SensitivitySerumHepatocellularRecombinantBiomarkersUnwarranted diagnosticUltrasonographyProteinUltrasoundHighLevelsClinicalCancerPatientsDeficiencySurveillanceELISACELLSSerum alpha-fetoproteinBeta human chorionic goFetal tissueMarkerDiagnosticAlbuminAccuracyFeto-proteinHepatitisClinicalAffinityMaternalReceiverTestIncrease
Sensitivity31
- The sensitivity, specificity and positive predictive value (PPV) for DCP was 87%, 85% and 86.8%, for AFP 69%, 87% and 69.8%, and for AFP-L3 56%, 90% and 56.1%, respectively. (nih.gov)
- This assay has high sensitivity and excellent specificity for the detection of aFP. (biossusa.com)
- However, if a first imaging modality, such as a contrast-enhanced CT or MRI, is not conclusive, sequential imaging with a different modality can improve sensitivity for HCC detection (from 33% to 41% for either CT or MRI to 76% for both studies when performed sequentially) without a decrease in specificity. (oncolink.org)
- According to the authors, at the time of the study endpoint, the test had maintained 100 percent sensitivity and 94 percent specificity with a 17 percent positive predictive value. (genomeweb.com)
- In this group, the assay separated cancer cases from non-cancers with 85 percent sensitivity and 93 percent specificity. (genomeweb.com)
- Alpha fetoprotein ≥4.75 ng/mL had 90% specificity and 71% sensitivity for HCC occurrence. (bvsalud.org)
- In general, serum tumor markers are characterized by low sensitivity and low specificity. (doctorlib.info)
- With the exception of prostate-specific antigen (PSA), tumor markers do not have sufficient sensitivity or specificity for use in screening. (aafp.org)
- Current diagnostic approaches of Hepatocellular Carcinoma (HCC) such as ultrasonography and serum alpha-fetoprotein lack satisfactory sensitivity and specificity. (ntnu.edu.tw)
- It has high sensitivity and specificity in diagnosing HCC and is negatively associated with prognosis. (biomedcentral.com)
- Background & Aims: Measurements of α-fetoprotein (AFP) detect hepatocellular carcinoma (HCC) with low levels of sensitivity and specificity and are therefore not recommended for use in liver cancer surveillance. (biomasswars.com)
- We calculated levels of AFP that detect HCC with the highest levels of sensitivity and specificity in subgroups using ROC analysis. (biomasswars.com)
- Levels of AFP >20 ng/mL detected HCC with 70.1% sensitivity and 89.8% specificity. (biomasswars.com)
- However the most recent guidelines from your American Association for the Study of Liver Diseases (AASLD) no longer recommend using AFP citing poor level of sensitivity and specificity of AFP for early stage HCC. (biomasswars.com)
- At a cut-off of 20ng/mL the most commonly used cut-off in medical practice AFP has a level of sensitivity and specificity of approximately 60% and 80% for HCC respectively(8). (biomasswars.com)
- Therefore the primary aim of our research was to recognize determinants for level of sensitivity specificity and general precision of AFP inside a cohort of individuals with cirrhosis. (biomasswars.com)
- In a prospective phase II study, HelioLiver demonstrated high specificity (91%) and high sensitivity (76%) in detecting early-stage (stage I and II) HCC. (labpulse.com)
- Pooled sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the summary receiver operating characteristic curve (AUC) were analyzed. (e-jlc.org)
- Alpha-fetoprotein (AFP) is the gold standard biomarker in HCC, but its levels are affected by flares of HBV and hepatitis C virus (HCV) or deterioration of liver condition in addition to its low sensitivity in detection of early and small HCC [ 12 ]. (termedia.pl)
- On the basis of these thresholds, group participants were appropriately classified as recurrence-positive with a sensitivity of between 77-81 % and with a specificity of 69-82 % as being relapse-free. (uni-goettingen.de)
- However, with an application-specific specificity of ≥ 95 %, post LTx serum AFP values at 1, 3 and 5 years after the LTx showed sensitivity values of only 50 %, 52 % and 50 % respectively. (uni-goettingen.de)
- This study in the Islamic Republic of Iran compared the sensitivity and specificity of the evaporation test that requires no special equipment with the standard fern test requiring a microscope. (who.int)
- quad) has lower sensitivity and specificity than in singleton pregnancies. (msdmanuals.com)
- The overall diagnostic accuracy of CgA was 75% (CI 66-82), with a sensitivity of 70% (CI 50.6-85.2) and a specificity of 67% (CI 55.9-76.3). (unimi.it)
- VEGF showed high sensitivity (80%) and moderate specificity (70%) at a threshold of 200 pg/ml, while in the one hand, AFP showed high sensitivity (80%) and low specificity (35%) at a threshold of 100 ng/ml. (sciepub.com)
