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Spinal CordSpinal Cord InjuriesSpinal Cord DiseasesSpinal Cord CompressionSpinal Cord NeoplasmsSpinal Cord IschemiaInjections, SpinalSelf AdministrationParaplegiaSpinal Nerve RootsSpinal NervesMotor NeuronsSpinal Cord RegenerationCocaineSpinal CanalHeroinSpinal NeoplasmsCervical VertebraeAnesthesia, SpinalQuadriplegiaThoracic VertebraeSpinal DiseasesUmbilical CordPosterior Horn CellsLaminectomyRats, Sprague-DawleyLumbosacral RegionRecovery of FunctionNerve RegenerationAxonsSpinal StenosisGanglia, SpinalSpinal Cord StimulationLocomotionSpinal FusionSpinal InjuriesDopamine Uptake InhibitorsAnterior Horn CellsReinforcement ScheduleMyelitisBehavior, AnimalCordotomyParalysisMuscular Atrophy, SpinalPainDose-Response Relationship, DrugNeuronsHyperalgesiaElectric Stimulation TherapyReinforcement (Psychology)NeuralgiaDisease Models, AnimalMacaca mulattaConditioning, OperantMyelographyElectric StimulationSpineEpidural SpaceAfferent PathwaysUrinary Bladder, NeurogenicHematoma, Epidural, SpinalHindlimbNeurons, AfferentNociceptorsLumbar VertebraeReflexTime FactorsLampreysMotor ActivityAutonomic DysreflexiaInterneuronsPyramidal TractsElectromyographyMagnetic Resonance ImagingPain MeasurementTuberculosis, SpinalMyelin SheathCatsCentral Nervous SystemFetal BloodPhysical StimulationNeurogliaImmunohistochemistryContusionsEvoked Potentials, SomatosensoryBrain StemSpinal CurvaturesOligodendrogliaSpermatic CordSciatic NerveSyringomyeliaMuscle SpasticityEfferent PathwaysStrychnineCauda EquinaSpinal Muscular Atrophies of ChildhoodDecompression, SurgicalParaparesisAnimals, NewbornSpinal Fractures
RehabilInjuriesSustained spinal cord iTraumaticInduced by spinal cord iAssociated with spinal cord iCohort studyParalysisRehabilitationCervicalLower urinary tract dysfunctionUrinaryBrainDeformityDeficitsSystematic ReviewNeurologicalGlialNeurologicPatientsChronic inflammationSevereBladderIndividualsBurdenComplicationsNeuralAcuteNerveClinicalSecondaryExerciseLevelResultBackgroundPeopleLifetimeQuality of lPersonsPermanentEffectsHealthStudyResearch
Rehabil2
Injuries14
  • Millions of people in the U.S. suffer from stroke, multiple sclerosis, postpolio, spinal cord injuries, or various other ailments that benefit from the use of orthoses. (wikipedia.org)
  • See also Spinal Cord Injuries , Autonomic Dysreflexia in Spinal Cord Injury , Functional Outcomes per level of Spinal Cord Injury , Heterotopic Ossification in Spinal Cord Injury , Hypercalcemia in Spinal Cord Injury , Prevention of Thromboembolism in Spinal Cord Injury , Rehabilitation of Persons with Spinal Cord Injuries , and Spinal Cord Injury and Aging . (medscape.com)
  • Background The objectives of this research were to determine the savings of loss-of-life expectancy (LE) and lifetime medical costs (LMC) from prevention of spinal cord injuries (SCI) in Taiwan. (bmj.com)
  • Spinal cord injuries (SCIs) can have catastrophic effects on individuals resulting in loss of physical abilities and independence. (dovepress.com)
  • Currently there are approximately 294,000 people living in the United States with a spinal cord injury (SCI) and approximately 17,810 new spinal cord injuries each year in the United States. (rehabpub.com)
  • Clients living with spinal cord injuries are at increased risk for skin breakdown. (rehabpub.com)
  • This article reviews and summarises the sparse research on direct catastrophic injuries in youth sports, a direct catastrophic sports injury being defined as a sport injury that resulted from participation in the skills of the sport, and resulted in a fatality or in a non-fatal brain or spinal cord injury, or skull or spinal fracture. (bmj.com)
  • Background: Individuals with spinal cord injuries (SCI) experience high rates of prescription opioid use, yet there is limited data on frequency of opioid use and specific medications being taken. (bvsalud.org)
  • Between 249,000 to 363,000 persons live with disabilities due to spinal cord injuries (SCI) in the United States, and approximately 17,730 individuals experience new SCI each year [ 1 ]. (biomedcentral.com)
  • Occurrence and predictors of employment after traumatic spinal cord injuries: the GISEM study. (paom.pl)
  • Conclusion TENS of pelvic floor muscles is a promising, safe, effective, and inexpensive physical therapy technique to improve urinary and erectile dysfunction in patients with partial suprasacral spinal cord injuries. (eg.net)
  • Thus, these findings suggest a potential role of MVIIC in preventing secondary injuries after spinal trauma. (biomedcentral.com)
  • Traumatic injuries to the brain, cranial nerves, spinal cord, autonomic nervous system, or neuromuscular system, including iatrogenic injuries induced by surgical procedures. (bvsalud.org)
  • Back injuries , including spinal cord injuries, can result in permanent disabilities. (billallenlaw.com)
Sustained spinal cord i1
