PhosphotyrosineSignal TransductionShc Signaling Adaptor Proteinssrc Homology DomainsAdaptor Proteins, Signal TransducingMolecular Sequence DataBinding SitesTyrosineAmino Acid SequenceAdaptor Proteins, Vesicular TransportPhosphorylationPhosphoproteinsInsulin Receptor Substrate ProteinsProtein BindingProtein Structure, TertiaryCell LineProteinsSequence Homology, Amino AcidRecombinant Fusion ProteinsProtein-Tyrosine KinasesRecombinant ProteinsMutagenesis, Site-DirectedSubstrate SpecificityProtein Tyrosine PhosphatasesPhosphopeptidesCloning, MolecularMutationSensitivity and SpecificityBase SequenceSequence AlignmentTransduction, GeneticTransfectionCarrier ProteinsAmino Acid MotifsModels, MolecularIntracellular Signaling Peptides and ProteinsEnzyme ActivationProtein Sorting SignalsGRB2 Adaptor ProteinDNA, ComplementaryCOS CellsTwo-Hybrid System Techniques3T3 CellsProto-Oncogene ProteinsDNA-Binding ProteinsPrecipitin TestsReceptor Protein-Tyrosine KinasesKineticsCell MembraneProto-Oncogene Proteins c-cblPeptidesNerve Tissue ProteinsTranscription FactorsProtein ConformationReceptor, InsulinCells, CulturedPhosphatidylinositol 3-KinasesMembrane ProteinsLigandsStructure-Activity RelationshipProtein Interaction Domains and MotifsModels, BiologicalEscherichia coliBacterial ProteinsProtein Structure, SecondaryDNATranscription, GeneticCrystallography, X-RayPeptide FragmentsProtein KinasesVanadatesDimerizationRNA, MessengerBlotting, WesternTumor Cells, CulturedCalciumDNA PrimersAmyloid beta-Protein PrecursorGene Expression RegulationNuclear ProteinsPlasmidsSequence DeletionTrans-ActivatorsMutagenesisConserved SequenceEnzyme InhibitorsCytoplasmMitogen-Activated Protein KinasesGene ExpressionHeLa CellsElectrophoresis, Polyacrylamide Gelsrc-Family KinasesPromoter Regions, GeneticProtein TransportCricetinaeCell DivisionImmunoblottingReceptors, Cell SurfaceProtein Kinase CTime Factors