• SCF ligases have four subunits: SKP1, CUL1, RBX1, and an F-box protein for substrate recognition. (1library.net)
  • The substrate recognition subunits of the SCF are the adaptor SKP1-like protein (ASK1 in plants) and a substrate binding F-box protein (reviewed in Cardozoand Pagano 2004). (1library.net)
  • For instance, CRL1 complexes (also called SkpCCulCF-box, or SCF, complexes) come with an adaptor proteins known as Skp1 that forms a connection between the Cul1 scaffolding proteins as well as the substrate receptor (an F-box proteins). (kentlandsinitiative.org)
  • GGAs (Golgi-localising, Gamma-adaptin ear domain homology, ARF-binding proteins) are a group of related proteins (three in humans) that act as monomeric clathrin adaptor proteins in various important membrane vesicle traffickings, but are not similar to any of the AP complexes and will not be discussed in detail in this article. (wikipedia.org)
  • AP-5 is associated with 2 proteins, SPG11 and SPG15, which have some structural similarity to clathrin, and may form the coat around the AP-5 complex, but the ultrastructure of that coat is not known. (wikipedia.org)
  • These clathrin-associated complexes are ancient and found in most eukaryotes. (eu.org)
  • They serve to initiate clathrin-mediated endocytosis or protein sorting and can work synergistically with the adaptin mu subunit binding YxxPhi-type motifs ( TRG_ENDOCYTIC_2 ). (eu.org)
  • CRLs are multisubunit complexes nucleated with a cullin (Cul) proteins that acts as a scaffold onto which an E3 ubiquitin ligase (Rbx1), an adaptor subunit, and a substrate receptor are set up (4, 5). (kentlandsinitiative.org)
  • CRLs could be subdivided based on the relationship between their Cul scaffold subunits and their adaptors. (kentlandsinitiative.org)
  • This gene encodes a DNA-binding protein which has high specificity for scaffold or matrixattachment region DNA elements (S/MAR DNA). (immune-source.com)
  • Depending on organism, cell type as well as the nature of the adaptin complex bound, they can target either to cell surface or to specific, internal membrane-bound organelles (endosomes, lysosomes, melanosomes, synaptic vesicles, etc. (eu.org)
  • All these motifs are believed to bind to the sigma subunit of activated adaptin complexes (AP-1, AP-2 and AP-3). (eu.org)
  • One should avoid confusing the adaptin sigma-binding classical dileucine motifs discussed here, and the GGA-binding lysosomal targeting motifs (sometimes also called dileucine motifs). (eu.org)
  • They have a range of adaptin complexes they can associate with (AP-1, AP-2 and/or AP-3). (eu.org)
  • Adaptin-binding acidic dileucine motifs and variants thereof occur almost exclusively on the cytosolic side of membrane proteins, mostly integral (transmembrane) proteins. (eu.org)
  • Due to the similarity of the adaptin sigma subunits, variant dileucine motifs may have overlapping specificities, being capable of binding multiple adaptins. (eu.org)
  • Aps1, sigma subunit of the adaptin 1 complex [Ensembl]. (ntu.edu.sg)
  • Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus. (lookformedical.com)
  • HE ubiquitin pathway catalyzes the post-translational modification of substrate proteins with the small protein ubiquitin, and it includes the enzymes catabo-lizing ubiquitylated proteins and additional proteins regulating the process. (1library.net)
  • E3 ubiquitin ligases formulated with a Band area are more prevalent, and these E3s provide as a bridge between an E2 enzyme having ubiquitin as well as the substrate proteins getting targeted for degradation (1,C3). (kentlandsinitiative.org)
  • It bears no evident homology to any identified protein Recentin and its expression pattern is quite much like that of tau. (aktinhibitor.com)
  • The Bcl-2 homology 3 (BH3) domain is crucial for the death-inducing and dimerization properties of pro-apoptotic members of the Bcl-2 protein family, including Bak, Bax, and Bad. (lookformedical.com)
  • All NSP proteins contain an NH 2 -terminal SH2 (Src homology domain 2) domain, a central proline/serine-rich domain, and a COOH-terminal domain with modest homology to Ras subfamily GDP-exchange factors (GEFs). (molvis.org)
  • The substantial reduction in synthesis of α-zeins results in smaller, less numerous protein bodies and a concomitant increase in non-zein endosperm proteins [ 3 ]. (biomedcentral.com)