  • The body that has sustained spinal cord injury has been considered the model of premature aging, and the role of parathyroid hormone (PTH) in osteoporosis following spinal cord injury illustrates this point. (medscape.com)
Traumatic8
  • A longitudinal cohort study by Rodriguez et al found the 4-year incidence of musculoskeletal morbidities (such as osteoporosis, sarcopenia, osteoarthritis, and fractures) to be 82.4% in adults with traumatic spinal cord injury, compared with 47.5% in adults without such injury. (medscape.com)
  • The report included over 9000 patients with traumatic spinal cord injury and nearly 1.5 million without. (medscape.com)
  • Globally, over 250,000 suffer a traumatic spinal cord injury every year and most become wheelchair users as a result. (thegivingblock.com)
  • Life Satisfaction Trend and Mortality After Traumatic Spinal Cord Injury: A Cohort Study. (fullscope.org)
  • Caregivers burden in rehabilitation of patients with neurological deficits following traumatic spinal cord injury. (sci-rep.com)
  • Objective This study compared the efficacy of transcutaneous electrical nerve stimulation (TENS) with pelvic floor biofeedback (PFBFB) training in the treatment of bladder and erectile dysfunction for male patients with traumatic partial spinal cord injury. (eg.net)
  • Methods The study included 30 male patients with bladder and erectile dysfunction (precipitancy overactive bladder) after traumatic partial spinal cord injury above the level of T12 within 6-18 months after injury. (eg.net)
  • Ongoing research utilizes computer and statistical models to develop personalized medicine for spinal disorders, develop response corridors and injury risk functions for the head and spine, and determine human head-spine responses under physiologic and traumatic loads. (mcw.edu)
Induced by spinal cord i1
  • The differences between osteoporosis induced by spinal cord injury and other causes of bone loss (disuse), such as prolonged bed rest, space travel, and lower motor neuron disorders, have since become clearer. (medscape.com)
Associated with spinal cord i2
  • The loss of bone also may be enhanced by lack of muscle traction on bone or by other neural factors associated with spinal cord injury. (medscape.com)
  • An A to Z listing of words and phrased commonly associated with spinal cord injury and disorders. (unitedspinal.org)
Cohort study1
  • Frotzler A, Coupaud S, Perret C, Kakebeeke TH, Hunt KJ, Eser P. Effect of detraining on bone and muscle tissue in subjects with chronic spinal cord injury after a period of electrically-stimulated cycling: a small cohort study. (paraplegie.ch)
Paralysis2
  • Spinal cord injury (SCI) can result in full or partial paralysis, which limits mobility-producing muscular activation. (dovepress.com)
  • serious injury: no permanent functional disability, but a severe brain or spinal cord injury (eg, a fractured vertebra with no permanent paralysis). (bmj.com)
Rehabilitation3
  • Passive shoulder range of motion impairment in spinal cord injury during one year after rehabilitation. (paraplegie.ch)
  • The purpose of this study was to estimate the budget impact of adding robotic exoskeleton over-ground training to existing locomotor training strategies in the rehabilitation of people with spinal cord injury. (biomedcentral.com)
  • A Budget Impact Analysis (BIA) was conducted using data provided by four Spinal Cord Injury (SCI) Model Systems rehabilitation hospitals. (biomedcentral.com)
Cervical2
  • The aim of the study was to assess life satisfaction of men with the cervical spinal cord injury (CSCI), wheelchair rugby players (WR) against a control group. (paom.pl)
  • The brachial plexus which innervates the upper limb has afferent from the cervical and thoracic part of the spinal cord. (clinmedjournals.org)
Lower urinary tract dysfunction1
  • Neurological lower urinary tract dysfunction - there is usually chronic urinary retention from a neuropathic bladder condition: for example, multiple sclerosis , diabetic neuropathy, spina bifida , spinal cord injury or spinal tumour . (patient.info)
Urinary2
  • Background Spinal cord injury is associated with urinary and erectile dysfunction. (eg.net)
  • Plain X-ray to show urinary calculi and spinal abnormalities. (patient.info)
Brain4
Deformity1
  • Severe disability is not a contra-indication since patients in wheelchairs have mastered the technique despite paraplegia, an anaesthetic perineum, spinal deformity, intention tremor, learning disability, old age or severe sight impairment. (patient.info)
Deficits1
  • [ 6 , 7 ] These mechanisms differ from those observed in subjects without spinal cord injury after prolonged bed rest and in subjects with other neurologic deficits. (medscape.com)
Systematic Review1
  • Wilson JR, Hashimoto RE, Dettori JR, Fehlings MG. Spinal cord injury and quality of life: a systematic review of outcome measures. (paom.pl)
Neurological2
  • An accurate assessment can be obtained using the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) as the gold standard for assessment of the patient's ASIA (American Spinal Cord Injury) level. (rehabpub.com)
