease (AD) pathology play an important role in the investigation of therapeutic targets to help pharmaceutical research in the development of new drugs and in the attempt. (awionline.org)
Animal wellbeing, radiological contrast studies, gross intra-abdominal pathology and histological evaluation at post-operative days 5, 7, and 10. (omicsonline.org)

Interestingly, adults with spontaneous bacterial peritonitis typically have ascites, but most children with spontaneous bacterial peritonitis do not have ascites. (medscape.com)

Traditionally, three fourths of spontaneous bacterial peritonitis infections have been caused by aerobic gram-negative organisms (50% of these being Escherichia coli ). (medscape.com)
Bioluminescence imaging (BLI) of gene expression in live animals is a powerful method for monitoring development, tumor growth, infections, healing, and other progressive, long-term biological processes. (awionline.org)

CONCLUSIONS A simple technique for creating an arteriovenous malformation model in swine is now possible and is promising for future studies. (ajnr.org)
A gelatin-based liquid sealant is safe to use on colorectal closure in a swine model and shows a favorable performance profile. (omicsonline.org)

Possible immunological influences in the host immune response were studied by a comparison of tumor growth in normal and thymectomized animals. (uni-wuerzburg.de)

Her role will be to provide imaging and quantification methods to study, in cells and eventually animals, which parts of the influenza virus genome have mutated and to what degree. (rutgers.edu)
Methods A static 3D model of the specimen was generated from a computed tomography scan of the stifle of a dog and a kinematic model was generated from data collected, every 5 degrees from full extension (131 degrees) through 80 degrees of stifle flexion, from four sensors attached to the tibia. (thieme-connect.com)

In mouse models with vitamin D receptor overexpression, you actually can reduce the animal-related colitis . (medscape.com)
2023. Longitudinal studies on Alzheimer disease mouse models with multiple tracer PET/CT: Application of reduction and refinement principles in daily practice to safeguard animal welfare during progressive aging. (awionline.org)
Therefore, this study aims to explore the potential mechanism of QZF in the treatment of Sjögren's syndrome based on network pharmacology and SS mouse model. (hindawi.com)
The SS mouse model was constructed and divided into 6 groups: control, SS, SS + hydroxychloroquine (HCQ)-treated, SS + low-dose QZF-treated, SS + medium-dose QZF-treated, and SS + high-dose QZF-treated group. (hindawi.com)
Our observations suggest that the DC-Flip-KO mouse is a novel model of RA that may provide important insights and permit in depth interrogation of the pathogenesis of RA. (acrabstracts.org)
Transgenic mouse models pro- fection. (who.int)

When the lung was healthy, the two catheters provided similar measurements irrespective of mode or spontaneous effort. (medscape.com)

This may be improved by performing drug screens in animal models of chronic epilepsy. (jle.com)

The aim of this study is to examine the effect of rh-EPO in a pig model of ventricular fibrillation (VF)-induced CA. (nih.gov)
The goal of this study was to examine the feasibility of α v β 3 integrin-targeted molecular imaging agent in enhancing the detection of spontaneous ovarian tumor in laying hens, a preclinical model of OVCA. (bmj.com)
2 Therefore, the purpose of this study was to elucidate the impact of caffeine and taurine on arrhythmogenesis in a sensitive whole-heart model. (researchgate.net)
Objective The aim of this study was to develop a three-dimensional (3D) model to identify the isometric component of the cranial cruciate ligament (CCL) in dogs. (thieme-connect.com)
This request was initially approved but later rejected because preclinical evidence in animals showed that laetrile was not likely to be effective as an anticancer agent,[ 3 , 11 , 12 ] and because there were questions about how the proposed study was to be conducted. (cancer.gov)
STUDY DESIGN, SIZE, DURATION: We used a Markov model to generate probabilities. (bvsalud.org)

If performed incorrectly due to technical difficulties, inexperience, or animal resistance, oral gavage may have animal welfare implications such as esophageal and gastric rupture. (awionline.org)
The inbred Lou/C rat, originating from the Wistar strain, has been described as a model of resistance to diet-induced obesity, but little is known about its metabolism. (unige.ch)

The glutamate receptor agonist kainic acid [21] and the cholinergic agonist pilocarpine [22] are commonly used in SE models. (jle.com)

Based on a set of label-free CARS images of atherosclerotic plaques (i.e. foam cell clusters) from a Watanabe heritable hyperlipidemic rabbit model, we developed an automated pipeline to classify atherosclerotic lesions based on their major morphological features. (springer.com)