  • Reduced synthesis of the lysine-poor zein proteins and compensatory increases in other proteins dramatically improves the nutritional quality of the grain. (biomedcentral.com)
  • The underlying mechanism for rebalancing amino acid content for both o2 and RNAi is unclear, although it depends on reduced synthesis of the zein storage proteins and a compensatory increase in non-zein protein content [ 17 ]. (biomedcentral.com)
  • Moreover, protein synthesis by the cytosolic ribosomes of eukaryotes does not involve the formylation of N-terminal Met. (microbialcell.com)
  • Additionally, we detected increased levels of active glycogen synthase kinase 3 β, a physiological kinase of TAU, in neurons derived from AD iPSCs, as well as significant upregulation of amyloid precursor protein (APP) synthesis and APP carboxy-terminal fragment cleavage. (biomedcentral.com)
  • Biochemical reconstitution demonstrates that the mammalian complex possesses inherent E3 ubiquitin ligase activity, using Ube2H as its cognate E2. (elifesciences.org)
  • Particularly in yeast, an organism where gluconeogenesis and glycolytic activity are intermittently coordinated, the multi-subunit GID E3 ligase complex specifically targets the surplus of gluconeogenic enzymes, including the conserved Fructose-1,6-bisphosphatase 1 (Fbp1), for proteasomal degradation. (elifesciences.org)
  • Rab40c is a SOCS box-containing protein which binds Cullin5 to form a ubiquitin E3 ligase complex (Rab40c/CRL5) to regulate protein ubiquitylation. (life-science-alliance.org)
  • Right here, we present that NSP1 protein from different rotavirus strains associate using the scaffolding protein Cul1 and Cul3 of CRL ubiquitin ligase complexes. (kentlandsinitiative.org)
  • Thecul1-7mutation affects the C terminus of the protein, results in reduced cul1-7 levels, and interferes with RBX1 interaction.cul1-7seedlings are defective in degradation of an endogenous SCF substrate, Repressor ofga1-3(RGA), and have altered responses to gibberellins.cul1-7seedlings exhibit slower degradation of the light-labile red/far-red photoreceptor phytochrome A and are photomorpho-genic in the dark. (1library.net)
  • The most recent common ancestor (MRCA) of the eukaryotes must have had a mechanism for trafficking molecules between its endomembranes and organelles, and the likely identity of the adaptor complex involved has been reported. (wikipedia.org)
  • In higher eukaryotes, dynein/dynactin requires additional components such as Bicaudal D to form an active motor complex and for regulating its cellular localization. (biologists.com)
  • One possibility is that the similarity of the formyl and acetyl groups, their identical locations in N‑terminally formylated (Nt‑formylated) and Nt-acetylated proteins, and the recently discovered proteolytic function of Nt-acetylation in eukaryotes might also signify a proteolytic role of Nt‑formylation in bacteria. (microbialcell.com)
  • We suggest that the faster emergence of nascent proteins from bacterial ribosomes is one mechanistic and evolutionary reason for the pretranslational design of bacterial fMet/N‑degrons, in contrast to the cotranslational design of analogous Ac/N‑degrons in eukaryotes. (microbialcell.com)
  • This mutation represents the first reported allele ofCUL1to directly affect subunit interactions at the CUL1 C terminus. (1library.net)
  • non-etheless, knockdown of Cul1 and Cul3 shows that NSP1 induces the degradation of some focus on protein separately of its association with S1PR4 CRL complexes, stressing a have to additional investigate the mechanistic information on how NSP1 subverts the web host IFN response. (kentlandsinitiative.org)
  • In the latter, they are frequently located near the protein N- or C-termini, with relative proximity (within 10-100aa) to a transmembrane segment. (eu.org)
  • Mechanistically, we found that Rab40c binds the protein phosphatase 6 (PP6) complex and ubiquitylates one of its subunits, ankyrin repeat domain 28 (ANKRD28), thus leading to its lysosomal degradation. (life-science-alliance.org)
  • protein_coding" "Cz01g27080.t1","No alias","Chromochloris zofingiensis","Solute-binding protein family 5 domain [Interproscan]. (ntu.edu.sg)
  • protein_coding" "Cz02g09110.t1","No alias","Chromochloris zofingiensis","2-hydroxy-palmitic acid dioxygenase Mpo1-like [Interproscan]. (ntu.edu.sg)