  • Currently, Dr. Hulsebosch is part of the scientific advisory board for both the Neurological Recovery Network and the North American Clinical Trials Network, which are actively involved in advancing clinical trials in spinal cord injury. (uth.edu)
Glial3
  • An SCI results in a complex series of events that include a lesion within the spinal cord, glial scarring around the lesion, release of chemicals that inhibit axonal growth in the damaged area, and axonal demyelination of nearby but initially unaffected neurons. (dovepress.com)
  • Spinal cord injury results in a variety of changes that continue to be cytotoxic to cells that are at risk of dying, both nerve cells and glial cells-cells that are not nerve cells but are critical for normal spinal cord function. (uth.edu)
  • Her group reports that both glial and nerve cells are changed permanently after spinal cord injury. (uth.edu)
Neurologic1
  • LaVela S, Landers K, Etingen B, Karalius V, Miskevics S. Factors related to caregiving for individuals with spinal cord injury compared to caregiving for individuals with other neurologic conditions. (sci-rep.com)
Patients8
  • [ 1 , 2 ] The acute treatment of patients with spinal cord injury has always focused on the injury itself and on the immediate complications that subsequently arise. (medscape.com)
  • Background: Osteoporotic fractures occur in almost half of patients with a spinal cord injury (SCI) and are associated with significant morbidity and excess mortality. (bvsalud.org)
  • Spinal cord injury (SCI) is a distressing disorder that can cause of loss of physical, psychological and social functioning, that can cause high level of disability in patients. (sci-rep.com)
  • Ma H, Lu H, Xiong X, Yao J, Yang Z. The investigation of care burden and coping style in caregivers of spinal cord injury patients. (sci-rep.com)
  • Bardak A, Erhan B, Gűndűz B. Low back pain among caregivers of spinal cord injured patients. (sci-rep.com)
  • Shendy WS, El Semary MM, Battecha KH, Abdel-Azim MS, Mourad HS, El Gohary AM. Efficacy of transcutaneous electrical nerve stimulation versus biofeedback training on bladder and erectile dysfunction in patients with spinal cord injury. (eg.net)
  • Urological complications are common in patients with chronic spinal cord injury (SCI). (e-urol-sci.com)
  • NLUTD is the most difficult disorder to manage in patients with spinal cord injury (SCI). (e-urol-sci.com)
Chronic inflammation1
Severe1
  • A young school teacher and mother of two is hit by a drunk driver while sitting at a red light, and suffers a severe spinal cord injury requiring surgery. (spencelawyers.com)
Bladder1
  • It has been shown to improve the quality of life of those rendered housebound by bladder problems and has preserved the kidneys of children with spina bifida , and of adults with spinal cord injury . (patient.info)
Individuals5
  • The relationship between physical and mental health variables in individuals with spinal cord injury from Latin America. (paom.pl)
  • Burden of care in primary caregivers of individuals with spinal cord injury in Iran: its association with sociodemographic factors. (sci-rep.com)
  • Caregivers of individuals with spinal cord injury: caregiver burden. (sci-rep.com)
  • To demonstrate the association between the physical and functional characteristics of individuals with spinal cord injury (SCI) and suicidality, an area of research that is less understood than the association with demographic, social, and psychological characteristics. (e-arm.org)
  • Spinal cord injury (SCI) is a devastating condition that often results in significant physical, psychological, and social consequences for affected individuals, potentially leading to even more serious outcomes such as suicide [ 1 , 2 ]. (e-arm.org)
Burden1
  • In addition to the physical burden, spinal cord injury accounts for significant health care costs ranging from $368,562 to $1,129,302 in first year costs and $44,766 to $196,107 in annual health care costs depending on the severity of injury [ 1 ]. (biomedcentral.com)
Complications1
  • One of the inevitable complications of spinal cord injury (SCI) is the associated osteoporosis that occurs predominantly in the pelvis and the lower extremities (see the image below). (medscape.com)
Neural1
  • Her collaborative manuscripts demonstrate numerous and permanent changes that are many segments above and below the spinal cord injury and persistent changes in neural circuits in these regions that lead to dysfunction. (uth.edu)
Acute1
  • The mechanism behind spinal cord injury (SCI)-induced osteoporosis is accepted as being multifactorial in the acute and chronic stages. (medscape.com)
Nerve4
  • For example, her laboratory has demonstrated that molecularly engineered cells transplanted onto the surface of the spinal cord can return the abnormal characteristics of the nerve cells that develop after SCI, to more normal behavior. (uth.edu)
