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  • spectroscopy
  • J. F. J. Todd, "Recommendations for nomenclature and symbolism for mass spectroscopy," Pure and Applied Chemistry , vol. 63, pp. 1541-1566, 1991. (hindawi.com)
  • Lipidomics is a relatively recent research field that has been driven by rapid advances in technologies such as mass spectrometry (MS), nuclear magnetic resonance (NMR) spectroscopy, fluorescence spectroscopy, dual polarisation interferometry and computational methods, coupled with the recognition of the role of lipids in many metabolic diseases such as obesity, atherosclerosis, stroke, hypertension and diabetes. (wikipedia.org)
  • In modern times, H-D exchange has primarily been monitored by the methods: NMR spectroscopy, mass spectrometry and neutron crystallography. (wikipedia.org)
  • Imaging
  • The IR-MALDESI source can be used for mass spectrometry imaging (MSI), a technique using MS data collected over the sample area to visualize the spatial distribution of specific analyte molecules. (wikipedia.org)
  • Using the IR-MALDESI imaging source, a variety of dye classes were analyzed from various fabrics with little to no sample preparation allowing for the identification of the dye mass and in some cases the fiber polymer. (wikipedia.org)
  • Vertes, A., In Situ Cell-by-Cell Imaging and Analysis of Small Cell Populations by Mass Spectrometry. (wikipedia.org)
  • molecular
  • Han and Gross first defined the field of lipidomics through integrating the specific chemical properties inherent in lipid molecular species with a comprehensive mass spectrometric approach. (wikipedia.org)
  • Starting in the 1970s Smith published peer-reviewed papers on several subjects, including mass spectrometry, ion cyclotron resonance mass spectrometry, ion-molecule reactions, molecular assemblies, and supercritical fluid solutions. (wikipedia.org)
  • This pioneer interface for LC-MS had the same analysis capabilities of GC-MS and was limited to rather volatile analytes and non-polar compounds with low molecular mass (below 400 Da). (wikipedia.org)
  • Instrumentation
  • This early work has led him to be considered an internationally recognized expert in mass spectrometry and separation techniques, and his research has led to advancements in instrumentation for the medical and environmental analysis fields, as well as biological research. (wikipedia.org)
  • He applied it for increasing the sensitivity of ESI-MS. His group has continued to refine and extend ion funnel technology, which is now widely applied in mass spectrometry and ion mobility instrumentation. (wikipedia.org)
  • ambient
  • Performing ionization in an ambient environment, this technique requires little sample preparation and no additional matrix, and can be performed on natural, uneven surfaces. (springer.com)
  • biological
  • A water cooled Peltier thermoelectric plate is used to control the sample temperature (−10 °C to 80 °C). The IR-MALDESI source is currently used to investigate the fundamentals of the ionization process, in addition to being routinely employed for visualizing analyte distributions in biological, forensic, and pharmaceutical samples. (wikipedia.org)
  • liquid
  • In early versions of thermospray, an infrared laser was directed at a liquid spray tip to heat the sample and aid in ionization. (wikipedia.org)
  • The name electrospray is used for an apparatus that employs electricity to disperse a liquid or for the fine aerosol resulting from this process. (wikipedia.org)
  • This effect is clearly related to electrosprays, even though Gilbert did not record any observation related to liquid dispersion under the effect of the electric field. (wikipedia.org)
  • organic
  • Zare used two-step laser mass spectrometry (L2MS), a technique that is particularly sensitive to organic molecules, to examine samples from the interior of the meteorite. (wikipedia.org)
  • 1990s
  • By the end of the 1990s, Smith's achievements included the electrodynamic ion funnel and a micro-dialysis device for the rapid purification of samples analyzed using mass spectrometry. (wikipedia.org)
  • In the late 1990s, Smith's group was also extensively involved in the development and application of Fourier transform ion cyclotron resonance (FTICR) mass spectrometry, which provided the basis for much greater MS resolution and mass measurement accuracy, and particularly in the development of these technologies for applications in proteomics. (wikipedia.org)
  • source
  • The ablated material is captured in an exposed flowing solvent stream that carries the ablated material to the electrospray source. (biomedsearch.com)
  • M. Yamashita and J. B. Fenn, "Electrospray ion source. (hindawi.com)
  • A versatile IR-MALDESI MSI source was designed and implemented, which is currently coupled to a high resolving power hybrid Quadrupole-Orbitrap mass spectrometer. (wikipedia.org)
  • deconvolution
  • The abundance of ten fatty acyl chains at 46 TAG masses (mass-to-charge ratio, m/z) were determined after isotopic deconvolution and correction by adjustment factors at each TAG mass. (osti.gov)
  • techniques
  • Allmaier, G. and Schmid, E. R. (1991) New mass spectrometric techniques for peptidoglycan analysis, see this volume. (springer.com)
  • Hydrogen
  • The nitrogen rule states that organic molecules that contain hydrogen, carbon, nitrogen, oxygen, silicon, phosphorus, sulfur, and the halogens have an odd nominal mass if they have an odd number of nitrogen atoms or an even mass if they have an even number of nitrogen atoms are present. (wikipedia.org)
  • The first step in applying the rule is to assume that only carbon and hydrogen are present in the molecule and that the molecule comprises some number of CH "units" each of which has a nominal mass of 13. (wikipedia.org)
  • fragmentation
  • The mass fragmentation patterns of steroidal glycosides substituted with an orthoacetate group were summarized, and the fragmentation patterns were applied to the online structure identification of the steroidal glycosides in the extract. (mysciencework.com)
  • The energy of the electron beam is typically 70 electronvolts and the ionization process typically produces extensive fragmentation of the chemical bonds of the molecule. (wikipedia.org)
  • Once the fragmentation is initiated, the electron is first excited from the site with the lowest ionization energy. (wikipedia.org)
  • Peaks with mass less than the molecular ion are the result of fragmentation of the molecule. (wikipedia.org)
  • Many reaction pathways exist for fragmentation, but only newly formed cations will show up in the mass spectrum, not radical fragments or neutral fragments. (wikipedia.org)
  • method
  • Research in Cooks' laboratory (the Aston Laboratory) has contributed to a diverse assortment of areas within mass spectrometry, ranging from fundamental research to instrument and method development to applications. (wikipedia.org)
  • processes
  • Due to the high vacuum pressure in the ionization chamber, the mean free path of molecules are varying from 10 cm to 1 km and then the fragmentations are unimolecular processes. (wikipedia.org)
  • spectrum
  • The peak in the mass spectrum with the greatest intensity is called the base peak. (wikipedia.org)
  • In the spectrum for toluene for example, the molecular ion peak is located at 92 m/z corresponding to its molecular mass. (wikipedia.org)
  • interface
  • The original interface between capillary zone electrophoresis and mass spectrometry was developed in 1987 by Richard D. Smith and coworkers at Pacific Northwest National Laboratory, and who also later were involved in development of interfaces with other CE variants, including capillary isotachophoresis and capillary isoelectric focusing. (wikipedia.org)