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  • angiotensin conver
  • Objective Heart chymase instead of angiotensin converting enzyme offers higher specificity for angiotensin (Ang) We transformation into Ang II in human beings. (researchassistantresume.com)
  • Recent biomedical research on collagenase, enkephlinase, and angiotensin-converting enzyme used carboxypeptidase A for inhibitor synthesis and kinetic testing. (wikipedia.org)
  • Carboxypeptidase A and the target enzyme of Captopril, angiotensin-converting enzyme, have very similar structures, as they both contain a zinc ion within the active site. (wikipedia.org)
  • promiscuous
  • The reality is that enzymes with varying degrees of specify, promiscuous enzymes, etc., are a dime a dozen, out there in the diversity of real biology (which can be very different from the small subset of study enzymes and study organisms someone may have been exposed to in their particular graduate training). (blogspot.co.nz)
  • This means firstly that a specialist enzyme (monofunctional) when evolved goes through a generalist stage (multifunctional), before becoming a specialist again-presumably after gene duplication according to the IAD model-and secondly that promiscuous activities are more plastic than the main activity. (wikipedia.org)
  • Escherichia
  • Gilbert was educated at the University of Southampton graduating with a Bachelor of Science degree in 1975 followed by a PhD for research investigating mutant forms of the enzyme IMP dehydrogenase in Escherichia coli K12 in 1978. (wikipedia.org)
  • Structural
  • We combine structure-sequence information andfunctional annotation from various data sources to create structural alignmentsfor homologous enzymes and functional partitions therein. (duhnnae.com)
  • The Rossmann fold is a structural motif found in proteins that bind nucleotides, such as enzyme cofactors FAD, NAD+, and NADP+. (wikipedia.org)
  • The motif is named after Michael Rossman who first noticed this structural motif in the enzyme lactate dehydrogenase in 1970 and who later observed that this was a frequently occurring motif in nucleotide binding proteins. (wikipedia.org)
  • He was the first to deduce the structure of lactate dehydrogenase and characterized the structural motif within this enzyme which would later be called the Rossmann fold. (wikipedia.org)
  • Conformational proofreading (CPR) or Conformational selection is a general mechanism of molecular recognition systems in which introducing a structural mismatch between a molecular recognizer and its target, or an energetic barrier, enhances the recognition specificity and quality. (wikipedia.org)
  • Digestion
  • Proteolysis is typically catalysed by cellular enzymes called proteases, but may also occur by intra-molecular digestion. (wikipedia.org)
  • In digestion of food, digestive enzymes may be released into the environment for extracellular digestion whereby proteolytic cleavage breaks down proteins into smaller peptides and amino acids so that they may be absorbed and used by an organism. (wikipedia.org)
  • Structures
  • Gilbert has used structure-function studies to dissect the contribution of non-catalytic carbohydrate binding modules (CBMs) in targeting enzymes to complex insoluble structures exemplified by the plant cell wall, thereby overcoming the access problem. (wikipedia.org)
  • dehydrogenase
  • Corticosteroid 11-β-dehydrogenase isozyme 2 is an NAD+-dependent enzyme expressed in aldosterone-selective epithelial tissues such as the kidney, colon, salivary and sweat glands. (wikipedia.org)
  • The multifunctional enzymes are found in bacteria and in the peroxisomes of some eukaryotes, but they serve two functions: the N-terminal domain works the same as the other classes of enoyl-CoA isomerases and the C-terminal domain works as a dehydrogenase, specifically, to 3-hydroxyactyl-CoA. (wikipedia.org)
  • To begin with, the peroxisomes of rat liver are a multifunctional enzyme including enoyl-CoA isomerase, enoyl-CoA hydratase, and L-(−)-3-hydroxyacyl-CoA dehydrogenase. (wikipedia.org)
  • sequence
  • Chromatin accessibility data sets show bias due to sequence specificity of the DNase I enzyme. (ox.ac.uk)
  • The two major protocols in current use each show a different pattern, but for a given protocol the pattern of sequence specificity seems to be quite consistent. (ox.ac.uk)
  • CONCLUSIONS: DNase I is a sequence-specific enzyme, with a specificity that may depend on experimental conditions. (ox.ac.uk)
  • This sequence specificity is not taken into account by existing pipelines for identifying open chromatin regions. (ox.ac.uk)
  • In 1989, Israel Hanukoglu from the Weizmann Institute of Science discovered that the consensus sequence for NADP+ binding site in some enzymes that utilize NADP+ differs from the NAD+ binding motif. (wikipedia.org)
  • Phylogenetic analysis of the NADP binding enzyme adrenodoxin reductase revealed that from prokaryotes, through metazoa and up to primates the sequence motif difference from that of most FAD and NAD-binding sites is strictly conserved. (wikipedia.org)
  • reactions
  • This is of immense relevance in the context of white biotechnology as enzyme catalysed reactions use greener conditions. (springeropen.com)
  • Although enzymes are remarkably specific catalysts, they can often perform side reactions in addition to their main, native catalytic activity. (wikipedia.org)
  • Enzyme catalysis of chemical reactions occur with high selectivity and rate. (wikipedia.org)
  • induction
  • These data suggest that there may be multiple mechanisms by which NGF regulates enzyme induction. (jneurosci.org)
  • As compared to NGF, cAMP produces a different pattern of enzyme induction (in addition to TH, DBH, PNMT, and AChE, dopa decarboxylase (DDC) is also induced), it acts rapidly (a 12-hr exposure produces the full effect), and it acts only at the transcriptional level (its effects are blocked by alpha-amanitin). (jneurosci.org)
  • These data provide evidence that cAMP does not act as a second messenger for NGF with regard to enzyme induction. (jneurosci.org)
  • specific
  • Is this behaviour typical or are most enzymes highly specific? (blogspot.co.nz)
  • Aminoacyl tRNA synthetases are the classic examples of enzymes that are highly specific. (blogspot.co.nz)
  • This is precisely what Ann Gauger is doing with her assumption that all / almost all enzymes are highly specific. (blogspot.co.nz)
  • The aldehyde group of PLP forms a Schiff-base linkage (internal aldimine) with the ε-amino group of a specific lysine group of the aminotransferase enzyme. (wikipedia.org)
  • contributes
  • Also, it has been found to be a subunit of the peroxisomal trifunctional enzyme (pTFE) and contributes only to minor cleavages of the fatty acid chain. (wikipedia.org)
  • organisms
  • In that sense, for many higher organisms, the mitochondrial enzyme is essential for deriving maximum energy from lipids and fueling muscles. (wikipedia.org)
  • metabolism
  • In the early 1960s, P450 was thought to be one enzyme, and by the mid 1960s it was associated with drug and steroid metabolism. (wikipedia.org)