  • They hypothesize that persistent neuroinflammation in the spinal cord contributes to permanent alterations in nerve cell circuits, and that the abnormal reaction of microglia and astrocytes after SCI (she calls this "gliopathy"), even many segments away continues to contribute to the neuroinflammation leading to impaired nerve cell function. (uth.edu)
  • She pioneered the concept of nerve cell process reorganization and the formation of new nerve connections (synaptogenesis) in the spinal cord after injury. (uth.edu)
  • She has numerous publications that demonstrate the ability of nerve cells to reorganize after spinal cord injury. (uth.edu)
Clinical4
  • We fund world-class scientific research and clinical trials around the globe aimed at healing the injured spinal cord. (thegivingblock.com)
  • We fund the world's most promising scientific research and clinical trials around the globe, aimed at finding a cure for spinal cord injury. (thegivingblock.com)
  • Therefore, the present study aimed to investigate the potential toxic effects of MVIIC on organs and to evaluate clinical and blood profiles of rats submitted to spinal cord injury and treated with this marine toxin. (biomedcentral.com)
  • Three of the interventions described by her laboratory are in clinical trials, or are in use as an off label clinical strategy to improve function after spinal cord injury. (uth.edu)
Secondary1
Exercise1
  • Long-term exercise training in persons with spinal cord injury: effects on strength, arm ergometry performance and psychological well-being. (paom.pl)
Level2
  • This level of hypercalciuria is 2-4 times that of persons without spinal cord injury who undergo prolonged bed rest. (medscape.com)
  • This model at the skeletal level following spinal cord injury resembles the high bone turnover rate seen in postmenopausal osteoporosis. (medscape.com)
Result2
  • We operate in a saturated market, competing with prevalent causes such as cancer, child poverty and heart disease and as a result scientific research into curing spinal cord injury is desperately underfunded. (thegivingblock.com)
  • The result is an increase in bone reabsorption or osteoporosis related to parathyroid dysfunction in the chronic stages of spinal cord injury. (medscape.com)
Background1
  • Background: Obstructive sleep apnea (OSA) is highly prevalent and poorly managed in spinal cord injury (SCI). (bvsalud.org)
People6
  • At Wings for Life, we believe in a different future where people affected by spinal cord injury have a set of treatment options available to them. (thegivingblock.com)
  • After an injury most people live through months if not years of rehabilitative therapy, living in hospital spinal units. (thegivingblock.com)
  • Hospitals provided estimates of therapy utilization and costs about people with spinal cord injury who participated in locomotor training in the calendar year 2017. (biomedcentral.com)
  • Lund ML, Nordlund A, Bernspång B, Lexell J. Perceived participation and problems in participation are determinants of life satisfaction in people with spinal cord injury. (paom.pl)
  • Athletic identity, sport participation, and psychological adjustment in people with spinal cord injury. (paom.pl)
  • Tasiemski T, Priebe MM, Wilski M. Life satisfaction and life values in people with spinal cord injury living in three Asian countries: a multicultural study. (paom.pl)
Lifetime1
  • Since Wings for Life was first founded, a number of vital breakthroughs have been made and there is now real and legitimate hope spinal cord injury can be cured in our lifetime. (thegivingblock.com)
Quality of l1
  • Lynch J, Cahalan R. The impact of spinal cord injury on the quality of life of primary family caregivers: a literature review. (sci-rep.com)
Persons1
  • Osteoporosis in persons with spinal cord injury was first studied in relation to calcium metabolism and the associated hypercalcemia and renal calculi that followed. (medscape.com)
Permanent2
  • Spinal cord injury causes immediate and, in some regions, permanent gravitational unloading. (medscape.com)
  • They are in the process of using molecular, behavioral, physiological, immunocytochemical and electrophysiological approaches to study the mechanisms that underlie the permanent changes that will help restore the spinal cord to normal function. (uth.edu)
Effects1
  • These findings suggest that MVIIC at 15, 30 and 60 pmol are safe for intralesional administration after spinal cord injury and could be further investigated in relation to its neuroprotective effects. (biomedcentral.com)
Health2
  • All-cause mortality and life expectancy are key endpoint measures of individual health after a spinal cord injury (SCI). (karger.com)
  • Toward a health services research capacity in spinal cord injury. (paom.pl)
Study1
  • An electron microscopic study of cells undergoing dna synthesis in injured spinal cord. (jax.org)
Research1
  • The new discovery of chronic neuroinflammation provides a mechanism for continued research to improve function after spinal cord injury. (uth.edu)