  • protein_coding" "Cz03g01030.t1","No alias","Chromochloris zofingiensis","Rieske [2Fe-2S] iron-sulphur domain [Interproscan]. (ntu.edu.sg)
  • These complexes concentrate the correct cargo molecules in vesicles that bud or extrude off of one organelle and travel to another location, where the cargo is delivered. (wikipedia.org)
  • These are examples of the much larger set of cargo adaptors. (wikipedia.org)
  • small subunit sigma of AP-1 trans-Golgi network cargo. (ntu.edu.sg)
  • small subunit sigma of AP-3 Golgi to vacuole cargo. (ntu.edu.sg)
  • A hallmark of proteome balance is the ubiquitin-proteasome system (UPS) that degrades roughly 80% of multi-ubiquitinated proteins ( Collins and Goldberg, 2017 ). (elifesciences.org)
  • Many aspects of plant biology depend on the ubiquitin proteasome system for degradation of regulatory proteins. (1library.net)
  • The latter dileucine motifs were implicated in membrane protein sorting to vacuoles or tonoplasts. (eu.org)
  • In fungi and plants, dileucine motifs are often responsible for the vacuolar or tonoplast localization of proteins carrying these motifs. (eu.org)
  • Triangle network motifs predict complexes by complementing high-error interactomes with structural information. (leibniz-fli.de)
  • AP complex, mu/sigma subunit [Interproscan]. (ntu.edu.sg)
  • Interestingly, ID-associated genes exhibit promoter-localized MER41 LTRs that harbor TF binding sites (TFBSs) for not only STAT1 but also other immune TFs such as, in particular, NFKB1 (Nuclear Factor Kappa B Subunit 1) and STAT3 (Signal Transducer And Activator Of Transcription 3). (biorxiv.org)
  • Intersecting analysis, molecular docking, and pathway validation analysis showed that risperidone influences the adipocytokine signaling pathway by targeting MAPK14 (mitogen-activated protein kinase 14), MAPK8 (mitogen-activated protein kinase 8), and RXRA (retinoic acid receptor RXR-alpha), thereby inhibiting long-chain fatty acid β-oxidation by decreasing STAT3 (signal transducer and activator of transcription 3) expression and phosphorylation. (frontiersin.org)
  • Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. (lookformedical.com)
  • It is involved in theregulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressorand is a candidate for breast tumorigenesis. (immune-source.com)
  • Newly formed nascent adhesions gradually grow and change their protein composition to mature into FAs. (life-science-alliance.org)
  • NASCENT: An automatic protein interaction network generation tool for non-model organisms. (leibniz-fli.de)
  • Starting with a degron: N-terminal formyl-methionine of nascent bacterial proteins contributes to their proteolytic control. (microbialcell.com)
  • In bacteria, all nascent proteins bear the pretranslationally formed N-terminal formyl-methionine (fMet) residue. (microbialcell.com)
  • By developing a holistic approach to tackle the complexity of interactions, we decipher the complex intra-host interactions underlying Pacific oyster mortality syndrome affecting juveniles of Crassostrea gigas , the main oyster species exploited worldwide. (nature.com)
  • The objective of the present work was to examine one disease of complex aetiology affecting one of the most utilized invertebrate species in the world, the Pacific oyster Crassostrea gigas , applying a holistic approach to decipher the phenomenon. (nature.com)
  • Avian species do not have brown adipose tissue (BAT), and lack Uncoupling Protein 1 ( UCP1 ) [ 12 ]. (biomedcentral.com)
  • Proteins that originate from insect species belonging to the genus DROSOPHILA. (lookformedical.com)
  • The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development. (lookformedical.com)
  • Ubiquitin E3 ligases confer substrate specificity in this pathway, and SCF-type ligases comprise a major class of E3s. (1library.net)
  • Ubiquitin ligases constitute the largest enzyme class in the ubiquitin pathway and in most cases confer substrate specificity. (1library.net)
  • E3 ubiquitin ligases will be the primary determinant of substrate specificity and could exist as one protein or as multisubunit complexes. (kentlandsinitiative.org)
  • Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. (lookformedical.com)
  • In mammals CASK was discovered due to its ability to bind to the cytosolic tail of neuronal adhesion molecules neurexins and therefore is primarily identified as a scaffolding protein at the neuronal synapse [ 21 ]. (biomedcentral.com)
