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  • diuretics
  • In this Anglo-Scandinavian Cardiac Outcomes Trial subgroup it appears that less than half the subjects defined as being resistant had been exposed to diuretics and their response to spironolactone was not different. (ahajournals.org)
  • Endocrine
  • Hyperkalaemia is the most common side-effect of exposure to spironolactone in humans, and a number of endocrine effects have been observed, the most common of which is gynaecomastia in men. (inchem.org)
  • hypertensive
  • Interestingly, recent data suggest that spironolactone may have significant pain ameliorating effects that may prove to be an additional benefit of its use in hypertensive and cardiac patients. (ahajournals.org)
  • Spironolactone prevents chlorthalidone-induced sympathetic activation and insulin resistance in hypertensive patients. (ahajournals.org)
  • reduction
  • Given the preferential reduction in systolic blood pressure, it is possible an effect of spironolactone on arterial stiffness may contribute. (ahajournals.org)
  • The reduction in both brachial and aortic BP and arterial stiffness, measured by wave reflection, were all positively related to baseline ARR in patients receiving spironolactone only. (ahajournals.org)
  • Prenatal treatment of rats with spironolactone caused a reduction in the weight of the prostate and seminal vesicles in male offspring. (inchem.org)