- On another hand, IL-6 showed moderate sensitivity (60%) and high specificity (80%) at a threshold of 25 pg/ml. (sciepub.com)
- However, there have been some controversies regarding the usage of AFP concerning its low sensitivity and specificity in detecting HCC. (biomedcentral.com)
- The sensitivity and specificity of AFP in the surveillance of HCC in Indonesia with a cut-off of 10 ng/ml were 82.6 and 71.2%, respectively. (biomedcentral.com)
- However, in recent years, there have been studies showing controversies regarding the use of AFP in clinical settings-because of the low sensitivity and specificity of AFP when used to screen HCC [ 8 ]. (biomedcentral.com)
- Utilization of body mass index(BMI) for abnormal liver function group in diagnosis of fatty liver had high specificity(97.6%) but sensitivity (22.3%) was low. (jpmph.org)
- However, the sensitivity and specificity of serum AFP levels for HCC have been reported to range from 39-64% and 76-91%, respectively, indicating that elevated serum AFP levels are not a sufficient indicator of HCC ( 3 , 4 ). (spandidos-publications.com)
Serum6
- Specificities of serum alpha-fetoprotein in HBsAg+ and HBsAg- patients in the diagnosis of hepatocellular carcinoma. (calbiotech.com)
- In the study, published this Monday in the Proceedings of the National Academy of Sciences , investigators from the Chinese Academy of Medical Sciences working with Genetron followed more than 300 individuals with hepatitis B who had normal liver ultrasonography and serum alpha fetoprotein (AFP) levels to see if the company's test could identify those who would go on to be diagnosed with hepatocellular carcinoma (HCC). (genomeweb.com)
- In addition, it significantly outperformed other clinically available detection tools such as serum alpha-fetoprotein (AFP) (57%), GALAD (gender, age, Lens culinaris agglutinin-reactive AFP, and des-gamma-carboxy prothrombin [DCP]) scores (65%), and ultrasound (47%) (Hepatology Communications, March 3, 2022). (labpulse.com)
- Lee Biosolutions is the leading producer of human cord serum Alpha-Fetoprotein (AFP) for clinical diagnostic manufacturers and research uses. (leebio.com)
- Alpha fetoprotein (AFP) is not produced by seminoma cells, and its serum detection usually indicates a nonseminomatous component. (medscape.com)
- A common approach used for screening HCC in a high risk-population is to examine serum tumor markers, such as α-fetoprotein (AFP). (spandidos-publications.com)
Hepatocellular9
- Mass screening of primary hepatocellular carcinoma by alpha-fetoprotein in a rural area of Taiwan-a dried blood spot method. (calbiotech.com)
- Early recognition of hepatocellular carcinoma based on altered profiles of alpha-fetoprotein. (calbiotech.com)
- Des-gamma-carboxyprothrombin, alpha-fetoprotein and AFP-L3 in patients with chronic hepatitis, cirrhosis and hepatocellular carcinoma. (nih.gov)
- Lu, Zhi-Ming 2020-12-01 00:00:00 Background: To explore the value of alpha fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA-II) in diagnosis of HBV-related hepatocellular carcinoma (HCC) and their relationship with vascular invasion, tumor differentiation and size. (sagepub.com)
- Alpha-fetoprotein (AFP), a marker for hepatocellular carcinoma, sometimes is used to screen highly selected populations and to assess hepatic masses in patients at particular risk for developing hepatic malignancy. (aafp.org)
- Even though the combined use of ultrasound (US) and alpha-fetoprotein (AFP) is recommended for the surveillance of hepatocellular carcinoma (HCC), the utilization of AFP has its challenges, including accuracy dependent on its cut-off levels, degree of liver necroinflammation, and etiology of liver disease. (e-cmh.org)
- Background: Alpha-1-fetoprotein (AFP) is used as tumor marker in a number of clinical settings including recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LTx) but the optimal post liver transplant AFP cut-off values for the detection of a HCC recurrence have not been well described. (uni-goettingen.de)
- This protein or tumor marker, called alpha-fetoprotein (AFP), although not completely specific to liver cancer is virtually diagnostic of hepatocellular carcinoma if present at levels above 400 ng/mL. (usaoncologycenters.com)
- The diagnosis of hepatocellular carcinoma (HCC) is currently limited by the use of Alpha-fetoprotein (AFP) levels and medical imaging. (sciepub.com)
Recombinant12
- Specificity: Natural and recombinant Bovine Alpha-lactalbumin GeneName: LALBA ProteinName: Alpha-lactalbumin Alternative: Lactose synthase B protein,ALACTA Assay. (researchd.com)