  • Efficient phosphorylation requires that PKA be anchored close to its targets by A-kinase anchoring proteins (AKAPs). (biomedcentral.com)
  • However, since these kinases regulate a broad range of cellular responses, their compartmentalization in close proximity to their sarcomeric targets is required to facilitate control over which proteins are phosphorylated in response to second messenger signalling [ 8 , 9 ]. (biomedcentral.com)
  • However, the exact functions of Rab40c remain to be determined, and what proteins are the targets of Rab40c-Cullin5-mediated ubiquitylation in mammalian cells are unknown. (life-science-alliance.org)
  • Spindly is a protein that targets dynein/dynactin to kinetochores in mitosis and can activate its motility in vitro . (biologists.com)
  • Protein-protein interaction inhibition (2P2I): fewer and fewer undruggable targets. (leibniz-fli.de)
  • At the same time, co-compartmentalization of enzymes or proteins that generate or terminate these second messenger metabolites, such as the phosphodiesterases (PDEs) which degrade cAMP and cGMP, with the relevant responsive kinases helps to optimise the precision and speed of response to second messenger signaling [ 10 ]. (biomedcentral.com)
  • Conjugation of ubiquitin to a focus on proteins occurs with the sequential actions of three types of enzymes: a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin-ligating enzyme (E3). (kentlandsinitiative.org)
  • We found that Homer3, the predominant isoform in Purkinje cells, is phosphorylated by calcium/calmodulin-dependent protein kinase II (CaMKII) both in vitro and in vivo . (jneurosci.org)
  • In this study, we revealed that Homer3 was phosphorylated by calcium/calmodulin-dependent protein kinase II (CaMKII) in Purkinje cells, and the phosphorylation reduces the affinity for Homer target molecules, resulting in change of the solubility. (jneurosci.org)
  • Cardiac contractility is regulated by dynamic phosphorylation of sarcomeric proteins by kinases such as cAMP-activated protein kinase A (PKA). (biomedcentral.com)
  • The phenotypic spectrum among girls with heterozygous mutations in the X-linked intellectual disability (XLID) gene CASK (calcium/calmodulin-dependent serine protein kinase) includes postnatal microcephaly, ponto-cerebellar hypoplasia, seizures, optic nerve hypoplasia, growth retardation and hypotonia. (biomedcentral.com)
  • CASK is an evolutionarily conserved gene which encodes for a member of the membrane-associated guanylate kinase (MAGUK) protein family [ 31 ]. (biomedcentral.com)
  • The rcrB gene encodes a hypothetical membrane protein, deletion of which substantially increases UPEC's susceptibility to HOCl. (bvsalud.org)
  • The quantitative expression of ESBLs, outer membrane protein and multidrug efflux systems encoding genes of UE210113, Δpk1 and Δpk1-C were performed by using qRT-PCR analysis. (bvsalud.org)
  • The expression levels of ESBLs-enconding genes blaTEM and blaCTX-M-14 in Δpk1 were significantly down-regulated compared with UE210113, but the expression was not restored in Δpk1-C. The expression of outer membrane protein gene omp F in Δpk1 was significantly up-regulated, while the expression of omp A and omp C were down-regulated. (bvsalud.org)
  • Deciphering soluble and membrane protein function using yeast systems. (leibniz-fli.de)
  • Our biochemical and cellular analysis thus demonstrates that the GID/CTLH complex prevents cell cycle exit in G1, at least in part by degrading Hbp1. (elifesciences.org)
  • Cellular proteostasis involves the coordinated and compensatory action of pathways that control biogenesis, folding, trafficking and breakdown of proteins allowing the cell to adapt to physiological or pathological environmental changes. (elifesciences.org)
  • The full total outcomes indicate that, rather than positively using CRL complexes to induce degradation of focus on proteins necessary for IFN creation, NSP1 might use cullin-containing complexes to avoid another cellular activity. (kentlandsinitiative.org)
  • Ethanol can interfere with cell membrane's ability to act as a barrier, and interrupt key cellular processes such as protein biosynthesis, energy transduction and transport[ 8 ]. (biomedcentral.com)
