• Methods Rat striatum or frontal cortex was incubated for 10 min with 3H-spiperone,3H-haloperidol or 3H-LSD. (erowid.org)
  • haloperidol, droperidol and spiperone, as NorA efflux pump inhibitors that reverse ciprofloxacin resistance in S. aureus 1199B. (confex.com)
  • Checkerboard assays resulted in average FIC for droperidol, haloperidol, and spiperone of 0.195, 0.2 and 0.172 respectively, demonstrating a synergistic mechanism with ciprofloxacin for all three compounds (FIC ≤ 0.5). (confex.com)
  • A complete inhibition of ethidium bromide efflux was achieved at a concentration of 200 ug/mL for haloperidol and droperidol while only 100 ug/mL of spiperone was needed to achieve the same effect. (confex.com)
  • They demonstrated that, as opposed to the various other antagonists, spiperone and haloperidol respectively elevated the atomic length between guide carbon atoms of transmembrane domains IV and V and I and II, both which offer essential interfaces for D3R dimerization. (nuche.org)
  • These results provide a molecular explanation for the exclusive ability of haloperidol and spiperone to disrupt D3R dimerization. (nuche.org)
  • These outcomes provide a molecular description for the distinct capability of spiperone and haloperidol to disrupt D3R dimerization. (nuche.org)
  • Serotonergic ligands displaced specific [3H]5-HT binding with a rank order of potency expected of a 5-HT1D receptor subtype, 5-carboxyamidotryptamine greater than 5-HT greater than yohimbine greater than 8-hydroxy-2-(di-n-propylamino)tetralin greater than ketanserin = spiperone greater than zacopride. (aspetjournals.org)
  • N-Methylspiperone (NMSP) is a derivate of spiperone that is used to study the dopamine and serotonin neurotransmitter system. (wikipedia.org)
  • The dopamine-induced hyperpolarization of locust acinar cells could be blocked using the selective D1 receptor antagonist SCH23390 whilst the D2 receptor antagonists sulpiride and spiperone were inactive. (herts.ac.uk)
  • 3) K. V. Niessen, G. H fner and K. T. Wanner, 'Competetive MS Binding Assays for Dopamine D 2 Receptors Employing Spiperone as a Native Marker', ChemBioChem 6 ( 2005 ) , 1769-1775. (monikasimon.eu)
  • The radioactivity curve of the cerebellum in a control positron-emission tomographic study almost equaled that of the striatum in the dog pretreated with spiperone (2 mg). (elsevierpure.com)
  • The data obtained by the pretreatment study was different from that of displacement, which suggested that displaceable [ 11 C]NMSP in the specific binding sites of the striatum was not completely cleared from the brain tissue by a large amount of unlabeled spiperone. (elsevierpure.com)
  • 4. Chemistry, Behavioral Pharmacology, and Inhibition of [ 3 H]Spiperone Binding of 3,5-Disubstituted N-[(1-Ethyl-2-pyrrolidinyl)methyl] -6-methoxy-salicylamides. (nucmedcor.com)
  • In vivo displacement of 3H-spiperone by pipamperone and LSD occurred at low doses (both 0.63 mg/kg) in the frontal cortex but not in brain dopaminergic areas, while labeling in these fatter regions was reduced by high doses of LSD (10 mg/kg) but only significantly after 2 hr. (erowid.org)
  • The inhibitory action of DOI is blocked by the 5-HT2 antagonists, ritanserin, metergoline and spiperone, but not other receptor antagonists. (erowid.org)
  • The dissociation constants of spiperone for the high-affinity binding site (KH) for all the tissues and species, except cat FC and rabbit DH, were very close to those previously found in the rat (2-13 nM). (nih.gov)
  • binding sites labeled with high affinity by [ 3 H]spiperone were termed 5-HT 2 receptors. (nih.gov)
  • The [ 3 H]5-HT-binding site that showed high affinity for spiperone was termed the 5-HT 1A subtype, whereas the component of [ 3 H]5-HT binding that showed low affinity for spiperone was called the 5-HT 1B subtype. (nih.gov)
  • Displacement of [3H]spiperone from high-affinity state of human dopamine D2L receptor transfected in HEK293 cells after 2 hrs by scintillation counti. (bindingdb.org)
  • Displacement of [3H]-spiperone from high-affinity state of recombinant human dopamine D2L receptor expressed in CHO cells after 45 mins by scintillat. (bindingdb.org)
  • The binding of [ 3 H] 5-HT to 5-HT 1 receptors was shown to be displaced by spiperone in a biphasic manner, suggesting that what was termed the 5-HT 1 receptor might be a heterogeneous population of receptors. (nih.gov)
  • Pre-treatment with the D 2 antagonist spiperone, but not the selective D 1 antagonist SCH-23390, prevented this quinpirole-elicited decrease. (edu.au)
  • AHR -5645B fumarate is a substituted benzamide that has been shown to inhibit 3H-spiperone binding to bovine anterior pit. (targetmol.com)
  • Aim of this study is investigates the influence of spiperone on hydrolase activity pathway in chronic obstructive pulmonary disease (COPD). (nih.gov)
  • Western blotting and reverse transcription quantitative polymerase chain reaction (RT-qPCR) were used to investigate the effect of spiperone on regulation of hydrolase activity pathway in vitro experiment. (nih.gov)