- Specificity: Natural and recombinant Bovine Alpha-enolase GeneName: ENO1 ProteinName: Alpha-enolase Alternative: 2-phospho-D-glycerate hydro-lyase,Enolase. (researchd.com)
- Specificity: Natural and recombinant Bovine Alpha-2-HS-glycoprotein GeneName: AHSG ProteinName: Alpha-2-HS-glycoprotein Alternative: Asialofetuin,Fetuin-A,FETUA. (researchd.com)
- Specificity: Natural and recombinant Bovine Alpha-actinin-3 GeneName: ACTN3 ProteinName: Alpha-actinin-3 Alternative: Alpha-actinin skeletal muscle isoform 3,F-actin. (researchd.com)
- Specificity: Natural and recombinant Bovine Alpha-hemoglobin-stabilizing protein GeneName: AHSP ProteinName: Alpha-hemoglobin-stabilizing protein. (researchd.com)
- Specificity: Natural and recombinant Bovine Alpha-2A adrenergic receptor GeneName: ADRA2A ProteinName: Alpha-2A adrenergic receptor Alternative: Alpha-2A. (researchd.com)
- Specificity: Natural and recombinant Bovine Alpha-actinin-1 GeneName: ACTN1 ProteinName: Alpha-actinin-1 Alternative: Alpha-actinin cytoskeletal isoform,F-actin. (researchd.com)
- Specificity: Natural and recombinant Bovine Alpha-1A adrenergic receptor GeneName: ADRA1A ProteinName: Alpha-1A adrenergic receptor Alternative: Alpha-1A. (researchd.com)
- Specificity: Natural and recombinant Bovine Alpha-1-acid glycoprotein GeneName: ORM1 ProteinName: Alpha-1-acid glycoprotein Alternative: Orosomucoid,OMD,AGP. (researchd.com)
- Recombinant human alpha fetoprotein synergistically potentiates the anti-cancer effects of 1'-S-1'-acetoxychavicol acetate when used as a complex against. (oncotarget.com)
- In the present study, all the problems above were addressed using the novel drug complex formulation involving recombinant human alpha fetoprotein (rhAFP) and ACA. (oncotarget.com)
- The company's drug products use ACT's patented recombinant human alpha fetoprotein (AFP or ACT-101). (alpha-cancer.com)
Biomarkers1
- He also said that the company worked with Mayo Clinic to find biomarkers to improve Cologuard's performance, especially its specificity. (genomeweb.com)
Unwarranted diagnostic1
- These tests also must have sufficient specificity to protect patients with false-positive results from unwarranted diagnostic evaluations. (aafp.org)
Ultrasonography1
- Therefore, surveillance of patients with high-risk features on ultrasonography (US), with or without the measurement of α-fetoprotein (AFP) levels, is important. (e-jlc.org)
Protein2
- Alpha-fetoprotein or AFP is the major protein in fetal circulation and is closely related to albumin both genetically and structurally. (aacc.org)
- Alpha Fetoprotein (AFP) is a protein that is normally only produced in the fetus during its development, and its measurement during pregnancy has been useful to detect certain abnormalities. (leebio.com)
Ultrasound1
- HCC guidelines worldwide have provided surveillance recommendation through the examination of α-fetoprotein (AFP) and ultrasound for patients at risk in developing HCC. (biomedcentral.com)
High3
- The most important advantage of the CA 72‑4 marker over others is its particularly high diagnostic specificity for benign illnesses. (pfeiffertheface.com)
- In conclusion, the high specificity of this marker for gastrointestinal neoplasms may be very interesting in follow-up studies. (pfeiffertheface.com)
- The HHLs did not express high levels of p53 or alpha-fetoprotein. (ox.ac.uk)
Levels2
- Maternal levels of alpha-fetoprotein should be measured during the second trimester to check for neural tube defects. (msdmanuals.com)
- Measure maternal levels of alpha-fetoprotein during the second trimester to check for neural tube defects regardless of other tests planned and the timing of those tests. (msdmanuals.com)
Clinical1
- Alpha Cancer Technologies Inc., (ACT) is a private clinical stage biotechnology company with Immuno-oncology, Theranostics and Immunomodulation platforms under development. (alpha-cancer.com)
Cancer1
- Advancing proprietary Alpha Fetoprotein (AFP) platforms to treat cancer and auto-immune diseases. (alpha-cancer.com)
Patients1
- B19 is the primary etiologic agent causing TAC in patients with chronic hemolytic anemias (e.g., sickle cell disease, hemoglobin SC disease, hereditary spherocytosis, alpha-thalassemia, and autoimmune hemolytic anemia) (22,23). (cdc.gov)
Deficiency3
- Certain diseases, such as hemochromatosis and alpha 1-antitrypsin deficiency, markedly increase the risk of developing HCC. (wikipedia.org)
- Alpha-1 antitrypsin deficiency. (oncolink.org)
- Further, the presence of hemochromatosis and AAD (alpha 1-antitrypsin deficiency) elevates the chances of HCC. (ccimindia.org)
Surveillance1