Early pathophysiologic evolution occurred in two animals, consisting of recruitment of previously unseen collateral vessels. (ajnr.org)
[ 6 ] The logic is that positive-pressure breaths aren't synchronized with spontaneous effort, so you get the benefit of dependent recruitment without excessive PL swings. (medscape.com)

Compared with the control, the EPO group had higher rates of return of spontaneous circulation (ROSC) (100% vs 60%, P = .011) and higher 48-hour survival (100% vs 40%, P = .001). (nih.gov)
Administration of rh-EPO in a pig model of VF-induced CA just before reperfusion facilitates ROSC and improves survival rates as well as hemodynamic variables. (nih.gov)
The spontaneous reactivation rates of the inhibited AChE for CPO and PO were 0.084-0.087 (two determinations) and 0.091 +/- 0.023 h-1, respectively. (cdc.gov)

We have numerous syngeneic and xenogeneic tumor models, immunological models, and radiobiological partial and whole body, transplantation and tumor models. (uclahealth.org)

Previous studies have demonstrated efficacy of nimodipine, an L-type calcium channel blocker, on reversing these changes in salicylate and quinine induced tinnitus in rat models (Jastreboff, 1991). (cdc.gov)

When animals initiated breaths, PL was twice as high according to the intrapleural vs the esophageal catheter. (medscape.com)
When animals were paralyzed, the opposite occurred: PL was higher via the esophageal catheter. (medscape.com)

Linear mixed-effects models were used to evaluate the modifying effect of baseline frailty on the intervention effect of CY on primary outcomes. (cdc.gov)

A piebald or pied animal is one that has a pattern of unpigmented spots (white) on a pigmented background of hair, feathers or scales. (wikipedia.org)

The objective of this chapter is to present current concept on animal models of inflammatory bowel diseases. (intechopen.com)
These models are crucial for the understanding of inflammatory bowel diseases, development of alternative treatments and more effective therapeutic agents thus contributing to the control of the disease. (intechopen.com)
In all 12 sealant arm animals, bowel motility was restored within 24 hours. (omicsonline.org)

Erythropoietin-treated animals required fewer number of shocks in comparison with animals that received normal saline (P = .04). (nih.gov)
One result of MRI and histological examinations was a larger maximum tumorsize in the thymectomy group (31 % larger than in normal animals). (uni-wuerzburg.de)
Xenogeneic and syngeneic transplant models include tumor and normal cells and biobanked samples. (uclahealth.org)
Epileptogenesis refers to the multiphase process in which a normal brain undergoes alterations to support the generation of spontaneous seizures. (jle.com)

[ 1 ] Of patients with cirrhosis who have spontaneous bacterial peritonitis, 70% are Child-Pugh class C. In these patients, the development of spontaneous bacterial peritonitis is associated with a poor long-term prognosis. (medscape.com)
[ 4 ] Bacterial translocation (viable microorganism passage from the intestinal lumen to mesenteric lymph nodes) is a key factor in the development of spontaneous bacterial peritonitis. (medscape.com)
and iii) followed over time by the development of a measurable level of spontaneous afferent traffic in both myelinated and unmyelinated axons. (asra.com)

It also seeks to determine whether TIPs, through spontaneous mutations, can keep up with new tricks that viruses may develop while evolving. (rutgers.edu)

Anatomy26

Organisms57

Diseases46

Chemicals and Drugs33

Analytical, Diagnostic and Therapeutic Techniques and Equipment50

Psychiatry and Psychology12

Phenomena and Processes46

Disciplines and Occupations6

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science3

Health Care6

Rats7

Neuronal6

Exploratory3

Alternation1

Epileptic2

Vivo4

Regression1

Acute4

Mice10

Status epilepticus2

Tumour3

Postnatal2

Immunocompetent1

Neurons2

Physiology2

Tumors1

Activity7

Statistical1

19801

Xenograft Models1

Inflammation1

Vitro1

Human9

Occur4

Laboratory3

Placental1

Mechanisms3

Humans2

Occurs1

Experimental model2

Orthotopic2

Preclinical data1

Species1

Murine1

Mortality2

Pathology2

Typically1

Infections2

Swine2

Tumor growth1

Methods2

Mouse6

Measurements1

Chronic1

Study6

Resistance2

Pilocarpine1

Rabbit1

Recruitment2

Rates3

Transplantation1

Studies1

Esophageal2

Effects1

Background1

Bowel3

Normal4

Development3

Develop1