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  • outcomes
  • Outcomes that will be measured in spinal cord injured patients include the eligibility and recruitment rate of patients, the time required to institute lumbar drainage, and adverse effects related to CSF drain insertion and CSF drainage. (clinicaltrials.gov)
  • patients
  • These individuals will be patients undergoing hip or knee surgery under a spinal anesthetic, where a small sample of CSF can be taken when their intrathecal space is accessed for the anesthesia. (clinicaltrials.gov)
  • cerebral ischemia
  • Sharma SS, Munusamy S, Thiyagarajan M, Kaul CL (2004) Neuroprotective effect of peroxynitrite decomposition catalyst and poly(adenosine diphosphate-ribose)polymerase inhibitor alone and in combination in rats with focal cerebral ischemia. (springer.com)
  • 9 Riluzole was found to be neuroprotective in behavioral and histologic models of cerebral ischemia. (asahq.org)
  • The anesthetic agent ketamine, which has known properties of a noncompetitive NMDA receptor antagonist, reduces neuronal damage from incomplete cerebral ischemia 1,13 and has been used as part of the anesthetic technique in some surgical procedures that carry a risk of paraplegia. (asahq.org)
  • Expression of Caspases and Their Substrates in the Rat Model of Focal Cerebral Ischemia (2000) Krupinski Jerzy et al. (naver.com)
  • tissue
  • 3. If spinal cord ischemia has resulted from a known or suspected embolic origin, consider IV tissue plasminogen activator (tPA). (psychiatryadvisor.com)
  • Spinal cord tissue damage was evaluated in tissue collected at the end of experiment using hematoxylin and eosin and Nissl staining. (springeropen.com)
  • In rhesus monkeys subjected to circulatory arrest, studies were made of the relationship of lactate production in the spinal cord to the duration of circulatory arrest and magnitude of lactate accumulation, and the results were compared to the magnitude of rise in cerebral tissue lactate. (thejns.org)
  • Spinal cord tissue was excised for lactate assay at the upper laminectomy as a control, and a second tissue specimen was excised at the lower laminectomy site at time increments of 30 sec to 30 min after circulatory arrest. (thejns.org)
  • Anoxic spinal tissue lactate was elevated above controls in each instance, and tissue lactate peaked between 5 to 10 min after circulatory arrest and remained stable with mild fluctuations beyond that time. (thejns.org)
  • Thus, the spinal cord responds to circulatory arrest much as cerebral tissue, but with some delay in the accumulation of lactic acid. (thejns.org)
  • Lactate accumulation in spinal cord tissue following trauma was determined to ascertain the role and magnitude of ischemia. (thejns.org)
  • Nonvolatile residue in spinal cord tissue following impact trauma was determined to ascertain the magnitude and persistence of edema. (thejns.org)
  • therapeutic
  • 2. If spinal ischemia has occurred after thoracoabdominal surgery, consider placement of a lumbar drain for therapeutic drainage of cerebrospinal fluid. (psychiatryadvisor.com)
  • Our data indicated that tc-MEP monitoring could detect the onset of SCI so rapidly in comparison with segmental SCEP monitoring, which could provide therapeutic windows in a surgical approach that includes spinal cord protection. (springer.com)
  • limb
  • This can become severe and cause critical limb ischaemia which can result in rest pain, leg ulceration, and gangrene that requires amputation. (cochrane.org)
  • Spinal cord function was assessed by motor evoked potentials (MEPs) and lower limb reflexes using a modified Tarlov score. (springeropen.com)
  • Opioid peptide response to spinal cord stimulation in chronic critical limb ischemia. (unibo.it)
  • Twelve patients with chronic critical limb ischemia in whom a spinal cord stimulation (SCS) system had been implanted for at least one year had increased microvascular flow and achieved healing of trophic acral lesions. (unibo.it)
  • Adamkiewicz
  • the best known is the artery of Adamkiewicz, which is usually found between T8 and L3, making the lumbar region fairly resistant to ischemia as well. (psychiatryadvisor.com)
  • Recent breakthroughs in imaging methods have expanded the non-invasive diagnostic ability to determine a patient's spinal cord vascular pattern, particularly in detecting the presence and location of the artery of Adamkiewicz. (semanticscholar.org)
  • Because there is no way to reestablish blood flow to the Adamkiewicz artery when it is occluded by a stent graft after EVAR, the debate over the role of thr Adamkiewicz artery on the mechanism of spinal cord ischemia has resurfaced again. (biomedsearch.com)
  • stimulation
  • Another option for patients who cannot have surgery is spinal cord stimulation (SCS). (cochrane.org)
  • Spinal cord stimulation (SCS) has been proposed as a helpful treatment in addition to standard conservative treatment. (cochrane.org)
  • Ubbink DT, Vermeulen H. Spinal cord stimulation for non-reconstructable chronic critical leg ischaemia. (cochrane.org)
  • The persistence of high plasma opioid levels after switching off the spinal cord stimulation explains the absence of subjective complaints and suggests an involvement of opioids in the regulation and improvement of the microcirculation. (unibo.it)
  • Spinal cord stimulation for chronic pain of spinal origin: a valuable long-term solution. (rutgers.edu)
  • edema
  • Disruption from the bloodstream brain barrier takes place under several pathological conditions, such as for example Itga1 stroke and spinal-cord damage, leading to an elevated cerebrovascular permeability with following development of tissues edema . (stopvivisection.info)
  • In today's study, IPC considerably attenuated the consequences on I-R damage on bloodstream spinal cord hurdle permeability and spinal-cord edema at both 4 and 24 h after damage. (stopvivisection.info)