  • Of note, functionally-relevant differences between humans and chimpanzees are observed regarding the 3 main components of this pathway: i) the protein sequences of immunes TFs binding MER41 LTRs, ii) the insertion sites of MER41 LTRs in the promoter regions of ID-associated genes and iii) the protein sequences of the targeted ID-associated genes. (biorxiv.org)
  • 2,693 sequences were identified in orthology groups spanning flukes, tapeworms and planaria, with 441 highlighted as belonging to druggable protein families. (biomedcentral.com)
  • Here, we report characterization of a mutant isolated from a genetic screen in Arabidopsis thalianadesigned to identify plants defective in degradation of an Aux/IAA fusion protein, Aux/IAA1-luciferase (IAA1-LUC). (1library.net)
  • Over 700 different F-box proteins have been postulated in Arabidopsis and rice (Gagne et al. (1library.net)
  • Sigma subunits of AP complexes differ slightly in their surface charge densities and binding groove geometry, allowing for both generic and selective interactions with protein partners. (eu.org)
  • Introduced to France in the 1970s, C . gigas suffers mass mortalities associated with complex interactions between the host, the environment and pathogens 5 . (nature.com)
  • The pathway maps illustrate protein interactions and regulation to provide a comprehensive picture of signaling and disease processes. (bio-rad.com)
  • Indeed, Hbp1 accumulates in cells lacking GID/CTLH activity, and Hbp1 physically interacts and is ubiquitinated in vitro by reconstituted GID/CTLH complexes. (elifesciences.org)
  • The F-box protein is the variable subunit of the complex and interacts directly with the substrate. (1library.net)
  • Classification of nonenzymatic homologues of protein kinases. (leibniz-fli.de)
  • To investigate this possibility, we assessed the ability of MMGL isoform 4 to interact with PKA regulatory subunits R1A and R2A using Y2H-based direct protein-protein interaction assays. (biomedcentral.com)
  • assays using purified protein verified that NSP1 particularly interacted with Cul3 which the N-terminal area TD-0212 of Cul3 was in charge of binding to NSP1. (kentlandsinitiative.org)
  • We addressed this hypothesis about fMet‑based degradation signals, termed fMet/N-degrons, using specific E. coli mutants, pulse-chase degradation assays, and protein reporters whose deformylation was altered, through site-directed mutagenesis, to be either rapid or relatively slow. (microbialcell.com)
  • Components of COPI (cop one) a coatomer, and TSET (T-set) a membrane trafficking complex have similar heterotetramers of the AP complexes. (wikipedia.org)
  • The exception is COPI, in which the 7 proteins are recruited to the membrane as a heptamer. (wikipedia.org)
  • To check if NSP1 utilized CRL3 to induce degradation of the mark proteins IRF3 or -TrCP, Cul3 amounts had been knocked down utilizing a little interfering RNA (siRNA) strategy. (kentlandsinitiative.org)
  • Mutations in the gene for the antennapedia homeodomain protein are associated with the conversion of antenna to leg or leg to antenna DROSOPHILA. (lookformedical.com)
  • Most cases of early-onset AD are linked to autosomal dominant inherited mutations in the genes encoding amyloid precursor protein ( APP ), presenilin 1 ( PSEN1 ), and presenilin 2 ( PSEN2 ). (biomedcentral.com)
  • The specificity and regulation of ubiquitylation remains a major focus of research. (1library.net)
  • An almost universal feature of coat assembly is the recruitment of the various adaptor complexes to the "donor" membrane by the protein Arf1. (wikipedia.org)
  • Another almost universal feature of coat assembly is that the adaptors are recruited first, and they then recruit the coats. (wikipedia.org)
  • Launch Proteins ubiquitination has become the utilized posttranslational adjustments and regulates many areas of cell biology broadly, including cell signaling, DNA harm responses, and proteins degradation (1). (kentlandsinitiative.org)
  • However, transcriptional dynamic regulation of adipose differentiation driven by complex signal cascades remains largely unexplored in this model. (biomedcentral.com)
  • Using biochemical assay, we also demonstrate that CASK can interact with metabolic proteins. (biomedcentral.com)
  • RESEARCH positive bacteria that contain accessory pilus proteins, that primers sipA_up and sipA_dn (Table 1) designed against serve as adhesins ( 15 - 17 ) or adaptors for pilus attachment the PI-2-specifi c gene sipA . (cdc.gov)