- Alpha fetoprotein (AFP) the best-studied serologic test is attractive for surveillance as it is definitely relatively inexpensive and easily obtainable. (biomasswars.com)
ELISA4
- Bovine NAGA/Alpha-N-acetylgalactosaminidase ELISA Kitis available at Gentaur for Next week Delivery. (researchd.com)
- Bovine CSN1S2/Alpha-S2-casein ELISA Kitis available at Gentaur for Next week Delivery. (researchd.com)
- Bovine ACTN4/Alpha-actinin-4 ELISA Kitis available at Gentaur for Next week Delivery. (researchd.com)
- Bovine ADRA1A/Alpha-1A adrenergic receptor ELISA Kitis available at Gentaur for Next week Delivery. (researchd.com)
CELLS1
- We also demonstrate that HHLs contained active gap junctions, and that the cells respond to stimulation with IFN-alpha by upregulation of major histocompatibility complex (MHC)-I and -II. (ox.ac.uk)
Serum alpha-fetoprotein2
Beta human chorionic go1
- If a malignant germ cell tumor is suspected at presentation, blood should be examined for tumor markers, including beta human chorionic gonadotropin, alpha-fetoprotein, and lactate dehydrogenase. (medscape.com)
Fetal tissue2
- Alpha-fetoprotein (AFP) is a protein produced by fetal tissue. (testing.com)
- In the absence of embryonic or fetal tissue, such as vaginal blood sampled in cases of ectopic pregnancy, threatened or complete miscarriage, or nonpregnant individuals, the test strip had a specificity of 97.7% for obtaining a negative result," the authors wrote. (medscape.com)
Marker1
- Alpha-fetoprotein is a marker of advanced HCC. (medscape.com)
Diagnostic5
- [ 41 ] Smaller cancers may not secrete diagnostic levels of alpha-fetoprotein, and elevations are also seen in chronic liver disease in the absence of detectable cancer. (medscape.com)
- These tests also must have sufficient specificity to protect patients with false-positive results from unwarranted diagnostic evaluations. (aafp.org)
- Conclusion : Le diagnostic du CHC est tardif en Centrafrique et repose principalement sur l'échographie. (bvsalud.org)
- la mortalité reste élevée en raison du diagnostic souvent tardif du CHC. (bvsalud.org)
- The lower the specificity of the diagnostic method being utilised, the higher the likelihood of false positives. (ogpnews.com)
Albumin2
- Various procedures for nonpolar and polar resin embedment were applied to mouse and rat livers for the study of postembedment immunolocalization of alpha-1-fetoprotein, albumin and the microsomal enzyme epoxide hydrolase. (kuhlmann-biomed.de)
- Apart from purified immunological reagents, the addition of high molarity sodium chloride and bovine serum albumin to the wash solutions enhanced immunohistological specificity. (kuhlmann-biomed.de)
Accuracy1
- Validation of the method The method was validated with respect to parameters like linearity, precision, accuracy, specificity, and robustness. (mirnaassay.com)
Feto-protein1
- Three novel glycoforms of alpha Feto Protein (AFP-L1, AFP-L2 and AFP-L3) have also been identified. (medkonect.com)
Hepatitis1
- All groups will be subjected to history taking, clinical examination, abdominal ultasonography with or without triphasic CT scanning, routine laboratory investigations, alpha fetoprotien, hepatitis viral markers and detection of mutations in exon 7 of p53 gene by PCR-RFLEP followed by confirmatory direct DNA sequencing. (madridge.org)
Clinical1
- Participants underwent complete history taking, comprehensive clinical examination, laboratory investigations including viral markers and alpha-fetoprotein. (bvsalud.org)
Affinity2
- 12. Lectin affinity electrophoresis of alpha-fetoprotein. (nih.gov)
- Lee Biosolutions adheres to the highest standards as a producer of affinity purified antibodies, generated with high specificity and reactivity, used in a variety of immunohistochemistry applications. (leebio.com)
Maternal1
- The performance of screening using maternal age and serum-free beta-hCG and PAPP-A at 10 weeks of pregnancy was better than the double test (alpha-fetoprotein and hCG with maternal age) and similar to the triple test (alpha-fetoprotein, unconjugated oestriol and hCG with maternal age) at 15-22 weeks. (nih.gov)
Receiver1
- Receiver operating characteristic (ROC) analysis was used to determine the prognostic value of the neutrophil to lymphocyte ratio (NLR) and alpha-fetoprotein (AFP) value. (who.int)
Test1
- The strip, called the ROM Plus test, can detect alpha-fetoprotein (AFP) and insulin-like growth factor-binding protein 1 (IGFBP-1) to identify the presence of the tissue, researchers say. (medscape.com)
Increase1
- Certain diseases, such as hemochromatosis and alpha 1-antitrypsin deficiency, markedly increase the risk of developing HCC. (wikipedia.org)