  • Risperidone upregulates fatty acid synthase (FASN) and sterol regulatory element-binding protein 1 (SREBP1) expression in hepatocyte cultures and mouse liver by targeting the hepatic SREBP-1c/FASN couple, which is also one of the mechanisms by which risperidone induces weight gain ( 24 ). (frontiersin.org)
  • Finally, a survey of the human proteome has allowed us to map a protein-protein network which links the identified immune/MER41/cognition pathway to FOXP2 (Forkhead Box P2), a key TF involved in the emergence of human speech. (biorxiv.org)
  • Systematic characterization of the protein interaction network and protein complexes in Saccharomyces cerevisiae using tandem affinity purification and mass spectrometry. (leibniz-fli.de)
  • Vesicular transport adaptor proteins are proteins involved in forming complexes that function in the trafficking of molecules from one subcellular location to another. (wikipedia.org)
  • Homer proteins are components of postsynaptic density (PSD) and play a crucial role in coupling diverse target molecules. (jneurosci.org)
  • Endocytosis and/or vesicular sorting signals for membrane proteins. (eu.org)
  • The two smaller proteins are a medium subunit named μ (mu ~50 kD) and a small subunit σ (sigma ~20 kD), and named 1 through 5 corresponding to the 5 AP complexes. (wikipedia.org)
  • Small molecule protein-protein interaction inhibitors as CNS therapeutic agents: current progress and future hurdles. (leibniz-fli.de)
  • Drosophila Decapping Protein 1, dDcp1, is a small but significant reduction in CycB levels in the pole cells (yellow arrow heads) are indicated. (gemologue.com)
  • Cardiac Myosin Binding Protein-C (cMyBPC) and cardiac troponin I (cTNI) are hypertrophic cardiomyopathy (HCM)-causing sarcomeric proteins which regulate contractility in response to PKA phosphorylation. (biomedcentral.com)
  • Proteins which bind to DNA. (lookformedical.com)
  • The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)
  • Scaffoldattachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind toS/MAR. The encoded protein is thought to serve as a molecular base to assemble atranscriptosome complex in the vicinity of actively transcribed genes. (immune-source.com)
  • 240 million paired-end reads were assembled de novo to produce a strictly filtered predicted proteome consisting of over 22,000 proteins. (biomedcentral.com)
  • Recently, we isolated a novel negative regulator of epidermal growth factor receptor (EGFR), termed EGFR-related protein (ERRP), whose expression attenuates EGFR activation. (aacrjournals.org)
  • Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL). (lookformedical.com)
  • Lamellipodial protrusion and directional migration of carcinoma cells towards chemoattractants, such as epidermal growth factor (EGF), depend upon the spatial and temporal regulation of actin cytoskeleton by actin-binding proteins (ABPs). (rupress.org)
  • Originally thought to have only a structural role, cMyBPC has been shown to play an important role in the regulation of cardiac contractility [ 1 ], for which the N-terminal region of the protein appears to be crucial. (biomedcentral.com)
  • CASK ortholog lin-2 was identified in C. elegans as early as 1980 and was found in screens for cell lineage specificity rather than synaptic function [ 16 , 24 ]. (biomedcentral.com)
  • There are several human disorders associated with defects in components of these complexes including Alzheimer's and Parkinson's diseases. (wikipedia.org)
  • Network properties of complex human disease genes identified through genome-wide association studies. (leibniz-fli.de)
  • Epsin and AP180 in the ANTH domain are other adaptor proteins that have been reviewed. (wikipedia.org)
  • Here, high mobility group box-1 (HMGB-1) protein was explored as a potential mediator of stress-induced microglial priming and whether HMGB-1 does so via the nucleotide-binding domain, leucine-rich repeat, pyrin domain containing protein 3 (NLRP3) inflammasome. (jneurosci.org)
  • Several other genetic backgrounds result in enlargement of the haltere significantly beyond the normal range of haploinsufficient phenotypes, suggesting genetic variation in cofactors that mediate homeotic protein function. (lookformedical.com)